Diagnosis of Disseminated Toxoplasmosis by Bronchoalveolar Lavage PCR in a Patient with AIDS
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Clinical and Biomedical Research |
Texto Completo: | https://seer.ufrgs.br/index.php/hcpa/article/view/6937 |
Resumo: | Pulmonary toxoplasmosis is a challenging diagnosis in immunosuppressed patients with nonspecific clinical picture and radiologic findings. We present a case of pneumonia due to Toxoplasma gondii diagnosed by polymerase chain reaction (PCR) in the bronchoalveolar lavage (BAL) fluid of a patient with acquired immunodeficiency syndrome (AIDS). Coinfection with Pneumocystis jirovecii was found in the same specimen. Direct examination and culture for bacteria, mycobacteria and other fungus were negative. Despite the intensive management, respiratory compromise evolved rapidly, with the need for ventilatory support. Acute respiratory distress syndrome developed, and the patient died of multiple organ failure. This case illustrates that a high index of suspicion is necessary for diagnosis of pulmonary toxoplasmosis, a potentially fatal condition. Due to high diagnostic performance, PCR in BAL fluid should be included in the evaluation of immunosuppressed patients with nonspecific pulmonary diseases. |
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Clinical and Biomedical Research |
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Diagnosis of Disseminated Toxoplasmosis by Bronchoalveolar Lavage PCR in a Patient with AIDSDiagnosis of Disseminated Toxoplasmosis by Polymerase Chain Reaction in Bronchoalveolar Lavage Fluid of a Patient with AIDSPCRHIVAIDStoxoplasmosisdisseminated toxoplasmosisPCRHIVAIDStoxoplasmosisdisseminated toxoplasmosisPulmonary toxoplasmosis is a challenging diagnosis in immunosuppressed patients with nonspecific clinical picture and radiologic findings. We present a case of pneumonia due to Toxoplasma gondii diagnosed by polymerase chain reaction (PCR) in the bronchoalveolar lavage (BAL) fluid of a patient with acquired immunodeficiency syndrome (AIDS). Coinfection with Pneumocystis jirovecii was found in the same specimen. Direct examination and culture for bacteria, mycobacteria and other fungus were negative. Despite the intensive management, respiratory compromise evolved rapidly, with the need for ventilatory support. Acute respiratory distress syndrome developed, and the patient died of multiple organ failure. This case illustrates that a high index of suspicion is necessary for diagnosis of pulmonary toxoplasmosis, a potentially fatal condition. Due to high diagnostic performance, PCR in BAL fluid should be included in the evaluation of immunosuppressed patients with nonspecific pulmonary diseases. Pulmonary toxoplasmosis is a challenging diagnosis in immunosuppressed patients with nonspecific clinical picture and radiologic findings. We present a case of pneumonia due to Toxoplasma gondii diagnosed by polymerase chain reaction (PCR) in the bronchoalveolar lavage (BAL) fluid of a patient with acquired immunodeficiency syndrome (AIDS). Coinfection with Pneumocystis jirovecii was found in the same specimen. Direct examination and culture for bacteria, mycobacteria and other fungus were negative. Despite the intensive management, respiratory compromise evolved rapidly, with the need for ventilatory support. Acute respiratory distress syndrome developed, and the patient died of multiple organ failure. This case illustrates that a high index of suspicion is necessary for diagnosis of pulmonary toxoplasmosis, a potentially fatal condition. Due to high diagnostic performance, PCR in BAL fluid should be included in the evaluation of immunosuppressed patients with nonspecific pulmonary diseases. HCPA/FAMED/UFRGS2009-08-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPeer-reviewed ArticleAvaliado por paresapplication/pdfhttps://seer.ufrgs.br/index.php/hcpa/article/view/6937Clinical & Biomedical Research; Vol. 29 No. 2 (2009): Revista HCPAClinical and Biomedical Research; v. 29 n. 2 (2009): Revista HCPA2357-9730reponame:Clinical and Biomedical Researchinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSporhttps://seer.ufrgs.br/index.php/hcpa/article/view/6937/5817Dora, Jose MiguelGeib, Guilhermede-Paris, FernandaMachado, Alice BeatrizFurlanetto, Tania Weberde Souza, Carolina Fischinger Mourados Santos, Rodrigo Piresinfo:eu-repo/semantics/openAccess2020-01-16T16:20:25Zoai:seer.ufrgs.br:article/6937Revistahttps://www.seer.ufrgs.br/index.php/hcpaPUBhttps://seer.ufrgs.br/index.php/hcpa/oai||cbr@hcpa.edu.br2357-97302357-9730opendoar:2020-01-16T16:20:25Clinical and Biomedical Research - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.none.fl_str_mv |
Diagnosis of Disseminated Toxoplasmosis by Bronchoalveolar Lavage PCR in a Patient with AIDS Diagnosis of Disseminated Toxoplasmosis by Polymerase Chain Reaction in Bronchoalveolar Lavage Fluid of a Patient with AIDS |
title |
Diagnosis of Disseminated Toxoplasmosis by Bronchoalveolar Lavage PCR in a Patient with AIDS |
spellingShingle |
Diagnosis of Disseminated Toxoplasmosis by Bronchoalveolar Lavage PCR in a Patient with AIDS Dora, Jose Miguel PCR HIV AIDS toxoplasmosis disseminated toxoplasmosis PCR HIV AIDS toxoplasmosis disseminated toxoplasmosis |
title_short |
Diagnosis of Disseminated Toxoplasmosis by Bronchoalveolar Lavage PCR in a Patient with AIDS |
title_full |
Diagnosis of Disseminated Toxoplasmosis by Bronchoalveolar Lavage PCR in a Patient with AIDS |
title_fullStr |
Diagnosis of Disseminated Toxoplasmosis by Bronchoalveolar Lavage PCR in a Patient with AIDS |
title_full_unstemmed |
Diagnosis of Disseminated Toxoplasmosis by Bronchoalveolar Lavage PCR in a Patient with AIDS |
title_sort |
Diagnosis of Disseminated Toxoplasmosis by Bronchoalveolar Lavage PCR in a Patient with AIDS |
author |
Dora, Jose Miguel |
author_facet |
Dora, Jose Miguel Geib, Guilherme de-Paris, Fernanda Machado, Alice Beatriz Furlanetto, Tania Weber de Souza, Carolina Fischinger Moura dos Santos, Rodrigo Pires |
author_role |
author |
author2 |
Geib, Guilherme de-Paris, Fernanda Machado, Alice Beatriz Furlanetto, Tania Weber de Souza, Carolina Fischinger Moura dos Santos, Rodrigo Pires |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Dora, Jose Miguel Geib, Guilherme de-Paris, Fernanda Machado, Alice Beatriz Furlanetto, Tania Weber de Souza, Carolina Fischinger Moura dos Santos, Rodrigo Pires |
dc.subject.por.fl_str_mv |
PCR HIV AIDS toxoplasmosis disseminated toxoplasmosis PCR HIV AIDS toxoplasmosis disseminated toxoplasmosis |
topic |
PCR HIV AIDS toxoplasmosis disseminated toxoplasmosis PCR HIV AIDS toxoplasmosis disseminated toxoplasmosis |
description |
Pulmonary toxoplasmosis is a challenging diagnosis in immunosuppressed patients with nonspecific clinical picture and radiologic findings. We present a case of pneumonia due to Toxoplasma gondii diagnosed by polymerase chain reaction (PCR) in the bronchoalveolar lavage (BAL) fluid of a patient with acquired immunodeficiency syndrome (AIDS). Coinfection with Pneumocystis jirovecii was found in the same specimen. Direct examination and culture for bacteria, mycobacteria and other fungus were negative. Despite the intensive management, respiratory compromise evolved rapidly, with the need for ventilatory support. Acute respiratory distress syndrome developed, and the patient died of multiple organ failure. This case illustrates that a high index of suspicion is necessary for diagnosis of pulmonary toxoplasmosis, a potentially fatal condition. Due to high diagnostic performance, PCR in BAL fluid should be included in the evaluation of immunosuppressed patients with nonspecific pulmonary diseases. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-08-04 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article Avaliado por pares |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://seer.ufrgs.br/index.php/hcpa/article/view/6937 |
url |
https://seer.ufrgs.br/index.php/hcpa/article/view/6937 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://seer.ufrgs.br/index.php/hcpa/article/view/6937/5817 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
HCPA/FAMED/UFRGS |
publisher.none.fl_str_mv |
HCPA/FAMED/UFRGS |
dc.source.none.fl_str_mv |
Clinical & Biomedical Research; Vol. 29 No. 2 (2009): Revista HCPA Clinical and Biomedical Research; v. 29 n. 2 (2009): Revista HCPA 2357-9730 reponame:Clinical and Biomedical Research instname:Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS |
instname_str |
Universidade Federal do Rio Grande do Sul (UFRGS) |
instacron_str |
UFRGS |
institution |
UFRGS |
reponame_str |
Clinical and Biomedical Research |
collection |
Clinical and Biomedical Research |
repository.name.fl_str_mv |
Clinical and Biomedical Research - Universidade Federal do Rio Grande do Sul (UFRGS) |
repository.mail.fl_str_mv |
||cbr@hcpa.edu.br |
_version_ |
1799767051314659328 |