Association of adipokines and adhesion molecules with indicators of obesity in women undergoing mammography screening

• Autor(a) principal: Souza, Caroline Isoppo de
• Data de Publicação: 2012
• Outros Autores: Rosa, Daniela Dornelles, Ettrich, Betina da Gama, Cibeira, Gabriela Herrmann, Giacomazzi, Juliana, Tusset, Paloma, Prolla, Patrícia Ashton, Medeiros, Lídia Rosi de Freitas, Caleffi, Maira, Camargo Neto, Eurico, Moriguchi, Emílio Hideyuki, Graudenz, Márcia Silveira
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFRGS
• Texto Completo: http://hdl.handle.net/10183/109963
• topic: Obesidade; Adiponectina; Inibidor 1 de ativador de plasminogênio; Molécula 1 de adesão de célula vascular; Molécula 1 de adesão intercelular; Obesity; Adiponectin; Plasminogen Activator Inhibitor type-1; Vascular Cell Adhesion Molecule-1; Intercellular Adhesion Molecule-1

Background: The soluble cell adhesion molecules and adipokines are elevated in patients with obesity, hypertension, type 2 diabetes mellitus, breast cancer and atherosclerosis. Objective: To investigate the relationship between anthropometric profile, dietary intake, lipid profile and fasting glycemia with serum levels of adipokines (adiponectin and PAI-1) and adhesion molecules (ICAM-1 and VCAM-1) in women without breast cancer undergoing routine mammographic screening. Design: Transversal study. Subjects: One hundred and forty-five women over 40-years old participated in this study. Results: In 39.3% of cases the BMI was above 30 kg/m2; 46.9% had hypertension, 14.5% had type 2 Diabetes Mellitus, 31.7% had dyslipidemia and 88.3% presented a waist-to-hip ratio ≥ 0.8. A linear correlation was found between serum levels of PAI-1 and triglycerides, between serum levels of PAI-1 and WHR and between serum levels of VCAM-1 and BMI. Conclusion: We found a high prevalence of obesity and metabolic syndrome. PAI-1 and VCAM-1 levels were correlated with clinical indicators of obesity and overweight.