Green propolis phenolic compounds act as vaccine adjuvants, improving humoral and cellular responses in mice inoculated with inactivated vaccines

• Autor(a) principal: Fischer, Geferson
• Data de Publicação: 2009
• Outros Autores: Paulino, Niraldo, Ribeiro, Maria Cristina Marcucci, Siedler, Bianca Sica, Munhoz, Lívia Silveira, Finger, Paula Fonseca, Vargas, Gilberto D`Avila, Hübner, Sílvia de Oliveira, Vidor, Telmo, Roehe, Paulo Michel
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFRGS
• Texto Completo: http://hdl.handle.net/10183/28852
• topic: Propolis; Compostos fenólicos; Vacinas; Imunidade celular; Imunidade humoral; Propolis; Phenolic compounds; Vaccines; Humoral immunity; Cellular immunity

Adjuvants play an important role in vaccine formulations by increasing their immunogenicity. In this study, the phenolic compound-rich J fraction (JFR) of a Brazilian green propolis methanolic extract stimulated cellular and humoral immune responses when co-administered with an inactivated vaccine against swine herpesvirus type 1 (SuHV-1). When compared to control vaccines that used aluminium hydroxide as an adjuvant, the use of 10 mg/dose of JFR significantly increased (p < 0.05) neutralizing antibody titres against SuHV-1, as well as the percentage of protected animals following SuHV-1 challenge (p < 0.01). Furthermore, addition of phenolic compounds potentiated the performance of the control vaccine, leading to increased cellular and humoral immune responses and enhanced protection of animals after SuHV-1 challenge (p < 0.05). Prenylated compounds such as Artepillin C that are found in large quantities in JFR are likely to be the substances that are responsible for the adjuvant activity.