The brief methylprednisolone administration is crucial to mitigate cardiac dysfunction after myocardial infarction
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/232629 |
Resumo: | Acute myocardial infarction (AMI) is one of the major causes of heart failure and mortality. Glucocorticoids administration post-infarction has long been proposed, but it has shown conflicting results so far. This controversy may be associated with the glucocorticoid type and the period when it is administered. To elucidate these, the present aims to evaluate if the brief methylprednisolone acetate administration is determinant for heart adaptation after AMI. Male Wistar rats were divided into 3 groups: sham-operated (SHAM); infarcted (AMI); infarcted treated with methylprednisolone acetate (AMI+M). Immediately after surgery, the AMI+M group received a single dose of methylprednisolone acetate (40 mg/kg i.m.). After 56 days, the cardiac function was assessed and lungs, liver and heart were collected to determine rates of hypertrophy and congestion. Heart was used for oxidative stress and metalloproteinase activity analyses. Methylprednisolone acetate attenuated matrix metalloproteinase-2 activity, cardiac dilatation, and prevented the onset of pulmonary congestion, as well as avoided cardiac hypertrophy. Our data indicate that administration of methylprednisolone acetate shortly after AMI may be a therapeutic alternative for attenuation of detrimental ventricular remodeling. |
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Bahr, Alan ChristhianLuz, Julia Paim daTeixeira, Rayane BrinckTurck, PatrickZimmer, AlexsandraCastro, Alexandre Luz deReis, Eduardo Echer dosVisioli, FernandaBelló-Klein, AdrianeAraújo, Alex Sander da RosaSchenkel, Paulo Cavalheiro2021-12-07T04:31:11Z20210001-3765http://hdl.handle.net/10183/232629001134416Acute myocardial infarction (AMI) is one of the major causes of heart failure and mortality. Glucocorticoids administration post-infarction has long been proposed, but it has shown conflicting results so far. This controversy may be associated with the glucocorticoid type and the period when it is administered. To elucidate these, the present aims to evaluate if the brief methylprednisolone acetate administration is determinant for heart adaptation after AMI. Male Wistar rats were divided into 3 groups: sham-operated (SHAM); infarcted (AMI); infarcted treated with methylprednisolone acetate (AMI+M). Immediately after surgery, the AMI+M group received a single dose of methylprednisolone acetate (40 mg/kg i.m.). After 56 days, the cardiac function was assessed and lungs, liver and heart were collected to determine rates of hypertrophy and congestion. Heart was used for oxidative stress and metalloproteinase activity analyses. Methylprednisolone acetate attenuated matrix metalloproteinase-2 activity, cardiac dilatation, and prevented the onset of pulmonary congestion, as well as avoided cardiac hypertrophy. Our data indicate that administration of methylprednisolone acetate shortly after AMI may be a therapeutic alternative for attenuation of detrimental ventricular remodeling.application/pdfengAnais da Academia Brasileira de Ciências. Rio de Janeiro. Vol. 93, supl. 4 (2021), e20210297, 15 p.Infarto do miocárdioAcetato de metilprednisolonaEstresse oxidativoMetaloproteinase 2 da matrizAcute myocardial infarctionHeart failureMetalloproteinaseMethylprednisolone acetateThe brief methylprednisolone administration is crucial to mitigate cardiac dysfunction after myocardial infarctioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001134416.pdf.txt001134416.pdf.txtExtracted Texttext/plain43628http://www.lume.ufrgs.br/bitstream/10183/232629/2/001134416.pdf.txtb99170c1a6982d2e5b416501c0d6846eMD52ORIGINAL001134416.pdfTexto completo (inglês)application/pdf6746212http://www.lume.ufrgs.br/bitstream/10183/232629/1/001134416.pdf6a00d7902d7633b6513c9e123e6d1ad1MD5110183/2326292021-12-09 05:34:33.491393oai:www.lume.ufrgs.br:10183/232629Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2021-12-09T07:34:33Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
The brief methylprednisolone administration is crucial to mitigate cardiac dysfunction after myocardial infarction |
title |
The brief methylprednisolone administration is crucial to mitigate cardiac dysfunction after myocardial infarction |
spellingShingle |
The brief methylprednisolone administration is crucial to mitigate cardiac dysfunction after myocardial infarction Bahr, Alan Christhian Infarto do miocárdio Acetato de metilprednisolona Estresse oxidativo Metaloproteinase 2 da matriz Acute myocardial infarction Heart failure Metalloproteinase Methylprednisolone acetate |
title_short |
The brief methylprednisolone administration is crucial to mitigate cardiac dysfunction after myocardial infarction |
title_full |
The brief methylprednisolone administration is crucial to mitigate cardiac dysfunction after myocardial infarction |
title_fullStr |
The brief methylprednisolone administration is crucial to mitigate cardiac dysfunction after myocardial infarction |
title_full_unstemmed |
The brief methylprednisolone administration is crucial to mitigate cardiac dysfunction after myocardial infarction |
title_sort |
The brief methylprednisolone administration is crucial to mitigate cardiac dysfunction after myocardial infarction |
author |
Bahr, Alan Christhian |
author_facet |
Bahr, Alan Christhian Luz, Julia Paim da Teixeira, Rayane Brinck Turck, Patrick Zimmer, Alexsandra Castro, Alexandre Luz de Reis, Eduardo Echer dos Visioli, Fernanda Belló-Klein, Adriane Araújo, Alex Sander da Rosa Schenkel, Paulo Cavalheiro |
author_role |
author |
author2 |
Luz, Julia Paim da Teixeira, Rayane Brinck Turck, Patrick Zimmer, Alexsandra Castro, Alexandre Luz de Reis, Eduardo Echer dos Visioli, Fernanda Belló-Klein, Adriane Araújo, Alex Sander da Rosa Schenkel, Paulo Cavalheiro |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Bahr, Alan Christhian Luz, Julia Paim da Teixeira, Rayane Brinck Turck, Patrick Zimmer, Alexsandra Castro, Alexandre Luz de Reis, Eduardo Echer dos Visioli, Fernanda Belló-Klein, Adriane Araújo, Alex Sander da Rosa Schenkel, Paulo Cavalheiro |
dc.subject.por.fl_str_mv |
Infarto do miocárdio Acetato de metilprednisolona Estresse oxidativo Metaloproteinase 2 da matriz |
topic |
Infarto do miocárdio Acetato de metilprednisolona Estresse oxidativo Metaloproteinase 2 da matriz Acute myocardial infarction Heart failure Metalloproteinase Methylprednisolone acetate |
dc.subject.eng.fl_str_mv |
Acute myocardial infarction Heart failure Metalloproteinase Methylprednisolone acetate |
description |
Acute myocardial infarction (AMI) is one of the major causes of heart failure and mortality. Glucocorticoids administration post-infarction has long been proposed, but it has shown conflicting results so far. This controversy may be associated with the glucocorticoid type and the period when it is administered. To elucidate these, the present aims to evaluate if the brief methylprednisolone acetate administration is determinant for heart adaptation after AMI. Male Wistar rats were divided into 3 groups: sham-operated (SHAM); infarcted (AMI); infarcted treated with methylprednisolone acetate (AMI+M). Immediately after surgery, the AMI+M group received a single dose of methylprednisolone acetate (40 mg/kg i.m.). After 56 days, the cardiac function was assessed and lungs, liver and heart were collected to determine rates of hypertrophy and congestion. Heart was used for oxidative stress and metalloproteinase activity analyses. Methylprednisolone acetate attenuated matrix metalloproteinase-2 activity, cardiac dilatation, and prevented the onset of pulmonary congestion, as well as avoided cardiac hypertrophy. Our data indicate that administration of methylprednisolone acetate shortly after AMI may be a therapeutic alternative for attenuation of detrimental ventricular remodeling. |
publishDate |
2021 |
dc.date.accessioned.fl_str_mv |
2021-12-07T04:31:11Z |
dc.date.issued.fl_str_mv |
2021 |
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0001-3765 |
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dc.relation.ispartof.pt_BR.fl_str_mv |
Anais da Academia Brasileira de Ciências. Rio de Janeiro. Vol. 93, supl. 4 (2021), e20210297, 15 p. |
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