Histaminergic system in brain disorders : lessons from the translational approach and future perspectives
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Data de Publicação: | 2014 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/179086 |
Resumo: | Histamine and its receptors were first described as part of immune and gastrointestinal systems, but their presence in the central nervous system and importance in behavior are gaining more attention. The histaminergic system modulates different processes including wakefulness, feeding, and learning and memory consolidation. Histamine receptors (H1R, H2R, H3R, and H4R) belong to the rhodopsin-like family of G protein-coupled receptors, present constitutive activity, and are subjected to inverse agonist action. The involvement of the histaminergic system in brain disorders, such as Alzheimer’s disease, schizophrenia, sleep disorders, drug dependence, and Parkinson’s disease, is largely studied. Data obtained from preclinical studies point antagonists of histamine receptors as promising alternatives to treat brain disorders. Thus, clinical trials are currently ongoing to assess the effects of these drugs on humans. This review summarizes the role of histaminergic system in brain disorders, as well as the effects of different histamine antagonists on animal models and humans. |
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Baronio, Diego MouraGonchoroski, TaylorCastro, KamilaZanatta, GeancarloGottfried, Carmem Juracy SilveiraRiesgo, Rudimar dos Santos2018-06-05T02:28:48Z20141744-859Xhttp://hdl.handle.net/10183/179086001068142Histamine and its receptors were first described as part of immune and gastrointestinal systems, but their presence in the central nervous system and importance in behavior are gaining more attention. The histaminergic system modulates different processes including wakefulness, feeding, and learning and memory consolidation. Histamine receptors (H1R, H2R, H3R, and H4R) belong to the rhodopsin-like family of G protein-coupled receptors, present constitutive activity, and are subjected to inverse agonist action. The involvement of the histaminergic system in brain disorders, such as Alzheimer’s disease, schizophrenia, sleep disorders, drug dependence, and Parkinson’s disease, is largely studied. Data obtained from preclinical studies point antagonists of histamine receptors as promising alternatives to treat brain disorders. Thus, clinical trials are currently ongoing to assess the effects of these drugs on humans. This review summarizes the role of histaminergic system in brain disorders, as well as the effects of different histamine antagonists on animal models and humans.application/pdfengAnnals of general psychiatry. London. Vol. 13 (Nov. 2014), 34, [10 p.]HistaminaEncefalopatiasTranstorno do espectro autistaAntagonistAutismBrain disordersHistamineHistaminergic systemHistaminergic system in brain disorders : lessons from the translational approach and future perspectivesEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL001068142.pdf001068142.pdfTexto completo (inglês)application/pdf257987http://www.lume.ufrgs.br/bitstream/10183/179086/1/001068142.pdfc59f4986abd5600e3c70c4d894fbca9cMD51TEXT001068142.pdf.txt001068142.pdf.txtExtracted Texttext/plain61175http://www.lume.ufrgs.br/bitstream/10183/179086/2/001068142.pdf.txtc9a5738df63107a7215f41812702cc7dMD5210183/1790862018-06-06 02:29:23.884869oai:www.lume.ufrgs.br:10183/179086Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2018-06-06T05:29:23Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Histaminergic system in brain disorders : lessons from the translational approach and future perspectives |
title |
Histaminergic system in brain disorders : lessons from the translational approach and future perspectives |
spellingShingle |
Histaminergic system in brain disorders : lessons from the translational approach and future perspectives Baronio, Diego Moura Histamina Encefalopatias Transtorno do espectro autista Antagonist Autism Brain disorders Histamine Histaminergic system |
title_short |
Histaminergic system in brain disorders : lessons from the translational approach and future perspectives |
title_full |
Histaminergic system in brain disorders : lessons from the translational approach and future perspectives |
title_fullStr |
Histaminergic system in brain disorders : lessons from the translational approach and future perspectives |
title_full_unstemmed |
Histaminergic system in brain disorders : lessons from the translational approach and future perspectives |
title_sort |
Histaminergic system in brain disorders : lessons from the translational approach and future perspectives |
author |
Baronio, Diego Moura |
author_facet |
Baronio, Diego Moura Gonchoroski, Taylor Castro, Kamila Zanatta, Geancarlo Gottfried, Carmem Juracy Silveira Riesgo, Rudimar dos Santos |
author_role |
author |
author2 |
Gonchoroski, Taylor Castro, Kamila Zanatta, Geancarlo Gottfried, Carmem Juracy Silveira Riesgo, Rudimar dos Santos |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Baronio, Diego Moura Gonchoroski, Taylor Castro, Kamila Zanatta, Geancarlo Gottfried, Carmem Juracy Silveira Riesgo, Rudimar dos Santos |
dc.subject.por.fl_str_mv |
Histamina Encefalopatias Transtorno do espectro autista |
topic |
Histamina Encefalopatias Transtorno do espectro autista Antagonist Autism Brain disorders Histamine Histaminergic system |
dc.subject.eng.fl_str_mv |
Antagonist Autism Brain disorders Histamine Histaminergic system |
description |
Histamine and its receptors were first described as part of immune and gastrointestinal systems, but their presence in the central nervous system and importance in behavior are gaining more attention. The histaminergic system modulates different processes including wakefulness, feeding, and learning and memory consolidation. Histamine receptors (H1R, H2R, H3R, and H4R) belong to the rhodopsin-like family of G protein-coupled receptors, present constitutive activity, and are subjected to inverse agonist action. The involvement of the histaminergic system in brain disorders, such as Alzheimer’s disease, schizophrenia, sleep disorders, drug dependence, and Parkinson’s disease, is largely studied. Data obtained from preclinical studies point antagonists of histamine receptors as promising alternatives to treat brain disorders. Thus, clinical trials are currently ongoing to assess the effects of these drugs on humans. This review summarizes the role of histaminergic system in brain disorders, as well as the effects of different histamine antagonists on animal models and humans. |
publishDate |
2014 |
dc.date.issued.fl_str_mv |
2014 |
dc.date.accessioned.fl_str_mv |
2018-06-05T02:28:48Z |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/179086 |
dc.identifier.issn.pt_BR.fl_str_mv |
1744-859X |
dc.identifier.nrb.pt_BR.fl_str_mv |
001068142 |
identifier_str_mv |
1744-859X 001068142 |
url |
http://hdl.handle.net/10183/179086 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Annals of general psychiatry. London. Vol. 13 (Nov. 2014), 34, [10 p.] |
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info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
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application/pdf |
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