Long-term treatment with clozapine and verbal memory performance in schizophrenia
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/201440 |
Resumo: | Clozapine is more efficacious than first-generation antipsychotics for positive and negative symptoms, although it is related with serious adverse effects. Because of this profile, it could also have an impact on cognition. Therefore, we evaluated learning ability of 31 treatment-resistant individuals with SZ using clozapine uninterruptedly for 18.23 ± 4.71 years and 26 non-treatment-resistant using other antipsychotics that never used clozapine. Long-term treatment with clozapine did not improve verbal learning ability better than other antipsychotics. Although clozapine has a unique profile for reducing clinical symptoms, it may not have an additional benefit for cognition when started later on the course of schizophrenia. |
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Czepielewski, Letícia SanguinettiLondero, Marina Dalla BarbaSousa, Mathias Hasse dePerin, Carolina PetryMaldonado, Helena CarvalhoClaudino, Felipe Cesar de AlmeidaGama, Clarissa Severino2019-11-08T03:43:14Z20182215-0013http://hdl.handle.net/10183/201440001073498Clozapine is more efficacious than first-generation antipsychotics for positive and negative symptoms, although it is related with serious adverse effects. Because of this profile, it could also have an impact on cognition. Therefore, we evaluated learning ability of 31 treatment-resistant individuals with SZ using clozapine uninterruptedly for 18.23 ± 4.71 years and 26 non-treatment-resistant using other antipsychotics that never used clozapine. Long-term treatment with clozapine did not improve verbal learning ability better than other antipsychotics. Although clozapine has a unique profile for reducing clinical symptoms, it may not have an additional benefit for cognition when started later on the course of schizophrenia.application/pdfengSchizophrenia research : cognition. New York. Vol. 12 (June 2018), p. 40-41ClozapinaEsquizofreniaAntipsicóticosLong-term treatment with clozapine and verbal memory performance in schizophreniaEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001073498.pdf.txt001073498.pdf.txtExtracted Texttext/plain10323http://www.lume.ufrgs.br/bitstream/10183/201440/2/001073498.pdf.txt07de551cde879806a7984440fae09f9aMD52ORIGINAL001073498.pdfTexto completo (inglês)application/pdf164040http://www.lume.ufrgs.br/bitstream/10183/201440/1/001073498.pdfa9bc2453f53413bbed94ca71492c3b6aMD5110183/2014402023-11-05 04:24:30.083987oai:www.lume.ufrgs.br:10183/201440Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-11-05T06:24:30Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Long-term treatment with clozapine and verbal memory performance in schizophrenia |
title |
Long-term treatment with clozapine and verbal memory performance in schizophrenia |
spellingShingle |
Long-term treatment with clozapine and verbal memory performance in schizophrenia Czepielewski, Letícia Sanguinetti Clozapina Esquizofrenia Antipsicóticos |
title_short |
Long-term treatment with clozapine and verbal memory performance in schizophrenia |
title_full |
Long-term treatment with clozapine and verbal memory performance in schizophrenia |
title_fullStr |
Long-term treatment with clozapine and verbal memory performance in schizophrenia |
title_full_unstemmed |
Long-term treatment with clozapine and verbal memory performance in schizophrenia |
title_sort |
Long-term treatment with clozapine and verbal memory performance in schizophrenia |
author |
Czepielewski, Letícia Sanguinetti |
author_facet |
Czepielewski, Letícia Sanguinetti Londero, Marina Dalla Barba Sousa, Mathias Hasse de Perin, Carolina Petry Maldonado, Helena Carvalho Claudino, Felipe Cesar de Almeida Gama, Clarissa Severino |
author_role |
author |
author2 |
Londero, Marina Dalla Barba Sousa, Mathias Hasse de Perin, Carolina Petry Maldonado, Helena Carvalho Claudino, Felipe Cesar de Almeida Gama, Clarissa Severino |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Czepielewski, Letícia Sanguinetti Londero, Marina Dalla Barba Sousa, Mathias Hasse de Perin, Carolina Petry Maldonado, Helena Carvalho Claudino, Felipe Cesar de Almeida Gama, Clarissa Severino |
dc.subject.por.fl_str_mv |
Clozapina Esquizofrenia Antipsicóticos |
topic |
Clozapina Esquizofrenia Antipsicóticos |
description |
Clozapine is more efficacious than first-generation antipsychotics for positive and negative symptoms, although it is related with serious adverse effects. Because of this profile, it could also have an impact on cognition. Therefore, we evaluated learning ability of 31 treatment-resistant individuals with SZ using clozapine uninterruptedly for 18.23 ± 4.71 years and 26 non-treatment-resistant using other antipsychotics that never used clozapine. Long-term treatment with clozapine did not improve verbal learning ability better than other antipsychotics. Although clozapine has a unique profile for reducing clinical symptoms, it may not have an additional benefit for cognition when started later on the course of schizophrenia. |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018 |
dc.date.accessioned.fl_str_mv |
2019-11-08T03:43:14Z |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/201440 |
dc.identifier.issn.pt_BR.fl_str_mv |
2215-0013 |
dc.identifier.nrb.pt_BR.fl_str_mv |
001073498 |
identifier_str_mv |
2215-0013 001073498 |
url |
http://hdl.handle.net/10183/201440 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Schizophrenia research : cognition. New York. Vol. 12 (June 2018), p. 40-41 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
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application/pdf |
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reponame:Repositório Institucional da UFRGS instname:Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS |
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Repositório Institucional da UFRGS |
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Repositório Institucional da UFRGS |
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