Human immunodeficiency virus in a cohort of systemic lupus erythematosus patients
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/196856 |
Resumo: | Background: Systemic lupus erythematosus (SLE) and acquired immunodeficiency syndrome (AIDS) share many clinical manifestations and laboratory findings, therefore, concomitant diagnosis of SLE and human immunodeficiency virus (HIV) can be challenging. Methods: Prospective cohort with 602 patients with SLE who attended the Rheumatology Clinic of the Hospital de Clínicas de Porto Alegre since 2000. All patients were followed until 01 May 2015 or until death, if earlier. Demographic, clinical and laboratory data were prospectively collected. Results: Out of the 602 patients, 11 presented with the diagnosis of AIDS (1.59%). The following variables were significantly more prevalent in patients with concomitant HIV and SLE: neuropsychiatric lupus (10.9% vs. 36.4%; p = 0.028) and smoking (37.6% vs. 80%; p = 0.0009) while malar rash was significantly less prevalent in this population (56% vs. 18.2%; p = 0.015). Nephritis (40.5% vs. 63.6%; p = 0.134) and hemolytic anemia (28.6% vs. 54.5%; p = 0.089) were more prevalent in SLE patients with HIV, but with no statistical significance compared with SLE patients without HIV. The SLICC damage index median in the last medical consultation was significantly higher in SLE patients with HIV (1 vs. 2; p = 0,047). Conclusions: Our patients with concomitant HIV and SLE have clinically more neuropsychiatric manifestations. For the first time, according to our knowledge, higher cumulative damage was described in lupus patients with concomitant HIV infection. Further studies are needed to elucidate this complex association, its outcomes, prognosis and which therapeutic approach it’s best for each case. |
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Hax, VanessaMoro, Ana Laura DidonetPiovesan, Rafaella RomeiroGoldani, Luciano ZubaranXavier, Ricardo MachadoMonticielo, Odirlei André2019-07-12T02:36:16Z20182523-3106http://hdl.handle.net/10183/196856001081783Background: Systemic lupus erythematosus (SLE) and acquired immunodeficiency syndrome (AIDS) share many clinical manifestations and laboratory findings, therefore, concomitant diagnosis of SLE and human immunodeficiency virus (HIV) can be challenging. Methods: Prospective cohort with 602 patients with SLE who attended the Rheumatology Clinic of the Hospital de Clínicas de Porto Alegre since 2000. All patients were followed until 01 May 2015 or until death, if earlier. Demographic, clinical and laboratory data were prospectively collected. Results: Out of the 602 patients, 11 presented with the diagnosis of AIDS (1.59%). The following variables were significantly more prevalent in patients with concomitant HIV and SLE: neuropsychiatric lupus (10.9% vs. 36.4%; p = 0.028) and smoking (37.6% vs. 80%; p = 0.0009) while malar rash was significantly less prevalent in this population (56% vs. 18.2%; p = 0.015). Nephritis (40.5% vs. 63.6%; p = 0.134) and hemolytic anemia (28.6% vs. 54.5%; p = 0.089) were more prevalent in SLE patients with HIV, but with no statistical significance compared with SLE patients without HIV. The SLICC damage index median in the last medical consultation was significantly higher in SLE patients with HIV (1 vs. 2; p = 0,047). Conclusions: Our patients with concomitant HIV and SLE have clinically more neuropsychiatric manifestations. For the first time, according to our knowledge, higher cumulative damage was described in lupus patients with concomitant HIV infection. Further studies are needed to elucidate this complex association, its outcomes, prognosis and which therapeutic approach it’s best for each case.application/pdfengAdvances in rheumatology. São Paulo. Vol. 58 (2018), 12, 7 p.Lupus eritematoso sistêmicoHIVSíndrome de imunodeficiência adquiridaInfecções oportunistasSystemic lupus erythematosusHuman immunodeficiency virusAcquired immunodeficiency syndromeNeuropsychiatric lupusOpportunistic infectionsHuman immunodeficiency virus in a cohort of systemic lupus erythematosus patientsinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001081783.pdf.txt001081783.pdf.txtExtracted Texttext/plain32601http://www.lume.ufrgs.br/bitstream/10183/196856/2/001081783.pdf.txta7e2a601c9a72848a024656cd61196afMD52ORIGINAL001081783.pdfTexto completo (inglês)application/pdf578465http://www.lume.ufrgs.br/bitstream/10183/196856/1/001081783.pdf127526d07338200257c9ee3e138176f2MD5110183/1968562023-05-24 03:25:50.804054oai:www.lume.ufrgs.br:10183/196856Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-05-24T06:25:50Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Human immunodeficiency virus in a cohort of systemic lupus erythematosus patients |
title |
Human immunodeficiency virus in a cohort of systemic lupus erythematosus patients |
spellingShingle |
Human immunodeficiency virus in a cohort of systemic lupus erythematosus patients Hax, Vanessa Lupus eritematoso sistêmico HIV Síndrome de imunodeficiência adquirida Infecções oportunistas Systemic lupus erythematosus Human immunodeficiency virus Acquired immunodeficiency syndrome Neuropsychiatric lupus Opportunistic infections |
title_short |
Human immunodeficiency virus in a cohort of systemic lupus erythematosus patients |
title_full |
Human immunodeficiency virus in a cohort of systemic lupus erythematosus patients |
title_fullStr |
Human immunodeficiency virus in a cohort of systemic lupus erythematosus patients |
title_full_unstemmed |
Human immunodeficiency virus in a cohort of systemic lupus erythematosus patients |
title_sort |
Human immunodeficiency virus in a cohort of systemic lupus erythematosus patients |
author |
Hax, Vanessa |
author_facet |
Hax, Vanessa Moro, Ana Laura Didonet Piovesan, Rafaella Romeiro Goldani, Luciano Zubaran Xavier, Ricardo Machado Monticielo, Odirlei André |
author_role |
author |
author2 |
Moro, Ana Laura Didonet Piovesan, Rafaella Romeiro Goldani, Luciano Zubaran Xavier, Ricardo Machado Monticielo, Odirlei André |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Hax, Vanessa Moro, Ana Laura Didonet Piovesan, Rafaella Romeiro Goldani, Luciano Zubaran Xavier, Ricardo Machado Monticielo, Odirlei André |
dc.subject.por.fl_str_mv |
Lupus eritematoso sistêmico HIV Síndrome de imunodeficiência adquirida Infecções oportunistas |
topic |
Lupus eritematoso sistêmico HIV Síndrome de imunodeficiência adquirida Infecções oportunistas Systemic lupus erythematosus Human immunodeficiency virus Acquired immunodeficiency syndrome Neuropsychiatric lupus Opportunistic infections |
dc.subject.eng.fl_str_mv |
Systemic lupus erythematosus Human immunodeficiency virus Acquired immunodeficiency syndrome Neuropsychiatric lupus Opportunistic infections |
description |
Background: Systemic lupus erythematosus (SLE) and acquired immunodeficiency syndrome (AIDS) share many clinical manifestations and laboratory findings, therefore, concomitant diagnosis of SLE and human immunodeficiency virus (HIV) can be challenging. Methods: Prospective cohort with 602 patients with SLE who attended the Rheumatology Clinic of the Hospital de Clínicas de Porto Alegre since 2000. All patients were followed until 01 May 2015 or until death, if earlier. Demographic, clinical and laboratory data were prospectively collected. Results: Out of the 602 patients, 11 presented with the diagnosis of AIDS (1.59%). The following variables were significantly more prevalent in patients with concomitant HIV and SLE: neuropsychiatric lupus (10.9% vs. 36.4%; p = 0.028) and smoking (37.6% vs. 80%; p = 0.0009) while malar rash was significantly less prevalent in this population (56% vs. 18.2%; p = 0.015). Nephritis (40.5% vs. 63.6%; p = 0.134) and hemolytic anemia (28.6% vs. 54.5%; p = 0.089) were more prevalent in SLE patients with HIV, but with no statistical significance compared with SLE patients without HIV. The SLICC damage index median in the last medical consultation was significantly higher in SLE patients with HIV (1 vs. 2; p = 0,047). Conclusions: Our patients with concomitant HIV and SLE have clinically more neuropsychiatric manifestations. For the first time, according to our knowledge, higher cumulative damage was described in lupus patients with concomitant HIV infection. Further studies are needed to elucidate this complex association, its outcomes, prognosis and which therapeutic approach it’s best for each case. |
publishDate |
2018 |
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2018 |
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2019-07-12T02:36:16Z |
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2523-3106 |
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001081783 |
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Advances in rheumatology. São Paulo. Vol. 58 (2018), 12, 7 p. |
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