Interaction between repeated restraint stress and concomitant midazolam administration on sweet food ingestion in rats

Detalhes bibliográficos
Autor(a) principal: Silveira, Patrícia Pelufo
Data de Publicação: 2000
Outros Autores: Xavier, Marcia Henriques, Souza, Fabiano Hahn, Manoli, Luciana Pacheco, Rosat, Renata Menezes, Ferreira, Maria Beatriz Cardoso, Dalmaz, Carla
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/21165
Resumo: Emotional changes can influence feeding behavior. Previous studies have shown that chronically stressed animals present increased ingestion of sweet food, an effect reversed by a single dose of diazepam administered before testing the animals. The aim of the present study was to evaluate the response of animals chronically treated with midazolam and/or submitted to repeated restraint stress upon the ingestion of sweet food. Male adult Wistar rats were divided into two groups: controls and exposed to restraint 1 h/day, 5 days/week for 40 days. Both groups were subdivided into two other groups treated or not with midazolam (0.06 mg/ml in their drinking water during the 40- day treatment). The animals were placed in a lighted area in the presence of 10 pellets of sweet food (Froot loops®). The number of ingested pellets was measured during a period of 3 min, in the presence or absence of fasting. The group chronically treated with midazolam alone presented increased ingestion when compared to control animals (control group: 2.0 ± 0.44 pellets and midazolam group: 3.60 ± 0.57 pellets). The group submitted to restraint stress presented an increased ingestion compared to controls (control group: 2.0 ± 0.44 pellets and stressed group: 4.18 ± 0.58 pellets). Chronically administered midazolam reduced the ingestion in stressed animals (stressed/ water group: 4.18 ± 0.58 pellets; stressed/midazolam group: 3.2 ± 0.49 pellets). Thus, repeated stress increases appetite for sweet food independently of hunger and chronic administration of midazolam can decrease this behavioral effect.
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spelling Silveira, Patrícia PelufoXavier, Marcia HenriquesSouza, Fabiano HahnManoli, Luciana PachecoRosat, Renata MenezesFerreira, Maria Beatriz CardosoDalmaz, Carla2010-04-24T04:15:33Z20000100-879Xhttp://hdl.handle.net/10183/21165000297409Emotional changes can influence feeding behavior. Previous studies have shown that chronically stressed animals present increased ingestion of sweet food, an effect reversed by a single dose of diazepam administered before testing the animals. The aim of the present study was to evaluate the response of animals chronically treated with midazolam and/or submitted to repeated restraint stress upon the ingestion of sweet food. Male adult Wistar rats were divided into two groups: controls and exposed to restraint 1 h/day, 5 days/week for 40 days. Both groups were subdivided into two other groups treated or not with midazolam (0.06 mg/ml in their drinking water during the 40- day treatment). The animals were placed in a lighted area in the presence of 10 pellets of sweet food (Froot loops®). The number of ingested pellets was measured during a period of 3 min, in the presence or absence of fasting. The group chronically treated with midazolam alone presented increased ingestion when compared to control animals (control group: 2.0 ± 0.44 pellets and midazolam group: 3.60 ± 0.57 pellets). The group submitted to restraint stress presented an increased ingestion compared to controls (control group: 2.0 ± 0.44 pellets and stressed group: 4.18 ± 0.58 pellets). Chronically administered midazolam reduced the ingestion in stressed animals (stressed/ water group: 4.18 ± 0.58 pellets; stressed/midazolam group: 3.2 ± 0.49 pellets). Thus, repeated stress increases appetite for sweet food independently of hunger and chronic administration of midazolam can decrease this behavioral effect.application/pdfengBrazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Ribeirão Preto, SP. Vol. 33, no. 11 (Nov. 2000), p. 1343-1350BioquímicaFeeding behaviorChronic stressBenzodiazepinesMidazolamSweet tasteRatsInteraction between repeated restraint stress and concomitant midazolam administration on sweet food ingestion in ratsinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000297409.pdf000297409.pdfTexto completo (inglês)application/pdf110222http://www.lume.ufrgs.br/bitstream/10183/21165/1/000297409.pdf2cd78b8faba05441a31a37ef5423acddMD51TEXT000297409.pdf.txt000297409.pdf.txtExtracted Texttext/plain29034http://www.lume.ufrgs.br/bitstream/10183/21165/2/000297409.pdf.txtcad999ac5f6393083f7094a7374d0b48MD52THUMBNAIL000297409.pdf.jpg000297409.pdf.jpgGenerated Thumbnailimage/jpeg1718http://www.lume.ufrgs.br/bitstream/10183/21165/3/000297409.pdf.jpg5fa96f2a16e2f4fa7a15ded849535fc6MD5310183/211652021-11-20 05:59:45.924927oai:www.lume.ufrgs.br:10183/21165Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2021-11-20T07:59:45Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Interaction between repeated restraint stress and concomitant midazolam administration on sweet food ingestion in rats
title Interaction between repeated restraint stress and concomitant midazolam administration on sweet food ingestion in rats
spellingShingle Interaction between repeated restraint stress and concomitant midazolam administration on sweet food ingestion in rats
Silveira, Patrícia Pelufo
Bioquímica
Feeding behavior
Chronic stress
Benzodiazepines
Midazolam
Sweet taste
Rats
title_short Interaction between repeated restraint stress and concomitant midazolam administration on sweet food ingestion in rats
title_full Interaction between repeated restraint stress and concomitant midazolam administration on sweet food ingestion in rats
title_fullStr Interaction between repeated restraint stress and concomitant midazolam administration on sweet food ingestion in rats
title_full_unstemmed Interaction between repeated restraint stress and concomitant midazolam administration on sweet food ingestion in rats
title_sort Interaction between repeated restraint stress and concomitant midazolam administration on sweet food ingestion in rats
author Silveira, Patrícia Pelufo
author_facet Silveira, Patrícia Pelufo
Xavier, Marcia Henriques
Souza, Fabiano Hahn
Manoli, Luciana Pacheco
Rosat, Renata Menezes
Ferreira, Maria Beatriz Cardoso
Dalmaz, Carla
author_role author
author2 Xavier, Marcia Henriques
Souza, Fabiano Hahn
Manoli, Luciana Pacheco
Rosat, Renata Menezes
Ferreira, Maria Beatriz Cardoso
Dalmaz, Carla
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silveira, Patrícia Pelufo
Xavier, Marcia Henriques
Souza, Fabiano Hahn
Manoli, Luciana Pacheco
Rosat, Renata Menezes
Ferreira, Maria Beatriz Cardoso
Dalmaz, Carla
dc.subject.por.fl_str_mv Bioquímica
topic Bioquímica
Feeding behavior
Chronic stress
Benzodiazepines
Midazolam
Sweet taste
Rats
dc.subject.eng.fl_str_mv Feeding behavior
Chronic stress
Benzodiazepines
Midazolam
Sweet taste
Rats
description Emotional changes can influence feeding behavior. Previous studies have shown that chronically stressed animals present increased ingestion of sweet food, an effect reversed by a single dose of diazepam administered before testing the animals. The aim of the present study was to evaluate the response of animals chronically treated with midazolam and/or submitted to repeated restraint stress upon the ingestion of sweet food. Male adult Wistar rats were divided into two groups: controls and exposed to restraint 1 h/day, 5 days/week for 40 days. Both groups were subdivided into two other groups treated or not with midazolam (0.06 mg/ml in their drinking water during the 40- day treatment). The animals were placed in a lighted area in the presence of 10 pellets of sweet food (Froot loops®). The number of ingested pellets was measured during a period of 3 min, in the presence or absence of fasting. The group chronically treated with midazolam alone presented increased ingestion when compared to control animals (control group: 2.0 ± 0.44 pellets and midazolam group: 3.60 ± 0.57 pellets). The group submitted to restraint stress presented an increased ingestion compared to controls (control group: 2.0 ± 0.44 pellets and stressed group: 4.18 ± 0.58 pellets). Chronically administered midazolam reduced the ingestion in stressed animals (stressed/ water group: 4.18 ± 0.58 pellets; stressed/midazolam group: 3.2 ± 0.49 pellets). Thus, repeated stress increases appetite for sweet food independently of hunger and chronic administration of midazolam can decrease this behavioral effect.
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dc.relation.ispartof.pt_BR.fl_str_mv Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Ribeirão Preto, SP. Vol. 33, no. 11 (Nov. 2000), p. 1343-1350
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