Interaction between repeated restraint stress and concomitant midazolam administration on sweet food ingestion in rats
Autor(a) principal: | |
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Data de Publicação: | 2000 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/21165 |
Resumo: | Emotional changes can influence feeding behavior. Previous studies have shown that chronically stressed animals present increased ingestion of sweet food, an effect reversed by a single dose of diazepam administered before testing the animals. The aim of the present study was to evaluate the response of animals chronically treated with midazolam and/or submitted to repeated restraint stress upon the ingestion of sweet food. Male adult Wistar rats were divided into two groups: controls and exposed to restraint 1 h/day, 5 days/week for 40 days. Both groups were subdivided into two other groups treated or not with midazolam (0.06 mg/ml in their drinking water during the 40- day treatment). The animals were placed in a lighted area in the presence of 10 pellets of sweet food (Froot loops®). The number of ingested pellets was measured during a period of 3 min, in the presence or absence of fasting. The group chronically treated with midazolam alone presented increased ingestion when compared to control animals (control group: 2.0 ± 0.44 pellets and midazolam group: 3.60 ± 0.57 pellets). The group submitted to restraint stress presented an increased ingestion compared to controls (control group: 2.0 ± 0.44 pellets and stressed group: 4.18 ± 0.58 pellets). Chronically administered midazolam reduced the ingestion in stressed animals (stressed/ water group: 4.18 ± 0.58 pellets; stressed/midazolam group: 3.2 ± 0.49 pellets). Thus, repeated stress increases appetite for sweet food independently of hunger and chronic administration of midazolam can decrease this behavioral effect. |
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Silveira, Patrícia PelufoXavier, Marcia HenriquesSouza, Fabiano HahnManoli, Luciana PachecoRosat, Renata MenezesFerreira, Maria Beatriz CardosoDalmaz, Carla2010-04-24T04:15:33Z20000100-879Xhttp://hdl.handle.net/10183/21165000297409Emotional changes can influence feeding behavior. Previous studies have shown that chronically stressed animals present increased ingestion of sweet food, an effect reversed by a single dose of diazepam administered before testing the animals. The aim of the present study was to evaluate the response of animals chronically treated with midazolam and/or submitted to repeated restraint stress upon the ingestion of sweet food. Male adult Wistar rats were divided into two groups: controls and exposed to restraint 1 h/day, 5 days/week for 40 days. Both groups were subdivided into two other groups treated or not with midazolam (0.06 mg/ml in their drinking water during the 40- day treatment). The animals were placed in a lighted area in the presence of 10 pellets of sweet food (Froot loops®). The number of ingested pellets was measured during a period of 3 min, in the presence or absence of fasting. The group chronically treated with midazolam alone presented increased ingestion when compared to control animals (control group: 2.0 ± 0.44 pellets and midazolam group: 3.60 ± 0.57 pellets). The group submitted to restraint stress presented an increased ingestion compared to controls (control group: 2.0 ± 0.44 pellets and stressed group: 4.18 ± 0.58 pellets). Chronically administered midazolam reduced the ingestion in stressed animals (stressed/ water group: 4.18 ± 0.58 pellets; stressed/midazolam group: 3.2 ± 0.49 pellets). Thus, repeated stress increases appetite for sweet food independently of hunger and chronic administration of midazolam can decrease this behavioral effect.application/pdfengBrazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Ribeirão Preto, SP. Vol. 33, no. 11 (Nov. 2000), p. 1343-1350BioquímicaFeeding behaviorChronic stressBenzodiazepinesMidazolamSweet tasteRatsInteraction between repeated restraint stress and concomitant midazolam administration on sweet food ingestion in ratsinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000297409.pdf000297409.pdfTexto completo (inglês)application/pdf110222http://www.lume.ufrgs.br/bitstream/10183/21165/1/000297409.pdf2cd78b8faba05441a31a37ef5423acddMD51TEXT000297409.pdf.txt000297409.pdf.txtExtracted Texttext/plain29034http://www.lume.ufrgs.br/bitstream/10183/21165/2/000297409.pdf.txtcad999ac5f6393083f7094a7374d0b48MD52THUMBNAIL000297409.pdf.jpg000297409.pdf.jpgGenerated Thumbnailimage/jpeg1718http://www.lume.ufrgs.br/bitstream/10183/21165/3/000297409.pdf.jpg5fa96f2a16e2f4fa7a15ded849535fc6MD5310183/211652021-11-20 05:59:45.924927oai:www.lume.ufrgs.br:10183/21165Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2021-11-20T07:59:45Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Interaction between repeated restraint stress and concomitant midazolam administration on sweet food ingestion in rats |
title |
Interaction between repeated restraint stress and concomitant midazolam administration on sweet food ingestion in rats |
spellingShingle |
Interaction between repeated restraint stress and concomitant midazolam administration on sweet food ingestion in rats Silveira, Patrícia Pelufo Bioquímica Feeding behavior Chronic stress Benzodiazepines Midazolam Sweet taste Rats |
title_short |
Interaction between repeated restraint stress and concomitant midazolam administration on sweet food ingestion in rats |
title_full |
Interaction between repeated restraint stress and concomitant midazolam administration on sweet food ingestion in rats |
title_fullStr |
Interaction between repeated restraint stress and concomitant midazolam administration on sweet food ingestion in rats |
title_full_unstemmed |
Interaction between repeated restraint stress and concomitant midazolam administration on sweet food ingestion in rats |
title_sort |
Interaction between repeated restraint stress and concomitant midazolam administration on sweet food ingestion in rats |
author |
Silveira, Patrícia Pelufo |
author_facet |
Silveira, Patrícia Pelufo Xavier, Marcia Henriques Souza, Fabiano Hahn Manoli, Luciana Pacheco Rosat, Renata Menezes Ferreira, Maria Beatriz Cardoso Dalmaz, Carla |
author_role |
author |
author2 |
Xavier, Marcia Henriques Souza, Fabiano Hahn Manoli, Luciana Pacheco Rosat, Renata Menezes Ferreira, Maria Beatriz Cardoso Dalmaz, Carla |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Silveira, Patrícia Pelufo Xavier, Marcia Henriques Souza, Fabiano Hahn Manoli, Luciana Pacheco Rosat, Renata Menezes Ferreira, Maria Beatriz Cardoso Dalmaz, Carla |
dc.subject.por.fl_str_mv |
Bioquímica |
topic |
Bioquímica Feeding behavior Chronic stress Benzodiazepines Midazolam Sweet taste Rats |
dc.subject.eng.fl_str_mv |
Feeding behavior Chronic stress Benzodiazepines Midazolam Sweet taste Rats |
description |
Emotional changes can influence feeding behavior. Previous studies have shown that chronically stressed animals present increased ingestion of sweet food, an effect reversed by a single dose of diazepam administered before testing the animals. The aim of the present study was to evaluate the response of animals chronically treated with midazolam and/or submitted to repeated restraint stress upon the ingestion of sweet food. Male adult Wistar rats were divided into two groups: controls and exposed to restraint 1 h/day, 5 days/week for 40 days. Both groups were subdivided into two other groups treated or not with midazolam (0.06 mg/ml in their drinking water during the 40- day treatment). The animals were placed in a lighted area in the presence of 10 pellets of sweet food (Froot loops®). The number of ingested pellets was measured during a period of 3 min, in the presence or absence of fasting. The group chronically treated with midazolam alone presented increased ingestion when compared to control animals (control group: 2.0 ± 0.44 pellets and midazolam group: 3.60 ± 0.57 pellets). The group submitted to restraint stress presented an increased ingestion compared to controls (control group: 2.0 ± 0.44 pellets and stressed group: 4.18 ± 0.58 pellets). Chronically administered midazolam reduced the ingestion in stressed animals (stressed/ water group: 4.18 ± 0.58 pellets; stressed/midazolam group: 3.2 ± 0.49 pellets). Thus, repeated stress increases appetite for sweet food independently of hunger and chronic administration of midazolam can decrease this behavioral effect. |
publishDate |
2000 |
dc.date.issued.fl_str_mv |
2000 |
dc.date.accessioned.fl_str_mv |
2010-04-24T04:15:33Z |
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info:eu-repo/semantics/article info:eu-repo/semantics/other |
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publishedVersion |
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http://hdl.handle.net/10183/21165 |
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0100-879X |
dc.identifier.nrb.pt_BR.fl_str_mv |
000297409 |
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url |
http://hdl.handle.net/10183/21165 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Ribeirão Preto, SP. Vol. 33, no. 11 (Nov. 2000), p. 1343-1350 |
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openAccess |
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