Renin–angiotensin–aldosterone system inhibitors in COVID-19 : a review
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/226306 |
Resumo: | Among the multiple uncertainties surrounding the novel coronavirus disease (COVID-19) pandemic, a research letter published in The Lancet implicated drugs that antagonize the renin-angiotensin-aldosterone system (RAAS) in an unfavorable prognosis of COVID-19. This report prompted investigations to identify mechanisms by which blocking angiotensin-converting enzyme 2 (ACE2) could lead to serious consequences in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The possible association between RAAS inhibitors use and unfavorable prognosis in this disease may have been biased by the presence of underlying cardiovascular diseases. As the number of COVID-19 cases has increased worldwide, it has now become possible to investigate the association between RAAS inhibitors and unfavorable prognosis in larger cohorts. Observational studies and one randomized clinical trial failed to identify any consistent association between the use of these drugs and unfavorable prognosis in COVID-19. In view of the accumulated clinical evidence, several scientific societies recommend that treatment with RAAS inhibitors should not be discontinued in patients diagnosed with COVID-19 (unless contraindicated). This recommendation should be followed by clinicians and patients. |
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Lacerda, Filipe Ferrari Ribeiro deMartins, Vitor MagnusFuchs, Flávio DanniStein, Ricardo2021-08-31T04:20:31Z20211980-5322http://hdl.handle.net/10183/226306001130055Among the multiple uncertainties surrounding the novel coronavirus disease (COVID-19) pandemic, a research letter published in The Lancet implicated drugs that antagonize the renin-angiotensin-aldosterone system (RAAS) in an unfavorable prognosis of COVID-19. This report prompted investigations to identify mechanisms by which blocking angiotensin-converting enzyme 2 (ACE2) could lead to serious consequences in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The possible association between RAAS inhibitors use and unfavorable prognosis in this disease may have been biased by the presence of underlying cardiovascular diseases. As the number of COVID-19 cases has increased worldwide, it has now become possible to investigate the association between RAAS inhibitors and unfavorable prognosis in larger cohorts. Observational studies and one randomized clinical trial failed to identify any consistent association between the use of these drugs and unfavorable prognosis in COVID-19. In view of the accumulated clinical evidence, several scientific societies recommend that treatment with RAAS inhibitors should not be discontinued in patients diagnosed with COVID-19 (unless contraindicated). This recommendation should be followed by clinicians and patients.application/pdfengClinics. São Paulo. Vol. 76 (2021), e2342, 14 p.RevisãoCOVID-19Infecções por coronavirusSARS-CoV-2HipertensãoInsuficiência cardíacaPandemicInfectionSARS-CoV-2HypertensionHeart failureRenin–angiotensin–aldosterone system inhibitors in COVID-19 : a reviewinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001130055.pdf.txt001130055.pdf.txtExtracted Texttext/plain71977http://www.lume.ufrgs.br/bitstream/10183/226306/2/001130055.pdf.txt53e096693a648cf7cc1c1ab57734150bMD52ORIGINAL001130055.pdfTexto completo (inglês)application/pdf575625http://www.lume.ufrgs.br/bitstream/10183/226306/1/001130055.pdf1ceaa31afeaa34fb2a39cf5853b5ed2dMD5110183/2263062021-09-19 04:30:02.0185oai:www.lume.ufrgs.br:10183/226306Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2021-09-19T07:30:02Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Renin–angiotensin–aldosterone system inhibitors in COVID-19 : a review |
title |
Renin–angiotensin–aldosterone system inhibitors in COVID-19 : a review |
spellingShingle |
Renin–angiotensin–aldosterone system inhibitors in COVID-19 : a review Lacerda, Filipe Ferrari Ribeiro de Revisão COVID-19 Infecções por coronavirus SARS-CoV-2 Hipertensão Insuficiência cardíaca Pandemic Infection SARS-CoV-2 Hypertension Heart failure |
title_short |
Renin–angiotensin–aldosterone system inhibitors in COVID-19 : a review |
title_full |
Renin–angiotensin–aldosterone system inhibitors in COVID-19 : a review |
title_fullStr |
Renin–angiotensin–aldosterone system inhibitors in COVID-19 : a review |
title_full_unstemmed |
Renin–angiotensin–aldosterone system inhibitors in COVID-19 : a review |
title_sort |
Renin–angiotensin–aldosterone system inhibitors in COVID-19 : a review |
author |
Lacerda, Filipe Ferrari Ribeiro de |
author_facet |
Lacerda, Filipe Ferrari Ribeiro de Martins, Vitor Magnus Fuchs, Flávio Danni Stein, Ricardo |
author_role |
author |
author2 |
Martins, Vitor Magnus Fuchs, Flávio Danni Stein, Ricardo |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Lacerda, Filipe Ferrari Ribeiro de Martins, Vitor Magnus Fuchs, Flávio Danni Stein, Ricardo |
dc.subject.por.fl_str_mv |
Revisão COVID-19 Infecções por coronavirus SARS-CoV-2 Hipertensão Insuficiência cardíaca |
topic |
Revisão COVID-19 Infecções por coronavirus SARS-CoV-2 Hipertensão Insuficiência cardíaca Pandemic Infection SARS-CoV-2 Hypertension Heart failure |
dc.subject.eng.fl_str_mv |
Pandemic Infection SARS-CoV-2 Hypertension Heart failure |
description |
Among the multiple uncertainties surrounding the novel coronavirus disease (COVID-19) pandemic, a research letter published in The Lancet implicated drugs that antagonize the renin-angiotensin-aldosterone system (RAAS) in an unfavorable prognosis of COVID-19. This report prompted investigations to identify mechanisms by which blocking angiotensin-converting enzyme 2 (ACE2) could lead to serious consequences in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The possible association between RAAS inhibitors use and unfavorable prognosis in this disease may have been biased by the presence of underlying cardiovascular diseases. As the number of COVID-19 cases has increased worldwide, it has now become possible to investigate the association between RAAS inhibitors and unfavorable prognosis in larger cohorts. Observational studies and one randomized clinical trial failed to identify any consistent association between the use of these drugs and unfavorable prognosis in COVID-19. In view of the accumulated clinical evidence, several scientific societies recommend that treatment with RAAS inhibitors should not be discontinued in patients diagnosed with COVID-19 (unless contraindicated). This recommendation should be followed by clinicians and patients. |
publishDate |
2021 |
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2021-08-31T04:20:31Z |
dc.date.issued.fl_str_mv |
2021 |
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info:eu-repo/semantics/article info:eu-repo/semantics/other |
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article |
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http://hdl.handle.net/10183/226306 |
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Clinics. São Paulo. Vol. 76 (2021), e2342, 14 p. |
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openAccess |
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