Ethanol binge drinking exposure affects alveolar bone quality and aggravates bone loss in experimentally-induced periodontitis
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/229532 |
Resumo: | Background: Periodontitis is a multifactorial inflammatory disease of tooth supporting tissues caused by oral biofilms, influenced by environmental and genetic factors, among others. Ethanol consumption has been considered a factor that enhances alveolar bone loss, especially in high doses. The present study aims to investigate the changes promoted by ethanol binge drinking per se or associated with ligature-induced periodontal breakdown on alveolar bone loss. Materials and methods: Thirty-two Wistar rats were randomly allocated into four groups: control (C), ethanol (3g/kg/ day; 3 days On-4 days Off protocol by gavage for 28 days, EtOH), experimental periodontitis (EP) and experimental periodontitis plus ethanol administration (EP+EtOH). On day 14th, periodontitis was induced by ligatures that were placed around the lower first molars. On day 28th, the animals were euthanized and mandibles were submitted to stereomicroscopy for exposed root area analysis and micro-computed tomography (micro-CT) for the evaluation of alveolar bone loss and microstructural parameters. Results: The results revealed that ligature-induced alveolar bone loss is aggravated by ethanol binge drinking compared to controls (1.06 ± 0.10 vs 0.77 ± 0.04; p<0.0001). In addition, binge drinking per se altered the alveolar bone quality and density demonstrating a reduction in trabecular thickness, trabecular number parameter and bone density percentual. Periodontal disorder plus ethanol binge drinking group also demonstrated reduction of the quality of bone measured by trabecular thickness. Conclusions In conclusion, intense and episodic ethanol intake decreased alveolar bone quality in all microstructural parameters analyzed which may be considered a modifying factor of periodontitis, intensifying the already installed disease. |
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Frazão, Deborah RibeiroMaia, Cristiane do Socorro FerrazChamelo, Victória dos SantosSouza-Monteiro, DeiwesonFerreira, Railson de OliveiraBittencourt, Leonardo de OliveiraBalbinot, Gabriela de SouzaCollares, Fabrício MezzomoRösing, Cassiano KuchenbeckerMartins, Manoela DominguesLima, Rafael Rodrigues2021-09-03T04:27:43Z20201932-6203http://hdl.handle.net/10183/229532001130883Background: Periodontitis is a multifactorial inflammatory disease of tooth supporting tissues caused by oral biofilms, influenced by environmental and genetic factors, among others. Ethanol consumption has been considered a factor that enhances alveolar bone loss, especially in high doses. The present study aims to investigate the changes promoted by ethanol binge drinking per se or associated with ligature-induced periodontal breakdown on alveolar bone loss. Materials and methods: Thirty-two Wistar rats were randomly allocated into four groups: control (C), ethanol (3g/kg/ day; 3 days On-4 days Off protocol by gavage for 28 days, EtOH), experimental periodontitis (EP) and experimental periodontitis plus ethanol administration (EP+EtOH). On day 14th, periodontitis was induced by ligatures that were placed around the lower first molars. On day 28th, the animals were euthanized and mandibles were submitted to stereomicroscopy for exposed root area analysis and micro-computed tomography (micro-CT) for the evaluation of alveolar bone loss and microstructural parameters. Results: The results revealed that ligature-induced alveolar bone loss is aggravated by ethanol binge drinking compared to controls (1.06 ± 0.10 vs 0.77 ± 0.04; p<0.0001). In addition, binge drinking per se altered the alveolar bone quality and density demonstrating a reduction in trabecular thickness, trabecular number parameter and bone density percentual. Periodontal disorder plus ethanol binge drinking group also demonstrated reduction of the quality of bone measured by trabecular thickness. Conclusions In conclusion, intense and episodic ethanol intake decreased alveolar bone quality in all microstructural parameters analyzed which may be considered a modifying factor of periodontitis, intensifying the already installed disease.application/pdfengPloS one. San Francisco. vol. 15, no. 7 (July 2020), e0236161, 12 p.EtanolPerda do osso alveolarPeriodontiteBiofilmesTecidosDoençaRatosEthanol binge drinking exposure affects alveolar bone quality and aggravates bone loss in experimentally-induced periodontitisEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001130883.pdf.txt001130883.pdf.txtExtracted Texttext/plain41017http://www.lume.ufrgs.br/bitstream/10183/229532/2/001130883.pdf.txtb81758034768f4f69ab57c09e375fb67MD52ORIGINAL001130883.pdfTexto completo (inglês)application/pdf1736028http://www.lume.ufrgs.br/bitstream/10183/229532/1/001130883.pdfc8fc2595ae73a8968fb35a9fe9b579e9MD5110183/2295322023-09-24 03:40:13.93008oai:www.lume.ufrgs.br:10183/229532Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-09-24T06:40:13Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Ethanol binge drinking exposure affects alveolar bone quality and aggravates bone loss in experimentally-induced periodontitis |
title |
Ethanol binge drinking exposure affects alveolar bone quality and aggravates bone loss in experimentally-induced periodontitis |
spellingShingle |
Ethanol binge drinking exposure affects alveolar bone quality and aggravates bone loss in experimentally-induced periodontitis Frazão, Deborah Ribeiro Etanol Perda do osso alveolar Periodontite Biofilmes Tecidos Doença Ratos |
title_short |
Ethanol binge drinking exposure affects alveolar bone quality and aggravates bone loss in experimentally-induced periodontitis |
title_full |
Ethanol binge drinking exposure affects alveolar bone quality and aggravates bone loss in experimentally-induced periodontitis |
title_fullStr |
Ethanol binge drinking exposure affects alveolar bone quality and aggravates bone loss in experimentally-induced periodontitis |
title_full_unstemmed |
Ethanol binge drinking exposure affects alveolar bone quality and aggravates bone loss in experimentally-induced periodontitis |
title_sort |
Ethanol binge drinking exposure affects alveolar bone quality and aggravates bone loss in experimentally-induced periodontitis |
author |
Frazão, Deborah Ribeiro |
author_facet |
Frazão, Deborah Ribeiro Maia, Cristiane do Socorro Ferraz Chamelo, Victória dos Santos Souza-Monteiro, Deiweson Ferreira, Railson de Oliveira Bittencourt, Leonardo de Oliveira Balbinot, Gabriela de Souza Collares, Fabrício Mezzomo Rösing, Cassiano Kuchenbecker Martins, Manoela Domingues Lima, Rafael Rodrigues |
author_role |
author |
author2 |
Maia, Cristiane do Socorro Ferraz Chamelo, Victória dos Santos Souza-Monteiro, Deiweson Ferreira, Railson de Oliveira Bittencourt, Leonardo de Oliveira Balbinot, Gabriela de Souza Collares, Fabrício Mezzomo Rösing, Cassiano Kuchenbecker Martins, Manoela Domingues Lima, Rafael Rodrigues |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Frazão, Deborah Ribeiro Maia, Cristiane do Socorro Ferraz Chamelo, Victória dos Santos Souza-Monteiro, Deiweson Ferreira, Railson de Oliveira Bittencourt, Leonardo de Oliveira Balbinot, Gabriela de Souza Collares, Fabrício Mezzomo Rösing, Cassiano Kuchenbecker Martins, Manoela Domingues Lima, Rafael Rodrigues |
dc.subject.por.fl_str_mv |
Etanol Perda do osso alveolar Periodontite Biofilmes Tecidos Doença Ratos |
topic |
Etanol Perda do osso alveolar Periodontite Biofilmes Tecidos Doença Ratos |
description |
Background: Periodontitis is a multifactorial inflammatory disease of tooth supporting tissues caused by oral biofilms, influenced by environmental and genetic factors, among others. Ethanol consumption has been considered a factor that enhances alveolar bone loss, especially in high doses. The present study aims to investigate the changes promoted by ethanol binge drinking per se or associated with ligature-induced periodontal breakdown on alveolar bone loss. Materials and methods: Thirty-two Wistar rats were randomly allocated into four groups: control (C), ethanol (3g/kg/ day; 3 days On-4 days Off protocol by gavage for 28 days, EtOH), experimental periodontitis (EP) and experimental periodontitis plus ethanol administration (EP+EtOH). On day 14th, periodontitis was induced by ligatures that were placed around the lower first molars. On day 28th, the animals were euthanized and mandibles were submitted to stereomicroscopy for exposed root area analysis and micro-computed tomography (micro-CT) for the evaluation of alveolar bone loss and microstructural parameters. Results: The results revealed that ligature-induced alveolar bone loss is aggravated by ethanol binge drinking compared to controls (1.06 ± 0.10 vs 0.77 ± 0.04; p<0.0001). In addition, binge drinking per se altered the alveolar bone quality and density demonstrating a reduction in trabecular thickness, trabecular number parameter and bone density percentual. Periodontal disorder plus ethanol binge drinking group also demonstrated reduction of the quality of bone measured by trabecular thickness. Conclusions In conclusion, intense and episodic ethanol intake decreased alveolar bone quality in all microstructural parameters analyzed which may be considered a modifying factor of periodontitis, intensifying the already installed disease. |
publishDate |
2020 |
dc.date.issued.fl_str_mv |
2020 |
dc.date.accessioned.fl_str_mv |
2021-09-03T04:27:43Z |
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Estrangeiro info:eu-repo/semantics/article |
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http://hdl.handle.net/10183/229532 |
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1932-6203 |
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001130883 |
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http://hdl.handle.net/10183/229532 |
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PloS one. San Francisco. vol. 15, no. 7 (July 2020), e0236161, 12 p. |
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