Thrifty-eating behavior phenotype at the food court : programming goes beyond food preferences
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Publication Date: | 2022 |
Other Authors: | , , , , , , , , , , , , , , , |
Format: | Article |
Language: | eng |
Source: | Repositório Institucional da UFRGS |
Download full: | http://hdl.handle.net/10183/247686 |
Summary: | Introduction: Prenatal growth impairment leads to higher preference for palatable foods in comparison to normal prenatal growth subjects, which can contribute to increased body fat mass and a higher risk for developing chronic diseases in small-for-gestational-age (SGA) individuals throughout life. This study aimed to investigate the effect of SGA on feeding behavior in children and adolescents, as well as resting-state connectivity between areas related to reward, self-control, and value determination, such as orbitofrontal cortex (OFC), dorsolateral prefrontal cortex (DL-PFC), amygdala and dorsal striatum (DS). Methods: Caregivers and their offspring were recruited from two independent cohorts in Brazil (PROTAIA) and Canada (MAVAN). Both cohorts included anthropometric measurements, food choice tasks, and resting-state functional magnetic resonance imaging (fMRI) data. Results: In the Brazilian sample (17 ± 0.28 years, n=70), 21.4% of adolescents were classified as SGA. They exhibited lower monetary-related expenditure to buy a snack compared to controls in the food choice test. Decreased functional connectivity (n=40) between left OFC and left DL-PFC; and between right OFC and: left amygdala, right DS, and left DS were observed in the Brazilian SGA participants. Canadian SGA participants (14.9%) had non-significant differences in comparison with controls in a food choice task at 4 years old ( ± 0.01, n=315). At a follow-up brain scan visit (10.21 ± 0.140 years, n=49), SGA participants (28.6%) exhibited higher connectivity between the left OFC and left DL-PFC, also higher connectivity between the left OFC and right DL-PFC. We did not observe significant anthropometric neither nutrients’ intake differences between groups in both samples. Conclusions: Resting-state fMRI results showed that SGA individuals had altered connectivity between areas involved in encoding the subjective value for available goods and decision-making in both samples, which can pose them in disadvantage when facing food options daily. Over the years, the cumulative exposure to particular food cues together with the altered behavior towards food, such as food purchasing, as seen in the adolescent cohort, can play a role in the long-term risk for developing chronic noncommunicable diseases. |
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Dalle Molle, RobertaMendonça Filho, Euclides José deMinuzzi, LucianoMachado, Tania DinizReis, Roberta SenaRodrigues, Danitsa MarcosMucellini, Amanda BrondaniFranco, Alexandre RosaBuchweitz, AugustoToazza, RudineiaBortoluzzi, AndressaSalum Junior, Giovanni AbrahãoBoscenco, SoniaMeaney, Michael J.Levitan, Robert D.Manfro, Gisele GusSilveira, Patrícia Pelufo2022-08-21T04:39:42Z20221664-2392http://hdl.handle.net/10183/247686001147530Introduction: Prenatal growth impairment leads to higher preference for palatable foods in comparison to normal prenatal growth subjects, which can contribute to increased body fat mass and a higher risk for developing chronic diseases in small-for-gestational-age (SGA) individuals throughout life. This study aimed to investigate the effect of SGA on feeding behavior in children and adolescents, as well as resting-state connectivity between areas related to reward, self-control, and value determination, such as orbitofrontal cortex (OFC), dorsolateral prefrontal cortex (DL-PFC), amygdala and dorsal striatum (DS). Methods: Caregivers and their offspring were recruited from two independent cohorts in Brazil (PROTAIA) and Canada (MAVAN). Both cohorts included anthropometric measurements, food choice tasks, and resting-state functional magnetic resonance imaging (fMRI) data. Results: In the Brazilian sample (17 ± 0.28 years, n=70), 21.4% of adolescents were classified as SGA. They exhibited lower monetary-related expenditure to buy a snack compared to controls in the food choice test. Decreased functional connectivity (n=40) between left OFC and left DL-PFC; and between right OFC and: left amygdala, right DS, and left DS were observed in the Brazilian SGA participants. Canadian SGA participants (14.9%) had non-significant differences in comparison with controls in a food choice task at 4 years old ( ± 0.01, n=315). At a follow-up brain scan visit (10.21 ± 0.140 years, n=49), SGA participants (28.6%) exhibited higher connectivity between the left OFC and left DL-PFC, also higher connectivity between the left OFC and right DL-PFC. We did not observe significant anthropometric neither nutrients’ intake differences between groups in both samples. Conclusions: Resting-state fMRI results showed that SGA individuals had altered connectivity between areas involved in encoding the subjective value for available goods and decision-making in both samples, which can pose them in disadvantage when facing food options daily. Over the years, the cumulative exposure to particular food cues together with the altered behavior towards food, such as food purchasing, as seen in the adolescent cohort, can play a role in the long-term risk for developing chronic noncommunicable diseases.application/pdfengFrontiers in endocrinology. Lausanne. Vol. 13 (May 2022), artigo 882532, 12 p.Recém-nascido pequeno para a idade gestacionalComportamento alimentarImageamento por ressonância magnéticaCórtex pré-frontalFenótipoSmall for gestational ageFeeding behaviorResting state fMRIFunctional connectivityOrbitofrontal cortexThrifty-eating behavior phenotype at the food court : programming goes beyond food preferencesEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001147530.pdf.txt001147530.pdf.txtExtracted Texttext/plain66559http://www.lume.ufrgs.br/bitstream/10183/247686/2/001147530.pdf.txtdd9a38e7a8167d2179248ae01b194a46MD52ORIGINAL001147530.pdfTexto completo (inglês)application/pdf1184998http://www.lume.ufrgs.br/bitstream/10183/247686/1/001147530.pdfe9d188b19ce4111267b93c46f6196e5aMD5110183/2476862023-05-11 03:39:24.185309oai:www.lume.ufrgs.br:10183/247686Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-05-11T06:39:24Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Thrifty-eating behavior phenotype at the food court : programming goes beyond food preferences |
title |
Thrifty-eating behavior phenotype at the food court : programming goes beyond food preferences |
spellingShingle |
Thrifty-eating behavior phenotype at the food court : programming goes beyond food preferences Dalle Molle, Roberta Recém-nascido pequeno para a idade gestacional Comportamento alimentar Imageamento por ressonância magnética Córtex pré-frontal Fenótipo Small for gestational age Feeding behavior Resting state fMRI Functional connectivity Orbitofrontal cortex |
title_short |
Thrifty-eating behavior phenotype at the food court : programming goes beyond food preferences |
title_full |
Thrifty-eating behavior phenotype at the food court : programming goes beyond food preferences |
title_fullStr |
Thrifty-eating behavior phenotype at the food court : programming goes beyond food preferences |
title_full_unstemmed |
Thrifty-eating behavior phenotype at the food court : programming goes beyond food preferences |
title_sort |
Thrifty-eating behavior phenotype at the food court : programming goes beyond food preferences |
author |
Dalle Molle, Roberta |
author_facet |
Dalle Molle, Roberta Mendonça Filho, Euclides José de Minuzzi, Luciano Machado, Tania Diniz Reis, Roberta Sena Rodrigues, Danitsa Marcos Mucellini, Amanda Brondani Franco, Alexandre Rosa Buchweitz, Augusto Toazza, Rudineia Bortoluzzi, Andressa Salum Junior, Giovanni Abrahão Boscenco, Sonia Meaney, Michael J. Levitan, Robert D. Manfro, Gisele Gus Silveira, Patrícia Pelufo |
author_role |
author |
author2 |
Mendonça Filho, Euclides José de Minuzzi, Luciano Machado, Tania Diniz Reis, Roberta Sena Rodrigues, Danitsa Marcos Mucellini, Amanda Brondani Franco, Alexandre Rosa Buchweitz, Augusto Toazza, Rudineia Bortoluzzi, Andressa Salum Junior, Giovanni Abrahão Boscenco, Sonia Meaney, Michael J. Levitan, Robert D. Manfro, Gisele Gus Silveira, Patrícia Pelufo |
author2_role |
author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Dalle Molle, Roberta Mendonça Filho, Euclides José de Minuzzi, Luciano Machado, Tania Diniz Reis, Roberta Sena Rodrigues, Danitsa Marcos Mucellini, Amanda Brondani Franco, Alexandre Rosa Buchweitz, Augusto Toazza, Rudineia Bortoluzzi, Andressa Salum Junior, Giovanni Abrahão Boscenco, Sonia Meaney, Michael J. Levitan, Robert D. Manfro, Gisele Gus Silveira, Patrícia Pelufo |
dc.subject.por.fl_str_mv |
Recém-nascido pequeno para a idade gestacional Comportamento alimentar Imageamento por ressonância magnética Córtex pré-frontal Fenótipo |
topic |
Recém-nascido pequeno para a idade gestacional Comportamento alimentar Imageamento por ressonância magnética Córtex pré-frontal Fenótipo Small for gestational age Feeding behavior Resting state fMRI Functional connectivity Orbitofrontal cortex |
dc.subject.eng.fl_str_mv |
Small for gestational age Feeding behavior Resting state fMRI Functional connectivity Orbitofrontal cortex |
description |
Introduction: Prenatal growth impairment leads to higher preference for palatable foods in comparison to normal prenatal growth subjects, which can contribute to increased body fat mass and a higher risk for developing chronic diseases in small-for-gestational-age (SGA) individuals throughout life. This study aimed to investigate the effect of SGA on feeding behavior in children and adolescents, as well as resting-state connectivity between areas related to reward, self-control, and value determination, such as orbitofrontal cortex (OFC), dorsolateral prefrontal cortex (DL-PFC), amygdala and dorsal striatum (DS). Methods: Caregivers and their offspring were recruited from two independent cohorts in Brazil (PROTAIA) and Canada (MAVAN). Both cohorts included anthropometric measurements, food choice tasks, and resting-state functional magnetic resonance imaging (fMRI) data. Results: In the Brazilian sample (17 ± 0.28 years, n=70), 21.4% of adolescents were classified as SGA. They exhibited lower monetary-related expenditure to buy a snack compared to controls in the food choice test. Decreased functional connectivity (n=40) between left OFC and left DL-PFC; and between right OFC and: left amygdala, right DS, and left DS were observed in the Brazilian SGA participants. Canadian SGA participants (14.9%) had non-significant differences in comparison with controls in a food choice task at 4 years old ( ± 0.01, n=315). At a follow-up brain scan visit (10.21 ± 0.140 years, n=49), SGA participants (28.6%) exhibited higher connectivity between the left OFC and left DL-PFC, also higher connectivity between the left OFC and right DL-PFC. We did not observe significant anthropometric neither nutrients’ intake differences between groups in both samples. Conclusions: Resting-state fMRI results showed that SGA individuals had altered connectivity between areas involved in encoding the subjective value for available goods and decision-making in both samples, which can pose them in disadvantage when facing food options daily. Over the years, the cumulative exposure to particular food cues together with the altered behavior towards food, such as food purchasing, as seen in the adolescent cohort, can play a role in the long-term risk for developing chronic noncommunicable diseases. |
publishDate |
2022 |
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2022-08-21T04:39:42Z |
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2022 |
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Estrangeiro info:eu-repo/semantics/article |
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Frontiers in endocrinology. Lausanne. Vol. 13 (May 2022), artigo 882532, 12 p. |
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