Response to treatment in Brazilian patients with chronic hepatitis C is associated with a single-nucleotide polymorphism near the interleukin-28B gene
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/72262 |
Resumo: | A single-nucleotide polymorphism (SNP) upstream of interleukin (IL)28B was recently identified as an important predictor of the outcome of chronic hepatitis C patients treated with pegylated interferon plus ribavirin (PEG-IFN/ RBV). The aim of this study was to investigate the association between the IL28B gene polymorphism (rs12979860) and virological response in chronic hepatitis C patients. Brazilian patients (n = 263) who were infected with hepati- tis C virus (HCV) genotype 1 and were receiving PEG-IFN/RBV were genotyped. Early virological response (EVR) (12 weeks), end-of-treatment response (EOTR) (48 weeks), sustained virological response (SVR) (72 weeks) and re- lapse were evaluated using conventional and quantitative polymerase chain reaction (PCR) assays. The frequency of the C allele in the population was 39%. Overall, 43% of patients experienced SVR. The IL28B CC genotype was sig- nificantly associated with higher treatment response rates and a lower relapse rate compared to the other genotypes [84% vs. 58% EVR, 92% vs. 63% EOTR, 76% vs. 38% SVR and 17% vs. 40% relapse rate in CC vs. other genotypes (CT and TT), respectively]. Thus, the IL28B genotype appears to be a strong predictor of SVR following PEG-IFN/ RBV therapy in treatment-naïve Brazilian patients infected with HCV genotype 1. This study, together with similar research examining other SNPs, should help to define adequate protocols for the treatment of patients infected with HCV genotype 1, especially those with a poor prognosis. |
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Grandi, TarcianaSilva, Cláudia Maria Dornelles daAmaral, Karine MedeirosPicon, Paulo DornellesCosti, CintiaDa Fré, Nicole NascimentoFiegenbaum, MariluNiel, ChristianRossetti, Maria Lucia Rosa2013-06-07T01:45:09Z20130074-0276http://hdl.handle.net/10183/72262000879081A single-nucleotide polymorphism (SNP) upstream of interleukin (IL)28B was recently identified as an important predictor of the outcome of chronic hepatitis C patients treated with pegylated interferon plus ribavirin (PEG-IFN/ RBV). The aim of this study was to investigate the association between the IL28B gene polymorphism (rs12979860) and virological response in chronic hepatitis C patients. Brazilian patients (n = 263) who were infected with hepati- tis C virus (HCV) genotype 1 and were receiving PEG-IFN/RBV were genotyped. Early virological response (EVR) (12 weeks), end-of-treatment response (EOTR) (48 weeks), sustained virological response (SVR) (72 weeks) and re- lapse were evaluated using conventional and quantitative polymerase chain reaction (PCR) assays. The frequency of the C allele in the population was 39%. Overall, 43% of patients experienced SVR. The IL28B CC genotype was sig- nificantly associated with higher treatment response rates and a lower relapse rate compared to the other genotypes [84% vs. 58% EVR, 92% vs. 63% EOTR, 76% vs. 38% SVR and 17% vs. 40% relapse rate in CC vs. other genotypes (CT and TT), respectively]. Thus, the IL28B genotype appears to be a strong predictor of SVR following PEG-IFN/ RBV therapy in treatment-naïve Brazilian patients infected with HCV genotype 1. This study, together with similar research examining other SNPs, should help to define adequate protocols for the treatment of patients infected with HCV genotype 1, especially those with a poor prognosis.application/pdfengMemórias do Instituto Oswaldo Cruz : an international journal of biological and biomedical research. Vol. 108, n. 1 (fev. 2013), p. 48-53Hepatite CIL28BHCVVirological responseTreatmentBrazilResponse to treatment in Brazilian patients with chronic hepatitis C is associated with a single-nucleotide polymorphism near the interleukin-28B geneinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000879081.pdf000879081.pdfTexto completo (inglês)application/pdf411878http://www.lume.ufrgs.br/bitstream/10183/72262/1/000879081.pdf6b196038de4ac3d694deb3a6509f7f27MD51TEXT000879081.pdf.txt000879081.pdf.txtExtracted Texttext/plain32331http://www.lume.ufrgs.br/bitstream/10183/72262/2/000879081.pdf.txt3fe1a806a9a47595e41b701ed93b97daMD52THUMBNAIL000879081.pdf.jpg000879081.pdf.jpgGenerated Thumbnailimage/jpeg2123http://www.lume.ufrgs.br/bitstream/10183/72262/3/000879081.pdf.jpg6e53010cf2b4f33e122b8bdc91b85286MD5310183/722622018-10-15 09:03:43.225oai:www.lume.ufrgs.br:10183/72262Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2018-10-15T12:03:43Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Response to treatment in Brazilian patients with chronic hepatitis C is associated with a single-nucleotide polymorphism near the interleukin-28B gene |
title |
Response to treatment in Brazilian patients with chronic hepatitis C is associated with a single-nucleotide polymorphism near the interleukin-28B gene |
spellingShingle |
Response to treatment in Brazilian patients with chronic hepatitis C is associated with a single-nucleotide polymorphism near the interleukin-28B gene Grandi, Tarciana Hepatite C IL28B HCV Virological response Treatment Brazil |
title_short |
Response to treatment in Brazilian patients with chronic hepatitis C is associated with a single-nucleotide polymorphism near the interleukin-28B gene |
title_full |
Response to treatment in Brazilian patients with chronic hepatitis C is associated with a single-nucleotide polymorphism near the interleukin-28B gene |
title_fullStr |
Response to treatment in Brazilian patients with chronic hepatitis C is associated with a single-nucleotide polymorphism near the interleukin-28B gene |
title_full_unstemmed |
Response to treatment in Brazilian patients with chronic hepatitis C is associated with a single-nucleotide polymorphism near the interleukin-28B gene |
title_sort |
Response to treatment in Brazilian patients with chronic hepatitis C is associated with a single-nucleotide polymorphism near the interleukin-28B gene |
author |
Grandi, Tarciana |
author_facet |
Grandi, Tarciana Silva, Cláudia Maria Dornelles da Amaral, Karine Medeiros Picon, Paulo Dornelles Costi, Cintia Da Fré, Nicole Nascimento Fiegenbaum, Marilu Niel, Christian Rossetti, Maria Lucia Rosa |
author_role |
author |
author2 |
Silva, Cláudia Maria Dornelles da Amaral, Karine Medeiros Picon, Paulo Dornelles Costi, Cintia Da Fré, Nicole Nascimento Fiegenbaum, Marilu Niel, Christian Rossetti, Maria Lucia Rosa |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Grandi, Tarciana Silva, Cláudia Maria Dornelles da Amaral, Karine Medeiros Picon, Paulo Dornelles Costi, Cintia Da Fré, Nicole Nascimento Fiegenbaum, Marilu Niel, Christian Rossetti, Maria Lucia Rosa |
dc.subject.por.fl_str_mv |
Hepatite C |
topic |
Hepatite C IL28B HCV Virological response Treatment Brazil |
dc.subject.eng.fl_str_mv |
IL28B HCV Virological response Treatment Brazil |
description |
A single-nucleotide polymorphism (SNP) upstream of interleukin (IL)28B was recently identified as an important predictor of the outcome of chronic hepatitis C patients treated with pegylated interferon plus ribavirin (PEG-IFN/ RBV). The aim of this study was to investigate the association between the IL28B gene polymorphism (rs12979860) and virological response in chronic hepatitis C patients. Brazilian patients (n = 263) who were infected with hepati- tis C virus (HCV) genotype 1 and were receiving PEG-IFN/RBV were genotyped. Early virological response (EVR) (12 weeks), end-of-treatment response (EOTR) (48 weeks), sustained virological response (SVR) (72 weeks) and re- lapse were evaluated using conventional and quantitative polymerase chain reaction (PCR) assays. The frequency of the C allele in the population was 39%. Overall, 43% of patients experienced SVR. The IL28B CC genotype was sig- nificantly associated with higher treatment response rates and a lower relapse rate compared to the other genotypes [84% vs. 58% EVR, 92% vs. 63% EOTR, 76% vs. 38% SVR and 17% vs. 40% relapse rate in CC vs. other genotypes (CT and TT), respectively]. Thus, the IL28B genotype appears to be a strong predictor of SVR following PEG-IFN/ RBV therapy in treatment-naïve Brazilian patients infected with HCV genotype 1. This study, together with similar research examining other SNPs, should help to define adequate protocols for the treatment of patients infected with HCV genotype 1, especially those with a poor prognosis. |
publishDate |
2013 |
dc.date.accessioned.fl_str_mv |
2013-06-07T01:45:09Z |
dc.date.issued.fl_str_mv |
2013 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/other |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/72262 |
dc.identifier.issn.pt_BR.fl_str_mv |
0074-0276 |
dc.identifier.nrb.pt_BR.fl_str_mv |
000879081 |
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0074-0276 000879081 |
url |
http://hdl.handle.net/10183/72262 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Memórias do Instituto Oswaldo Cruz : an international journal of biological and biomedical research. Vol. 108, n. 1 (fev. 2013), p. 48-53 |
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openAccess |
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