Type 2 deiodinase Thr92Ala polymorphism is not associated with cognitive impairment in older adults : a cross-sectional study
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/241631 |
Resumo: | Background: Type 2 Deiodinase (DIO2) converts thyroxine (T4) into the active hormone triiodothyronine (T3). Thr92Ala DIO2 polymorphism has been associated with reduced conversion of T4 into T3 and central nervous system hypothyroidism. However, how Thr92Ala DIO2 polymorphism affects cognitive function is still unclear. Objective: To assess the association between Thr92Ala DIO2 polymorphism and cognitive performance in older adults. Design: Cross-sectional study. Setting: University-based tertiary hospital in Brazil. Patients: > 65-year-old with no limiting clinical disease. Interventions: All participants answered a standard questionnaire before undergoing thyroid function laboratory evaluation and genotyping of the Thr92Ala DIO2 polymorphism. Main Outcomes: Cognitive impairment measured by the Word List Memory task from the Consortium to Establish a Registry for Alzheimer’s Disease Neuropsychological Battery (CERAD-NB) and the Brief Cognitive Screening Battery (BCSB). Results: A hundred individuals were included. Clinical and laboratory characteristics were similar among DIO2 genotypes (all p > 0.05). No differences were found in the Word List Memory, recall, or recognition tests of the CERAD-NB assuming a recessive model for the Ala/Ala vs. Thr/Ala-Thr/Thr genotypes. Results of Clock Drawing Test, Animal Fluency Test, Mini-Mental State Exam, and Figure Memory Test of the BCSB were similar between groups. Conclusions: These findings suggest that Thr92Ala DIO2 polymorphism is not associated with relevant cognitive impairment in older adults. |
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Schwengber, Wallace KleinSilveira, Vítor BöckHetzel, Guilherme MoreiraRobaina, AmandaCeolin, LucieliCamelier, Marli Teresinha ViapianaGoemann, Iuri MartinDalla Corte, Roberta RigoScheffel, Rafael SelbachMello, Renato Gorga Bandeira deMaia, Ana Luiza SilvaDora, José Miguel Silva2022-07-02T05:13:19Z20222218-1989http://hdl.handle.net/10183/241631001143218Background: Type 2 Deiodinase (DIO2) converts thyroxine (T4) into the active hormone triiodothyronine (T3). Thr92Ala DIO2 polymorphism has been associated with reduced conversion of T4 into T3 and central nervous system hypothyroidism. However, how Thr92Ala DIO2 polymorphism affects cognitive function is still unclear. Objective: To assess the association between Thr92Ala DIO2 polymorphism and cognitive performance in older adults. Design: Cross-sectional study. Setting: University-based tertiary hospital in Brazil. Patients: > 65-year-old with no limiting clinical disease. Interventions: All participants answered a standard questionnaire before undergoing thyroid function laboratory evaluation and genotyping of the Thr92Ala DIO2 polymorphism. Main Outcomes: Cognitive impairment measured by the Word List Memory task from the Consortium to Establish a Registry for Alzheimer’s Disease Neuropsychological Battery (CERAD-NB) and the Brief Cognitive Screening Battery (BCSB). Results: A hundred individuals were included. Clinical and laboratory characteristics were similar among DIO2 genotypes (all p > 0.05). No differences were found in the Word List Memory, recall, or recognition tests of the CERAD-NB assuming a recessive model for the Ala/Ala vs. Thr/Ala-Thr/Thr genotypes. Results of Clock Drawing Test, Animal Fluency Test, Mini-Mental State Exam, and Figure Memory Test of the BCSB were similar between groups. Conclusions: These findings suggest that Thr92Ala DIO2 polymorphism is not associated with relevant cognitive impairment in older adults.application/pdfengMetabolites. Basel. Vol. 12, no. 5 (May 2022), 375, 10 p.Iodeto peroxidaseCogniçãoDisfunção cognitivaPolimorfismo genéticoHipotireoidismo congênitoType 2 deiodinaseDIO2 Thr92Ala polymorphismIodothyronine deiodinase Type IIThr92Ala polymorphismCognitionOlder adultsType 2 deiodinase Thr92Ala polymorphism is not associated with cognitive impairment in older adults : a cross-sectional studyEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001143218.pdf.txt001143218.pdf.txtExtracted Texttext/plain34699http://www.lume.ufrgs.br/bitstream/10183/241631/2/001143218.pdf.txtda2b08d3af7d8cdd6d6ef8e437153a32MD52ORIGINAL001143218.pdfTexto completo (inglês)application/pdf542269http://www.lume.ufrgs.br/bitstream/10183/241631/1/001143218.pdffeef11d16ece3ea6d0ced85ae178ba74MD5110183/2416312023-06-07 03:41:38.558776oai:www.lume.ufrgs.br:10183/241631Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-06-07T06:41:38Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Type 2 deiodinase Thr92Ala polymorphism is not associated with cognitive impairment in older adults : a cross-sectional study |
title |
Type 2 deiodinase Thr92Ala polymorphism is not associated with cognitive impairment in older adults : a cross-sectional study |
spellingShingle |
Type 2 deiodinase Thr92Ala polymorphism is not associated with cognitive impairment in older adults : a cross-sectional study Schwengber, Wallace Klein Iodeto peroxidase Cognição Disfunção cognitiva Polimorfismo genético Hipotireoidismo congênito Type 2 deiodinase DIO2 Thr92Ala polymorphism Iodothyronine deiodinase Type II Thr92Ala polymorphism Cognition Older adults |
title_short |
Type 2 deiodinase Thr92Ala polymorphism is not associated with cognitive impairment in older adults : a cross-sectional study |
title_full |
Type 2 deiodinase Thr92Ala polymorphism is not associated with cognitive impairment in older adults : a cross-sectional study |
title_fullStr |
Type 2 deiodinase Thr92Ala polymorphism is not associated with cognitive impairment in older adults : a cross-sectional study |
title_full_unstemmed |
Type 2 deiodinase Thr92Ala polymorphism is not associated with cognitive impairment in older adults : a cross-sectional study |
title_sort |
Type 2 deiodinase Thr92Ala polymorphism is not associated with cognitive impairment in older adults : a cross-sectional study |
author |
Schwengber, Wallace Klein |
author_facet |
Schwengber, Wallace Klein Silveira, Vítor Böck Hetzel, Guilherme Moreira Robaina, Amanda Ceolin, Lucieli Camelier, Marli Teresinha Viapiana Goemann, Iuri Martin Dalla Corte, Roberta Rigo Scheffel, Rafael Selbach Mello, Renato Gorga Bandeira de Maia, Ana Luiza Silva Dora, José Miguel Silva |
author_role |
author |
author2 |
Silveira, Vítor Böck Hetzel, Guilherme Moreira Robaina, Amanda Ceolin, Lucieli Camelier, Marli Teresinha Viapiana Goemann, Iuri Martin Dalla Corte, Roberta Rigo Scheffel, Rafael Selbach Mello, Renato Gorga Bandeira de Maia, Ana Luiza Silva Dora, José Miguel Silva |
author2_role |
author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Schwengber, Wallace Klein Silveira, Vítor Böck Hetzel, Guilherme Moreira Robaina, Amanda Ceolin, Lucieli Camelier, Marli Teresinha Viapiana Goemann, Iuri Martin Dalla Corte, Roberta Rigo Scheffel, Rafael Selbach Mello, Renato Gorga Bandeira de Maia, Ana Luiza Silva Dora, José Miguel Silva |
dc.subject.por.fl_str_mv |
Iodeto peroxidase Cognição Disfunção cognitiva Polimorfismo genético Hipotireoidismo congênito |
topic |
Iodeto peroxidase Cognição Disfunção cognitiva Polimorfismo genético Hipotireoidismo congênito Type 2 deiodinase DIO2 Thr92Ala polymorphism Iodothyronine deiodinase Type II Thr92Ala polymorphism Cognition Older adults |
dc.subject.eng.fl_str_mv |
Type 2 deiodinase DIO2 Thr92Ala polymorphism Iodothyronine deiodinase Type II Thr92Ala polymorphism Cognition Older adults |
description |
Background: Type 2 Deiodinase (DIO2) converts thyroxine (T4) into the active hormone triiodothyronine (T3). Thr92Ala DIO2 polymorphism has been associated with reduced conversion of T4 into T3 and central nervous system hypothyroidism. However, how Thr92Ala DIO2 polymorphism affects cognitive function is still unclear. Objective: To assess the association between Thr92Ala DIO2 polymorphism and cognitive performance in older adults. Design: Cross-sectional study. Setting: University-based tertiary hospital in Brazil. Patients: > 65-year-old with no limiting clinical disease. Interventions: All participants answered a standard questionnaire before undergoing thyroid function laboratory evaluation and genotyping of the Thr92Ala DIO2 polymorphism. Main Outcomes: Cognitive impairment measured by the Word List Memory task from the Consortium to Establish a Registry for Alzheimer’s Disease Neuropsychological Battery (CERAD-NB) and the Brief Cognitive Screening Battery (BCSB). Results: A hundred individuals were included. Clinical and laboratory characteristics were similar among DIO2 genotypes (all p > 0.05). No differences were found in the Word List Memory, recall, or recognition tests of the CERAD-NB assuming a recessive model for the Ala/Ala vs. Thr/Ala-Thr/Thr genotypes. Results of Clock Drawing Test, Animal Fluency Test, Mini-Mental State Exam, and Figure Memory Test of the BCSB were similar between groups. Conclusions: These findings suggest that Thr92Ala DIO2 polymorphism is not associated with relevant cognitive impairment in older adults. |
publishDate |
2022 |
dc.date.accessioned.fl_str_mv |
2022-07-02T05:13:19Z |
dc.date.issued.fl_str_mv |
2022 |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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http://hdl.handle.net/10183/241631 |
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2218-1989 |
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001143218 |
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2218-1989 001143218 |
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http://hdl.handle.net/10183/241631 |
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eng |
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eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Metabolites. Basel. Vol. 12, no. 5 (May 2022), 375, 10 p. |
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info:eu-repo/semantics/openAccess |
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