Esquizofrenia : quarenta anos da hipótese dopaminérgica sob a ótica da química medicinal

Detalhes bibliográficos
Autor(a) principal: Menegatti, Ricardo
Data de Publicação: 2004
Outros Autores: Fraga, Carlos Alberto Manssour, Barreiro, Eliezer J., Eifler-Lima, Vera Lucia, Rates, Stela Maris Kuze, Dalla Costa, Teresa Cristina Tavares
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/72986
Resumo: Schizophrenia is a devastating psychiatric illness that affects 1-2% of the world population and continues as a challenge to neuroscience. In this work, we describe an account about the historical evolution of the dopaminergic hypothesis of schizophrenia discussing, from the medicinal chemistry point of view all different classes of antipsychotic drugs, emphasizing the rational design, structure activity relationships (SAR) and physico-chemical properties related with its molecular mechanism of action.
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spelling Menegatti, RicardoFraga, Carlos Alberto ManssourBarreiro, Eliezer J.Eifler-Lima, Vera LuciaRates, Stela Maris KuzeDalla Costa, Teresa Cristina Tavares2013-07-03T01:42:46Z20040100-4042http://hdl.handle.net/10183/72986000419540Schizophrenia is a devastating psychiatric illness that affects 1-2% of the world population and continues as a challenge to neuroscience. In this work, we describe an account about the historical evolution of the dopaminergic hypothesis of schizophrenia discussing, from the medicinal chemistry point of view all different classes of antipsychotic drugs, emphasizing the rational design, structure activity relationships (SAR) and physico-chemical properties related with its molecular mechanism of action.application/pdfporQuímica nova. Vol. 27, n. 3 (2004), p. 447-455EsquizofreniaAntipsicóticosReceptores dopaminérgicosSchizophreniaAntipsychotic drugsDopamine receptor ligandsEsquizofrenia : quarenta anos da hipótese dopaminérgica sob a ótica da química medicinalSchizophrenia : forty years of the dopaminergic hypothesis from the medicinal chemistry point of viewinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000419540.pdf000419540.pdfTexto completoapplication/pdf1172214http://www.lume.ufrgs.br/bitstream/10183/72986/1/000419540.pdf1f2244365f6c746adde1e7a637b633dcMD51TEXT000419540.pdf.txt000419540.pdf.txtExtracted Texttext/plain48226http://www.lume.ufrgs.br/bitstream/10183/72986/2/000419540.pdf.txt7d309385225540f767472c808024ff69MD52THUMBNAIL000419540.pdf.jpg000419540.pdf.jpgGenerated Thumbnailimage/jpeg1951http://www.lume.ufrgs.br/bitstream/10183/72986/3/000419540.pdf.jpg609082307016aaedbdd676c7348941b4MD5310183/729862020-02-20 04:16:57.525393oai:www.lume.ufrgs.br:10183/72986Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2020-02-20T07:16:57Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Esquizofrenia : quarenta anos da hipótese dopaminérgica sob a ótica da química medicinal
dc.title.alternative.en.fl_str_mv Schizophrenia : forty years of the dopaminergic hypothesis from the medicinal chemistry point of view
title Esquizofrenia : quarenta anos da hipótese dopaminérgica sob a ótica da química medicinal
spellingShingle Esquizofrenia : quarenta anos da hipótese dopaminérgica sob a ótica da química medicinal
Menegatti, Ricardo
Esquizofrenia
Antipsicóticos
Receptores dopaminérgicos
Schizophrenia
Antipsychotic drugs
Dopamine receptor ligands
title_short Esquizofrenia : quarenta anos da hipótese dopaminérgica sob a ótica da química medicinal
title_full Esquizofrenia : quarenta anos da hipótese dopaminérgica sob a ótica da química medicinal
title_fullStr Esquizofrenia : quarenta anos da hipótese dopaminérgica sob a ótica da química medicinal
title_full_unstemmed Esquizofrenia : quarenta anos da hipótese dopaminérgica sob a ótica da química medicinal
title_sort Esquizofrenia : quarenta anos da hipótese dopaminérgica sob a ótica da química medicinal
author Menegatti, Ricardo
author_facet Menegatti, Ricardo
Fraga, Carlos Alberto Manssour
Barreiro, Eliezer J.
Eifler-Lima, Vera Lucia
Rates, Stela Maris Kuze
Dalla Costa, Teresa Cristina Tavares
author_role author
author2 Fraga, Carlos Alberto Manssour
Barreiro, Eliezer J.
Eifler-Lima, Vera Lucia
Rates, Stela Maris Kuze
Dalla Costa, Teresa Cristina Tavares
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Menegatti, Ricardo
Fraga, Carlos Alberto Manssour
Barreiro, Eliezer J.
Eifler-Lima, Vera Lucia
Rates, Stela Maris Kuze
Dalla Costa, Teresa Cristina Tavares
dc.subject.por.fl_str_mv Esquizofrenia
Antipsicóticos
Receptores dopaminérgicos
topic Esquizofrenia
Antipsicóticos
Receptores dopaminérgicos
Schizophrenia
Antipsychotic drugs
Dopamine receptor ligands
dc.subject.eng.fl_str_mv Schizophrenia
Antipsychotic drugs
Dopamine receptor ligands
description Schizophrenia is a devastating psychiatric illness that affects 1-2% of the world population and continues as a challenge to neuroscience. In this work, we describe an account about the historical evolution of the dopaminergic hypothesis of schizophrenia discussing, from the medicinal chemistry point of view all different classes of antipsychotic drugs, emphasizing the rational design, structure activity relationships (SAR) and physico-chemical properties related with its molecular mechanism of action.
publishDate 2004
dc.date.issued.fl_str_mv 2004
dc.date.accessioned.fl_str_mv 2013-07-03T01:42:46Z
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dc.relation.ispartof.pt_BR.fl_str_mv Química nova. Vol. 27, n. 3 (2004), p. 447-455
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