Ki-67 antigen overexpression is associated with the metaplasia-adenocarcinoma sequence in Barrett’s esophagus
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/89721 |
Resumo: | Introduction. The objective of this study was to evaluate Ki-67 antigen expression in patients with Barrett’s esophagus and esophageal adenocarcinoma and to assess its correlation with the metaplasia-esophageal adenocarcinoma progression. Methods. Using immunohistochemistry we evaluated the Ki-67 index in patients with Barrett’s esophagus, esophageal adenocarcinoma, and controls.We included patients with endoscopically visible columnar mucosa of the distal esophagus (whose biopsies revealed specialized intestinal-type metaplasia), patients with esophageal and esophagogastric tumors types I and II, and patients with histologically normal gastric mucosa (control). Results. In the 57 patients studied there were no statistically significant differences between the groups with respect to age or race. Patients with cancer were predominantly men. The Ki-67 index averaged 10 ± 4% in patients with normal gastric mucosa (n = 17), 21 ± 15% in patients with Barrett’s esophagus (n = 21), and 38 ± 16% in patients with cancer (n = 19). Ki-67 expression was significantly different between all groups (P < 0.05). There was a strong linear correlation between Ki-67 expression and the metaplasia-adenocarcinoma sequence (P < 0.01). In patients with cancer, Ki-67 was not associated with clinical or surgical staging. Conclusions. Ki-67 antigen has increased expression along the metaplasiaadenocarcinoma sequence. There is a strong linear correlation between Ki-67 proliferative activity and Barrett’s carcinogenesis. |
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Volkweis, Bernardo SilveiraGurski, Richard RicachenevskyMeurer, LuísePretto, Guilherme GonçalvesMazzini, Guilherme da SilvaEdelweiss, Maria Isabel Albano2014-03-26T01:51:15Z20121687-6121http://hdl.handle.net/10183/89721000856047Introduction. The objective of this study was to evaluate Ki-67 antigen expression in patients with Barrett’s esophagus and esophageal adenocarcinoma and to assess its correlation with the metaplasia-esophageal adenocarcinoma progression. Methods. Using immunohistochemistry we evaluated the Ki-67 index in patients with Barrett’s esophagus, esophageal adenocarcinoma, and controls.We included patients with endoscopically visible columnar mucosa of the distal esophagus (whose biopsies revealed specialized intestinal-type metaplasia), patients with esophageal and esophagogastric tumors types I and II, and patients with histologically normal gastric mucosa (control). Results. In the 57 patients studied there were no statistically significant differences between the groups with respect to age or race. Patients with cancer were predominantly men. The Ki-67 index averaged 10 ± 4% in patients with normal gastric mucosa (n = 17), 21 ± 15% in patients with Barrett’s esophagus (n = 21), and 38 ± 16% in patients with cancer (n = 19). Ki-67 expression was significantly different between all groups (P < 0.05). There was a strong linear correlation between Ki-67 expression and the metaplasia-adenocarcinoma sequence (P < 0.01). In patients with cancer, Ki-67 was not associated with clinical or surgical staging. Conclusions. Ki-67 antigen has increased expression along the metaplasiaadenocarcinoma sequence. There is a strong linear correlation between Ki-67 proliferative activity and Barrett’s carcinogenesis.application/pdfengGastroenterology Research and Practice. Cairo. Vol. 2012 (2012), ID 639748, [8] p.Antígeno Ki-67MetaplasiaAdenocarcinomaEsôfago de BarrettKi-67 antigen overexpression is associated with the metaplasia-adenocarcinoma sequence in Barrett’s esophagusEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000856047.pdf000856047.pdfTexto completo (inglês)application/pdf1974383http://www.lume.ufrgs.br/bitstream/10183/89721/1/000856047.pdfb765ad5bec1f3b8dccb6d682c4fe2533MD51TEXT000856047.pdf.txt000856047.pdf.txtExtracted Texttext/plain38622http://www.lume.ufrgs.br/bitstream/10183/89721/2/000856047.pdf.txt3fbeab7dd1e24842ec2f35fe3de1bd46MD52THUMBNAIL000856047.pdf.jpg000856047.pdf.jpgGenerated Thumbnailimage/jpeg1794http://www.lume.ufrgs.br/bitstream/10183/89721/3/000856047.pdf.jpg5869edec65b4d1def480d348e0490dc9MD5310183/897212018-10-18 08:57:28.33oai:www.lume.ufrgs.br:10183/89721Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2018-10-18T11:57:28Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Ki-67 antigen overexpression is associated with the metaplasia-adenocarcinoma sequence in Barrett’s esophagus |
title |
Ki-67 antigen overexpression is associated with the metaplasia-adenocarcinoma sequence in Barrett’s esophagus |
spellingShingle |
Ki-67 antigen overexpression is associated with the metaplasia-adenocarcinoma sequence in Barrett’s esophagus Volkweis, Bernardo Silveira Antígeno Ki-67 Metaplasia Adenocarcinoma Esôfago de Barrett |
title_short |
Ki-67 antigen overexpression is associated with the metaplasia-adenocarcinoma sequence in Barrett’s esophagus |
title_full |
Ki-67 antigen overexpression is associated with the metaplasia-adenocarcinoma sequence in Barrett’s esophagus |
title_fullStr |
Ki-67 antigen overexpression is associated with the metaplasia-adenocarcinoma sequence in Barrett’s esophagus |
title_full_unstemmed |
Ki-67 antigen overexpression is associated with the metaplasia-adenocarcinoma sequence in Barrett’s esophagus |
title_sort |
Ki-67 antigen overexpression is associated with the metaplasia-adenocarcinoma sequence in Barrett’s esophagus |
author |
Volkweis, Bernardo Silveira |
author_facet |
Volkweis, Bernardo Silveira Gurski, Richard Ricachenevsky Meurer, Luíse Pretto, Guilherme Gonçalves Mazzini, Guilherme da Silva Edelweiss, Maria Isabel Albano |
author_role |
author |
author2 |
Gurski, Richard Ricachenevsky Meurer, Luíse Pretto, Guilherme Gonçalves Mazzini, Guilherme da Silva Edelweiss, Maria Isabel Albano |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Volkweis, Bernardo Silveira Gurski, Richard Ricachenevsky Meurer, Luíse Pretto, Guilherme Gonçalves Mazzini, Guilherme da Silva Edelweiss, Maria Isabel Albano |
dc.subject.por.fl_str_mv |
Antígeno Ki-67 Metaplasia Adenocarcinoma Esôfago de Barrett |
topic |
Antígeno Ki-67 Metaplasia Adenocarcinoma Esôfago de Barrett |
description |
Introduction. The objective of this study was to evaluate Ki-67 antigen expression in patients with Barrett’s esophagus and esophageal adenocarcinoma and to assess its correlation with the metaplasia-esophageal adenocarcinoma progression. Methods. Using immunohistochemistry we evaluated the Ki-67 index in patients with Barrett’s esophagus, esophageal adenocarcinoma, and controls.We included patients with endoscopically visible columnar mucosa of the distal esophagus (whose biopsies revealed specialized intestinal-type metaplasia), patients with esophageal and esophagogastric tumors types I and II, and patients with histologically normal gastric mucosa (control). Results. In the 57 patients studied there were no statistically significant differences between the groups with respect to age or race. Patients with cancer were predominantly men. The Ki-67 index averaged 10 ± 4% in patients with normal gastric mucosa (n = 17), 21 ± 15% in patients with Barrett’s esophagus (n = 21), and 38 ± 16% in patients with cancer (n = 19). Ki-67 expression was significantly different between all groups (P < 0.05). There was a strong linear correlation between Ki-67 expression and the metaplasia-adenocarcinoma sequence (P < 0.01). In patients with cancer, Ki-67 was not associated with clinical or surgical staging. Conclusions. Ki-67 antigen has increased expression along the metaplasiaadenocarcinoma sequence. There is a strong linear correlation between Ki-67 proliferative activity and Barrett’s carcinogenesis. |
publishDate |
2012 |
dc.date.issued.fl_str_mv |
2012 |
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2014-03-26T01:51:15Z |
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dc.relation.ispartof.pt_BR.fl_str_mv |
Gastroenterology Research and Practice. Cairo. Vol. 2012 (2012), ID 639748, [8] p. |
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