Intensive care unit – acquired weakness in patients with COVID-19 : occurrence and associated factors
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/270716 |
Resumo: | Objective. The primary objective of this study was to identify the occurrence and factors associated with intensive care unit (ICU)-acquired weakness (ICUAW) in patients with COVID-19. Secondarily, we monitored the evolution of muscle strength and mobility among individuals with ICUAW and those without ICUAW and the association of these variables with length of stay, mechanical ventilation (MV), and other clinical variables. Methods. In this prospective observational study, individuals admitted to the ICU for >72 hours with COVID-19 were evaluated for muscle strength and mobility at 3 times: when being weaned from ventilatory support, discharged from the ICU, and discharged from the hospital. Risk factors for ICUAW were monitored. Results. The occurrences of ICUAW at the 3 times evaluated among the 75 patients included were 52%, 38%, and 13%. The length of the ICU stay (29.5 [IQR = 16.3–42.5] vs 11 [IQR = 6.5–16] days), the length of the hospital stay (43.5 [IQR = 22.8– 55.3] vs 16 [IQR = 12.5–24] days), and time on MV (25.5 [IQR = 13.8–41.3] vs 10 [IQR = 5–22.5] days) were greater in patients with ICUAW. Muscle strength and mobility were lower at all times assessed in patients with ICUAW. Bed rest time for all patients (relative risk = 1.14; 95% CI = 1.02 to 1.28) and use of corticosteroids (relative risk = 1.01; 95% CI = 1.00 to 1.03) for those who required MV were factors independently associated with ICUAW. Muscle strength was found to have a positive correlation with mobility and a negative correlation with lengths of stay in the ICU and hospital and time on MV. Conclusion. The occurrence of ICUAW was high on patients’ awakening in the ICU but decreased throughout hospitalization; however, strength and mobility remained compromised at hospital discharge. Bed rest time and use of corticosteroids (for those who needed MV) were factors independently associated with ICUAW in patients with COVID-19. Impact. Patients who had COVID-19 and developed ICUAW had longer periods of ICU stay, hospital stay, and MV. Bed rest time and use of corticosteroids (for those who required MV) were factors independently associated with ICUAW. |
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Schmidt, DéboraPiva, Taila CristinaGlaeser, Sheila SuzanaPiekala, Daniele MartinsBerto, Paula PinheiroFriedman, GilbertoSbruzzi, Graciele2024-01-09T03:35:31Z20221538-6724http://hdl.handle.net/10183/270716001148011Objective. The primary objective of this study was to identify the occurrence and factors associated with intensive care unit (ICU)-acquired weakness (ICUAW) in patients with COVID-19. Secondarily, we monitored the evolution of muscle strength and mobility among individuals with ICUAW and those without ICUAW and the association of these variables with length of stay, mechanical ventilation (MV), and other clinical variables. Methods. In this prospective observational study, individuals admitted to the ICU for >72 hours with COVID-19 were evaluated for muscle strength and mobility at 3 times: when being weaned from ventilatory support, discharged from the ICU, and discharged from the hospital. Risk factors for ICUAW were monitored. Results. The occurrences of ICUAW at the 3 times evaluated among the 75 patients included were 52%, 38%, and 13%. The length of the ICU stay (29.5 [IQR = 16.3–42.5] vs 11 [IQR = 6.5–16] days), the length of the hospital stay (43.5 [IQR = 22.8– 55.3] vs 16 [IQR = 12.5–24] days), and time on MV (25.5 [IQR = 13.8–41.3] vs 10 [IQR = 5–22.5] days) were greater in patients with ICUAW. Muscle strength and mobility were lower at all times assessed in patients with ICUAW. Bed rest time for all patients (relative risk = 1.14; 95% CI = 1.02 to 1.28) and use of corticosteroids (relative risk = 1.01; 95% CI = 1.00 to 1.03) for those who required MV were factors independently associated with ICUAW. Muscle strength was found to have a positive correlation with mobility and a negative correlation with lengths of stay in the ICU and hospital and time on MV. Conclusion. The occurrence of ICUAW was high on patients’ awakening in the ICU but decreased throughout hospitalization; however, strength and mobility remained compromised at hospital discharge. Bed rest time and use of corticosteroids (for those who needed MV) were factors independently associated with ICUAW in patients with COVID-19. Impact. Patients who had COVID-19 and developed ICUAW had longer periods of ICU stay, hospital stay, and MV. Bed rest time and use of corticosteroids (for those who required MV) were factors independently associated with ICUAW.application/pdfengPhysical therapy. Oxford. Vol. 102, no. 5 (May 2022), p. 1-9COVID-19Estado terminalCuidados críticosUnidades de terapia intensivaFatores de riscoDebilidade muscularCritical illnessMuscle weaknessRisk factorsIntensive care unit – acquired weakness in patients with COVID-19 : occurrence and associated factorsEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001148011.pdf.txt001148011.pdf.txtExtracted Texttext/plain41185http://www.lume.ufrgs.br/bitstream/10183/270716/2/001148011.pdf.txt1be736ebd9394b672b3c420cdb1140fcMD52ORIGINAL001148011.pdfTexto completo (inglês)application/pdf699403http://www.lume.ufrgs.br/bitstream/10183/270716/1/001148011.pdf77babc5f450b804a55f64eea17506a6dMD5110183/2707162024-01-10 04:36:07.552214oai:www.lume.ufrgs.br:10183/270716Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2024-01-10T06:36:07Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Intensive care unit – acquired weakness in patients with COVID-19 : occurrence and associated factors |
title |
Intensive care unit – acquired weakness in patients with COVID-19 : occurrence and associated factors |
spellingShingle |
Intensive care unit – acquired weakness in patients with COVID-19 : occurrence and associated factors Schmidt, Débora COVID-19 Estado terminal Cuidados críticos Unidades de terapia intensiva Fatores de risco Debilidade muscular Critical illness Muscle weakness Risk factors |
title_short |
Intensive care unit – acquired weakness in patients with COVID-19 : occurrence and associated factors |
title_full |
Intensive care unit – acquired weakness in patients with COVID-19 : occurrence and associated factors |
title_fullStr |
Intensive care unit – acquired weakness in patients with COVID-19 : occurrence and associated factors |
title_full_unstemmed |
Intensive care unit – acquired weakness in patients with COVID-19 : occurrence and associated factors |
title_sort |
Intensive care unit – acquired weakness in patients with COVID-19 : occurrence and associated factors |
author |
Schmidt, Débora |
author_facet |
Schmidt, Débora Piva, Taila Cristina Glaeser, Sheila Suzana Piekala, Daniele Martins Berto, Paula Pinheiro Friedman, Gilberto Sbruzzi, Graciele |
author_role |
author |
author2 |
Piva, Taila Cristina Glaeser, Sheila Suzana Piekala, Daniele Martins Berto, Paula Pinheiro Friedman, Gilberto Sbruzzi, Graciele |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Schmidt, Débora Piva, Taila Cristina Glaeser, Sheila Suzana Piekala, Daniele Martins Berto, Paula Pinheiro Friedman, Gilberto Sbruzzi, Graciele |
dc.subject.por.fl_str_mv |
COVID-19 Estado terminal Cuidados críticos Unidades de terapia intensiva Fatores de risco Debilidade muscular |
topic |
COVID-19 Estado terminal Cuidados críticos Unidades de terapia intensiva Fatores de risco Debilidade muscular Critical illness Muscle weakness Risk factors |
dc.subject.eng.fl_str_mv |
Critical illness Muscle weakness Risk factors |
description |
Objective. The primary objective of this study was to identify the occurrence and factors associated with intensive care unit (ICU)-acquired weakness (ICUAW) in patients with COVID-19. Secondarily, we monitored the evolution of muscle strength and mobility among individuals with ICUAW and those without ICUAW and the association of these variables with length of stay, mechanical ventilation (MV), and other clinical variables. Methods. In this prospective observational study, individuals admitted to the ICU for >72 hours with COVID-19 were evaluated for muscle strength and mobility at 3 times: when being weaned from ventilatory support, discharged from the ICU, and discharged from the hospital. Risk factors for ICUAW were monitored. Results. The occurrences of ICUAW at the 3 times evaluated among the 75 patients included were 52%, 38%, and 13%. The length of the ICU stay (29.5 [IQR = 16.3–42.5] vs 11 [IQR = 6.5–16] days), the length of the hospital stay (43.5 [IQR = 22.8– 55.3] vs 16 [IQR = 12.5–24] days), and time on MV (25.5 [IQR = 13.8–41.3] vs 10 [IQR = 5–22.5] days) were greater in patients with ICUAW. Muscle strength and mobility were lower at all times assessed in patients with ICUAW. Bed rest time for all patients (relative risk = 1.14; 95% CI = 1.02 to 1.28) and use of corticosteroids (relative risk = 1.01; 95% CI = 1.00 to 1.03) for those who required MV were factors independently associated with ICUAW. Muscle strength was found to have a positive correlation with mobility and a negative correlation with lengths of stay in the ICU and hospital and time on MV. Conclusion. The occurrence of ICUAW was high on patients’ awakening in the ICU but decreased throughout hospitalization; however, strength and mobility remained compromised at hospital discharge. Bed rest time and use of corticosteroids (for those who needed MV) were factors independently associated with ICUAW in patients with COVID-19. Impact. Patients who had COVID-19 and developed ICUAW had longer periods of ICU stay, hospital stay, and MV. Bed rest time and use of corticosteroids (for those who required MV) were factors independently associated with ICUAW. |
publishDate |
2022 |
dc.date.issued.fl_str_mv |
2022 |
dc.date.accessioned.fl_str_mv |
2024-01-09T03:35:31Z |
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Estrangeiro info:eu-repo/semantics/article |
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001148011 |
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http://hdl.handle.net/10183/270716 |
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dc.relation.ispartof.pt_BR.fl_str_mv |
Physical therapy. Oxford. Vol. 102, no. 5 (May 2022), p. 1-9 |
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