Manejo clínico e cirúrgico de um cão com colangiocarcinoma difuso
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/180831 |
Resumo: | Background: Cholangiocarcinoma is an epithelial cell malignancy arising at various locations within the biliary tree. Primary liver tumors can be classified morphologically as solid, when a single large tumor involves only one liver lobe; nodular, when multiple tumors are located in different liver lobes; diffuse, when either multifocal nodular changes occur in different liver lobes or when diffuse changes occur throughout the liver. Surgery is the treatment of choice for these tumors because there is no established, effective chemotherapy protocol. This paper reports on the management of a dog with diffuse cholangiocarcinoma. Case: A 13-year-old female, castrated Pinscher, weighting 6 kg, was admitted at the Veterinary Medical Teaching Hospital of the Federal University of Rio Grande do Sul (UFRGS) with clinical signs of abdominal distension and dyspnea that had started one month ago. The patient had been subjected to total unilateral mastectomy to remove an adenocarcinoma. At clinical examination, the animal presented anemia, an area of silence during pulmonary auscultation on the right hemithorax, and hepatomegaly. Because of the chronicity and nonspecific signs, additional tests were requested. Abdominal ultrasound exam showed hepatomegaly with irregular echotexture; cavity areas scattered throughout the organ, especially by the right medial lob; discrete presence of free abdominal fluid. Thoracic radiography showed increased radiopacity in the medial and caudal right hemithorax, suggesting metastasis. Laboratory tests included a complete blood count (normocytic mycrocytic anemia), an albumin count (27.49 g/L), an alanine amino-transferase test (77.40 U/L), an alkaline phosphatase test (284.94 U/L), a creatinine test (0.81 mg/dL), a conjugated bilirubin test (0.1 mg/dL), a not conjugated bilirubin test (0.1 mg/dL), and a total bilirubin test (0.2 mg/dL). After blood transfusion, a hepatic lobectomy was performed. An incision was made along the ventral midline. A tumoral mass, approximately 20 cm in diameter, was observed in the right medial lobe, as well as diffuse changes throughout all hepatic lobes. A total lobectomy was performed by applying the mass ligation technique by placement of a circumferential ligature around the liver hilus. The abdominal cavity was sutured routinely. Histopathological examination showed primary cholangiocarcinoma. The animal had excellent postoperative recovery after six days. Subsequently, the patient again succumbed to hepatomegaly, ascites, anemia, and lethargy, and the owner chose to euthanize the patient and did not authorize a necropsy. Discussion: The cholangiocarcinoma was classified as primary and diffuse because of the macroscopic characteristics of the liver, since there were diffuse changes throughout the organ. Surgical excision was the treatment of choice. Although the prognosis was better in the early stages, lobectomy was chosen in order to improve the patient’s respiratory condition and, consequently, improve the quality of life. There were no surgical complications and the patient presented good postoperative recovery. After 60 days of the surgical procedure, clinical signs recurred (anemia, hyporexia and abdominal distension) and euthanasia was performed. Hepatic lobectomy in an animal with advanced stage cholangiocarcinoma provided good quality of life for a period of 60 days. |
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Trindade, Anelise BonillaGerardi, Daniel Guimarães2018-07-31T02:33:36Z20181678-0345http://hdl.handle.net/10183/180831001072949Background: Cholangiocarcinoma is an epithelial cell malignancy arising at various locations within the biliary tree. Primary liver tumors can be classified morphologically as solid, when a single large tumor involves only one liver lobe; nodular, when multiple tumors are located in different liver lobes; diffuse, when either multifocal nodular changes occur in different liver lobes or when diffuse changes occur throughout the liver. Surgery is the treatment of choice for these tumors because there is no established, effective chemotherapy protocol. This paper reports on the management of a dog with diffuse cholangiocarcinoma. Case: A 13-year-old female, castrated Pinscher, weighting 6 kg, was admitted at the Veterinary Medical Teaching Hospital of the Federal University of Rio Grande do Sul (UFRGS) with clinical signs of abdominal distension and dyspnea that had started one month ago. The patient had been subjected to total unilateral mastectomy to remove an adenocarcinoma. At clinical examination, the animal presented anemia, an area of silence during pulmonary auscultation on the right hemithorax, and hepatomegaly. Because of the chronicity and nonspecific signs, additional tests were requested. Abdominal ultrasound exam showed hepatomegaly with irregular echotexture; cavity areas scattered throughout the organ, especially by the right medial lob; discrete presence of free abdominal fluid. Thoracic radiography showed increased radiopacity in the medial and caudal right hemithorax, suggesting metastasis. Laboratory tests included a complete blood count (normocytic mycrocytic anemia), an albumin count (27.49 g/L), an alanine amino-transferase test (77.40 U/L), an alkaline phosphatase test (284.94 U/L), a creatinine test (0.81 mg/dL), a conjugated bilirubin test (0.1 mg/dL), a not conjugated bilirubin test (0.1 mg/dL), and a total bilirubin test (0.2 mg/dL). After blood transfusion, a hepatic lobectomy was performed. An incision was made along the ventral midline. A tumoral mass, approximately 20 cm in diameter, was observed in the right medial lobe, as well as diffuse changes throughout all hepatic lobes. A total lobectomy was performed by applying the mass ligation technique by placement of a circumferential ligature around the liver hilus. The abdominal cavity was sutured routinely. Histopathological examination showed primary cholangiocarcinoma. The animal had excellent postoperative recovery after six days. Subsequently, the patient again succumbed to hepatomegaly, ascites, anemia, and lethargy, and the owner chose to euthanize the patient and did not authorize a necropsy. Discussion: The cholangiocarcinoma was classified as primary and diffuse because of the macroscopic characteristics of the liver, since there were diffuse changes throughout the organ. Surgical excision was the treatment of choice. Although the prognosis was better in the early stages, lobectomy was chosen in order to improve the patient’s respiratory condition and, consequently, improve the quality of life. There were no surgical complications and the patient presented good postoperative recovery. After 60 days of the surgical procedure, clinical signs recurred (anemia, hyporexia and abdominal distension) and euthanasia was performed. Hepatic lobectomy in an animal with advanced stage cholangiocarcinoma provided good quality of life for a period of 60 days.application/pdfporActa scientiae veterinariae. Porto Alegre, RS. Vol. 46, supl. 1 (2018), Pub. 290, 4 p.ColangiocarcinomaProcedimentos cirúrgicos operatóriosCãesNeoplasmLiverSurgeryHepatectomyManejo clínico e cirúrgico de um cão com colangiocarcinoma difusoClinical and surgical management of dog with diffuse cholangiocarcinoma info:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL001072949.pdfTexto completoapplication/pdf949035http://www.lume.ufrgs.br/bitstream/10183/180831/1/001072949.pdf935b4ba00c580da9a6eb49caed7858b3MD51TEXT001072949.pdf.txt001072949.pdf.txtExtracted Texttext/plain13354http://www.lume.ufrgs.br/bitstream/10183/180831/2/001072949.pdf.txt1ac037e3414d217e5e7b14c20e3f2673MD52THUMBNAIL001072949.pdf.jpg001072949.pdf.jpgGenerated Thumbnailimage/jpeg1826http://www.lume.ufrgs.br/bitstream/10183/180831/3/001072949.pdf.jpg930aa849e137888ddea5c0a89cad7fb1MD5310183/1808312018-10-05 07:33:54.643oai:www.lume.ufrgs.br:10183/180831Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2018-10-05T10:33:54Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Manejo clínico e cirúrgico de um cão com colangiocarcinoma difuso |
dc.title.alternative.en.fl_str_mv |
Clinical and surgical management of dog with diffuse cholangiocarcinoma |
title |
Manejo clínico e cirúrgico de um cão com colangiocarcinoma difuso |
spellingShingle |
Manejo clínico e cirúrgico de um cão com colangiocarcinoma difuso Trindade, Anelise Bonilla Colangiocarcinoma Procedimentos cirúrgicos operatórios Cães Neoplasm Liver Surgery Hepatectomy |
title_short |
Manejo clínico e cirúrgico de um cão com colangiocarcinoma difuso |
title_full |
Manejo clínico e cirúrgico de um cão com colangiocarcinoma difuso |
title_fullStr |
Manejo clínico e cirúrgico de um cão com colangiocarcinoma difuso |
title_full_unstemmed |
Manejo clínico e cirúrgico de um cão com colangiocarcinoma difuso |
title_sort |
Manejo clínico e cirúrgico de um cão com colangiocarcinoma difuso |
author |
Trindade, Anelise Bonilla |
author_facet |
Trindade, Anelise Bonilla Gerardi, Daniel Guimarães |
author_role |
author |
author2 |
Gerardi, Daniel Guimarães |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Trindade, Anelise Bonilla Gerardi, Daniel Guimarães |
dc.subject.por.fl_str_mv |
Colangiocarcinoma Procedimentos cirúrgicos operatórios Cães |
topic |
Colangiocarcinoma Procedimentos cirúrgicos operatórios Cães Neoplasm Liver Surgery Hepatectomy |
dc.subject.eng.fl_str_mv |
Neoplasm Liver Surgery Hepatectomy |
description |
Background: Cholangiocarcinoma is an epithelial cell malignancy arising at various locations within the biliary tree. Primary liver tumors can be classified morphologically as solid, when a single large tumor involves only one liver lobe; nodular, when multiple tumors are located in different liver lobes; diffuse, when either multifocal nodular changes occur in different liver lobes or when diffuse changes occur throughout the liver. Surgery is the treatment of choice for these tumors because there is no established, effective chemotherapy protocol. This paper reports on the management of a dog with diffuse cholangiocarcinoma. Case: A 13-year-old female, castrated Pinscher, weighting 6 kg, was admitted at the Veterinary Medical Teaching Hospital of the Federal University of Rio Grande do Sul (UFRGS) with clinical signs of abdominal distension and dyspnea that had started one month ago. The patient had been subjected to total unilateral mastectomy to remove an adenocarcinoma. At clinical examination, the animal presented anemia, an area of silence during pulmonary auscultation on the right hemithorax, and hepatomegaly. Because of the chronicity and nonspecific signs, additional tests were requested. Abdominal ultrasound exam showed hepatomegaly with irregular echotexture; cavity areas scattered throughout the organ, especially by the right medial lob; discrete presence of free abdominal fluid. Thoracic radiography showed increased radiopacity in the medial and caudal right hemithorax, suggesting metastasis. Laboratory tests included a complete blood count (normocytic mycrocytic anemia), an albumin count (27.49 g/L), an alanine amino-transferase test (77.40 U/L), an alkaline phosphatase test (284.94 U/L), a creatinine test (0.81 mg/dL), a conjugated bilirubin test (0.1 mg/dL), a not conjugated bilirubin test (0.1 mg/dL), and a total bilirubin test (0.2 mg/dL). After blood transfusion, a hepatic lobectomy was performed. An incision was made along the ventral midline. A tumoral mass, approximately 20 cm in diameter, was observed in the right medial lobe, as well as diffuse changes throughout all hepatic lobes. A total lobectomy was performed by applying the mass ligation technique by placement of a circumferential ligature around the liver hilus. The abdominal cavity was sutured routinely. Histopathological examination showed primary cholangiocarcinoma. The animal had excellent postoperative recovery after six days. Subsequently, the patient again succumbed to hepatomegaly, ascites, anemia, and lethargy, and the owner chose to euthanize the patient and did not authorize a necropsy. Discussion: The cholangiocarcinoma was classified as primary and diffuse because of the macroscopic characteristics of the liver, since there were diffuse changes throughout the organ. Surgical excision was the treatment of choice. Although the prognosis was better in the early stages, lobectomy was chosen in order to improve the patient’s respiratory condition and, consequently, improve the quality of life. There were no surgical complications and the patient presented good postoperative recovery. After 60 days of the surgical procedure, clinical signs recurred (anemia, hyporexia and abdominal distension) and euthanasia was performed. Hepatic lobectomy in an animal with advanced stage cholangiocarcinoma provided good quality of life for a period of 60 days. |
publishDate |
2018 |
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2018-07-31T02:33:36Z |
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2018 |
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Acta scientiae veterinariae. Porto Alegre, RS. Vol. 46, supl. 1 (2018), Pub. 290, 4 p. |
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