Vitamin D deficiency increases the risk of adverse neonatal otcomes in gestational diabetes
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/159012 |
Resumo: | Background: Gestational diabetes mellitus (GDM) and vitamin D deficiency have been associated with increased risk of adverse perinatal outcomes but the consequences of both conditions simultaneously present in pregnancy have not yet been evaluated. Our objective was to study the influence of vitamin D deficiency in neonatal outcomes of pregnancies with GDM. Methods: 184 pregnant women with GDM referred to specialized prenatal monitoring were included in this cohort and had blood sampled for 25-hydroxyvitamin D measurement. Vitamin D was measured by chemiluminescence and deficiency was defined as < 20 ng/mL. Participants were followed until puerperium and adverse neonatal outcomes were evaluated. Results: Newborns of women with vitamin D deficiency had higher incidences of hospitalization in intensive care units (ICU) (32 vs 19%, P = 0.048), of hypoglycemia (any, 17.3 vs 7.1%, P = 0.039 requiring ICU, 15.3 vs 3.6%, P = 0.008), and were more frequently small for gestational age (SGA) (17.3 vs 5.9%, P = 0.017). After adjustment, relative risk (RR) for hypoglycemia requiring ICU was 3.63 (95%CI 1.09±12.11) and for SGA was 4.32 (95%CI 1.75± 10.66). The incidence of prematurity, jaundice and shoulder dystocia was no statistically different between groups. Conclusions: In this cohort of pregnant women with GDM, vitamin D deficiency was associated with a major increase in the incidence of adverse neonatal outcomes such as SGA newborns and neonatal hypoglycemia. |
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Weinert, Letícia SchwerzReichelt, Angela de Azevedo JacobSchmitt, Leonardo RauberBoff, RobertaOppermann, Maria Lúcia RochaCamargo, Joiza LinsSilveiro, Sandra Pinho2017-06-02T02:42:15Z20161932-6203http://hdl.handle.net/10183/159012001022808Background: Gestational diabetes mellitus (GDM) and vitamin D deficiency have been associated with increased risk of adverse perinatal outcomes but the consequences of both conditions simultaneously present in pregnancy have not yet been evaluated. Our objective was to study the influence of vitamin D deficiency in neonatal outcomes of pregnancies with GDM. Methods: 184 pregnant women with GDM referred to specialized prenatal monitoring were included in this cohort and had blood sampled for 25-hydroxyvitamin D measurement. Vitamin D was measured by chemiluminescence and deficiency was defined as < 20 ng/mL. Participants were followed until puerperium and adverse neonatal outcomes were evaluated. Results: Newborns of women with vitamin D deficiency had higher incidences of hospitalization in intensive care units (ICU) (32 vs 19%, P = 0.048), of hypoglycemia (any, 17.3 vs 7.1%, P = 0.039 requiring ICU, 15.3 vs 3.6%, P = 0.008), and were more frequently small for gestational age (SGA) (17.3 vs 5.9%, P = 0.017). After adjustment, relative risk (RR) for hypoglycemia requiring ICU was 3.63 (95%CI 1.09±12.11) and for SGA was 4.32 (95%CI 1.75± 10.66). The incidence of prematurity, jaundice and shoulder dystocia was no statistically different between groups. Conclusions: In this cohort of pregnant women with GDM, vitamin D deficiency was associated with a major increase in the incidence of adverse neonatal outcomes such as SGA newborns and neonatal hypoglycemia.application/pdfengPLoS ONE. San Francisco. Vol. 11, no. 10 (Oct. 2016), e0164999, 11 p.Diabetes gestacionalDeficiência de vitamina DRecém-nascido pequeno para a idade gestacionalVitamin D deficiency increases the risk of adverse neonatal otcomes in gestational diabetesEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL001022808.pdf001022808.pdfTexto completo (inglês)application/pdf841049http://www.lume.ufrgs.br/bitstream/10183/159012/1/001022808.pdf809de062d8043a7e4abb195c77bbe94fMD51TEXT001022808.pdf.txt001022808.pdf.txtExtracted Texttext/plain35689http://www.lume.ufrgs.br/bitstream/10183/159012/2/001022808.pdf.txt848ef9456597aef1b2f5a96e4d31f412MD5210183/1590122023-09-24 03:37:00.217013oai:www.lume.ufrgs.br:10183/159012Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-09-24T06:37Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Vitamin D deficiency increases the risk of adverse neonatal otcomes in gestational diabetes |
title |
Vitamin D deficiency increases the risk of adverse neonatal otcomes in gestational diabetes |
spellingShingle |
Vitamin D deficiency increases the risk of adverse neonatal otcomes in gestational diabetes Weinert, Letícia Schwerz Diabetes gestacional Deficiência de vitamina D Recém-nascido pequeno para a idade gestacional |
title_short |
Vitamin D deficiency increases the risk of adverse neonatal otcomes in gestational diabetes |
title_full |
Vitamin D deficiency increases the risk of adverse neonatal otcomes in gestational diabetes |
title_fullStr |
Vitamin D deficiency increases the risk of adverse neonatal otcomes in gestational diabetes |
title_full_unstemmed |
Vitamin D deficiency increases the risk of adverse neonatal otcomes in gestational diabetes |
title_sort |
Vitamin D deficiency increases the risk of adverse neonatal otcomes in gestational diabetes |
author |
Weinert, Letícia Schwerz |
author_facet |
Weinert, Letícia Schwerz Reichelt, Angela de Azevedo Jacob Schmitt, Leonardo Rauber Boff, Roberta Oppermann, Maria Lúcia Rocha Camargo, Joiza Lins Silveiro, Sandra Pinho |
author_role |
author |
author2 |
Reichelt, Angela de Azevedo Jacob Schmitt, Leonardo Rauber Boff, Roberta Oppermann, Maria Lúcia Rocha Camargo, Joiza Lins Silveiro, Sandra Pinho |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Weinert, Letícia Schwerz Reichelt, Angela de Azevedo Jacob Schmitt, Leonardo Rauber Boff, Roberta Oppermann, Maria Lúcia Rocha Camargo, Joiza Lins Silveiro, Sandra Pinho |
dc.subject.por.fl_str_mv |
Diabetes gestacional Deficiência de vitamina D Recém-nascido pequeno para a idade gestacional |
topic |
Diabetes gestacional Deficiência de vitamina D Recém-nascido pequeno para a idade gestacional |
description |
Background: Gestational diabetes mellitus (GDM) and vitamin D deficiency have been associated with increased risk of adverse perinatal outcomes but the consequences of both conditions simultaneously present in pregnancy have not yet been evaluated. Our objective was to study the influence of vitamin D deficiency in neonatal outcomes of pregnancies with GDM. Methods: 184 pregnant women with GDM referred to specialized prenatal monitoring were included in this cohort and had blood sampled for 25-hydroxyvitamin D measurement. Vitamin D was measured by chemiluminescence and deficiency was defined as < 20 ng/mL. Participants were followed until puerperium and adverse neonatal outcomes were evaluated. Results: Newborns of women with vitamin D deficiency had higher incidences of hospitalization in intensive care units (ICU) (32 vs 19%, P = 0.048), of hypoglycemia (any, 17.3 vs 7.1%, P = 0.039 requiring ICU, 15.3 vs 3.6%, P = 0.008), and were more frequently small for gestational age (SGA) (17.3 vs 5.9%, P = 0.017). After adjustment, relative risk (RR) for hypoglycemia requiring ICU was 3.63 (95%CI 1.09±12.11) and for SGA was 4.32 (95%CI 1.75± 10.66). The incidence of prematurity, jaundice and shoulder dystocia was no statistically different between groups. Conclusions: In this cohort of pregnant women with GDM, vitamin D deficiency was associated with a major increase in the incidence of adverse neonatal outcomes such as SGA newborns and neonatal hypoglycemia. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016 |
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2017-06-02T02:42:15Z |
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1932-6203 |
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http://hdl.handle.net/10183/159012 |
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eng |
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PLoS ONE. San Francisco. Vol. 11, no. 10 (Oct. 2016), e0164999, 11 p. |
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