The mapping of cortical activation by near infra-red spectroscopy might be a biomarker related to the severity of fibromyalgia
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/231274 |
Resumo: | The delta value of oxyhemoglobin (Δ-HbO) determined by functional near-infrared spectroscopy at prefrontal cortex (PFC) and motor cortex (MC) based on primary (25 °C) and secondary (5 °C) thermal stimuli presented a larger peak latency at left MC in fibromyalgia than in controls. The difference between HbO concentration 15 s after the thermal stimuli ending and HbO concentration before the thermal stimuli onset (Δ-HbO*) at left PFC increased 47.82% in fibromyalgia and 76.66% in controls. This value had satisfactory discriminatory properties to differentiate cortical activation in fibromyalgia versus controls. A receiver operator characteristics (ROC) analysis showed the Δ-HbO* cutoffs of − 0.175 at left PFC and − 0.205 at right PFC offer sensitivity and specificity of at least 80% in screening fibromyalgia from controls. In fibromyalgia, a ROC analysis showed that these cutoffs could discriminate those with higher disability due to pain and more severe central sensitization symptoms (CSS). The ROC with the best discriminatory profile was the CSS score with the Δ-HbO* at left PFC (area under the curve = 0.82, 95% confidence interval = 0.61–100). These results indicate that cortical activation based on Δ-HbO* at left PFC might be a sensitive marker to identify fibromyalgia subjects with more severe clinical symptoms. |
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Donadel, Daniela GabiattiZortéa, MaxcielTorres, Iraci Lucena da SilvaFregni, FelipeCaumo, Wolnei2021-10-27T04:25:51Z20212045-2322http://hdl.handle.net/10183/231274001132848The delta value of oxyhemoglobin (Δ-HbO) determined by functional near-infrared spectroscopy at prefrontal cortex (PFC) and motor cortex (MC) based on primary (25 °C) and secondary (5 °C) thermal stimuli presented a larger peak latency at left MC in fibromyalgia than in controls. The difference between HbO concentration 15 s after the thermal stimuli ending and HbO concentration before the thermal stimuli onset (Δ-HbO*) at left PFC increased 47.82% in fibromyalgia and 76.66% in controls. This value had satisfactory discriminatory properties to differentiate cortical activation in fibromyalgia versus controls. A receiver operator characteristics (ROC) analysis showed the Δ-HbO* cutoffs of − 0.175 at left PFC and − 0.205 at right PFC offer sensitivity and specificity of at least 80% in screening fibromyalgia from controls. In fibromyalgia, a ROC analysis showed that these cutoffs could discriminate those with higher disability due to pain and more severe central sensitization symptoms (CSS). The ROC with the best discriminatory profile was the CSS score with the Δ-HbO* at left PFC (area under the curve = 0.82, 95% confidence interval = 0.61–100). These results indicate that cortical activation based on Δ-HbO* at left PFC might be a sensitive marker to identify fibromyalgia subjects with more severe clinical symptoms.application/pdfengScientific reports. London. vol. 11 (2021), 15754, 14 f.FibromialgiaEspectroscopia de luz próxima ao infravermelhoFibromyalgiaNeuroscienceRheumatic diseasesThe mapping of cortical activation by near infra-red spectroscopy might be a biomarker related to the severity of fibromyalgiaEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001132848.pdf.txt001132848.pdf.txtExtracted Texttext/plain70052http://www.lume.ufrgs.br/bitstream/10183/231274/2/001132848.pdf.txtdb30f44fe9c8100fc22054dfd6785383MD52ORIGINAL001132848.pdfTexto completo (inglês)application/pdf1750952http://www.lume.ufrgs.br/bitstream/10183/231274/1/001132848.pdfa9d2fbbb17ea5372439bedfcc5542c6cMD5110183/2312742021-11-20 05:47:07.149185oai:www.lume.ufrgs.br:10183/231274Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2021-11-20T07:47:07Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
The mapping of cortical activation by near infra-red spectroscopy might be a biomarker related to the severity of fibromyalgia |
title |
The mapping of cortical activation by near infra-red spectroscopy might be a biomarker related to the severity of fibromyalgia |
spellingShingle |
The mapping of cortical activation by near infra-red spectroscopy might be a biomarker related to the severity of fibromyalgia Donadel, Daniela Gabiatti Fibromialgia Espectroscopia de luz próxima ao infravermelho Fibromyalgia Neuroscience Rheumatic diseases |
title_short |
The mapping of cortical activation by near infra-red spectroscopy might be a biomarker related to the severity of fibromyalgia |
title_full |
The mapping of cortical activation by near infra-red spectroscopy might be a biomarker related to the severity of fibromyalgia |
title_fullStr |
The mapping of cortical activation by near infra-red spectroscopy might be a biomarker related to the severity of fibromyalgia |
title_full_unstemmed |
The mapping of cortical activation by near infra-red spectroscopy might be a biomarker related to the severity of fibromyalgia |
title_sort |
The mapping of cortical activation by near infra-red spectroscopy might be a biomarker related to the severity of fibromyalgia |
author |
Donadel, Daniela Gabiatti |
author_facet |
Donadel, Daniela Gabiatti Zortéa, Maxciel Torres, Iraci Lucena da Silva Fregni, Felipe Caumo, Wolnei |
author_role |
author |
author2 |
Zortéa, Maxciel Torres, Iraci Lucena da Silva Fregni, Felipe Caumo, Wolnei |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Donadel, Daniela Gabiatti Zortéa, Maxciel Torres, Iraci Lucena da Silva Fregni, Felipe Caumo, Wolnei |
dc.subject.por.fl_str_mv |
Fibromialgia Espectroscopia de luz próxima ao infravermelho |
topic |
Fibromialgia Espectroscopia de luz próxima ao infravermelho Fibromyalgia Neuroscience Rheumatic diseases |
dc.subject.eng.fl_str_mv |
Fibromyalgia Neuroscience Rheumatic diseases |
description |
The delta value of oxyhemoglobin (Δ-HbO) determined by functional near-infrared spectroscopy at prefrontal cortex (PFC) and motor cortex (MC) based on primary (25 °C) and secondary (5 °C) thermal stimuli presented a larger peak latency at left MC in fibromyalgia than in controls. The difference between HbO concentration 15 s after the thermal stimuli ending and HbO concentration before the thermal stimuli onset (Δ-HbO*) at left PFC increased 47.82% in fibromyalgia and 76.66% in controls. This value had satisfactory discriminatory properties to differentiate cortical activation in fibromyalgia versus controls. A receiver operator characteristics (ROC) analysis showed the Δ-HbO* cutoffs of − 0.175 at left PFC and − 0.205 at right PFC offer sensitivity and specificity of at least 80% in screening fibromyalgia from controls. In fibromyalgia, a ROC analysis showed that these cutoffs could discriminate those with higher disability due to pain and more severe central sensitization symptoms (CSS). The ROC with the best discriminatory profile was the CSS score with the Δ-HbO* at left PFC (area under the curve = 0.82, 95% confidence interval = 0.61–100). These results indicate that cortical activation based on Δ-HbO* at left PFC might be a sensitive marker to identify fibromyalgia subjects with more severe clinical symptoms. |
publishDate |
2021 |
dc.date.accessioned.fl_str_mv |
2021-10-27T04:25:51Z |
dc.date.issued.fl_str_mv |
2021 |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
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http://hdl.handle.net/10183/231274 |
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001132848 |
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dc.relation.ispartof.pt_BR.fl_str_mv |
Scientific reports. London. vol. 11 (2021), 15754, 14 f. |
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openAccess |
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