Thiopental alters long term nociceptive response of young rats
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/225965 |
Resumo: | The objective of this study was to evaluate the long term nociceptive response determined by use of two general anesthetics, one intravenous and the other inhalatory, in young animals. In the first experiment, the animals of 21 days of age were divided into control (saline) and thiopental (35 mg/kg, i.p.) groups. In the second experiment, rats of the same age were divided in two groups – halothane (2%) and control. In experiment 1, there was difference between groups – reduction of tail-flick latency in the group thiopental (P< 0.05). In experiment 2, there were no differences between groups or interaction between time versus group (F(1,19)=0.11 for groups, P>0.05; F(1,19)=0.032 for the interaction, P>0.05). The results obtained in this study showed that halothane did not alter the nociceptive response in young animals. However, the thiopental induced hyperalgesic response in rats. |
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Dantas, GiovanaLaste, GabrielaRozisky, Joanna RipollTorres, Iraci Lucena da SilvaFerreira, Maria Beatriz Cardoso2021-08-20T04:11:04Z20151808-4532http://hdl.handle.net/10183/225965000985165The objective of this study was to evaluate the long term nociceptive response determined by use of two general anesthetics, one intravenous and the other inhalatory, in young animals. In the first experiment, the animals of 21 days of age were divided into control (saline) and thiopental (35 mg/kg, i.p.) groups. In the second experiment, rats of the same age were divided in two groups – halothane (2%) and control. In experiment 1, there was difference between groups – reduction of tail-flick latency in the group thiopental (P< 0.05). In experiment 2, there were no differences between groups or interaction between time versus group (F(1,19)=0.11 for groups, P>0.05; F(1,19)=0.032 for the interaction, P>0.05). The results obtained in this study showed that halothane did not alter the nociceptive response in young animals. However, the thiopental induced hyperalgesic response in rats.application/pdfengRevista de ciências farmacêuticas básica e aplicada. Araraquara, SP. Vol. 36, no. 2 (2015), p. 233-238TiopentalHalotanoNociceptividadeAnestesiaRatosRatsSodium thiopentalHalothaneNociceptionTail flick latencyThiopental alters long term nociceptive response of young ratsTiopental altera a resposta nociceptiva de ratos jovens em longo prazo info:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT000985165.pdf.txt000985165.pdf.txtExtracted Texttext/plain26604http://www.lume.ufrgs.br/bitstream/10183/225965/2/000985165.pdf.txt9510ca7dd0e223a2005f80b55af17244MD52ORIGINAL000985165.pdfTexto completo (inglês)application/pdf318016http://www.lume.ufrgs.br/bitstream/10183/225965/1/000985165.pdf708c1d115aea05c529194c186fedd1e7MD5110183/2259652021-09-18 04:46:33.545896oai:www.lume.ufrgs.br:10183/225965Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2021-09-18T07:46:33Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Thiopental alters long term nociceptive response of young rats |
dc.title.alternative.pt.fl_str_mv |
Tiopental altera a resposta nociceptiva de ratos jovens em longo prazo |
title |
Thiopental alters long term nociceptive response of young rats |
spellingShingle |
Thiopental alters long term nociceptive response of young rats Dantas, Giovana Tiopental Halotano Nociceptividade Anestesia Ratos Rats Sodium thiopental Halothane Nociception Tail flick latency |
title_short |
Thiopental alters long term nociceptive response of young rats |
title_full |
Thiopental alters long term nociceptive response of young rats |
title_fullStr |
Thiopental alters long term nociceptive response of young rats |
title_full_unstemmed |
Thiopental alters long term nociceptive response of young rats |
title_sort |
Thiopental alters long term nociceptive response of young rats |
author |
Dantas, Giovana |
author_facet |
Dantas, Giovana Laste, Gabriela Rozisky, Joanna Ripoll Torres, Iraci Lucena da Silva Ferreira, Maria Beatriz Cardoso |
author_role |
author |
author2 |
Laste, Gabriela Rozisky, Joanna Ripoll Torres, Iraci Lucena da Silva Ferreira, Maria Beatriz Cardoso |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Dantas, Giovana Laste, Gabriela Rozisky, Joanna Ripoll Torres, Iraci Lucena da Silva Ferreira, Maria Beatriz Cardoso |
dc.subject.por.fl_str_mv |
Tiopental Halotano Nociceptividade Anestesia Ratos |
topic |
Tiopental Halotano Nociceptividade Anestesia Ratos Rats Sodium thiopental Halothane Nociception Tail flick latency |
dc.subject.eng.fl_str_mv |
Rats Sodium thiopental Halothane Nociception Tail flick latency |
description |
The objective of this study was to evaluate the long term nociceptive response determined by use of two general anesthetics, one intravenous and the other inhalatory, in young animals. In the first experiment, the animals of 21 days of age were divided into control (saline) and thiopental (35 mg/kg, i.p.) groups. In the second experiment, rats of the same age were divided in two groups – halothane (2%) and control. In experiment 1, there was difference between groups – reduction of tail-flick latency in the group thiopental (P< 0.05). In experiment 2, there were no differences between groups or interaction between time versus group (F(1,19)=0.11 for groups, P>0.05; F(1,19)=0.032 for the interaction, P>0.05). The results obtained in this study showed that halothane did not alter the nociceptive response in young animals. However, the thiopental induced hyperalgesic response in rats. |
publishDate |
2015 |
dc.date.issued.fl_str_mv |
2015 |
dc.date.accessioned.fl_str_mv |
2021-08-20T04:11:04Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/other |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/225965 |
dc.identifier.issn.pt_BR.fl_str_mv |
1808-4532 |
dc.identifier.nrb.pt_BR.fl_str_mv |
000985165 |
identifier_str_mv |
1808-4532 000985165 |
url |
http://hdl.handle.net/10183/225965 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Revista de ciências farmacêuticas básica e aplicada. Araraquara, SP. Vol. 36, no. 2 (2015), p. 233-238 |
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info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
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Repositório Institucional da UFRGS |
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