Mechanical ventilation in patients in the intensive care unit of a general university hospital in southern Brazil : an epidemiological study
Autor(a) principal: | |
---|---|
Data de Publicação: | 2016 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/147204 |
Resumo: | OBJECTIVES: To determine the characteristics, the frequency and the mortality rates of patients needing mechanical ventilation and to identify the risk factors associated with mortality in the intensive care unit (ICU) of a general university hospital in southern Brazil. METHOD: Prospective cohort study in patients admitted to the ICU who needed mechanical ventilation for at least 24 hours between March 2004 and April 2007. RESULTS: A total of 1,115 patients admitted to the ICU needed mechanical ventilation. The mortality rate was 51%. The mean age (± standard deviation) was 57±18 years, and the mean Acute Physiology and Chronic Health Evaluation II (APACHE II) score was 22.6±8.3. The variables independently associated with mortality were (i) conditions present at the beginning of mechanical ventilation, age (hazard ratio: 1.01; po0.001); the APACHE II score (hazard ratio: 1.01; po0.005); acute lung injury/acute respiratory distress syndrome (hazard ratio: 1.38; p=0.009), sepsis (hazard ratio: 1.33; p=0.003), chronic obstructive pulmonary disease (hazard ratio: 0.58; p=0.042), and pneumonia (hazard ratio: 0.78; p=0.013) as causes of mechanical ventilation; and renal (hazard ratio: 1.29; p=0.011) and neurological (hazard ratio: 1.25; p=0.024) failure, and (ii) conditions occurring during the course of mechanical ventilation, acute lung injuri/acute respiratory distress syndrome (hazard ratio: 1.31; po0.010); sepsis (hazard ratio: 1.53; po0.001); and renal (hazard ratio: 1.75; po0.001), cardiovascular (hazard ratio: 1.32; pp0.009), and hepatic (hazard ratio: 1.67; pp0.001) failure. CONCLUSIONS: This large cohort study provides a comprehensive profile of mechanical ventilation patients in South America. The mortality rate of patients who required mechanical ventilation was higher, which may have been related to the severity of illness of the patients admitted to our ICU. Risk factors for hospital mortality included conditions present at the start of mechanical ventilation conditions that occurred during mechanical support. |
id |
UFRGS-2_c1b9f3d33e6aebda844a7e9b413e6d7c |
---|---|
oai_identifier_str |
oai:www.lume.ufrgs.br:10183/147204 |
network_acronym_str |
UFRGS-2 |
network_name_str |
Repositório Institucional da UFRGS |
repository_id_str |
|
spelling |
Fialkow, LéaFarenzena, MauricioWawrzeniak, Iuri ChristmannBrauner, Janete SallesVieira, Silvia Regina RiosVigo, ÁlvaroBozzetti, Mary Clarisse2016-08-13T02:16:04Z20161807-5932http://hdl.handle.net/10183/147204000990935OBJECTIVES: To determine the characteristics, the frequency and the mortality rates of patients needing mechanical ventilation and to identify the risk factors associated with mortality in the intensive care unit (ICU) of a general university hospital in southern Brazil. METHOD: Prospective cohort study in patients admitted to the ICU who needed mechanical ventilation for at least 24 hours between March 2004 and April 2007. RESULTS: A total of 1,115 patients admitted to the ICU needed mechanical ventilation. The mortality rate was 51%. The mean age (± standard deviation) was 57±18 years, and the mean Acute Physiology and Chronic Health Evaluation II (APACHE II) score was 22.6±8.3. The variables independently associated with mortality were (i) conditions present at the beginning of mechanical ventilation, age (hazard ratio: 1.01; po0.001); the APACHE II score (hazard ratio: 1.01; po0.005); acute lung injury/acute respiratory distress syndrome (hazard ratio: 1.38; p=0.009), sepsis (hazard ratio: 1.33; p=0.003), chronic obstructive pulmonary disease (hazard ratio: 0.58; p=0.042), and pneumonia (hazard ratio: 0.78; p=0.013) as causes of mechanical ventilation; and renal (hazard ratio: 1.29; p=0.011) and neurological (hazard ratio: 1.25; p=0.024) failure, and (ii) conditions occurring during the course of mechanical ventilation, acute lung injuri/acute respiratory distress syndrome (hazard ratio: 1.31; po0.010); sepsis (hazard ratio: 1.53; po0.001); and renal (hazard ratio: 1.75; po0.001), cardiovascular (hazard ratio: 1.32; pp0.009), and hepatic (hazard ratio: 1.67; pp0.001) failure. CONCLUSIONS: This large cohort study provides a comprehensive profile of mechanical ventilation patients in South America. The mortality rate of patients who required mechanical ventilation was higher, which may have been related to the severity of illness of the patients admitted to our ICU. Risk factors for hospital mortality included conditions present at the start of mechanical ventilation conditions that occurred during mechanical support.application/pdfengClinics. São Paulo. Vol. 71, n. 3 (mar. 2016), p. 145-151Insuficiência respiratória agudaRespiração artificialEpidemiologiaAcute respiratory failureMechanical ventilationMortalityRisk factorsEpidemiologyMechanical ventilation in patients in the intensive care unit of a general university hospital in southern Brazil : an epidemiological studyinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000990935.pdf000990935.pdfTexto completo (inglês)application/pdf416558http://www.lume.ufrgs.br/bitstream/10183/147204/1/000990935.pdf569b23feecbe7b3d458474fc90082625MD51TEXT000990935.pdf.txt000990935.pdf.txtExtracted Texttext/plain38594http://www.lume.ufrgs.br/bitstream/10183/147204/2/000990935.pdf.txt4a48da5221a69a233d61fd40c22858a5MD52THUMBNAIL000990935.pdf.jpg000990935.pdf.jpgGenerated Thumbnailimage/jpeg2194http://www.lume.ufrgs.br/bitstream/10183/147204/3/000990935.pdf.jpg331586a71e8cad6538212743e5db37b3MD5310183/1472042023-05-13 03:28:59.383515oai:www.lume.ufrgs.br:10183/147204Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-05-13T06:28:59Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Mechanical ventilation in patients in the intensive care unit of a general university hospital in southern Brazil : an epidemiological study |
title |
Mechanical ventilation in patients in the intensive care unit of a general university hospital in southern Brazil : an epidemiological study |
spellingShingle |
Mechanical ventilation in patients in the intensive care unit of a general university hospital in southern Brazil : an epidemiological study Fialkow, Léa Insuficiência respiratória aguda Respiração artificial Epidemiologia Acute respiratory failure Mechanical ventilation Mortality Risk factors Epidemiology |
title_short |
Mechanical ventilation in patients in the intensive care unit of a general university hospital in southern Brazil : an epidemiological study |
title_full |
Mechanical ventilation in patients in the intensive care unit of a general university hospital in southern Brazil : an epidemiological study |
title_fullStr |
Mechanical ventilation in patients in the intensive care unit of a general university hospital in southern Brazil : an epidemiological study |
title_full_unstemmed |
Mechanical ventilation in patients in the intensive care unit of a general university hospital in southern Brazil : an epidemiological study |
title_sort |
Mechanical ventilation in patients in the intensive care unit of a general university hospital in southern Brazil : an epidemiological study |
author |
Fialkow, Léa |
author_facet |
Fialkow, Léa Farenzena, Mauricio Wawrzeniak, Iuri Christmann Brauner, Janete Salles Vieira, Silvia Regina Rios Vigo, Álvaro Bozzetti, Mary Clarisse |
author_role |
author |
author2 |
Farenzena, Mauricio Wawrzeniak, Iuri Christmann Brauner, Janete Salles Vieira, Silvia Regina Rios Vigo, Álvaro Bozzetti, Mary Clarisse |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Fialkow, Léa Farenzena, Mauricio Wawrzeniak, Iuri Christmann Brauner, Janete Salles Vieira, Silvia Regina Rios Vigo, Álvaro Bozzetti, Mary Clarisse |
dc.subject.por.fl_str_mv |
Insuficiência respiratória aguda Respiração artificial Epidemiologia |
topic |
Insuficiência respiratória aguda Respiração artificial Epidemiologia Acute respiratory failure Mechanical ventilation Mortality Risk factors Epidemiology |
dc.subject.eng.fl_str_mv |
Acute respiratory failure Mechanical ventilation Mortality Risk factors Epidemiology |
description |
OBJECTIVES: To determine the characteristics, the frequency and the mortality rates of patients needing mechanical ventilation and to identify the risk factors associated with mortality in the intensive care unit (ICU) of a general university hospital in southern Brazil. METHOD: Prospective cohort study in patients admitted to the ICU who needed mechanical ventilation for at least 24 hours between March 2004 and April 2007. RESULTS: A total of 1,115 patients admitted to the ICU needed mechanical ventilation. The mortality rate was 51%. The mean age (± standard deviation) was 57±18 years, and the mean Acute Physiology and Chronic Health Evaluation II (APACHE II) score was 22.6±8.3. The variables independently associated with mortality were (i) conditions present at the beginning of mechanical ventilation, age (hazard ratio: 1.01; po0.001); the APACHE II score (hazard ratio: 1.01; po0.005); acute lung injury/acute respiratory distress syndrome (hazard ratio: 1.38; p=0.009), sepsis (hazard ratio: 1.33; p=0.003), chronic obstructive pulmonary disease (hazard ratio: 0.58; p=0.042), and pneumonia (hazard ratio: 0.78; p=0.013) as causes of mechanical ventilation; and renal (hazard ratio: 1.29; p=0.011) and neurological (hazard ratio: 1.25; p=0.024) failure, and (ii) conditions occurring during the course of mechanical ventilation, acute lung injuri/acute respiratory distress syndrome (hazard ratio: 1.31; po0.010); sepsis (hazard ratio: 1.53; po0.001); and renal (hazard ratio: 1.75; po0.001), cardiovascular (hazard ratio: 1.32; pp0.009), and hepatic (hazard ratio: 1.67; pp0.001) failure. CONCLUSIONS: This large cohort study provides a comprehensive profile of mechanical ventilation patients in South America. The mortality rate of patients who required mechanical ventilation was higher, which may have been related to the severity of illness of the patients admitted to our ICU. Risk factors for hospital mortality included conditions present at the start of mechanical ventilation conditions that occurred during mechanical support. |
publishDate |
2016 |
dc.date.accessioned.fl_str_mv |
2016-08-13T02:16:04Z |
dc.date.issued.fl_str_mv |
2016 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/other |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/147204 |
dc.identifier.issn.pt_BR.fl_str_mv |
1807-5932 |
dc.identifier.nrb.pt_BR.fl_str_mv |
000990935 |
identifier_str_mv |
1807-5932 000990935 |
url |
http://hdl.handle.net/10183/147204 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Clinics. São Paulo. Vol. 71, n. 3 (mar. 2016), p. 145-151 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFRGS instname:Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS |
instname_str |
Universidade Federal do Rio Grande do Sul (UFRGS) |
instacron_str |
UFRGS |
institution |
UFRGS |
reponame_str |
Repositório Institucional da UFRGS |
collection |
Repositório Institucional da UFRGS |
bitstream.url.fl_str_mv |
http://www.lume.ufrgs.br/bitstream/10183/147204/1/000990935.pdf http://www.lume.ufrgs.br/bitstream/10183/147204/2/000990935.pdf.txt http://www.lume.ufrgs.br/bitstream/10183/147204/3/000990935.pdf.jpg |
bitstream.checksum.fl_str_mv |
569b23feecbe7b3d458474fc90082625 4a48da5221a69a233d61fd40c22858a5 331586a71e8cad6538212743e5db37b3 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS) |
repository.mail.fl_str_mv |
|
_version_ |
1792790336606568448 |