Dendritic cells and their relation to apical peridontitis
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/188809 |
Resumo: | The purpose of this manuscript was to re-discuss apical periodontitis, apical biofilm, and its possible relationship with dendritic cells (DC). DCs are potent regulators of the immune system and their function is divided into three categories that involve the presentation of antigens: the presentation of antigens and activation of T cells; a not well established category suggested that DCs induce and maintain immunological tolerance; and the maintenance of the immune memory in conjunction with B cells. DCs in periapical inflammatory lesions are composed of at least two subpopulations that can be distinguished on the basis of ultrastructure and phenotype. These populations might differ in lineage, state of maturation, differentiation, activation, and/or function. The authors hereby analyzed the root apexes of teeth under SEM, after performing apicoectomy due to the failure of conventional endodontic treatment. Microbial biofilm with multispecies and areas of resorption with the presence of Howship lacunae, and images suggestive of denditric cells could be observed. The presence of DCs in periapical lesion could be an indication of the severity of the lesion, with a constant presence of antigen in the periradicular region. |
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Figueiredo, Jose Antonio Poli deMachado, Audrey MoraesOliveira, Vinícius Pasqualotti deHartmann, Rafael ChiesWaltrick, Silvana Beltrami GonçalvesBorba, Maristela Gutierrez deBrew, Myrian CamaraEstrela, Cyntia Rodrigues de AraújoBöttcher, Daiana Elisabeth2019-02-15T02:33:40Z20181806-8324http://hdl.handle.net/10183/188809001087695The purpose of this manuscript was to re-discuss apical periodontitis, apical biofilm, and its possible relationship with dendritic cells (DC). DCs are potent regulators of the immune system and their function is divided into three categories that involve the presentation of antigens: the presentation of antigens and activation of T cells; a not well established category suggested that DCs induce and maintain immunological tolerance; and the maintenance of the immune memory in conjunction with B cells. DCs in periapical inflammatory lesions are composed of at least two subpopulations that can be distinguished on the basis of ultrastructure and phenotype. These populations might differ in lineage, state of maturation, differentiation, activation, and/or function. The authors hereby analyzed the root apexes of teeth under SEM, after performing apicoectomy due to the failure of conventional endodontic treatment. Microbial biofilm with multispecies and areas of resorption with the presence of Howship lacunae, and images suggestive of denditric cells could be observed. The presence of DCs in periapical lesion could be an indication of the severity of the lesion, with a constant presence of antigen in the periradicular region.application/pdfengBrazilian oral research. São Paulo. Vol. 32, supl. 1 (2018), e71, p. 119-125Periodontite periapicalCélulas dendríticasApicectomiaBiofilmesDendritic cellsPeriapical periodontitisApicoectomyBiofilmsDendritic cells and their relation to apical peridontitisinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001087695.pdf.txt001087695.pdf.txtExtracted Texttext/plain24904http://www.lume.ufrgs.br/bitstream/10183/188809/2/001087695.pdf.txta0b9f37cc9a8b202951e69de0493f37cMD52ORIGINAL001087695.pdfTexto completo (inglês)application/pdf936119http://www.lume.ufrgs.br/bitstream/10183/188809/1/001087695.pdfc39a4005feb2257e75a6f3aaed39d18bMD5110183/1888092019-02-16 02:34:27.173017oai:www.lume.ufrgs.br:10183/188809Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2019-02-16T04:34:27Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Dendritic cells and their relation to apical peridontitis |
title |
Dendritic cells and their relation to apical peridontitis |
spellingShingle |
Dendritic cells and their relation to apical peridontitis Figueiredo, Jose Antonio Poli de Periodontite periapical Células dendríticas Apicectomia Biofilmes Dendritic cells Periapical periodontitis Apicoectomy Biofilms |
title_short |
Dendritic cells and their relation to apical peridontitis |
title_full |
Dendritic cells and their relation to apical peridontitis |
title_fullStr |
Dendritic cells and their relation to apical peridontitis |
title_full_unstemmed |
Dendritic cells and their relation to apical peridontitis |
title_sort |
Dendritic cells and their relation to apical peridontitis |
author |
Figueiredo, Jose Antonio Poli de |
author_facet |
Figueiredo, Jose Antonio Poli de Machado, Audrey Moraes Oliveira, Vinícius Pasqualotti de Hartmann, Rafael Chies Waltrick, Silvana Beltrami Gonçalves Borba, Maristela Gutierrez de Brew, Myrian Camara Estrela, Cyntia Rodrigues de Araújo Böttcher, Daiana Elisabeth |
author_role |
author |
author2 |
Machado, Audrey Moraes Oliveira, Vinícius Pasqualotti de Hartmann, Rafael Chies Waltrick, Silvana Beltrami Gonçalves Borba, Maristela Gutierrez de Brew, Myrian Camara Estrela, Cyntia Rodrigues de Araújo Böttcher, Daiana Elisabeth |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Figueiredo, Jose Antonio Poli de Machado, Audrey Moraes Oliveira, Vinícius Pasqualotti de Hartmann, Rafael Chies Waltrick, Silvana Beltrami Gonçalves Borba, Maristela Gutierrez de Brew, Myrian Camara Estrela, Cyntia Rodrigues de Araújo Böttcher, Daiana Elisabeth |
dc.subject.por.fl_str_mv |
Periodontite periapical Células dendríticas Apicectomia Biofilmes |
topic |
Periodontite periapical Células dendríticas Apicectomia Biofilmes Dendritic cells Periapical periodontitis Apicoectomy Biofilms |
dc.subject.eng.fl_str_mv |
Dendritic cells Periapical periodontitis Apicoectomy Biofilms |
description |
The purpose of this manuscript was to re-discuss apical periodontitis, apical biofilm, and its possible relationship with dendritic cells (DC). DCs are potent regulators of the immune system and their function is divided into three categories that involve the presentation of antigens: the presentation of antigens and activation of T cells; a not well established category suggested that DCs induce and maintain immunological tolerance; and the maintenance of the immune memory in conjunction with B cells. DCs in periapical inflammatory lesions are composed of at least two subpopulations that can be distinguished on the basis of ultrastructure and phenotype. These populations might differ in lineage, state of maturation, differentiation, activation, and/or function. The authors hereby analyzed the root apexes of teeth under SEM, after performing apicoectomy due to the failure of conventional endodontic treatment. Microbial biofilm with multispecies and areas of resorption with the presence of Howship lacunae, and images suggestive of denditric cells could be observed. The presence of DCs in periapical lesion could be an indication of the severity of the lesion, with a constant presence of antigen in the periradicular region. |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018 |
dc.date.accessioned.fl_str_mv |
2019-02-15T02:33:40Z |
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info:eu-repo/semantics/article info:eu-repo/semantics/other |
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http://hdl.handle.net/10183/188809 |
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1806-8324 |
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001087695 |
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http://hdl.handle.net/10183/188809 |
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eng |
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dc.relation.ispartof.pt_BR.fl_str_mv |
Brazilian oral research. São Paulo. Vol. 32, supl. 1 (2018), e71, p. 119-125 |
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