Pressure-support ventilation or T-piece spontaneous breathing trials for patients with chronic obstructive pulmonary disease : a randomized controlled trial
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/200542 |
Resumo: | Background Little is known about the best strategy for weaning patients with chronic obstructive pulmonary disease (COPD) from mechanical ventilation. Spontaneous breathing trials (SBT) using a T-piece or pressure-support ventilation (PSV) have a central role in this process. Our aim was to compare T-piece and PSV SBTs according to the duration of mechanical ventilation (MV) in patients with COPD. Methods Patients with COPD who had at least 48 hours of invasive MV support were randomized to 30 minutes of T-piece or PSV at 10 cm H2O after being considered able to undergo a SBT. All patients were preemptively connected to non-invasive ventilation after extubation. Tracheostomized patients were excluded. The primary outcome was total invasive MV duration. Time to liberation from MV was assessed as secondary outcome. Results Between 2012 and 2016, 190 patients were randomized to T-piece (99) or PSV (91) groups. Extubation at first SBT was achieved in 78% of patients. The mean total MV duration was 10.82 ± 9.1 days for the T-piece group and 7.31 ± 4.9 days for the PSV group (p < 0.001); however, the pre-SBT duration also differed (7.35 ± 3.9 and 5.84 ± 3.3, respectively; p = 0.002). The time to liberation was 8.36 ± 11.04 days for the T-piece group and 4.06 ± 4.94 for the PSV group (univariate mean ratio = 2.06 [1.29±3.27], p = 0.003) for the subgroup of patients with difficult or prolonged weaning. The study group was independently associated with the time to liberation in this subgroup.Conclusions The SBT technique did not influence MV duration for patients with COPD. For the difficult/ prolonged weaning subgroup, the T-piece may be associated with a longer time to liberation, although this should be clarified by further studies. |
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Pellegrini, José Augusto SantosBoniatti, Márcio ManozzoBoniatti, Viviane M. CorrêaZigiotto, Crislene CattelanViana, Marina VerçozaNedel, Wagner LuísMarques, Leonardo da SilvaSantos, Moreno Calcagnotto dosAlmeida, Clarissa Balbão deDal Pizzol, Cláudia PellizzerZiegelmann, Patricia KlarmannVieira, Silvia Regina Rios2019-10-11T03:56:07Z20181932-6203http://hdl.handle.net/10183/200542001083774Background Little is known about the best strategy for weaning patients with chronic obstructive pulmonary disease (COPD) from mechanical ventilation. Spontaneous breathing trials (SBT) using a T-piece or pressure-support ventilation (PSV) have a central role in this process. Our aim was to compare T-piece and PSV SBTs according to the duration of mechanical ventilation (MV) in patients with COPD. Methods Patients with COPD who had at least 48 hours of invasive MV support were randomized to 30 minutes of T-piece or PSV at 10 cm H2O after being considered able to undergo a SBT. All patients were preemptively connected to non-invasive ventilation after extubation. Tracheostomized patients were excluded. The primary outcome was total invasive MV duration. Time to liberation from MV was assessed as secondary outcome. Results Between 2012 and 2016, 190 patients were randomized to T-piece (99) or PSV (91) groups. Extubation at first SBT was achieved in 78% of patients. The mean total MV duration was 10.82 ± 9.1 days for the T-piece group and 7.31 ± 4.9 days for the PSV group (p < 0.001); however, the pre-SBT duration also differed (7.35 ± 3.9 and 5.84 ± 3.3, respectively; p = 0.002). The time to liberation was 8.36 ± 11.04 days for the T-piece group and 4.06 ± 4.94 for the PSV group (univariate mean ratio = 2.06 [1.29±3.27], p = 0.003) for the subgroup of patients with difficult or prolonged weaning. The study group was independently associated with the time to liberation in this subgroup.Conclusions The SBT technique did not influence MV duration for patients with COPD. For the difficult/ prolonged weaning subgroup, the T-piece may be associated with a longer time to liberation, although this should be clarified by further studies.application/pdfengPLoS ONE. San Francisco. Vol. 13, no. 8 (Aug. 2018), e0202404, 14 p.Doença pulmonar obstrutiva crônicaRespiração artificialVentiladores mecânicosRespiração com pressão positivaEnsaio clínico controlado aleatórioPressure-support ventilation or T-piece spontaneous breathing trials for patients with chronic obstructive pulmonary disease : a randomized controlled trialEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001083774.pdf.txt001083774.pdf.txtExtracted Texttext/plain47693http://www.lume.ufrgs.br/bitstream/10183/200542/2/001083774.pdf.txt6c7b3fedd96d37ae1849e67f70dc781fMD52ORIGINAL001083774.pdfTexto completo (inglês)application/pdf934128http://www.lume.ufrgs.br/bitstream/10183/200542/1/001083774.pdfd470fd82725d5e2bb2095e2541a9ea66MD5110183/2005422023-09-24 03:40:12.190212oai:www.lume.ufrgs.br:10183/200542Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-09-24T06:40:12Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Pressure-support ventilation or T-piece spontaneous breathing trials for patients with chronic obstructive pulmonary disease : a randomized controlled trial |
title |
Pressure-support ventilation or T-piece spontaneous breathing trials for patients with chronic obstructive pulmonary disease : a randomized controlled trial |
spellingShingle |
Pressure-support ventilation or T-piece spontaneous breathing trials for patients with chronic obstructive pulmonary disease : a randomized controlled trial Pellegrini, José Augusto Santos Doença pulmonar obstrutiva crônica Respiração artificial Ventiladores mecânicos Respiração com pressão positiva Ensaio clínico controlado aleatório |
title_short |
Pressure-support ventilation or T-piece spontaneous breathing trials for patients with chronic obstructive pulmonary disease : a randomized controlled trial |
title_full |
Pressure-support ventilation or T-piece spontaneous breathing trials for patients with chronic obstructive pulmonary disease : a randomized controlled trial |
title_fullStr |
Pressure-support ventilation or T-piece spontaneous breathing trials for patients with chronic obstructive pulmonary disease : a randomized controlled trial |
title_full_unstemmed |
Pressure-support ventilation or T-piece spontaneous breathing trials for patients with chronic obstructive pulmonary disease : a randomized controlled trial |
title_sort |
Pressure-support ventilation or T-piece spontaneous breathing trials for patients with chronic obstructive pulmonary disease : a randomized controlled trial |
author |
Pellegrini, José Augusto Santos |
author_facet |
Pellegrini, José Augusto Santos Boniatti, Márcio Manozzo Boniatti, Viviane M. Corrêa Zigiotto, Crislene Cattelan Viana, Marina Verçoza Nedel, Wagner Luís Marques, Leonardo da Silva Santos, Moreno Calcagnotto dos Almeida, Clarissa Balbão de Dal Pizzol, Cláudia Pellizzer Ziegelmann, Patricia Klarmann Vieira, Silvia Regina Rios |
author_role |
author |
author2 |
Boniatti, Márcio Manozzo Boniatti, Viviane M. Corrêa Zigiotto, Crislene Cattelan Viana, Marina Verçoza Nedel, Wagner Luís Marques, Leonardo da Silva Santos, Moreno Calcagnotto dos Almeida, Clarissa Balbão de Dal Pizzol, Cláudia Pellizzer Ziegelmann, Patricia Klarmann Vieira, Silvia Regina Rios |
author2_role |
author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Pellegrini, José Augusto Santos Boniatti, Márcio Manozzo Boniatti, Viviane M. Corrêa Zigiotto, Crislene Cattelan Viana, Marina Verçoza Nedel, Wagner Luís Marques, Leonardo da Silva Santos, Moreno Calcagnotto dos Almeida, Clarissa Balbão de Dal Pizzol, Cláudia Pellizzer Ziegelmann, Patricia Klarmann Vieira, Silvia Regina Rios |
dc.subject.por.fl_str_mv |
Doença pulmonar obstrutiva crônica Respiração artificial Ventiladores mecânicos Respiração com pressão positiva Ensaio clínico controlado aleatório |
topic |
Doença pulmonar obstrutiva crônica Respiração artificial Ventiladores mecânicos Respiração com pressão positiva Ensaio clínico controlado aleatório |
description |
Background Little is known about the best strategy for weaning patients with chronic obstructive pulmonary disease (COPD) from mechanical ventilation. Spontaneous breathing trials (SBT) using a T-piece or pressure-support ventilation (PSV) have a central role in this process. Our aim was to compare T-piece and PSV SBTs according to the duration of mechanical ventilation (MV) in patients with COPD. Methods Patients with COPD who had at least 48 hours of invasive MV support were randomized to 30 minutes of T-piece or PSV at 10 cm H2O after being considered able to undergo a SBT. All patients were preemptively connected to non-invasive ventilation after extubation. Tracheostomized patients were excluded. The primary outcome was total invasive MV duration. Time to liberation from MV was assessed as secondary outcome. Results Between 2012 and 2016, 190 patients were randomized to T-piece (99) or PSV (91) groups. Extubation at first SBT was achieved in 78% of patients. The mean total MV duration was 10.82 ± 9.1 days for the T-piece group and 7.31 ± 4.9 days for the PSV group (p < 0.001); however, the pre-SBT duration also differed (7.35 ± 3.9 and 5.84 ± 3.3, respectively; p = 0.002). The time to liberation was 8.36 ± 11.04 days for the T-piece group and 4.06 ± 4.94 for the PSV group (univariate mean ratio = 2.06 [1.29±3.27], p = 0.003) for the subgroup of patients with difficult or prolonged weaning. The study group was independently associated with the time to liberation in this subgroup.Conclusions The SBT technique did not influence MV duration for patients with COPD. For the difficult/ prolonged weaning subgroup, the T-piece may be associated with a longer time to liberation, although this should be clarified by further studies. |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018 |
dc.date.accessioned.fl_str_mv |
2019-10-11T03:56:07Z |
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Estrangeiro info:eu-repo/semantics/article |
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info:eu-repo/semantics/publishedVersion |
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article |
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http://hdl.handle.net/10183/200542 |
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1932-6203 |
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001083774 |
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eng |
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PLoS ONE. San Francisco. Vol. 13, no. 8 (Aug. 2018), e0202404, 14 p. |
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