Metabolomics applied to maternal and perinatal health : a review of new frontiers with a translation potential
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Publication Date: | 2019 |
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Format: | Article |
Language: | eng |
Source: | Repositório Institucional da UFRGS |
Download full: | http://hdl.handle.net/10183/195647 |
Summary: | The prediction or early diagnosis of maternal complications is challenging mostly because the main conditions, such as preeclampsia, preterm birth, fetal growth restriction, and gestational diabetes mellitus, are complex syndromes with multiple underlying mechanisms related to their occurrence. Limited advances in maternal and perinatal health in recent decades with respect to preventing these disorders have led to new approaches, and “omics” sciences have emerged as a potential field to be explored. Metabolomics is the study of a set of metabolites in a given sample and can represent the metabolic functioning of a cell, tissue or organism. Metabolomics has some advantages over genomics, transcriptomics, and proteomics, as metabolites are the final result of the interactions of genes, RNAs and proteins. Considering the recent “boom” in metabolomic studies and their importance in the research agenda, we here review the topic, explaining the rationale and theory of the metabolomic approach in different areas of maternal and perinatal health research for clinical practitioners. We also demonstrate the main exploratory studies of these maternal complications, commenting on their promising findings. The potential translational application of metabolomic studies, especially for the identification of predictive biomarkers, is supported by the current findings, although they require external validation in larger datasets and with alternative methodologies. |
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Souza, Renato TeixeiraNovais, Jussara de Souza MayrinkLeite, Debora Farias BatistaNascimento, Maria Laura Costa doCalderon, Iracema de Mattos ParanhosRocha Filho, Edilberto Alves Pereira daVettorazzi, JaneteFeitosa, Francisco Edson de LucenaCecatti, Jose Guilherme2019-06-12T02:31:43Z20191980-5322http://hdl.handle.net/10183/195647001093172The prediction or early diagnosis of maternal complications is challenging mostly because the main conditions, such as preeclampsia, preterm birth, fetal growth restriction, and gestational diabetes mellitus, are complex syndromes with multiple underlying mechanisms related to their occurrence. Limited advances in maternal and perinatal health in recent decades with respect to preventing these disorders have led to new approaches, and “omics” sciences have emerged as a potential field to be explored. Metabolomics is the study of a set of metabolites in a given sample and can represent the metabolic functioning of a cell, tissue or organism. Metabolomics has some advantages over genomics, transcriptomics, and proteomics, as metabolites are the final result of the interactions of genes, RNAs and proteins. Considering the recent “boom” in metabolomic studies and their importance in the research agenda, we here review the topic, explaining the rationale and theory of the metabolomic approach in different areas of maternal and perinatal health research for clinical practitioners. We also demonstrate the main exploratory studies of these maternal complications, commenting on their promising findings. The potential translational application of metabolomic studies, especially for the identification of predictive biomarkers, is supported by the current findings, although they require external validation in larger datasets and with alternative methodologies.application/pdfengClinics. São Paulo. vol. 74 (2019), e894, 12 f.MetabolômicaRecém-nascidoGestantesMaternal health (MeSH)Metabolomics (MeSH)Translational medical research (MeSH)PredictionMetabolomics applied to maternal and perinatal health : a review of new frontiers with a translation potentialinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001093172.pdf.txt001093172.pdf.txtExtracted Texttext/plain89350http://www.lume.ufrgs.br/bitstream/10183/195647/2/001093172.pdf.txt2c8b4d3a4baab2212c833c23687e6bedMD52ORIGINAL001093172.pdfTexto completo (inglês)application/pdf766293http://www.lume.ufrgs.br/bitstream/10183/195647/1/001093172.pdfd3694a392a2120b7b8d5e91ffe93d3f0MD5110183/1956472019-06-13 02:30:35.602774oai:www.lume.ufrgs.br:10183/195647Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2019-06-13T05:30:35Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Metabolomics applied to maternal and perinatal health : a review of new frontiers with a translation potential |
title |
Metabolomics applied to maternal and perinatal health : a review of new frontiers with a translation potential |
spellingShingle |
Metabolomics applied to maternal and perinatal health : a review of new frontiers with a translation potential Souza, Renato Teixeira Metabolômica Recém-nascido Gestantes Maternal health (MeSH) Metabolomics (MeSH) Translational medical research (MeSH) Prediction |
title_short |
Metabolomics applied to maternal and perinatal health : a review of new frontiers with a translation potential |
title_full |
Metabolomics applied to maternal and perinatal health : a review of new frontiers with a translation potential |
title_fullStr |
Metabolomics applied to maternal and perinatal health : a review of new frontiers with a translation potential |
title_full_unstemmed |
Metabolomics applied to maternal and perinatal health : a review of new frontiers with a translation potential |
title_sort |
Metabolomics applied to maternal and perinatal health : a review of new frontiers with a translation potential |
author |
Souza, Renato Teixeira |
author_facet |
Souza, Renato Teixeira Novais, Jussara de Souza Mayrink Leite, Debora Farias Batista Nascimento, Maria Laura Costa do Calderon, Iracema de Mattos Paranhos Rocha Filho, Edilberto Alves Pereira da Vettorazzi, Janete Feitosa, Francisco Edson de Lucena Cecatti, Jose Guilherme |
author_role |
author |
author2 |
Novais, Jussara de Souza Mayrink Leite, Debora Farias Batista Nascimento, Maria Laura Costa do Calderon, Iracema de Mattos Paranhos Rocha Filho, Edilberto Alves Pereira da Vettorazzi, Janete Feitosa, Francisco Edson de Lucena Cecatti, Jose Guilherme |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Souza, Renato Teixeira Novais, Jussara de Souza Mayrink Leite, Debora Farias Batista Nascimento, Maria Laura Costa do Calderon, Iracema de Mattos Paranhos Rocha Filho, Edilberto Alves Pereira da Vettorazzi, Janete Feitosa, Francisco Edson de Lucena Cecatti, Jose Guilherme |
dc.subject.por.fl_str_mv |
Metabolômica Recém-nascido Gestantes |
topic |
Metabolômica Recém-nascido Gestantes Maternal health (MeSH) Metabolomics (MeSH) Translational medical research (MeSH) Prediction |
dc.subject.eng.fl_str_mv |
Maternal health (MeSH) Metabolomics (MeSH) Translational medical research (MeSH) Prediction |
description |
The prediction or early diagnosis of maternal complications is challenging mostly because the main conditions, such as preeclampsia, preterm birth, fetal growth restriction, and gestational diabetes mellitus, are complex syndromes with multiple underlying mechanisms related to their occurrence. Limited advances in maternal and perinatal health in recent decades with respect to preventing these disorders have led to new approaches, and “omics” sciences have emerged as a potential field to be explored. Metabolomics is the study of a set of metabolites in a given sample and can represent the metabolic functioning of a cell, tissue or organism. Metabolomics has some advantages over genomics, transcriptomics, and proteomics, as metabolites are the final result of the interactions of genes, RNAs and proteins. Considering the recent “boom” in metabolomic studies and their importance in the research agenda, we here review the topic, explaining the rationale and theory of the metabolomic approach in different areas of maternal and perinatal health research for clinical practitioners. We also demonstrate the main exploratory studies of these maternal complications, commenting on their promising findings. The potential translational application of metabolomic studies, especially for the identification of predictive biomarkers, is supported by the current findings, although they require external validation in larger datasets and with alternative methodologies. |
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2019 |
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