Standard dose 131 I therapy for toxic multinodular goiter in an endemic goiter region
Autor(a) principal: | |
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Data de Publicação: | 1986 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/247375 |
Resumo: | 1. The effect of the standard 15 mCi dose of 131 I on the thyroid function of 25 patients from an endemic goiter region with toxic multinodular goiter of different sizes was determined. 2. The patients were followed for 1 to 5 years and 7 months (mean: 2 years and 10 months). Eighteen patients were treated with the antithyroid drugs propylthiouracil or methimazole before 1 3 1 I and seven only received 131 I. 3. All but three patients achieved euthyroidism after a single dose of 131 1. Two patients in the antithyroid treatment group became hypothyroid 2 months and 2 years after the isotope therapy, respectively. Pretreatment with antithyroid drugs did not significantly modify the effectiveness of 131 I treatment. 4. This simplified dose regimen of 131 I was effective in the treatment of hyperthyroidism caused by multinodular goiter in an endemic region, and the efficacy was independent of the size of the goiter. |
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Gonçalves, E.Castro, Jose Augusto Sisson deGross, Jorge Luiz2022-08-19T04:44:26Z19860100-879Xhttp://hdl.handle.net/10183/2473750007058801. The effect of the standard 15 mCi dose of 131 I on the thyroid function of 25 patients from an endemic goiter region with toxic multinodular goiter of different sizes was determined. 2. The patients were followed for 1 to 5 years and 7 months (mean: 2 years and 10 months). Eighteen patients were treated with the antithyroid drugs propylthiouracil or methimazole before 1 3 1 I and seven only received 131 I. 3. All but three patients achieved euthyroidism after a single dose of 131 1. Two patients in the antithyroid treatment group became hypothyroid 2 months and 2 years after the isotope therapy, respectively. Pretreatment with antithyroid drugs did not significantly modify the effectiveness of 131 I treatment. 4. This simplified dose regimen of 131 I was effective in the treatment of hyperthyroidism caused by multinodular goiter in an endemic region, and the efficacy was independent of the size of the goiter.application/pdfengBrazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Ribeirão Preto, SP. Vol. 19, no. 6 (1986), p. 723-729Bócio endêmicoTireotoxicoseToxic multinodular goiter131 I therapyThyrotoxicosisStandard dose 131 I therapy for toxic multinodular goiter in an endemic goiter regioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT000705880.pdf.txt000705880.pdf.txtExtracted Texttext/plain22135http://www.lume.ufrgs.br/bitstream/10183/247375/2/000705880.pdf.txt6ff56fb02672ef3bedba2c42860c8d66MD52ORIGINAL000705880.pdfTexto completo (inglês)application/pdf2698391http://www.lume.ufrgs.br/bitstream/10183/247375/1/000705880.pdf3825817decbf6cb7c3fdf6aa2361a403MD5110183/2473752022-08-21 04:39:38.900047oai:www.lume.ufrgs.br:10183/247375Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2022-08-21T07:39:38Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Standard dose 131 I therapy for toxic multinodular goiter in an endemic goiter region |
title |
Standard dose 131 I therapy for toxic multinodular goiter in an endemic goiter region |
spellingShingle |
Standard dose 131 I therapy for toxic multinodular goiter in an endemic goiter region Gonçalves, E. Bócio endêmico Tireotoxicose Toxic multinodular goiter 131 I therapy Thyrotoxicosis |
title_short |
Standard dose 131 I therapy for toxic multinodular goiter in an endemic goiter region |
title_full |
Standard dose 131 I therapy for toxic multinodular goiter in an endemic goiter region |
title_fullStr |
Standard dose 131 I therapy for toxic multinodular goiter in an endemic goiter region |
title_full_unstemmed |
Standard dose 131 I therapy for toxic multinodular goiter in an endemic goiter region |
title_sort |
Standard dose 131 I therapy for toxic multinodular goiter in an endemic goiter region |
author |
Gonçalves, E. |
author_facet |
Gonçalves, E. Castro, Jose Augusto Sisson de Gross, Jorge Luiz |
author_role |
author |
author2 |
Castro, Jose Augusto Sisson de Gross, Jorge Luiz |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Gonçalves, E. Castro, Jose Augusto Sisson de Gross, Jorge Luiz |
dc.subject.por.fl_str_mv |
Bócio endêmico Tireotoxicose |
topic |
Bócio endêmico Tireotoxicose Toxic multinodular goiter 131 I therapy Thyrotoxicosis |
dc.subject.eng.fl_str_mv |
Toxic multinodular goiter 131 I therapy Thyrotoxicosis |
description |
1. The effect of the standard 15 mCi dose of 131 I on the thyroid function of 25 patients from an endemic goiter region with toxic multinodular goiter of different sizes was determined. 2. The patients were followed for 1 to 5 years and 7 months (mean: 2 years and 10 months). Eighteen patients were treated with the antithyroid drugs propylthiouracil or methimazole before 1 3 1 I and seven only received 131 I. 3. All but three patients achieved euthyroidism after a single dose of 131 1. Two patients in the antithyroid treatment group became hypothyroid 2 months and 2 years after the isotope therapy, respectively. Pretreatment with antithyroid drugs did not significantly modify the effectiveness of 131 I treatment. 4. This simplified dose regimen of 131 I was effective in the treatment of hyperthyroidism caused by multinodular goiter in an endemic region, and the efficacy was independent of the size of the goiter. |
publishDate |
1986 |
dc.date.issued.fl_str_mv |
1986 |
dc.date.accessioned.fl_str_mv |
2022-08-19T04:44:26Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/other |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/247375 |
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0100-879X |
dc.identifier.nrb.pt_BR.fl_str_mv |
000705880 |
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0100-879X 000705880 |
url |
http://hdl.handle.net/10183/247375 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Ribeirão Preto, SP. Vol. 19, no. 6 (1986), p. 723-729 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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