Is endogenous creatinine clearance still a reliable index of glomerular filtration rate in diabetic patients?
Autor(a) principal: | |
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Data de Publicação: | 1988 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/247344 |
Resumo: | Three methods routinely used for estimation of renal function - plasma creatinine, endogenous creaumne clearance and estimation of endogenous creatinine clearance from plasma creatinine - are compared with the measurement of glomerular filtration rate based on a single injection of 5lcr-EDTA, a technique that was standardized for this study in 20 healthy volunteers. The different creatinine methods were compared with the 5Icr-EDTA method in 30 diabetic patients, resulting in 68 sets of data in which all four estimates were made simultaneously. Spearman's correlation values (rs) for comparing the three creatinine methods with that of 5lcr-EDTA were 0.74, 0.40 and 0.82 (P<0.05). It is suggested that the use of endogenous creatinine clearance to estimate the glomerular filtration rate (GFR) requires caution and the recognition of the limitations of the method, and that simpler techniques (serum creatinine or estimated endogenous creatinine clearance) are preferable in routine practice. GFR based on 51Cr-EDTA injection is the method of choice for monitoring renal function in special situations such as renal transplantation and progressive nephropathies. |
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Friedman, RogérioAzevedo, Mirela Jobim deGross, Jorge Luiz2022-08-19T04:43:22Z19880100-879Xhttp://hdl.handle.net/10183/247344000061284Three methods routinely used for estimation of renal function - plasma creatinine, endogenous creaumne clearance and estimation of endogenous creatinine clearance from plasma creatinine - are compared with the measurement of glomerular filtration rate based on a single injection of 5lcr-EDTA, a technique that was standardized for this study in 20 healthy volunteers. The different creatinine methods were compared with the 5Icr-EDTA method in 30 diabetic patients, resulting in 68 sets of data in which all four estimates were made simultaneously. Spearman's correlation values (rs) for comparing the three creatinine methods with that of 5lcr-EDTA were 0.74, 0.40 and 0.82 (P<0.05). It is suggested that the use of endogenous creatinine clearance to estimate the glomerular filtration rate (GFR) requires caution and the recognition of the limitations of the method, and that simpler techniques (serum creatinine or estimated endogenous creatinine clearance) are preferable in routine practice. GFR based on 51Cr-EDTA injection is the method of choice for monitoring renal function in special situations such as renal transplantation and progressive nephropathies.application/pdfengBrazilian Journal of Medical and Biological Research. Ribeirao Preto. Vol. 21, n. 5 (1988), p. 941-944Diabetes mellitusNefropatias diabéticasTaxa de filtração glomerularCreatininaCreatinineGlomerular filtration rateDiabetes mellitus51Cr-EDTAIs endogenous creatinine clearance still a reliable index of glomerular filtration rate in diabetic patients?info:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT000061284.pdf.txt000061284.pdf.txtExtracted Texttext/plain10758http://www.lume.ufrgs.br/bitstream/10183/247344/2/000061284.pdf.txt42a07e26fec931c76cf0c7268aa12742MD52ORIGINAL000061284.pdfTexto completo (inglês)application/pdf1172227http://www.lume.ufrgs.br/bitstream/10183/247344/1/000061284.pdf814d08809ecea3f599d721f91be3fb79MD5110183/2473442022-08-21 04:40:08.323034oai:www.lume.ufrgs.br:10183/247344Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2022-08-21T07:40:08Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Is endogenous creatinine clearance still a reliable index of glomerular filtration rate in diabetic patients? |
title |
Is endogenous creatinine clearance still a reliable index of glomerular filtration rate in diabetic patients? |
spellingShingle |
Is endogenous creatinine clearance still a reliable index of glomerular filtration rate in diabetic patients? Friedman, Rogério Diabetes mellitus Nefropatias diabéticas Taxa de filtração glomerular Creatinina Creatinine Glomerular filtration rate Diabetes mellitus 51Cr-EDTA |
title_short |
Is endogenous creatinine clearance still a reliable index of glomerular filtration rate in diabetic patients? |
title_full |
Is endogenous creatinine clearance still a reliable index of glomerular filtration rate in diabetic patients? |
title_fullStr |
Is endogenous creatinine clearance still a reliable index of glomerular filtration rate in diabetic patients? |
title_full_unstemmed |
Is endogenous creatinine clearance still a reliable index of glomerular filtration rate in diabetic patients? |
title_sort |
Is endogenous creatinine clearance still a reliable index of glomerular filtration rate in diabetic patients? |
author |
Friedman, Rogério |
author_facet |
Friedman, Rogério Azevedo, Mirela Jobim de Gross, Jorge Luiz |
author_role |
author |
author2 |
Azevedo, Mirela Jobim de Gross, Jorge Luiz |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Friedman, Rogério Azevedo, Mirela Jobim de Gross, Jorge Luiz |
dc.subject.por.fl_str_mv |
Diabetes mellitus Nefropatias diabéticas Taxa de filtração glomerular Creatinina |
topic |
Diabetes mellitus Nefropatias diabéticas Taxa de filtração glomerular Creatinina Creatinine Glomerular filtration rate Diabetes mellitus 51Cr-EDTA |
dc.subject.eng.fl_str_mv |
Creatinine Glomerular filtration rate Diabetes mellitus 51Cr-EDTA |
description |
Three methods routinely used for estimation of renal function - plasma creatinine, endogenous creaumne clearance and estimation of endogenous creatinine clearance from plasma creatinine - are compared with the measurement of glomerular filtration rate based on a single injection of 5lcr-EDTA, a technique that was standardized for this study in 20 healthy volunteers. The different creatinine methods were compared with the 5Icr-EDTA method in 30 diabetic patients, resulting in 68 sets of data in which all four estimates were made simultaneously. Spearman's correlation values (rs) for comparing the three creatinine methods with that of 5lcr-EDTA were 0.74, 0.40 and 0.82 (P<0.05). It is suggested that the use of endogenous creatinine clearance to estimate the glomerular filtration rate (GFR) requires caution and the recognition of the limitations of the method, and that simpler techniques (serum creatinine or estimated endogenous creatinine clearance) are preferable in routine practice. GFR based on 51Cr-EDTA injection is the method of choice for monitoring renal function in special situations such as renal transplantation and progressive nephropathies. |
publishDate |
1988 |
dc.date.issued.fl_str_mv |
1988 |
dc.date.accessioned.fl_str_mv |
2022-08-19T04:43:22Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/other |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/247344 |
dc.identifier.issn.pt_BR.fl_str_mv |
0100-879X |
dc.identifier.nrb.pt_BR.fl_str_mv |
000061284 |
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0100-879X 000061284 |
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http://hdl.handle.net/10183/247344 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Brazilian Journal of Medical and Biological Research. Ribeirao Preto. Vol. 21, n. 5 (1988), p. 941-944 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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