Analysis of isotype-specific antibody responses to bovine herpesviruses 1.1 and 1.2a allows to estimate the stage of infection
Autor(a) principal: | |
---|---|
Data de Publicação: | 2012 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/87943 |
Resumo: | Specific IgM, IgA, IgG1, IgG2, as well as neutralizing antibody responses were evaluated in sera of calves experimentally infected with two isolates of bovine herpesvirus type 1 (BoHV1) of distinct subtypes (subtype 1, BoHV1.1; subtype 2a, BoHV-1.2a). No significant differences were observed in the antibody responses induced by each BoHV-1 subtype. The antibody responses following primary acute infection were characterized by an increase in specific IgM and IgA levels between days 2 and 14 post inoculation (pi). IgG1 was detected from days 11 to 30 pi. IgG2 was detected on the sample taken on day 30 pi. Reactivation of infection following dexamethasone administration induced a significant rise in IgA levels, whereas IgG1 and IgG2 levels, which were at high levels from the beginning of the reactivation process, showed a slight alteration after corticosteroid treatment. These results suggest that it is possible to estimate the dynamics of BoHV-1 infections with basis on the analysis of class- and subclass-specific antibody responses. Such information may be particularly useful for the study of the kinetics of the infection in a herd and to aid in the adoption of appropriate control measures.. |
id |
UFRGS-2_fb14cba0f2643447b6439601d9a20d85 |
---|---|
oai_identifier_str |
oai:www.lume.ufrgs.br:10183/87943 |
network_acronym_str |
UFRGS-2 |
network_name_str |
Repositório Institucional da UFRGS |
repository_id_str |
|
spelling |
Spilki, Fernando RosadoFranco, Ana ClaudiaRoehe, Paulo Michel2014-02-28T01:50:30Z20121517-8382http://hdl.handle.net/10183/87943000871712Specific IgM, IgA, IgG1, IgG2, as well as neutralizing antibody responses were evaluated in sera of calves experimentally infected with two isolates of bovine herpesvirus type 1 (BoHV1) of distinct subtypes (subtype 1, BoHV1.1; subtype 2a, BoHV-1.2a). No significant differences were observed in the antibody responses induced by each BoHV-1 subtype. The antibody responses following primary acute infection were characterized by an increase in specific IgM and IgA levels between days 2 and 14 post inoculation (pi). IgG1 was detected from days 11 to 30 pi. IgG2 was detected on the sample taken on day 30 pi. Reactivation of infection following dexamethasone administration induced a significant rise in IgA levels, whereas IgG1 and IgG2 levels, which were at high levels from the beginning of the reactivation process, showed a slight alteration after corticosteroid treatment. These results suggest that it is possible to estimate the dynamics of BoHV-1 infections with basis on the analysis of class- and subclass-specific antibody responses. Such information may be particularly useful for the study of the kinetics of the infection in a herd and to aid in the adoption of appropriate control measures..application/pdfengBrazilian journal of microbiology.[São Paulo]. Vol. 43, n. 2 (abr./jun. 2011), p. 586-593Herpesvirus bovino 1Rinotraqueíte infecciosa bovinabovine herpesvirus type 1infectious bovine rhinotracheitisimmunoglobulin subclassesAnalysis of isotype-specific antibody responses to bovine herpesviruses 1.1 and 1.2a allows to estimate the stage of infectioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000871712.pdf000871712.pdfTexto completo (inglês)application/pdf172925http://www.lume.ufrgs.br/bitstream/10183/87943/1/000871712.pdf3e1a0de42a6ebd33faf0078e17c3eaebMD51TEXT000871712.pdf.txt000871712.pdf.txtExtracted Texttext/plain22737http://www.lume.ufrgs.br/bitstream/10183/87943/2/000871712.pdf.txt99e3066eb2498ba7e62364a2115af1a2MD52THUMBNAIL000871712.pdf.jpg000871712.pdf.jpgGenerated Thumbnailimage/jpeg2100http://www.lume.ufrgs.br/bitstream/10183/87943/3/000871712.pdf.jpgb156865b56c76284264958ae1a30a2d0MD5310183/879432021-07-09 04:35:36.338441oai:www.lume.ufrgs.br:10183/87943Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2021-07-09T07:35:36Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Analysis of isotype-specific antibody responses to bovine herpesviruses 1.1 and 1.2a allows to estimate the stage of infection |
title |
Analysis of isotype-specific antibody responses to bovine herpesviruses 1.1 and 1.2a allows to estimate the stage of infection |
spellingShingle |
Analysis of isotype-specific antibody responses to bovine herpesviruses 1.1 and 1.2a allows to estimate the stage of infection Spilki, Fernando Rosado Herpesvirus bovino 1 Rinotraqueíte infecciosa bovina bovine herpesvirus type 1 infectious bovine rhinotracheitis immunoglobulin subclasses |
title_short |
Analysis of isotype-specific antibody responses to bovine herpesviruses 1.1 and 1.2a allows to estimate the stage of infection |
title_full |
Analysis of isotype-specific antibody responses to bovine herpesviruses 1.1 and 1.2a allows to estimate the stage of infection |
title_fullStr |
Analysis of isotype-specific antibody responses to bovine herpesviruses 1.1 and 1.2a allows to estimate the stage of infection |
title_full_unstemmed |
Analysis of isotype-specific antibody responses to bovine herpesviruses 1.1 and 1.2a allows to estimate the stage of infection |
title_sort |
Analysis of isotype-specific antibody responses to bovine herpesviruses 1.1 and 1.2a allows to estimate the stage of infection |
author |
Spilki, Fernando Rosado |
author_facet |
Spilki, Fernando Rosado Franco, Ana Claudia Roehe, Paulo Michel |
author_role |
author |
author2 |
Franco, Ana Claudia Roehe, Paulo Michel |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Spilki, Fernando Rosado Franco, Ana Claudia Roehe, Paulo Michel |
dc.subject.por.fl_str_mv |
Herpesvirus bovino 1 Rinotraqueíte infecciosa bovina |
topic |
Herpesvirus bovino 1 Rinotraqueíte infecciosa bovina bovine herpesvirus type 1 infectious bovine rhinotracheitis immunoglobulin subclasses |
dc.subject.eng.fl_str_mv |
bovine herpesvirus type 1 infectious bovine rhinotracheitis immunoglobulin subclasses |
description |
Specific IgM, IgA, IgG1, IgG2, as well as neutralizing antibody responses were evaluated in sera of calves experimentally infected with two isolates of bovine herpesvirus type 1 (BoHV1) of distinct subtypes (subtype 1, BoHV1.1; subtype 2a, BoHV-1.2a). No significant differences were observed in the antibody responses induced by each BoHV-1 subtype. The antibody responses following primary acute infection were characterized by an increase in specific IgM and IgA levels between days 2 and 14 post inoculation (pi). IgG1 was detected from days 11 to 30 pi. IgG2 was detected on the sample taken on day 30 pi. Reactivation of infection following dexamethasone administration induced a significant rise in IgA levels, whereas IgG1 and IgG2 levels, which were at high levels from the beginning of the reactivation process, showed a slight alteration after corticosteroid treatment. These results suggest that it is possible to estimate the dynamics of BoHV-1 infections with basis on the analysis of class- and subclass-specific antibody responses. Such information may be particularly useful for the study of the kinetics of the infection in a herd and to aid in the adoption of appropriate control measures.. |
publishDate |
2012 |
dc.date.issued.fl_str_mv |
2012 |
dc.date.accessioned.fl_str_mv |
2014-02-28T01:50:30Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/other |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/87943 |
dc.identifier.issn.pt_BR.fl_str_mv |
1517-8382 |
dc.identifier.nrb.pt_BR.fl_str_mv |
000871712 |
identifier_str_mv |
1517-8382 000871712 |
url |
http://hdl.handle.net/10183/87943 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Brazilian journal of microbiology.[São Paulo]. Vol. 43, n. 2 (abr./jun. 2011), p. 586-593 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFRGS instname:Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS |
instname_str |
Universidade Federal do Rio Grande do Sul (UFRGS) |
instacron_str |
UFRGS |
institution |
UFRGS |
reponame_str |
Repositório Institucional da UFRGS |
collection |
Repositório Institucional da UFRGS |
bitstream.url.fl_str_mv |
http://www.lume.ufrgs.br/bitstream/10183/87943/1/000871712.pdf http://www.lume.ufrgs.br/bitstream/10183/87943/2/000871712.pdf.txt http://www.lume.ufrgs.br/bitstream/10183/87943/3/000871712.pdf.jpg |
bitstream.checksum.fl_str_mv |
3e1a0de42a6ebd33faf0078e17c3eaeb 99e3066eb2498ba7e62364a2115af1a2 b156865b56c76284264958ae1a30a2d0 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS) |
repository.mail.fl_str_mv |
|
_version_ |
1792790261088124928 |