Paroxetine and bupropion have no in vitro effects on lynphocyte proliferation and viability
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Jornal Brasileiro de Psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0047-20852007000200007 |
Resumo: | OBJECTIVE: Initial studies with tricyclic antidepressants demonstrated that they jeopardize the immune system activity. Recent studies suggested that selective serotonin reuptake inhibitors would have stimulating immunological effects. Here, we explored the in vitro immunological effects of two antidepressants used in clinical practice, paroxetine (selective serotonin reuptake inhibitor) and bupropion (norepinephrine and dopamine reuptake inhibitor). METHOD: Peripheral blood samples were obtained from 16 healthy volunteers and the peripheral blood mononuclear cells were isolated and cultured in vitro. We evaluated the effects of bupropion and paroxetine on cell viability as well as the ability to suppress phytohemagglutinin-induced lymphocyte proliferation. RESULTS: Both antidepressants produced neither significant effect on cell viability nor on T-cell proliferation. CONCLUSIONS: This could be of valuable information for the clinical practice when these drugs are administered. These results indicate a more favorable effect of such psychopharmacological drugs when compared to reported immunological effects associated with tryciclic antidepressants. |
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Jornal Brasileiro de Psiquiatria (Online) |
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Paroxetine and bupropion have no in vitro effects on lynphocyte proliferation and viabilityPsychoneuroimmunologyantidepressive agentslymphocytescell proliferationOBJECTIVE: Initial studies with tricyclic antidepressants demonstrated that they jeopardize the immune system activity. Recent studies suggested that selective serotonin reuptake inhibitors would have stimulating immunological effects. Here, we explored the in vitro immunological effects of two antidepressants used in clinical practice, paroxetine (selective serotonin reuptake inhibitor) and bupropion (norepinephrine and dopamine reuptake inhibitor). METHOD: Peripheral blood samples were obtained from 16 healthy volunteers and the peripheral blood mononuclear cells were isolated and cultured in vitro. We evaluated the effects of bupropion and paroxetine on cell viability as well as the ability to suppress phytohemagglutinin-induced lymphocyte proliferation. RESULTS: Both antidepressants produced neither significant effect on cell viability nor on T-cell proliferation. CONCLUSIONS: This could be of valuable information for the clinical practice when these drugs are administered. These results indicate a more favorable effect of such psychopharmacological drugs when compared to reported immunological effects associated with tryciclic antidepressants.Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro2007-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0047-20852007000200007Jornal Brasileiro de Psiquiatria v.56 n.2 2007reponame:Jornal Brasileiro de Psiquiatria (Online)instname:Universidade Federal do Rio de Janeiro (UFRJ)instacron:UFRJ10.1590/S0047-20852007000200007info:eu-repo/semantics/openAccessRonchetti,RamiroDal Pizzol,MarianaLopes,Rodrigo PestanaSilva,Rachel Rubin daGauer,Gabriel José ChittóBauer,Moisés Evandroeng2007-10-15T00:00:00Zoai:scielo:S0047-20852007000200007Revistahttp://portalrev.enfermagem.bvs.br/index.php?issn=0047-2085&lang=ptONGhttps://old.scielo.br/oai/scielo-oai.php||editora@ipub.ufrj.br1982-02080047-2085opendoar:2007-10-15T00:00Jornal Brasileiro de Psiquiatria (Online) - Universidade Federal do Rio de Janeiro (UFRJ)false |
dc.title.none.fl_str_mv |
Paroxetine and bupropion have no in vitro effects on lynphocyte proliferation and viability |
title |
Paroxetine and bupropion have no in vitro effects on lynphocyte proliferation and viability |
spellingShingle |
Paroxetine and bupropion have no in vitro effects on lynphocyte proliferation and viability Ronchetti,Ramiro Psychoneuroimmunology antidepressive agents lymphocytes cell proliferation |
title_short |
Paroxetine and bupropion have no in vitro effects on lynphocyte proliferation and viability |
title_full |
Paroxetine and bupropion have no in vitro effects on lynphocyte proliferation and viability |
title_fullStr |
Paroxetine and bupropion have no in vitro effects on lynphocyte proliferation and viability |
title_full_unstemmed |
Paroxetine and bupropion have no in vitro effects on lynphocyte proliferation and viability |
title_sort |
Paroxetine and bupropion have no in vitro effects on lynphocyte proliferation and viability |
author |
Ronchetti,Ramiro |
author_facet |
Ronchetti,Ramiro Dal Pizzol,Mariana Lopes,Rodrigo Pestana Silva,Rachel Rubin da Gauer,Gabriel José Chittó Bauer,Moisés Evandro |
author_role |
author |
author2 |
Dal Pizzol,Mariana Lopes,Rodrigo Pestana Silva,Rachel Rubin da Gauer,Gabriel José Chittó Bauer,Moisés Evandro |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Ronchetti,Ramiro Dal Pizzol,Mariana Lopes,Rodrigo Pestana Silva,Rachel Rubin da Gauer,Gabriel José Chittó Bauer,Moisés Evandro |
dc.subject.por.fl_str_mv |
Psychoneuroimmunology antidepressive agents lymphocytes cell proliferation |
topic |
Psychoneuroimmunology antidepressive agents lymphocytes cell proliferation |
description |
OBJECTIVE: Initial studies with tricyclic antidepressants demonstrated that they jeopardize the immune system activity. Recent studies suggested that selective serotonin reuptake inhibitors would have stimulating immunological effects. Here, we explored the in vitro immunological effects of two antidepressants used in clinical practice, paroxetine (selective serotonin reuptake inhibitor) and bupropion (norepinephrine and dopamine reuptake inhibitor). METHOD: Peripheral blood samples were obtained from 16 healthy volunteers and the peripheral blood mononuclear cells were isolated and cultured in vitro. We evaluated the effects of bupropion and paroxetine on cell viability as well as the ability to suppress phytohemagglutinin-induced lymphocyte proliferation. RESULTS: Both antidepressants produced neither significant effect on cell viability nor on T-cell proliferation. CONCLUSIONS: This could be of valuable information for the clinical practice when these drugs are administered. These results indicate a more favorable effect of such psychopharmacological drugs when compared to reported immunological effects associated with tryciclic antidepressants. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0047-20852007000200007 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0047-20852007000200007 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0047-20852007000200007 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro |
publisher.none.fl_str_mv |
Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro |
dc.source.none.fl_str_mv |
Jornal Brasileiro de Psiquiatria v.56 n.2 2007 reponame:Jornal Brasileiro de Psiquiatria (Online) instname:Universidade Federal do Rio de Janeiro (UFRJ) instacron:UFRJ |
instname_str |
Universidade Federal do Rio de Janeiro (UFRJ) |
instacron_str |
UFRJ |
institution |
UFRJ |
reponame_str |
Jornal Brasileiro de Psiquiatria (Online) |
collection |
Jornal Brasileiro de Psiquiatria (Online) |
repository.name.fl_str_mv |
Jornal Brasileiro de Psiquiatria (Online) - Universidade Federal do Rio de Janeiro (UFRJ) |
repository.mail.fl_str_mv |
||editora@ipub.ufrj.br |
_version_ |
1750128244943749120 |