HIF-1alpha expression profile in intratumoral and peritumoral inflammatory cells as a prognostic marker for squamous cell carcinoma of the oral cavity

• Autor(a) principal: Mendes, Suzanny Oliveira
• Data de Publicação: 2014
• Outros Autores: Santos, Marcelo dos, Peterle, Gabriela Tonini, Maia, Lucas de Lima, Stur, Elaine, Agostini, Lidiane Pignaton, Carvalho, Marcos Brasilino de, Tajara, Eloiza Helena, Louro, Iúri Drumond, Trivilin, Leonardo Oliveira, Silva-Conforti, Adriana Madeira Álvares da
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFRN
• Texto Completo: https://repositorio.ufrn.br/handle/123456789/31589
• topic: Biomarkers, tumor; Carcinoma, squamous cell; Gene Expression Regulation, neoplastic; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammation, pathology; Lymphocytes, metabolism

The HIF-1 transcriptional complex is responsible for controlling transcription of over 100 genes involved in cell hypoxia response. HIF-1alpha subunit is stabilized in hypoxia conditions, creating the HIF-1 nuclear transcription factor. In inflammatory cells, high HIF-1alpha expression induces lymphocytic immunosuppression, decreasing tumoral antigen recognition, which promotes tumor growth. The present work investigated the relationship between HIF-1alpha expression in lymphocytes populating the intratumoral and peritumoral region of 56 patients with oral cancer. Our data indicates a prognostic value for this expression. High HIF-1alpha expression in peritumoral inflammatory cells is significantly related to worse patient outcome, whereas high expression in the intratumoral lymphoid cells correlates with a better prognosis. A risk profile indicating the chance of disease relapse and death was designed based on HIF-1alpha expression in tumoral inflammatory cells, defining low, intermediate and high risks. This risk profile was able to determine that high HIF-1alpha expression in peritumoral cells correlates with worse prognosis, independently of intratumoral expression. Low HIF-1alpha in tumor margins and high expression in the tumor was considered a low risk profile, showing no cases of disease relapse and disease related death. Intermediate risk was associated with low expression in tumor and tumor margins. Our results suggest that HIF-1alpha expression in tumor and peritumoral inflammatory cells may play an important role as prognostic tumor marker