Mast cells and matrix metalloproteinase 9 expression in actinic cheilitis and lip squamous cell carcinoma

Bibliographic Details
Main Author: Freitas, Valéria Souza
Publication Date: 2011
Other Authors: Santos, Pedro Paulo de Andrade, Freitas, Roseana de Almeida, Pinto, Leão Pereira, Souza, Lelia Batista de
Format: Article
Language: eng
Source: Repositório Institucional da UFRN
Download full: https://repositorio.ufrn.br/jspui/handle/123456789/21798
Summary: Objectives The aim of this study was to evaluate mast cell (MC) density and migration and their association with matrix metalloproteinase (MMP) 9 expression in squamous cell carcinoma (SCC) and actinic cheilitis (AC). Study design Tryptase, c-Kit, and MMP-9 expression was evaluated in 20 cases of SCC, 20 cases of AC, and 7 cases of normal lip (control samples) by immunohistochemistry techniques. Results Tryptase+ and c-Kit+ MC densities were significantly higher in SCCs than in ACs and control samples (P < .001). However, no significant difference was found when comparing tryptase+ and c-Kit+ MC densities between ACs and control samples (P values .185 and .516, respectively). MMP-9 was strongly expressed in SCCs and moderately expressed in ACs and control samples. A highly significant association was found between tryptase+ MC density and the expression of MMP-9 (P < .001). Conclusions The increase in MC density associated with the strong expression of MMP-9 may favor SCC progression.
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spelling Freitas, Valéria SouzaSantos, Pedro Paulo de AndradeFreitas, Roseana de AlmeidaPinto, Leão PereiraSouza, Lelia Batista de2017-01-30T12:52:52Z2017-01-30T12:52:52Z2011FREITAS, Valéria Souza et al. Mast cells and matrix metalloproteinase 9 expression in actinic cheilitis and lip squamous cell carcinoma. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics , v. 112, n. 3, p. 342-348, 2011.https://repositorio.ufrn.br/jspui/handle/123456789/21798engMast cellsMatrix metalloproteinase 9Mast cells and matrix metalloproteinase 9 expression in actinic cheilitis and lip squamous cell carcinomainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleObjectives The aim of this study was to evaluate mast cell (MC) density and migration and their association with matrix metalloproteinase (MMP) 9 expression in squamous cell carcinoma (SCC) and actinic cheilitis (AC). Study design Tryptase, c-Kit, and MMP-9 expression was evaluated in 20 cases of SCC, 20 cases of AC, and 7 cases of normal lip (control samples) by immunohistochemistry techniques. Results Tryptase+ and c-Kit+ MC densities were significantly higher in SCCs than in ACs and control samples (P < .001). However, no significant difference was found when comparing tryptase+ and c-Kit+ MC densities between ACs and control samples (P values .185 and .516, respectively). MMP-9 was strongly expressed in SCCs and moderately expressed in ACs and control samples. A highly significant association was found between tryptase+ MC density and the expression of MMP-9 (P < .001). Conclusions The increase in MC density associated with the strong expression of MMP-9 may favor SCC progression.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNORIGINALMastCellsMatrix_Freitas_2011.pdfMastCellsMatrix_Freitas_2011.pdfhttps://www.ncbi.nlm.nih.gov/pubmed/21612954application/pdf2262545https://repositorio.ufrn.br/bitstream/123456789/21798/1/MastCellsMatrix_Freitas_2011.pdf6b12aa4b7bf3feee7ae4f57944544f58MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81563https://repositorio.ufrn.br/bitstream/123456789/21798/2/license.txt2fca3d993fd069474a9dfb5156c39499MD52TEXTMast cells and matrix metalloproteinase 9_2011.pdf.txtMast cells and matrix metalloproteinase 9_2011.pdf.txtExtracted texttext/plain32549https://repositorio.ufrn.br/bitstream/123456789/21798/5/Mast%20cells%20and%20matrix%20metalloproteinase%209_2011.pdf.txt63ab2737e0f1e6dd92ac4aa4874f00c5MD55THUMBNAILMast cells and matrix metalloproteinase 9_2011.pdf.jpgMast cells and matrix metalloproteinase 9_2011.pdf.jpgIM Thumbnailimage/jpeg9368https://repositorio.ufrn.br/bitstream/123456789/21798/6/Mast%20cells%20and%20matrix%20metalloproteinase%209_2011.pdf.jpg54dc61fc010b8cc275c816a1cdf87accMD56123456789/217982021-12-20 15:48:51.37oai:https://repositorio.ufrn.br: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ório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2021-12-20T18:48:51Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false
dc.title.pt_BR.fl_str_mv Mast cells and matrix metalloproteinase 9 expression in actinic cheilitis and lip squamous cell carcinoma
title Mast cells and matrix metalloproteinase 9 expression in actinic cheilitis and lip squamous cell carcinoma
spellingShingle Mast cells and matrix metalloproteinase 9 expression in actinic cheilitis and lip squamous cell carcinoma
Freitas, Valéria Souza
Mast cells
Matrix metalloproteinase 9
title_short Mast cells and matrix metalloproteinase 9 expression in actinic cheilitis and lip squamous cell carcinoma
title_full Mast cells and matrix metalloproteinase 9 expression in actinic cheilitis and lip squamous cell carcinoma
title_fullStr Mast cells and matrix metalloproteinase 9 expression in actinic cheilitis and lip squamous cell carcinoma
title_full_unstemmed Mast cells and matrix metalloproteinase 9 expression in actinic cheilitis and lip squamous cell carcinoma
title_sort Mast cells and matrix metalloproteinase 9 expression in actinic cheilitis and lip squamous cell carcinoma
author Freitas, Valéria Souza
author_facet Freitas, Valéria Souza
Santos, Pedro Paulo de Andrade
Freitas, Roseana de Almeida
Pinto, Leão Pereira
Souza, Lelia Batista de
author_role author
author2 Santos, Pedro Paulo de Andrade
Freitas, Roseana de Almeida
Pinto, Leão Pereira
Souza, Lelia Batista de
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Freitas, Valéria Souza
Santos, Pedro Paulo de Andrade
Freitas, Roseana de Almeida
Pinto, Leão Pereira
Souza, Lelia Batista de
dc.subject.por.fl_str_mv Mast cells
Matrix metalloproteinase 9
topic Mast cells
Matrix metalloproteinase 9
description Objectives The aim of this study was to evaluate mast cell (MC) density and migration and their association with matrix metalloproteinase (MMP) 9 expression in squamous cell carcinoma (SCC) and actinic cheilitis (AC). Study design Tryptase, c-Kit, and MMP-9 expression was evaluated in 20 cases of SCC, 20 cases of AC, and 7 cases of normal lip (control samples) by immunohistochemistry techniques. Results Tryptase+ and c-Kit+ MC densities were significantly higher in SCCs than in ACs and control samples (P < .001). However, no significant difference was found when comparing tryptase+ and c-Kit+ MC densities between ACs and control samples (P values .185 and .516, respectively). MMP-9 was strongly expressed in SCCs and moderately expressed in ACs and control samples. A highly significant association was found between tryptase+ MC density and the expression of MMP-9 (P < .001). Conclusions The increase in MC density associated with the strong expression of MMP-9 may favor SCC progression.
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2017-01-30T12:52:52Z
dc.date.available.fl_str_mv 2017-01-30T12:52:52Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FREITAS, Valéria Souza et al. Mast cells and matrix metalloproteinase 9 expression in actinic cheilitis and lip squamous cell carcinoma. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics , v. 112, n. 3, p. 342-348, 2011.
dc.identifier.uri.fl_str_mv https://repositorio.ufrn.br/jspui/handle/123456789/21798
identifier_str_mv FREITAS, Valéria Souza et al. Mast cells and matrix metalloproteinase 9 expression in actinic cheilitis and lip squamous cell carcinoma. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics , v. 112, n. 3, p. 342-348, 2011.
url https://repositorio.ufrn.br/jspui/handle/123456789/21798
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFRN
instname:Universidade Federal do Rio Grande do Norte (UFRN)
instacron:UFRN
instname_str Universidade Federal do Rio Grande do Norte (UFRN)
instacron_str UFRN
institution UFRN
reponame_str Repositório Institucional da UFRN
collection Repositório Institucional da UFRN
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