Endocrine and Cognitive Adaptations to Cope with Stress in Immature Common Marmosets (Callithrix jacchus): Sex and Age Matter
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/jspui/handle/123456789/23125 |
Resumo: | Phenotypic sex differences in primates are associated with body differentiation during the early stages of life, expressed in both physiological and behavioral features. Hormones seem to play a pivotal role in creating a range of responses to meet environmental and social demands, resulting in better reactions to cope with challenges to survival and reproduction. Steroid hormones actively participate in neuroplasticity and steroids from both gonads and neurons seem to be involved in behavioral modulation in primates. Indirect evidence suggests the participation of sexual steroids in dimorphism of the stress response in common marmosets. This species is an important experimental model in psychiatry, and we found a dual profile for cortisol in the transition from juvenile to subadult, with females showing higher levels. Immature males and females at 6 and 9 months of age moved alone from the family group to a new cage, over a 21-day period, expressed distinct patterns of cortisol variation with respect to range and duration of response. Additional evidence showed that at 12 months of age, males and females buffered the hypothalamic-pituitary-adrenal axis during chronic stress. Moreover, chronic stressed juvenile marmoset males showed better cognitive performance in working memory tests and motivation when compared to those submitted to short-term stress living in family groups. Thus, as cortisol profile seems to be sexually dimorphic before adulthood, age and sex are critical variables to consider in approaches that require immature marmosets in their experimental protocols. Moreover, available cognitive tests should be scrutinized to allow better investigation of cognitive traits in this species. |
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Sousa, Maria Bernardete Cordeiro deGalvão, Ana Cecília de MenezesSales, Carla Jéssica RodriguesCastro, Dijenaide Chaves deGalvão-Coelho, Nicole Leite Galvão-Coelho2017-05-26T16:51:44Z2017-05-26T16:51:44Z2015-11-30https://repositorio.ufrn.br/jspui/handle/123456789/2312510.3389/fpsyt.2015.00160engstress copingcortisolcognitiondevelopmentnon-human primate modelEndocrine and Cognitive Adaptations to Cope with Stress in Immature Common Marmosets (Callithrix jacchus): Sex and Age Matterinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlePhenotypic sex differences in primates are associated with body differentiation during the early stages of life, expressed in both physiological and behavioral features. Hormones seem to play a pivotal role in creating a range of responses to meet environmental and social demands, resulting in better reactions to cope with challenges to survival and reproduction. Steroid hormones actively participate in neuroplasticity and steroids from both gonads and neurons seem to be involved in behavioral modulation in primates. Indirect evidence suggests the participation of sexual steroids in dimorphism of the stress response in common marmosets. This species is an important experimental model in psychiatry, and we found a dual profile for cortisol in the transition from juvenile to subadult, with females showing higher levels. Immature males and females at 6 and 9 months of age moved alone from the family group to a new cage, over a 21-day period, expressed distinct patterns of cortisol variation with respect to range and duration of response. Additional evidence showed that at 12 months of age, males and females buffered the hypothalamic-pituitary-adrenal axis during chronic stress. Moreover, chronic stressed juvenile marmoset males showed better cognitive performance in working memory tests and motivation when compared to those submitted to short-term stress living in family groups. Thus, as cortisol profile seems to be sexually dimorphic before adulthood, age and sex are critical variables to consider in approaches that require immature marmosets in their experimental protocols. 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dc.title.pt_BR.fl_str_mv |
Endocrine and Cognitive Adaptations to Cope with Stress in Immature Common Marmosets (Callithrix jacchus): Sex and Age Matter |
title |
Endocrine and Cognitive Adaptations to Cope with Stress in Immature Common Marmosets (Callithrix jacchus): Sex and Age Matter |
spellingShingle |
Endocrine and Cognitive Adaptations to Cope with Stress in Immature Common Marmosets (Callithrix jacchus): Sex and Age Matter Sousa, Maria Bernardete Cordeiro de stress coping cortisol cognition development non-human primate model |
title_short |
Endocrine and Cognitive Adaptations to Cope with Stress in Immature Common Marmosets (Callithrix jacchus): Sex and Age Matter |
title_full |
Endocrine and Cognitive Adaptations to Cope with Stress in Immature Common Marmosets (Callithrix jacchus): Sex and Age Matter |
title_fullStr |
Endocrine and Cognitive Adaptations to Cope with Stress in Immature Common Marmosets (Callithrix jacchus): Sex and Age Matter |
title_full_unstemmed |
Endocrine and Cognitive Adaptations to Cope with Stress in Immature Common Marmosets (Callithrix jacchus): Sex and Age Matter |
title_sort |
Endocrine and Cognitive Adaptations to Cope with Stress in Immature Common Marmosets (Callithrix jacchus): Sex and Age Matter |
author |
Sousa, Maria Bernardete Cordeiro de |
author_facet |
Sousa, Maria Bernardete Cordeiro de Galvão, Ana Cecília de Menezes Sales, Carla Jéssica Rodrigues Castro, Dijenaide Chaves de Galvão-Coelho, Nicole Leite Galvão-Coelho |
author_role |
author |
author2 |
Galvão, Ana Cecília de Menezes Sales, Carla Jéssica Rodrigues Castro, Dijenaide Chaves de Galvão-Coelho, Nicole Leite Galvão-Coelho |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Sousa, Maria Bernardete Cordeiro de Galvão, Ana Cecília de Menezes Sales, Carla Jéssica Rodrigues Castro, Dijenaide Chaves de Galvão-Coelho, Nicole Leite Galvão-Coelho |
dc.subject.por.fl_str_mv |
stress coping cortisol cognition development non-human primate model |
topic |
stress coping cortisol cognition development non-human primate model |
description |
Phenotypic sex differences in primates are associated with body differentiation during the early stages of life, expressed in both physiological and behavioral features. Hormones seem to play a pivotal role in creating a range of responses to meet environmental and social demands, resulting in better reactions to cope with challenges to survival and reproduction. Steroid hormones actively participate in neuroplasticity and steroids from both gonads and neurons seem to be involved in behavioral modulation in primates. Indirect evidence suggests the participation of sexual steroids in dimorphism of the stress response in common marmosets. This species is an important experimental model in psychiatry, and we found a dual profile for cortisol in the transition from juvenile to subadult, with females showing higher levels. Immature males and females at 6 and 9 months of age moved alone from the family group to a new cage, over a 21-day period, expressed distinct patterns of cortisol variation with respect to range and duration of response. Additional evidence showed that at 12 months of age, males and females buffered the hypothalamic-pituitary-adrenal axis during chronic stress. Moreover, chronic stressed juvenile marmoset males showed better cognitive performance in working memory tests and motivation when compared to those submitted to short-term stress living in family groups. Thus, as cortisol profile seems to be sexually dimorphic before adulthood, age and sex are critical variables to consider in approaches that require immature marmosets in their experimental protocols. Moreover, available cognitive tests should be scrutinized to allow better investigation of cognitive traits in this species. |
publishDate |
2015 |
dc.date.issued.fl_str_mv |
2015-11-30 |
dc.date.accessioned.fl_str_mv |
2017-05-26T16:51:44Z |
dc.date.available.fl_str_mv |
2017-05-26T16:51:44Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/jspui/handle/123456789/23125 |
dc.identifier.doi.none.fl_str_mv |
10.3389/fpsyt.2015.00160 |
url |
https://repositorio.ufrn.br/jspui/handle/123456789/23125 |
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10.3389/fpsyt.2015.00160 |
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eng |
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eng |
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UFRN |
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UFRN |
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Repositório Institucional da UFRN |
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