The control and prevention of COVID-19 transmission in children: a protocol for systematic review and meta-analysis

• Autor(a) principal: Medeiros, Gidyenne Christine Bandeira Silva de
• Data de Publicação: 2020
• Outros Autores: Nunes, Ana Clara de França, Azevedo, Kesley Pablo Morais de, Oliveira Segundo, Victor Hugo de, Santos, Gilberto Martins, Mata, Ádala Nayana de Sousa, Pimenta, Isac Davidson, Bezerra, Isaac Newton Machado, Braga, Liliane Pereira, Capucho, Helaine Carneiro, Piuvezam, Márcia Regina, Barbosa Filho, Valter Cordeiro, Leitão, José Carlos, Martínez, Daniel Guillén, Piuvezam, Grasiela
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFRN
• Texto Completo: https://repositorio.ufrn.br/handle/123456789/31176
• topic: Children; Adolescents; COVID-19; SARS-CoV-2 infection

Background: The pandemic following the rapid spread of the new SARS-CoV-2 virus has hit all continents and caused thousands of deaths worldwide. Evidence has been published on epidemiological and clinical characteristics of population groups considered at risk; however, information for the other population groups, especially for the child population, is needed. In this context, this protocol describes a systematic review that will aim to identify the evidence on control and prevention of COVID-19 transmission among children and adolescents, as well as to describe the epidemiological profile and clinical and immunological characteristics of COVID-19 in this population. Methods: This protocol will be developed in accordance with PRISMA-P. The searches will be conducted in PubMed, Web of Science, ScienceDirect, EMBASE, and Scopus, seeking clinical trials. Observational studies and case reports with Children and adolescents ( 19 years) infected with SARS-CoV-2 will be included whether they report information on the control of prevention and COVID-19 transmission. Two independent researchers will perform the selection of articles, removal of duplication, and screening by Rayyan QCRI application. Cochrane’s RoB 2.0, ROBINS-I, and CASP tools will be used to assess the risk of bias. Meta-analysis, subgroup analyses, and/or descriptive analyses will be carried out based on the data conditions included. Results: A high-quality synthesis of the available evidences on the epidemiological profile, the clinical and immunological characteristics involved in children, and adolescents diagnosed with COVID-19, as well as the participation of this population in the transmission dynamics of SARS-CoV-2 will be provided. Conclusion: This systematic review has an important relevance in the current context because it has a great potential to help the development of new control and prevention strategies in the pediatric population. Record of systematic review: CRD42020179263. Abbreviations: CASP = Critical Appraisal Skills Program, COVID-19 = Corona Virus Disease (2019), PRISMA = Preferred Reporting Items for Systematic Reviews and Meta-Analyses, PRISMA-P = Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols, RoB = Risk of bias, ROBINS-I = Risk of Bias in Non-Randomised Studies – of Interventions, SARS-CoV-2 = Severe Acute Respiratory Syndrome Coronavirus 2