Theta-gamma coupling during REM sleep depends on breathing rate
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/handle/123456789/33048 |
Resumo: | Temporal coupling between theta and gamma oscillations is a hallmark activity pattern of several cortical networks and becomes especially prominent during REM sleep. In a parallel approach, nasal breathing has been recently shown to generate phase-entrained network oscillations which also modulate gamma. Both slow rhythms (theta and respiration-entrained oscillations) have been suggested to aid large-scale integration but they differ in frequency, display low coherence, and modulate different gamma sub-bands. Respiration and theta are therefore believed to be largely independent. In the present work, however, we report an unexpected but robust relation between theta-gamma coupling and respiration in mice. Interestingly, this relation takes place not through the phase of individual respiration cycles, but through respiration rate: the strength of theta-gamma coupling exhibits an inverted V-shaped dependence on breathing rate, leading to maximal coupling at breathing frequencies of 4-6 Hz. Noteworthy, when subdividing sleep epochs into phasic and tonic REM patterns, we find that breathing differentially relates to theta-gamma coupling in each state, providing new evidence for their physiological distinctiveness. Altogether, our results reveal that breathing correlates with brain activity not only through phase-entrainment but also through rate-dependent relations with theta-gamma coupling. Thus, the link between respiration and other patterns of cortical network activity is more complex than previously assumed |
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Hammer, MaximilianSchwale, ChrysovalandisBrankačk, JurijDraguhn, AndreasTort, Adriano Bretanha Lopes2021-08-09T11:52:02Z2021-08-09T11:52:02Z2021-07-23HAMMER, Maximilian; SCHWALE, Chrysovalandis; BRANKAčK, Jurij; DRAGUHN, Andreas; TORT, Adriano B. L. Theta-gamma coupling during REM sleep depends on breathing rate. Sleep, [S.l.], p. zsab189, jul. 2021. Doi: http://dx.doi.org/10.1093/sleep/zsab189. Disponível em: https://academic.oup.com/sleep/advance-article-abstract/doi/10.1093/sleep/zsab189/6326772?redirectedFrom=fulltext. Acesso em: 6 ago. 2021.https://repositorio.ufrn.br/handle/123456789/3304810.1093/sleep/zsab189Oxford University PressCross-frequency couplingThetaGammaRespirationNeocortexREM sleepTheta-gamma coupling during REM sleep depends on breathing rateinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleTemporal coupling between theta and gamma oscillations is a hallmark activity pattern of several cortical networks and becomes especially prominent during REM sleep. In a parallel approach, nasal breathing has been recently shown to generate phase-entrained network oscillations which also modulate gamma. Both slow rhythms (theta and respiration-entrained oscillations) have been suggested to aid large-scale integration but they differ in frequency, display low coherence, and modulate different gamma sub-bands. Respiration and theta are therefore believed to be largely independent. In the present work, however, we report an unexpected but robust relation between theta-gamma coupling and respiration in mice. Interestingly, this relation takes place not through the phase of individual respiration cycles, but through respiration rate: the strength of theta-gamma coupling exhibits an inverted V-shaped dependence on breathing rate, leading to maximal coupling at breathing frequencies of 4-6 Hz. Noteworthy, when subdividing sleep epochs into phasic and tonic REM patterns, we find that breathing differentially relates to theta-gamma coupling in each state, providing new evidence for their physiological distinctiveness. Altogether, our results reveal that breathing correlates with brain activity not only through phase-entrainment but also through rate-dependent relations with theta-gamma coupling. Thus, the link between respiration and other patterns of cortical network activity is more complex than previously assumedengreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNinfo:eu-repo/semantics/openAccessORIGINALTheta-gammaCouplingREM_Tort_2021.pdfTheta-gammaCouplingREM_Tort_2021.pdfTheta-gammaCouplingREM_Tort_2021application/pdf2978064https://repositorio.ufrn.br/bitstream/123456789/33048/1/Theta-gammaCouplingREM_Tort_2021.pdf89e9035964148c9d4c855d7b88918672MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81569https://repositorio.ufrn.br/bitstream/123456789/33048/2/license.txt6e6f57145bc87daf99079f06b081ff9fMD52123456789/330482021-08-09 08:52:02.736oai:https://repositorio.ufrn.br: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ório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2021-08-09T11:52:02Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Theta-gamma coupling during REM sleep depends on breathing rate |
title |
Theta-gamma coupling during REM sleep depends on breathing rate |
spellingShingle |
Theta-gamma coupling during REM sleep depends on breathing rate Hammer, Maximilian Cross-frequency coupling Theta Gamma Respiration Neocortex REM sleep |
title_short |
Theta-gamma coupling during REM sleep depends on breathing rate |
title_full |
Theta-gamma coupling during REM sleep depends on breathing rate |
title_fullStr |
Theta-gamma coupling during REM sleep depends on breathing rate |
title_full_unstemmed |
Theta-gamma coupling during REM sleep depends on breathing rate |
title_sort |
Theta-gamma coupling during REM sleep depends on breathing rate |
author |
Hammer, Maximilian |
author_facet |
Hammer, Maximilian Schwale, Chrysovalandis Brankačk, Jurij Draguhn, Andreas Tort, Adriano Bretanha Lopes |
author_role |
author |
author2 |
Schwale, Chrysovalandis Brankačk, Jurij Draguhn, Andreas Tort, Adriano Bretanha Lopes |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Hammer, Maximilian Schwale, Chrysovalandis Brankačk, Jurij Draguhn, Andreas Tort, Adriano Bretanha Lopes |
dc.subject.por.fl_str_mv |
Cross-frequency coupling Theta Gamma Respiration Neocortex REM sleep |
topic |
Cross-frequency coupling Theta Gamma Respiration Neocortex REM sleep |
description |
Temporal coupling between theta and gamma oscillations is a hallmark activity pattern of several cortical networks and becomes especially prominent during REM sleep. In a parallel approach, nasal breathing has been recently shown to generate phase-entrained network oscillations which also modulate gamma. Both slow rhythms (theta and respiration-entrained oscillations) have been suggested to aid large-scale integration but they differ in frequency, display low coherence, and modulate different gamma sub-bands. Respiration and theta are therefore believed to be largely independent. In the present work, however, we report an unexpected but robust relation between theta-gamma coupling and respiration in mice. Interestingly, this relation takes place not through the phase of individual respiration cycles, but through respiration rate: the strength of theta-gamma coupling exhibits an inverted V-shaped dependence on breathing rate, leading to maximal coupling at breathing frequencies of 4-6 Hz. Noteworthy, when subdividing sleep epochs into phasic and tonic REM patterns, we find that breathing differentially relates to theta-gamma coupling in each state, providing new evidence for their physiological distinctiveness. Altogether, our results reveal that breathing correlates with brain activity not only through phase-entrainment but also through rate-dependent relations with theta-gamma coupling. Thus, the link between respiration and other patterns of cortical network activity is more complex than previously assumed |
publishDate |
2021 |
dc.date.accessioned.fl_str_mv |
2021-08-09T11:52:02Z |
dc.date.available.fl_str_mv |
2021-08-09T11:52:02Z |
dc.date.issued.fl_str_mv |
2021-07-23 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
HAMMER, Maximilian; SCHWALE, Chrysovalandis; BRANKAčK, Jurij; DRAGUHN, Andreas; TORT, Adriano B. L. Theta-gamma coupling during REM sleep depends on breathing rate. Sleep, [S.l.], p. zsab189, jul. 2021. Doi: http://dx.doi.org/10.1093/sleep/zsab189. Disponível em: https://academic.oup.com/sleep/advance-article-abstract/doi/10.1093/sleep/zsab189/6326772?redirectedFrom=fulltext. Acesso em: 6 ago. 2021. |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/handle/123456789/33048 |
dc.identifier.doi.none.fl_str_mv |
10.1093/sleep/zsab189 |
identifier_str_mv |
HAMMER, Maximilian; SCHWALE, Chrysovalandis; BRANKAčK, Jurij; DRAGUHN, Andreas; TORT, Adriano B. L. Theta-gamma coupling during REM sleep depends on breathing rate. Sleep, [S.l.], p. zsab189, jul. 2021. Doi: http://dx.doi.org/10.1093/sleep/zsab189. Disponível em: https://academic.oup.com/sleep/advance-article-abstract/doi/10.1093/sleep/zsab189/6326772?redirectedFrom=fulltext. Acesso em: 6 ago. 2021. 10.1093/sleep/zsab189 |
url |
https://repositorio.ufrn.br/handle/123456789/33048 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Oxford University Press |
publisher.none.fl_str_mv |
Oxford University Press |
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reponame:Repositório Institucional da UFRN instname:Universidade Federal do Rio Grande do Norte (UFRN) instacron:UFRN |
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