Procoagulant state after raloxifene therapy in postmenopausal women

Detalhes bibliográficos
Autor(a) principal: Azevedo, George Dantas de
Data de Publicação: 2005
Outros Autores: Franco, Rendrik França, Baggio, Márcia Sueli, Maranhão, Técia Maria de Oliveira, Sá, Marcos Felipe Silva de
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UFRN
Texto Completo: https://repositorio.ufrn.br/jspui/handle/1/2952
Resumo: AZEVEDO, George Dantas de et al. Procoagulant state after raloxifene therapy in postmenopausal women. Fertility and Sterility, Estados Unidos, v.84, n.6, p.1680-1684, 2005
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spelling Azevedo, George Dantas deFranco, Rendrik FrançaBaggio, Márcia SueliMaranhão, Técia Maria de OliveiraSá, Marcos Felipe Silva de2010-09-03T17:07:22Z2010-09-03T17:07:22Z2005AZEVEDO, G. D.; FRANCO, R. F.; BAGGIO, M. S.; MARANHÂO, T. M. O.; SÁ, M. F. S. ( 2005)https://repositorio.ufrn.br/jspui/handle/1/2952AZEVEDO, George Dantas de et al. Procoagulant state after raloxifene therapy in postmenopausal women. Fertility and Sterility, Estados Unidos, v.84, n.6, p.1680-1684, 2005Objective: To investigate the effects of raloxifene on the hemostatic system in postmenopausal women. Design: A prospective longitudinal study. Setting: Outpatient clinic of the Faculty of Medicine of Ribeirão Preto, Brazil. Patient(s): Sixteen postmenopausal women aged 56.8 5.9 years (mean SD). Intervention(s): Raloxifene hydrochloride (60 mg once daily) was administered orally for a period of 6 months. Main Outcome Measure(s): Plasma activities of coagulation factors (II, V, VII, VIII, IX, X, XI, XII, and fibrinogen), prothrombin-derived fragment 1 2, and activated protein C (APC) sensitivity ratio were measured at baseline and after 1, 3, and 6 months of treatment. Result(s): Factor VIII activity increased by 17.1% and 26.9% at 3 and 6 months of treatment, respectively, compared with baseline. Factor XI and FXII activities significantly increased by 10.9% and 43.1%, respectively, after 6 months compared with baseline. A significant reduction of APC sensitivity ratio also was observed after 6 months of treatment. Conclusion(s): A procoagulant state characterized by increased factor VIII, XI, and XII plasma levels and by reduced APC sensitivity was observed after raloxifene therapy in post-menopausal womenporClimactericHemostatic systemRaloxifeneSERMsSelective Estrogen Receptor ModulatorsPostmenopausal womenModuladores Seletivos de Receptor EstrogênicoProcoagulant state after raloxifene therapy in postmenopausal womeninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNORIGINALProcoagulantStateAfter_Azevedo_2005.pdfProcoagulantStateAfter_Azevedo_2005.pdfapplication/pdf91298https://repositorio.ufrn.br/bitstream/1/2952/1/ProcoagulantStateAfter_Azevedo_2005.pdf283147ffbf58133b25ced243da9ec5c9MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.ufrn.br/bitstream/1/2952/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52TEXT2005Art_TeciaMOM_Procoagulant.pdf.txt2005Art_TeciaMOM_Procoagulant.pdf.txtExtracted texttext/plain26087https://repositorio.ufrn.br/bitstream/1/2952/7/2005Art_TeciaMOM_Procoagulant.pdf.txt5d31bbe09a4f950075ff068bcb54c66fMD57THUMBNAIL2005Art_TeciaMOM_Procoagulant.pdf.jpg2005Art_TeciaMOM_Procoagulant.pdf.jpgIM Thumbnailimage/jpeg10032https://repositorio.ufrn.br/bitstream/1/2952/8/2005Art_TeciaMOM_Procoagulant.pdf.jpg854c71be093c54d13edba9bd06c327efMD581/29522021-11-12 15:42:36.455oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2021-11-12T18:42:36Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false
dc.title.pt_BR.fl_str_mv Procoagulant state after raloxifene therapy in postmenopausal women
title Procoagulant state after raloxifene therapy in postmenopausal women
spellingShingle Procoagulant state after raloxifene therapy in postmenopausal women
Azevedo, George Dantas de
Climacteric
Hemostatic system
Raloxifene
SERMs
Selective Estrogen Receptor Modulators
Postmenopausal women
Moduladores Seletivos de Receptor Estrogênico
title_short Procoagulant state after raloxifene therapy in postmenopausal women
title_full Procoagulant state after raloxifene therapy in postmenopausal women
title_fullStr Procoagulant state after raloxifene therapy in postmenopausal women
title_full_unstemmed Procoagulant state after raloxifene therapy in postmenopausal women
title_sort Procoagulant state after raloxifene therapy in postmenopausal women
author Azevedo, George Dantas de
author_facet Azevedo, George Dantas de
Franco, Rendrik França
Baggio, Márcia Sueli
Maranhão, Técia Maria de Oliveira
Sá, Marcos Felipe Silva de
author_role author
author2 Franco, Rendrik França
Baggio, Márcia Sueli
Maranhão, Técia Maria de Oliveira
Sá, Marcos Felipe Silva de
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Azevedo, George Dantas de
Franco, Rendrik França
Baggio, Márcia Sueli
Maranhão, Técia Maria de Oliveira
Sá, Marcos Felipe Silva de
dc.subject.por.fl_str_mv Climacteric
Hemostatic system
Raloxifene
SERMs
Selective Estrogen Receptor Modulators
Postmenopausal women
Moduladores Seletivos de Receptor Estrogênico
topic Climacteric
Hemostatic system
Raloxifene
SERMs
Selective Estrogen Receptor Modulators
Postmenopausal women
Moduladores Seletivos de Receptor Estrogênico
description AZEVEDO, George Dantas de et al. Procoagulant state after raloxifene therapy in postmenopausal women. Fertility and Sterility, Estados Unidos, v.84, n.6, p.1680-1684, 2005
publishDate 2005
dc.date.issued.fl_str_mv 2005
dc.date.accessioned.fl_str_mv 2010-09-03T17:07:22Z
dc.date.available.fl_str_mv 2010-09-03T17:07:22Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv AZEVEDO, G. D.; FRANCO, R. F.; BAGGIO, M. S.; MARANHÂO, T. M. O.; SÁ, M. F. S. ( 2005)
dc.identifier.uri.fl_str_mv https://repositorio.ufrn.br/jspui/handle/1/2952
identifier_str_mv AZEVEDO, G. D.; FRANCO, R. F.; BAGGIO, M. S.; MARANHÂO, T. M. O.; SÁ, M. F. S. ( 2005)
url https://repositorio.ufrn.br/jspui/handle/1/2952
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