Avoidance memory requires CaMKII activity to persist after recall

Detalhes bibliográficos
Autor(a) principal: Radiske, Andressa
Data de Publicação: 2021
Outros Autores: Gonzalez, Maria Carolina, Rossato, Janine Inez, Apolinário, Gênedy Karielly da Silva, Oliveira, João R. de, Bevilaqua, Lia Rejane Müller, Cammarota, Martín Pablo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRN
Texto Completo: https://repositorio.ufrn.br/handle/123456789/45699
https://doi.org/10.1186/s13041-021-00877-5
Resumo: Avoidance memory is destabilized when recalled concurrently with conficting information, and must undergo a hippocampus-dependent restabilization process called reconsolidation to persist. CaMKII is a serine/threonine protein kinase essential for memory processing; however, its possible involvement in avoidance memory reconsolidation has not yet been studied. Using pharmacological, electrophysiological and optogenetic tools, we found that in adult male Wistar rats hippocampal CaMKII is necessary to reconsolidate avoidance memory, but not to keep it stored while inactive, and that blocking reconsolidation via CaMKII inhibition erases learned avoidance responses
id UFRN_d1b4e31a0bcbb610645b38972bf5cd5a
oai_identifier_str oai:https://repositorio.ufrn.br:123456789/45699
network_acronym_str UFRN
network_name_str Repositório Institucional da UFRN
repository_id_str
spelling Radiske, AndressaGonzalez, Maria CarolinaRossato, Janine InezApolinário, Gênedy Karielly da SilvaOliveira, João R. deBevilaqua, Lia Rejane MüllerCammarota, Martín Pablo2022-01-20T12:44:59Z2022-01-20T12:44:59Z2021-11-14RADISKE, Andressa; GONZALEZ, Maria Carolina; ROSSATO, Janine Inez; APOLINÁRIO, Gênedy; OLIVEIRA, João R. de; BEVILAQUA, Lia Rejane Müller; CAMMAROTA, Martín Pablo. Avoidance memory requires CaMKII activity to persist after recall. Molecular Brain, [S. l.], v. 14, p. 167, nov. 2021. Doi: 10.1186/s13041-021-00877-5. Disponível em: https://molecularbrain.biomedcentral.com/articles/10.1186/s13041-021-00877-5. Acesso em: 20 jan. 2022.https://repositorio.ufrn.br/handle/123456789/45699https://doi.org/10.1186/s13041-021-00877-5Attribution 3.0 Brazilhttp://creativecommons.org/licenses/by/3.0/br/info:eu-repo/semantics/openAccessReconsolidationPTSDFearHippocampusRetrievalAvoidance memory requires CaMKII activity to persist after recallinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleAvoidance memory is destabilized when recalled concurrently with conficting information, and must undergo a hippocampus-dependent restabilization process called reconsolidation to persist. CaMKII is a serine/threonine protein kinase essential for memory processing; however, its possible involvement in avoidance memory reconsolidation has not yet been studied. Using pharmacological, electrophysiological and optogenetic tools, we found that in adult male Wistar rats hippocampal CaMKII is necessary to reconsolidate avoidance memory, but not to keep it stored while inactive, and that blocking reconsolidation via CaMKII inhibition erases learned avoidance responsesengreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNORIGINALAvoidanceMemoryRequires_Cammarota_2021.pdfAvoidanceMemoryRequires_Cammarota_2021.pdfapplication/pdf1404329https://repositorio.ufrn.br/bitstream/123456789/45699/1/AvoidanceMemoryRequires_Cammarota_2021.pdf7aa6a9917802313cc7bb7a4e81b7aeefMD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8914https://repositorio.ufrn.br/bitstream/123456789/45699/2/license_rdf4d2950bda3d176f570a9f8b328dfbbefMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81484https://repositorio.ufrn.br/bitstream/123456789/45699/3/license.txte9597aa2854d128fd968be5edc8a28d9MD53123456789/456992022-01-20 09:45:00.362oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2022-01-20T12:45Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false
dc.title.pt_BR.fl_str_mv Avoidance memory requires CaMKII activity to persist after recall
title Avoidance memory requires CaMKII activity to persist after recall
spellingShingle Avoidance memory requires CaMKII activity to persist after recall
Radiske, Andressa
Reconsolidation
PTSD
Fear
Hippocampus
Retrieval
title_short Avoidance memory requires CaMKII activity to persist after recall
title_full Avoidance memory requires CaMKII activity to persist after recall
title_fullStr Avoidance memory requires CaMKII activity to persist after recall
title_full_unstemmed Avoidance memory requires CaMKII activity to persist after recall
title_sort Avoidance memory requires CaMKII activity to persist after recall
author Radiske, Andressa
author_facet Radiske, Andressa
Gonzalez, Maria Carolina
Rossato, Janine Inez
Apolinário, Gênedy Karielly da Silva
Oliveira, João R. de
Bevilaqua, Lia Rejane Müller
Cammarota, Martín Pablo
author_role author
author2 Gonzalez, Maria Carolina
Rossato, Janine Inez
Apolinário, Gênedy Karielly da Silva
Oliveira, João R. de
Bevilaqua, Lia Rejane Müller
Cammarota, Martín Pablo
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Radiske, Andressa
Gonzalez, Maria Carolina
Rossato, Janine Inez
Apolinário, Gênedy Karielly da Silva
Oliveira, João R. de
Bevilaqua, Lia Rejane Müller
Cammarota, Martín Pablo
dc.subject.por.fl_str_mv Reconsolidation
PTSD
Fear
Hippocampus
Retrieval
topic Reconsolidation
PTSD
Fear
Hippocampus
Retrieval
description Avoidance memory is destabilized when recalled concurrently with conficting information, and must undergo a hippocampus-dependent restabilization process called reconsolidation to persist. CaMKII is a serine/threonine protein kinase essential for memory processing; however, its possible involvement in avoidance memory reconsolidation has not yet been studied. Using pharmacological, electrophysiological and optogenetic tools, we found that in adult male Wistar rats hippocampal CaMKII is necessary to reconsolidate avoidance memory, but not to keep it stored while inactive, and that blocking reconsolidation via CaMKII inhibition erases learned avoidance responses
publishDate 2021
dc.date.issued.fl_str_mv 2021-11-14
dc.date.accessioned.fl_str_mv 2022-01-20T12:44:59Z
dc.date.available.fl_str_mv 2022-01-20T12:44:59Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv RADISKE, Andressa; GONZALEZ, Maria Carolina; ROSSATO, Janine Inez; APOLINÁRIO, Gênedy; OLIVEIRA, João R. de; BEVILAQUA, Lia Rejane Müller; CAMMAROTA, Martín Pablo. Avoidance memory requires CaMKII activity to persist after recall. Molecular Brain, [S. l.], v. 14, p. 167, nov. 2021. Doi: 10.1186/s13041-021-00877-5. Disponível em: https://molecularbrain.biomedcentral.com/articles/10.1186/s13041-021-00877-5. Acesso em: 20 jan. 2022.
dc.identifier.uri.fl_str_mv https://repositorio.ufrn.br/handle/123456789/45699
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1186/s13041-021-00877-5
identifier_str_mv RADISKE, Andressa; GONZALEZ, Maria Carolina; ROSSATO, Janine Inez; APOLINÁRIO, Gênedy; OLIVEIRA, João R. de; BEVILAQUA, Lia Rejane Müller; CAMMAROTA, Martín Pablo. Avoidance memory requires CaMKII activity to persist after recall. Molecular Brain, [S. l.], v. 14, p. 167, nov. 2021. Doi: 10.1186/s13041-021-00877-5. Disponível em: https://molecularbrain.biomedcentral.com/articles/10.1186/s13041-021-00877-5. Acesso em: 20 jan. 2022.
url https://repositorio.ufrn.br/handle/123456789/45699
https://doi.org/10.1186/s13041-021-00877-5
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv Attribution 3.0 Brazil
http://creativecommons.org/licenses/by/3.0/br/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 3.0 Brazil
http://creativecommons.org/licenses/by/3.0/br/
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFRN
instname:Universidade Federal do Rio Grande do Norte (UFRN)
instacron:UFRN
instname_str Universidade Federal do Rio Grande do Norte (UFRN)
instacron_str UFRN
institution UFRN
reponame_str Repositório Institucional da UFRN
collection Repositório Institucional da UFRN
bitstream.url.fl_str_mv https://repositorio.ufrn.br/bitstream/123456789/45699/1/AvoidanceMemoryRequires_Cammarota_2021.pdf
https://repositorio.ufrn.br/bitstream/123456789/45699/2/license_rdf
https://repositorio.ufrn.br/bitstream/123456789/45699/3/license.txt
bitstream.checksum.fl_str_mv 7aa6a9917802313cc7bb7a4e81b7aeef
4d2950bda3d176f570a9f8b328dfbbef
e9597aa2854d128fd968be5edc8a28d9
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)
repository.mail.fl_str_mv
_version_ 1797777221387026432

Registros relacionados