Subacute effects of the psychedelic ayahuasca on the salience and default mode networks
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/jspui/handle/123456789/28819 |
Resumo: | Background: Neuroimaging studies have just begun to explore the acute effects of psychedelics on large-scale brain networks' functional organization. Even less is known about the neural correlates of subacute effects taking place days after the psychedelic experience. This study explores the subacute changes of primary sensory brain networks and networks supporting higher-order affective and self-referential functions 24 hours after a single session with the psychedelic ayahuasca. Methods: We leveraged task-free functional magnetic resonance imaging data 1 day before and 1 day after a randomized placebo-controlled trial exploring the effects of ayahuasca in naïve healthy participants (21 placebo/22 ayahuasca). We derived intra- and inter-network functional connectivity of the salience, default mode, visual, and sensorimotor networks, and assessed post-session connectivity changes between the ayahuasca and placebo groups. Connectivity changes were associated with Hallucinogen Rating Scale scores assessed during the acute effects. Results: Our findings revealed increased anterior cingulate cortex connectivity within the salience network, decreased posterior cingulate cortex connectivity within the default mode network, and increased connectivity between the salience and default mode networks 1 day after the session in the ayahuasca group compared to placebo. Connectivity of primary sensory networks did not differ between groups. Salience network connectivity increases correlated with altered somesthesia scores, decreased default mode network connectivity correlated with altered volition scores, and increased salience default mode network connectivity correlated with altered affect scores. Conclusion: These findings provide preliminary evidence for subacute functional changes induced by the psychedelic ayahuasca on higher-order cognitive brain networks that support interoceptive, affective, and self-referential functions. |
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Pasquini, LorenzoPalhano-Fontes, FernandaAraújo, Dráulio Barros de2020-04-20T15:41:55Z2020-04-20T15:41:55Z2020-04-07PASQUINI, L.; PALHANO-FONTES, F.; ARAUJO, D. B. Subacute effects of the psychedelic ayahuasca on the salience and default mode networks. J Psychopharmacol., [S. l.], abr. 2020.https://repositorio.ufrn.br/jspui/handle/123456789/2881910.1177/0269881120909409Ayahuascadefault mode networkfunctional connectivityinteroceptionsalience networkSubacute effects of the psychedelic ayahuasca on the salience and default mode networksinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleBackground: Neuroimaging studies have just begun to explore the acute effects of psychedelics on large-scale brain networks' functional organization. Even less is known about the neural correlates of subacute effects taking place days after the psychedelic experience. This study explores the subacute changes of primary sensory brain networks and networks supporting higher-order affective and self-referential functions 24 hours after a single session with the psychedelic ayahuasca. Methods: We leveraged task-free functional magnetic resonance imaging data 1 day before and 1 day after a randomized placebo-controlled trial exploring the effects of ayahuasca in naïve healthy participants (21 placebo/22 ayahuasca). We derived intra- and inter-network functional connectivity of the salience, default mode, visual, and sensorimotor networks, and assessed post-session connectivity changes between the ayahuasca and placebo groups. Connectivity changes were associated with Hallucinogen Rating Scale scores assessed during the acute effects. Results: Our findings revealed increased anterior cingulate cortex connectivity within the salience network, decreased posterior cingulate cortex connectivity within the default mode network, and increased connectivity between the salience and default mode networks 1 day after the session in the ayahuasca group compared to placebo. Connectivity of primary sensory networks did not differ between groups. Salience network connectivity increases correlated with altered somesthesia scores, decreased default mode network connectivity correlated with altered volition scores, and increased salience default mode network connectivity correlated with altered affect scores. Conclusion: These findings provide preliminary evidence for subacute functional changes induced by the psychedelic ayahuasca on higher-order cognitive brain networks that support interoceptive, affective, and self-referential functions.engreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNinfo:eu-repo/semantics/openAccessORIGINALDraulioAraujo_ICe_2020_Subacute effects.pdfDraulioAraujo_ICe_2020_Subacute effects.pdfDraulioAraujo_ICe_2020_Subacute effectsapplication/pdf2332020https://repositorio.ufrn.br/bitstream/123456789/28819/1/DraulioAraujo_ICe_2020_Subacute%20effects.pdfc83ea6e988bae0101304b41a4a4e5b69MD51TEXTDraulioAraujo_ICe_2020_Subacute effects.pdf.txtDraulioAraujo_ICe_2020_Subacute effects.pdf.txtExtracted texttext/plain65158https://repositorio.ufrn.br/bitstream/123456789/28819/3/DraulioAraujo_ICe_2020_Subacute%20effects.pdf.txt4f26800161e9428bbfe3ba16cc73a3d0MD53THUMBNAILDraulioAraujo_ICe_2020_Subacute effects.pdf.jpgDraulioAraujo_ICe_2020_Subacute effects.pdf.jpgGenerated Thumbnailimage/jpeg1703https://repositorio.ufrn.br/bitstream/123456789/28819/4/DraulioAraujo_ICe_2020_Subacute%20effects.pdf.jpg9e9d7e676539058cec23d95e00074dd2MD54LICENSElicense.txtlicense.txttext/plain; charset=utf-81484https://repositorio.ufrn.br/bitstream/123456789/28819/2/license.txte9597aa2854d128fd968be5edc8a28d9MD52123456789/288192021-07-08 15:27:47.228oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2021-07-08T18:27:47Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Subacute effects of the psychedelic ayahuasca on the salience and default mode networks |
title |
Subacute effects of the psychedelic ayahuasca on the salience and default mode networks |
spellingShingle |
Subacute effects of the psychedelic ayahuasca on the salience and default mode networks Pasquini, Lorenzo Ayahuasca default mode network functional connectivity interoception salience network |
title_short |
Subacute effects of the psychedelic ayahuasca on the salience and default mode networks |
title_full |
Subacute effects of the psychedelic ayahuasca on the salience and default mode networks |
title_fullStr |
Subacute effects of the psychedelic ayahuasca on the salience and default mode networks |
title_full_unstemmed |
Subacute effects of the psychedelic ayahuasca on the salience and default mode networks |
title_sort |
Subacute effects of the psychedelic ayahuasca on the salience and default mode networks |
author |
Pasquini, Lorenzo |
author_facet |
Pasquini, Lorenzo Palhano-Fontes, Fernanda Araújo, Dráulio Barros de |
author_role |
author |
author2 |
Palhano-Fontes, Fernanda Araújo, Dráulio Barros de |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Pasquini, Lorenzo Palhano-Fontes, Fernanda Araújo, Dráulio Barros de |
dc.subject.por.fl_str_mv |
Ayahuasca default mode network functional connectivity interoception salience network |
topic |
Ayahuasca default mode network functional connectivity interoception salience network |
description |
Background: Neuroimaging studies have just begun to explore the acute effects of psychedelics on large-scale brain networks' functional organization. Even less is known about the neural correlates of subacute effects taking place days after the psychedelic experience. This study explores the subacute changes of primary sensory brain networks and networks supporting higher-order affective and self-referential functions 24 hours after a single session with the psychedelic ayahuasca. Methods: We leveraged task-free functional magnetic resonance imaging data 1 day before and 1 day after a randomized placebo-controlled trial exploring the effects of ayahuasca in naïve healthy participants (21 placebo/22 ayahuasca). We derived intra- and inter-network functional connectivity of the salience, default mode, visual, and sensorimotor networks, and assessed post-session connectivity changes between the ayahuasca and placebo groups. Connectivity changes were associated with Hallucinogen Rating Scale scores assessed during the acute effects. Results: Our findings revealed increased anterior cingulate cortex connectivity within the salience network, decreased posterior cingulate cortex connectivity within the default mode network, and increased connectivity between the salience and default mode networks 1 day after the session in the ayahuasca group compared to placebo. Connectivity of primary sensory networks did not differ between groups. Salience network connectivity increases correlated with altered somesthesia scores, decreased default mode network connectivity correlated with altered volition scores, and increased salience default mode network connectivity correlated with altered affect scores. Conclusion: These findings provide preliminary evidence for subacute functional changes induced by the psychedelic ayahuasca on higher-order cognitive brain networks that support interoceptive, affective, and self-referential functions. |
publishDate |
2020 |
dc.date.accessioned.fl_str_mv |
2020-04-20T15:41:55Z |
dc.date.available.fl_str_mv |
2020-04-20T15:41:55Z |
dc.date.issued.fl_str_mv |
2020-04-07 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
PASQUINI, L.; PALHANO-FONTES, F.; ARAUJO, D. B. Subacute effects of the psychedelic ayahuasca on the salience and default mode networks. J Psychopharmacol., [S. l.], abr. 2020. |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/jspui/handle/123456789/28819 |
dc.identifier.doi.none.fl_str_mv |
10.1177/0269881120909409 |
identifier_str_mv |
PASQUINI, L.; PALHANO-FONTES, F.; ARAUJO, D. B. Subacute effects of the psychedelic ayahuasca on the salience and default mode networks. J Psychopharmacol., [S. l.], abr. 2020. 10.1177/0269881120909409 |
url |
https://repositorio.ufrn.br/jspui/handle/123456789/28819 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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