Immunohistochemical expression of PCNA, p53 and bcl-2 in pleomorphic adenomas

• Main Author: Górdon-Nunez, Manuel Antonio
• Publication Date: 2008
• Other Authors: Godoy, Gustavo Pina, Soares, Rosilene Calazans, Souza, Lélia Batista de, Freitas, Roseana de Almeida, Queiroz, Lélia Maria Guedes
• Format: Article
• Language: eng
• Source: Repositório Institucional da UFRN
• Download full: https://repositorio.ufrn.br/jspui/handle/123456789/23856
• topic: Pleomorphic adenoma; Salivary gland tumour; p53; PCNA; bcl-2

The aim of the study was to determine the immunohistochemical expression of the PCNA, p53 and bcl-2 proteins in pleomorphic adenomas. Nineteen specimens of pleomorphic adenomas were selected for analysis by the streptavidin-biotin-peroxidase method with antibodies against p53, PCNA and bcl-2 proteins. It was observed weak labeling for p53 in 12 cases (63.1%) and for PCNA in 8 (42.1%). With respect to the bcl-2 labeling index, no expression of this protein was detected in 12 cases, corresponding to 63.1% of the sample. Based on these findings, it was concluded that p53 and PCNA can favor the proliferative activity of pleomorphic adenomas, whereas bcl-2 probably does not effectively participate in the pathogenesis of this tumor.