Estudo sobre a sensibilidade dos caprinos ? toxidez de crotal?rias t?xicas para bovinos, visando a sua utiliza??o na profilaxia
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2015 |
| Tipo de documento: | Dissertação |
| Idioma: | por |
| Título da fonte: | Biblioteca Digital de Teses e Dissertações da UFRRJ |
| Texto Completo: | https://tede.ufrrj.br/jspui/handle/jspui/2817 |
Resumo: | Plant poisoning of farm animals in Brazil is known to be one of the most important causes of death. As there are not many possibilities for treatment of those cases, all efforts must focus on the application of alternative prophylactic measures, among them the use of a less sensitive animal species in areas of the occurrence of certain plants. This study aimed to ascertain the sensibility of goats to crotalarias (Crotalaria spectabilis and Crotalaria juncea), so that this animal species could be used as a prophylactic measure against those plants poisonous for cattle. In order to perform the experiments, 8 young adult goats of both sexes were used, which were randomly divided into two groups of 4 goats, e.g. one group for each plant. None of the 4 goats that received single or daily doses of Crotalaria juncea seeds, developed clinical signs of poisoning or showed changes in the biochemistry examinations, except one goat that exhibited an isolated rise in the levels of alkaline phosphatase. Out of the 4 goats that received single or daily doses of Crotalaria spectabilis seeds, three died. Among these, only the goat that received a 10g/kg single dose of the seeds survived and did not show any clinical sign or biochemical changes during the experiment. The goat that received a 20g/kg single dose of seeds died two days after the intake and exhibited loss of appetite, apathy and ruminal hypotonia. Postmortem and histopathological examination revealed marked centrilobular hemorrhagic necrosis. The goat that received daily doses of 2g/kg of Crotalaria spectabilis seeds for 35 days and died 58 days after the beginning of the experiment showed clinical signs of apathy, anorexia and a growing respiratory distress, besides the yellowish color of the blood serum. At histopathology the main lesion was interstitial pneumonia. This goat exhibited transient changes in the liver of AST, ALP, GGT, total protein, and direct and indirect bilirubin. The goat that received daily doses of 2g/kg of seeds for 150 days was euthanized in extremis. The clinical profile was loss of appetite, progressive emaciation, apathy, ruminal hypotonia and yellowish discoloration of mucous membranes and blood serum. At postmortem and histopathological examination, there was prevalence of the hepatic lesion. The most important microscopic lesions were megalocytosis and bizarre appearance of liver cells and epithelial cells of kidney tubules. Biochemistry showed transient changes in the activity of AST, ALT, ALP, GGT, total protein, urea and direct and indirect bilirubin levels. The results of the present study showed that goats are not indicated to be used as a prophylactic measure against poisoning by Crotalaria spectabilis, but can be recommended as an animal species to graze in areas invaded by Crotalaria juncea for the prevention of poisoning. |
| id |
UFRRJ-1_1eae615b8ec2edd614b0a660fd5ab704 |
|---|---|
| oai_identifier_str |
oai:localhost:jspui/2817 |
| network_acronym_str |
UFRRJ-1 |
| network_name_str |
Biblioteca Digital de Teses e Dissertações da UFRRJ |
| repository_id_str |
|
| spelling |
Brito, Marilene de Farias211.517.924-20http://lattes.cnpq.br/7980824063026281Tokarnia, Carlos Maria Antonio Hubinger239.959.637-49http://lattes.cnpq.br/7809700501564538Dobereiner, JurgenCaldas, Saulo Andrade057.429.074-51http://lattes.cnpq.br/8190878932268687Pires, Ana Paula de Castro2019-08-16T15:07:06Z2015-02-24PIRES, Ana Paula de Castro. Estudo sobre a sensibilidade dos caprinos ? toxidez de crotal?rias t?xicas para bovinos, visando a sua utiliza??o na profilaxia. 2015. 70 f. Disserta??o (Programa de P?s-Gradua??o em Medicina Veterin?ria (Patologia e Ci?ncias Cl?nicas)) - Universidade Federal Rural do Rio de Janeiro, Serop?dica.https://tede.ufrrj.br/jspui/handle/jspui/2817Plant poisoning of farm animals in Brazil is known to be one of the most important causes of death. As there are not many possibilities for treatment of those cases, all efforts must focus on the application of alternative prophylactic measures, among them the use of a less sensitive animal species in areas of the occurrence of certain plants. This study aimed to ascertain the sensibility of goats to crotalarias (Crotalaria spectabilis and Crotalaria juncea), so that this animal species could be used as a prophylactic measure against those plants poisonous for cattle. In order to perform the experiments, 8 young adult goats of both sexes were used, which were randomly divided into two groups of 4 goats, e.g. one group for each plant. None of the 4 goats that received single or daily doses of Crotalaria juncea seeds, developed clinical signs of poisoning or showed changes in the biochemistry examinations, except one goat that exhibited an isolated rise in the levels of alkaline phosphatase. Out of the 4 goats that received single or daily doses of Crotalaria spectabilis seeds, three died. Among these, only the goat that received a 10g/kg single dose of the seeds survived and did not show any clinical sign or biochemical changes during the experiment. The goat that received a 20g/kg single dose of seeds died two days after the intake and exhibited loss of appetite, apathy and ruminal hypotonia. Postmortem and histopathological examination revealed marked centrilobular hemorrhagic necrosis. The goat that received daily doses of 2g/kg of Crotalaria spectabilis seeds for 35 days and died 58 days after the beginning of the experiment showed clinical signs of apathy, anorexia and a growing respiratory distress, besides the yellowish color of the blood serum. At histopathology the main lesion was interstitial pneumonia. This goat exhibited transient changes in the liver of AST, ALP, GGT, total protein, and direct and indirect bilirubin. The goat that received daily doses of 2g/kg of seeds for 150 days was euthanized in extremis. The clinical profile was loss of appetite, progressive emaciation, apathy, ruminal hypotonia and yellowish discoloration of mucous membranes and blood serum. At postmortem and histopathological examination, there was prevalence of the hepatic lesion. The most important microscopic lesions were megalocytosis and bizarre appearance of liver cells and epithelial cells of kidney tubules. Biochemistry showed transient changes in the activity of AST, ALT, ALP, GGT, total protein, urea and direct and indirect bilirubin levels. The results of the present study showed that goats are not indicated to be used as a prophylactic measure against poisoning by Crotalaria spectabilis, but can be recommended as an animal species to graze in areas invaded by Crotalaria juncea for the prevention of poisoning.A intoxica??o por plantas em animais de produ??o no Brasil ? sabidamente uma das mais importantes causas de mortes. Tendo em vista que pouco pode ser feito no que diz respeito ao tratamento dessas intoxica??es, os esfor?os devem se concentrar na ado??o de medidas profil?ticas alternativas, entre estas a utiliza??o de uma esp?cie menos sens?vel no local de ocorr?ncia de determinadas plantas. Objetivou-se com esse trabalho verificar a sensibilidade de caprinos ?s crotal?rias (Crotalaria spectabilis e Crotalaria juncea) para que possam ser utilizados na profilaxia da intoxica??o por essas plantas em bovinos. Para a realiza??o dos experimentos foram utilizados oito caprinos adultos jovens, de ambos os sexos, divididos aleatoriamente em dois grupos de quatro animais (um grupo para cada planta). Dos quatro caprinos que receberam doses ?nicas ou di?rias de sementes de Crotalaria juncea, nenhum desenvolveu sinais cl?nicos de intoxica??o ou apresentou altera??es no exame bioqu?mico, com exce??o de um animal que apresentou aumento isolado nos n?veis de ALP e albumina. Entre os quatro caprinos que receberam doses ?nicas ou di?rias de sementes de Crotalaria spectabilis, tr?s morreram. Desses, apenas o animal que recebeu uma dose ?nica de 10g/kg de sementes da planta sobreviveu, e n?o apresentou altera??es cl?nicas ou bioqu?micas durante o per?odo experimental. O animal que recebeu uma dose ?nica de 20g/kg de sementes morreu dois dias ap?s a ingest?o e apresentou inapet?ncia, apatia e hipotonia ruminal. Tanto ? necropsia quanto ? histopatologia, se destacaram as les?es hep?ticas, caracterizadas por necrose hemorr?gica centrolobular. O caprino que recebeu doses di?rias de 2g/kg de sementes de Crotalaria spectabilis por 35 dias e morreu 58 dias ap?s o in?cio do experimento, apresentou sinais de apatia, anorexia e crescente dificuldade respirat?ria, al?m de soro sangu?neo amarelado. ? necropsia as les?es hep?ticas e pulmonares chamaram a aten??o, e na histologia as principais altera??es eram de pneumonia intersticial. Esse animal apresentou altera??es transit?rias nos valores de AST, ALP, GGT, prote?na total e bilirrubina total e conjugada. O caprino que recebeu doses di?rias de 2g/kg de sementes da planta por 150 dias foi eutanasiado in extremis. O quadro cl?nico foi de inapet?ncia, emagrecimento progressivo, apatia, hipotonia ruminal e mucosas e soro sangu?neo amarelados. ? necropsia e ao exame histopatol?gico havia predomin?ncia de les?es hep?ticas. ? microscopia, as les?es mais importantes foram megalocitose e aspecto bizarro de hepat?citos e das c?lulas epiteliais dos t?bulos renais. O estudo da bioqu?mica sangu?nea mostrou altera??es transit?rias de AST, ALT, ALP, GGT, prote?na total, ureia e bilirrubina (total e conjugada). Os resultados do trabalho mostraram que n?o se deve usar caprinos como medida profil?tica na intoxica??o por Crotalaria spectabilis, mas que pode se recomendar esta esp?cie na profilaxia da intoxica??o por Crotalaria juncea.Submitted by Celso Magalhaes (celsomagalhaes@ufrrj.br) on 2019-08-16T15:07:06Z No. of bitstreams: 1 2015 - Ana Paula de Castro Pires.pdf: 3053343 bytes, checksum: 63fda66938c1d4191344f6e4be9305c4 (MD5)Made available in DSpace on 2019-08-16T15:07:06Z (GMT). No. of bitstreams: 1 2015 - Ana Paula de Castro Pires.pdf: 3053343 bytes, checksum: 63fda66938c1d4191344f6e4be9305c4 (MD5) Previous issue date: 2015-02-24Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPESapplication/pdfhttps://tede.ufrrj.br/retrieve/10316/2015%20-%20Ana%20Paula%20de%20Castro%20Pires.pdf.jpghttps://tede.ufrrj.br/retrieve/15980/2015%20-%20Ana%20Paula%20de%20Castro%20Pires.pdf.jpghttps://tede.ufrrj.br/retrieve/22296/2015%20-%20Ana%20Paula%20de%20Castro%20Pires.pdf.jpghttps://tede.ufrrj.br/retrieve/27954/2015%20-%20Ana%20Paula%20de%20Castro%20Pires.pdf.jpghttps://tede.ufrrj.br/retrieve/34316/2015%20-%20Ana%20Paula%20de%20Castro%20Pires.pdf.jpghttps://tede.ufrrj.br/retrieve/40692/2015%20-%20Ana%20Paula%20de%20Castro%20Pires.pdf.jpghttps://tede.ufrrj.br/retrieve/47042/2015%20-%20Ana%20Paula%20de%20Castro%20Pires.pdf.jpghttps://tede.ufrrj.br/retrieve/53456/2015%20-%20Ana%20Paula%20de%20Castro%20Pires.pdf.jpgporUniversidade Federal Rural do Rio de JaneiroPrograma de P?s-Gradua??o em Medicina Veterin?ria (Patologia e Ci?ncias Cl?nicas)UFRRJBrasilInstituto de Veterin?ria7 REFER?NCIAS BIBLIOGR?FICAS ADAMS, R.; GIANTURCO, M. The alkaloids of Crotalaria juncea. Journal of the American Chemical Society, v. 78, n. 9, p. 1919-1921, 1956. ANJOS, B. L. et al. Poisoning of sheep by seeds of Crotalaria retusa: Acquired resistance by continuous administration of low doses. Toxicon, v. 55, n. 1, p. 28-32, 2010. ARA?JO, M. R.; COSTA, M. C.; ECCO, R. Mannheimia haemolytica em ovinos de Minas Gerais. Pesquisa Veterin?ria Brasileira, v. 29. n. 9, p. 719-724, 2009. BARBOSA, J. D. et al. Compara??o da sensibilidade de bovinos e b?falos ? intoxica??o por Palicourea marcgravii (Rubiaceae). Pesquisa Veterin?ria Brasileira, v. 23, n. 4, p. 167-172, 2003. BARROS, C. L. S. et al. Intoxica??o experimental por Senecio brasiliensis (Compositae) em ovinos. Pesquisa Veterin?ria Brasileira, v. 9, n. 3, p. 55-67, 1989. BELLODI, C. Intoxica??o experimental de c?es com sementes de Crotalaria spectabilis (Leg. Papilionoideae). 2010. 74 p. Disserta??o (Mestrado) ? Universidade Estadual J?lio de Mesquita Filho, 2010. BURKE, J. M. et al. Sunn hemp with chicory or pearl millet to minimize gastrointestinal nematode infection in weaned goats. Journal of Animal Sciences, v. 89, p. 17-18, 2011. CARVALHO, G. D.; BRAGAN?A, H. B. N.; PORF?RIO, L. C. Principias plantas t?xicas causadoras de morte s?bita em bovinos no estado do Esp?rito Santo ? Brasil. Arquivos de Zootecnia, v. 58, p. 87-98, 2009. CHAUDHURY, J.; SINGH, D. P.; HAZRA, S. K. Sunn hemp. Central Research Institute for jute and allied (ICAR). 1978. Dispon?vel em: <http://assamagribusiness.nic.in/sunnhemp.pdf>. Acesso em: 26 nov. 2014. CHEECKE, P. R. Natural toxicants in feeds, forages and poisonous plants. 2. ed. Danville: Interstate Publishers, 1998. 479 p. CHEEKE, P. P. Toxicity and metabolism of pyrrolizidine alkaloids. Journal of Animal Science, v. 66, p. 2243-2350, 1988. CHEEKE, P. R.; GARMAN, G. R. Influence of dietary protein and sulfur amino acid levels on the toxicity of Senecio jacobaea (Tansy Ragwort) to rats. Nutrition Reports International, v. 9, p. 197-207, 1974. CLARKE, E. C. G.; CLARKE, M. L. Garner's Veterinary Toxicology. 3. ed. Bailli?re: Tindall and Cassel, 1967. 477 p. COOPLE, B. L.; GANEY, P. E.; ROTH, R. A. Liver inflammation during monocrotaline hepatotoxicity. Toxicology, v. 190, n. 3, p. 155-169, 2003. 55 COSTA, M. B. B. Aduba??o verde no Sul do Brasil. Rio de Janeiro: ASPTA, 1993. 346 p. DANTAS, A. F. M. et al. Swainsonine-induced lysosomal storage disease in goats caused by the ingestion of Turbina cordata in Northeastern Brazil. Toxicon, v. 49, p. 111-116, 2007. DEINZER, M. L. et al. Pyrrolizidine alkaloids: Their occurrence in honey from tansy ragwort (Senecio jacobaea L.). Science, v.190, p. 497-499, 1977. DICKINSON, J. O.; COOKE, M. P.; MOHAMED, P. A. Milk transfer of pyrrolizidine alkaloids in cattle. Journal of the American Veterinary Medical Association, v. 169, n. 2, p. 1192-1196, 1976. DOLLAHITE, J. W. The use of sheep and goats to control Senecio poisoning in cattle. South Veterinary, v. 25, n. 3, p. 223-226, 1972. EMMEL, M. V.; SANDERS, D. A. Crotalaria spectabilis and C. retusa poisoning of livestock. Florida Agricultural Experiment Station, v. 574, p. 1-3, 1942. ESTIMA-SILVA, P. et al. Indu??o de resist?ncia ? intoxica??o por Senecio brasiliensis em ovinos. In: ENPOS- I AMOSTRA CIENT?FICA, 11., 2009, Pelotas. Anais... Pelotas, 2009. FLETCHER, M. T et al. Pyrrolizidine alkaloids in Crotalaria taxa from Northern Australia: risk to grazing livestock. Journal of Agricultural and Food Chemistry, n. 57, p. 311-319, 2009. FLORES, A. S.; MIOTTO, S. T. S. Aspectos fitogeogr?ficos das esp?cies de Crotalaria L. (Leguminosae-Faboideae) na regi?o Sul do Brasil. Acta Botanica Brasilica, v. 19, p. 245-249, 2005. FREITAS, F. L. C. et al. Aspectos anatomopatol?gicos e bioqu?micos da coccidiose hep?tica em coelho. Revista de Patologia Tropical, v. 38, n. 2, p. 125-155, 2009. FU, P. P. et al. Pyrrolizidine alkaloids tumorigenic components in Chinese herbal medicines and dietary supplements. Journal of Food and Drugs Analysis, v. 10, n. 4, p. 198-211, 2002. GRECCO, F. B. et al. Intoxica??o experimental aguda por Senecio brasiliensis em ovinos e indu??o de resist?ncia a intoxica??o. Pesquisa Veterin?ria Brasileira, v. 32, n. 9, p. 912-916, 2012. GROSH, T. K. et al. A note on the use of sunhemp (Crotalaria juncea) seeds in the feeding of goats. Indian Journal of Animal Nutrition, v. 7, n. 3, p. 215-216, 1990. HATAYDE, M. R. et al. Estudo experimental sobre a intoxica??o de Gallus gallus domesticus com sementes de Crotalaria spectabilis. I ? Efeito em aves na fase inicial de crescimento. Brazilian Journal of Veterinary Research and Animal Science, v. 34, p. 332-336, 1997. HATAYDE, M. R. et al. Efeitos da ingest?o de sementes de Crotalaria spectabilis sobre o desempenho produtivo de galinhas poedeiras. Veterin?ria Not?cias, v. 14, n. 2, p. 19-28, 2008. 56 HOOPER, P. T. Pyrrolizidine alkaloid poisoning - Pathology with particular reference to differences in animal and plant species. In: KEELER, R.; VAN KAMPEN, K. R.; JAMES, L. F. Effects of poisonous plants on livestock. New York: Academic Press, 1978. cap. s/n, p. 600. IBGE. Produ??o da Pecu?ria Municipal. 2014. Instituto Brasileiro de Geografia e Estat?stica. Dispon?vel em: <http://ibge.gov.br>. Acesso em 26 nov 2014. IZHAKI, I.; NE?EMAN, G. Hares (Lepus spp.) as seeds dispersers of Retama raetam (Fabracea) in a sandy ladscape. Journal of Arid Environments, v. 37, p. 343-354, 1997. JI, X. et al. Variability for the presence of pyrrolizidine alkaloids in Crotalaria juncea L. Pharmazie, v. 60, n. 8, p. 620-622, 2005. JOHSON, A. E.; MOLYNEUX, R. J.; MERRIL, G. B. Chemistry of toxic range plants. Variation in pyrrolizidine, alkaloid content of Senecio, Amsinckia, and Crotalaria species. Journal of Agricultural Food Chemistry, v. 33, n. 1, p. 50-55, 1985. JONES, R. M.; SIM?O NETO, M. Recovery of pasture seed ingest by ruminants. 3. The effects of the amount of seed in the diet and of diet quality on seed recovery from sheep. Australian Journal of Experimental Agriculture, v. 27, p. 253-256, 1987. JONES, T. C.; HUNT, R. D. Veterinary Pathology. 6 ed. Philadelphia: Lea & Febinger, 1997. 1792 p. KANEKO, J. J.; HARVEY, J. W.; BRUSS, M. Clinical Biochemistry of Domestic Animals. 5. ed. Philadelphia: Gulf Professional Publishing, 1997. 932 p. KARAM, F. C.; MORAES, J. C. F.; SCHILD, A. L. Controle de Senecio spp. com pastoreio ovino de acordo com sua infesta??o e fenologia. Pesquisa Veterin?ria Brasileira, v. 33, n. 9, p. 1109-1115, 2013. KEELER, R. F.; VAN KAMPEN, K. R.; JAMES, L. F. Effects of poisonous plants on livestock. New York: Academic Press, 1978. 600 p. KERR, M. G. Exames Laboratoriais em Medicina Veterin?ria: Bioqu?mica Cl?nica e Hematologia. 2 ed. S?o Paulo: Roca, 2003. 436 p. LALICH, J. J.; MERKOW, M. S. Pulmonary arteritis produced in rats by feeding Crotalaria spectabilis. Laboratory Investigation, v. 10, p. 744-750, 1961. LOGIE, C. G.; GRUE, M. R.; LIDDELL, J. R. NMR spectroscopy of pyrrolizidine alkaloids. Phytochemistry, v. 37, p. 43-109, 1994. LOPES, O. M. N. Crotalaria juncea L. e Crotalaria spectabilis ROTH leguminosas para aduba??o verde e alimenta??o animal. Altamira: Embrapa Amaz?nia oriental, 2000. 2 p. LORENZI, H. Plantas daninhas do Brasil: terrestres, aqu?ticas, parasitas, t?xicas e medicinais. 3. ed. Nova Odessa: Plantarum, 2008. 624 p. 57 LORDELLO, L. G. E. Nematoides das plantas cultivadas. 2. ed. S?o Paulo: Nobel, 1973. 197 p. LOVESIO, C. Insufici?ncia hep?tica aguda fulminante. Libro Virtual Intramed, 2001. Dispon?vel em: http://www.enfermeriaintensiva.files.wordpress.com/2011/04/insuficiencia-aguda-hepatica-fulminante-lovesio.pdf. Acesso em: 12 Dez 2014. LUCENA, R. B. et al. Intoxica??o por alcaloides pirrolizid?nicos em ruminantes e equinos no Brasil. Pesquisa Veterin?ria Brasileira, v. 30, n. 5, p. 447-452, 2010. MAIA, L. A. et al. Natural and experimental poisoning of goats with the pyrrolizidine alkaloid producing plant Crotalaria retusa L. Journal of Veterinary Diagnostic Investigation, v. 25, n. 5, p. 592-595, 2013. MAIA, L. A. et al. Duration of an induced resistance of sheep to acute poisoning by Crotalaria retusa seeds. Ci?ncia Rural, v. 44, n. 6, p. 1054-1059, 2014. MARTIN, J. H.; LEONARD, W. H.; STAMP, D. L. Principles of field crop production. 3. ed. New York: Macmillan Publishing Co, 1976. 1118 p. MATTOCKS, A. R. Chemistry and toxicology of pyrrolizidine alkaloids. New York: Academic Press, 1986. 393 p. MEDEIROS, R. M. T.; G?RNIAK, S. L.; GUERRA, J. L. Effects of milk from goat fed Crotalaria spectabilis seeds on growing rats. Brazilian Journal of Veterinary Research and Animal Science, v. 36, n. 2, 1999. M?NDEZ, M. C.; RIET-CORREA, F. Intoxication by Senecio tweediei in cattle in sourthern Brazil. Veterinary and Human Toxicology, v, 35, n. 1, p. 55, 1993. M?NDEZ, M. C.; RIET-CORREA, F. Plantas t?xicas e micotoxicoses. 2. ed. Pelotas: Editora e Gr?fica universit?ria, 2008. 298p. MEYER, D. J.; HARVEY, J. W. Veterinary Laboratory Medicine: Interpretation and diagnosis. 3. ed. Missouri: W. B. Saunders, 2004. 351 p. MIRANDA, C. L. et al. Toxicity of Senecio jacobaea (Tansy Ragwort) in rats. Toxicology and Applied Pharmacology, v. 56, p. 431-442, 1980. MONQUEIRO, P. A. et al. Efeito de adubos verdes na supress?o de esp?cies de plantas daninhas. Planta Daninha, v. 27, n. 1, p. 85-89, 2009. MOREIRA, J. A. A. et al. Espa?amento de Crotalaria juncea L. no controle de plantas daninhas visando o cultivo subsequente do milho org?nico no sistema de plantio direto. In: CONGRESSO BRASILEIRO DA CI?NCIA DAS PLANTAS DANINHAS NA ERA DA BIOTECNOLOGIA, 18., 2012, Campo Grande. Anais... Campo Grande: SPCPD, 2012. p. 781-785. MOSJIDIS, J. A.; WANG, M. L. Crotalaria. In: KOLE, C. Wild crop relatives: Genomic and breedingre sources. Springer-Verlag: Industrial Crops, 2011. p. 63-69. 58 MOSJIDIS, J. A.; BURKE, J. M.; HESS, J. B. The facts about sunhemp toxicity. Crop Science, v. 52, p. 1469-1474, 2012. NAKAGE, A. P. M. et al. Estudo hematol?gico e hormonal de frangos de corte tratados com contaminantes do milho: Crotalaria spectabilis e Senna occidentalis. Brazilian Journal of Veterinary Research and Animal Science, v. 37, n. 5, p. 377-381, 2000. NATIONAL ACADEMY OF SCIENCE. Tropical legumes: Resources for the future. Washington: National Academy of Science, 1979. 331 p. NEAL, W. M.; RUSOFF, L. L.; AHMANN, C. F. The isolation and some properties of an alkaloid from Crotalaria spectabilis roth. Journal of the American Chemical Society, v. 572, p. 2560-2561, 1935. NICHOLAS, R. A. J. Improvements in the diagnosis and control of diseases of small ruminants caused by mycoplasmas. Small Ruminants Research, v. 45, n. 2, p. 145-149, 2002. NOBRE, D.; DAGLL, M. L. Z.; HARAGUCHI, M. Crotalaria juncea intoxication in horses. Veterinary and Human Toxicology, v. 36, n. 5, p. 445-448, 1994. NOBRE, V. M. T. et al. Acute intoxication by Crotalaria retusa in sheep. Toxicon, v. 45, n. 3, p. 347-352, 2005. PANTER, K. E.; JAMES, L. F. Natural plant toxicants in milk: a review. Journal of Animal Science, v. 68, p. 892-904, 1990. PECKHAM, J. C.; SANGSTER, L. T.; JONES, Jr. O. H. Crotalaria spectabilis poisoning in swine. Journal of the Veterinary Medical Association, v. 165, p. 633-638, 1974. PEREIRA, W. A. B. et al. Altera??es cl?nico-patol?gicas de galinhas poedeiras (Gallus gallus domesticus) intoxicadas experimentalmente com sementes de Crotalaria spectabilis (Leg. Papilionoideae). Ars Veterin?ria, v. 27, n. 1, p. 45-50, 2011. PESSOA, C. R. M. et al. Pulmonary and hepatic lesions caused by dehydropyrrolizidine alkaloid-producing plants Crotalaria juncea and Crotalaria retusa in donkeys. Toxicon, v. 71, p. 113-120, 2013. PIERCY, P. L.; RUSSOF, L. L. Crotalaria spectabilis poisoning in Louisiana livestock. Journal of American Veterinary Medical Association, v. 108, n. 1946, p. 69-72, 1946. POISONOUS properties of sunn hemp (Crotalaria juncea). Rhodesia Agricultural Journal, v. 17, 1920. 1 p. POLHILL, R. M. Crotalaria in Africa and Madagascar. Rotterdan: A. A. Balkema, 1982. 186 p. PRAKASH, A. O.; DEHADRAI, S.; JONATHAN, S. Toxicological studies on the ethanolic extract of Crotalaria juncea seeds in rats. Journal of ethnopharmacology, v. 45, n. 3, p. 167-176, 1995. 59 PURSEGLOVE, J. W. Tropical crops: Dicotyledons. Essex: Longman Group, 1981. 719 p. QUIROGA-MADRIGAL, R. R. et al. Nematode populations and enzymatic activity in rhizospheres of tropical legumes in Auburn, Alabama. Nematropica, v. 29, n. 129, p. 2000-2017, 1999. REDDY, M. R.; MURTY, V. N. Nutritive value of sunhemp hay and its supplementation to paddy straw as a complete feed for cattle. Indian Journal of Animal Sciences, v. 42, p. 558-561, 1972. REDDY, M. R.; RAO, C. V.; SUBHAN, M. A. Studies on sunhemp meal as a component of poultry feeds. Indian Veterinary Journal, v. 48, p. 984-990, 1971. REDDY, V. et al. Nutritional evaluation of sunnhemp (Crotalaria juncea) hay as sole roughage and their use in complete ration for sheep. Indian Journal of Animal Nutrition, v.16, n. 1, p. 38-43, 1999. RIET-CORREA, F. et al. Doen?as de ruminantes e equinos. 2 ed. S?o Paulo: Varela editora e livraria LTDA, 2001. 1000 p. RIET-CORREA, F. et al. Toxic plants for livestock in Brazil: economic impact, toxic species, control measures and public health implications, p. 2-14. In: PANTER, K. E.; WIERENGA, T. L.; PFISER, J. A. Poisonous plants: global research and solutions. Wallinford: CAB International, 2007. 568 p. RIET-CORREA, F. et al. Spontaneous acute poisoning by Crotalaria retusa in sheep and biological control of this plant with sheep. Toxicon, v. 58, n. 7, p. 606-609, 2011. RIET-CORREA, F., M?NDEZ, M. C.; SCHILD, A. L. Intoxica??o por plantas e micotoxicoses em animais dom?sticos. Pelotas: Editorial Hemisf?rio Sul do Brasil, 1993. 340 p. RIET-CORREA, F.; MEDEIROS, R. M. T. Intoxica??o por plantas t?xicas em ruminantes no Brasil e no Uruguai: import?ncia econ?mica, controle e riscos para a sa?de p?blica. Pesquisa Veterin?ria Brasileira, v. 21, n. 1, p. 38-42, 2001. RITCHEY, G. E. et al. Crotalaria for forage. Florida: Gainesville, 1941. 361 p. RODRIGUES, A. F.; NOBRE, M. T. Intoxica??o experimental de asininos por sementes de Crotalaria retusa e Crotalaria juncea. In: CONGRESSO DE INICIA??O CIENT?FICA DA UNIVERSIDADE FEDERAL DE CAMPINA GRANDE, 8., 2011, Campina Grande. Anais... Campina Grande, 2011. ROMIN, A. E.; FITT, R. H. The feeding of sunnhemp hay (Crotalaria juncea) as compared with cowpea hay (Vigna catjang) in a fattening ration for bullocks. Rhodesia Agricultural Journal, v. 35, p. 15-19, 1938. ROTAR, P. P.; JOY, R. J. ?Tropic Sun? sunn hemp Crotalaria juncea L. Research Extension Series, v. 36, p. 1-7, 1983. 60 ROTH, R. A. et al. Effect of monocrotaline ingestion on liver, kidney and lungs of rats. Toxicology and Applied Pharmacology, v. 60, p. 193-203, 1981. RUGGIERI, A. C. et al. Principais plantas t?xicas que afetam bovinos de corte. In: PIRES, A. V. Bovinocultura de corte. v. 2. Piracicaba: FEALQ, 2010. p. 1191-1232. S?NCHEZ, D. C. C. Evid?ncias cl?nico-patol?gicas de ovinos intoxicados experimentalmente com sementes de Crotalaria spectabilis (Leg. Papilionoideae). 2011. 50 p. Disserta??o (Mestrado) ? Universidade Estadual Paulista J?lio de Mesquita Filho, 2011. SANDERS, D. A.; SHEALY, A. L.; EMMEL, M. W. The pathology of Crotalaria spectabilis ROTH poisoning in cattle. Journal of the American Veterinary Medical Association, v. 89, n. 2, p. 150-156, 1936. SEAWRIGHT, A. A. et al. Plant toxicology. Yeeronpilly: Queensland Poisonous Plants Committee, 1984. 664 p. SILVA, J. A. A.; DANODIO, L. C.; CARLOS, J. A. Aduba??o verde em citros. Jaboticabal: FUNEP, 1999. 37 p. SILVEIRA, P. M.; RAVA, C. A. Utiliza??o de crotal?ria no controle de nematoides da raiz do feijoeiro. Santo Ant?nio de Goi?s: Embrapa Arroz e Feij?o, 2004. 2 p. SIM?O NETO, M.; JONES, R. M. Recovery of pasture seed ingested by ruminants. 2. Digestion of seed in sacco and in vitro. Recovery of 1987. Australian Journal of Experimental Agriculture, v. 27, p. 247-251, 1987. SMITH, B. P. Tratado de Medicina Interna de Grandes Animais. 3. ed. S?o Paulo: Manole, 2006. 1784 p. SOARES, M. P. et al. Controle biol?gico de Senecio spp. com pastoreio de ovinos. In: II REUNI?N ARGENTINA DE PATOLOGIA VETERINARIA, 2000, Corrientes, Argentina. Anais... Corrientes, Argentina: Universidad Nacional del Nordeste, 2000. p. 79. SOUZA, A. C.; HATAYDE, M. R.; BECHARA, G. H. Aspectos patol?gicos da intoxica??o de su?nos por sementes de Crotalaria spectabilis. Pesquisa Veterin?ria Brasileira, v. 17, n. 1, p. 12-18, 1997. STEGELMEIER, B. L. et al. Pyrrolizidine alkaloid plants, metabolism and toxicity. Journal of Analytical Toxicology, v. 8, p. 95-116, 1999. STEGELMEIER, B. L. Pyrrolizidine alkaloid- containing toxic plants (Senecio, Crotalaria, Cynoglossum, Amsinckia, Heliotropium, and Echium spp.). Veterinary clinics of North America: Food Animal Practice, v. 27, n. 2, p. 419-428, 2011. TOKARNIA, C. H. et al. Plantas t?xicas do Brasil para animais de produ??o. 2. ed. Rio de Janeiro: Helianthus, 2012. 566 p. TORRES, M. B. A. et al. Intoxica??o experimental por sementes de Crotalaria spectabilis (Leguminosae) em su?nos. Ci?ncia Rural, v. 27, n. 2, p. 302-307, 1997. 61 UBIALI, D. G. et. al. Intoxica??o aguda com sementes de Crotalaria spectabilis (Fabaceae) em su?nos. Pesquisa Veterin?ria Brasileira, v. 31, n. 4, p. 313-318, 2011. VANDONI, R. Contribui??o para o conhecimento de algumas leguminosas como forrageiras ? aceita??o, palatibilidade e toxidez. In: E. S. A. L. Q., 9, 1952, Piracicaba. Anais... Piracicaba: USP, 1952. p. 196-214. WANG, K. H. B.; SIPES, B. S.; SCHMITT, D. P. Management Rotylenchulus reniformis in pineapple, Ananas comosus, by intercycle cover. Journal of Nematology, v. 34, p. 106-114, 2002. WANG, K. H. B.; SIPES, B. S.; SCHMITT, D. P. Suppresssion of Rotylenchulus reniformis by Crotalaria juncea, Brassica napus, and Target erecta. Nematropica, v. 31, p. 237-251, 2001. WANG, P. Y. et al. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid. Toxicology Letters, v. 155, n. 3, p. 411-420, 2005. WENNY, D. G.; LEVEY, D. J. Directed seed dispersal by bellbirds in a tropical cloud forest. Proceeding of the National Academy of Sciences, v. 95, p. 6204-6207, 1998. WEST, E.; EMMEL, M. W. Plants that poison farm animals. Florida: Gainesville, 1960. 26p. WILLIAMS, M. C.; MOLYNEUX, R. J. Occurrence, concentration, and toxicity of pyrrolizidine alkaloids in Crotalaria seeds. Weed Science, v. 35, p. 476-481, 1987. YAN, C. C.; COOPER, R. A.; HUXTABLE, R. J. The comparative metabolism of the four pyrrolizidine alkaloids seneciphylline, retrorsine, monocrotaline and trichodesmine in the isolated, perfused, rat liver. Toxicology and Applied Pharmacology, v. 133, p. 277-284, 1995. ZHANG, X. L. Toxic components of the seed of Crotalaria juncea and their toxicity for pigs. Journal of Veterinary Science and Technology, v. 7, p. 13-17, 1985.Crotalaria spp., ,caprinoscontrole biol?gicogoatsbiological control.Medicina Veterin?riaEstudo sobre a sensibilidade dos caprinos ? toxidez de crotal?rias t?xicas para bovinos, visando a sua utiliza??o na profilaxiaStudy on the sensitivity of goats to the toxicity of cattle toxic crotalaria, aiming its use in prophylaxisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da UFRRJinstname:Universidade Federal Rural do Rio de Janeiro (UFRRJ)instacron:UFRRJTHUMBNAIL2015 - Ana Paula de Castro Pires.pdf.jpg2015 - Ana Paula de Castro Pires.pdf.jpgimage/jpeg1943http://localhost:8080/tede/bitstream/jspui/2817/18/2015+-+Ana+Paula+de+Castro+Pires.pdf.jpgcc73c4c239a4c332d642ba1e7c7a9fb2MD518TEXT2015 - Ana Paula de Castro Pires.pdf.txt2015 - Ana Paula de Castro Pires.pdf.txttext/plain170693http://localhost:8080/tede/bitstream/jspui/2817/17/2015+-+Ana+Paula+de+Castro+Pires.pdf.txtc8517571452850bafaa6c1fd0d16625bMD517ORIGINAL2015 - Ana Paula de Castro Pires.pdf2015 - Ana Paula de Castro Pires.pdfapplication/pdf3053343http://localhost:8080/tede/bitstream/jspui/2817/2/2015+-+Ana+Paula+de+Castro+Pires.pdf63fda66938c1d4191344f6e4be9305c4MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82089http://localhost:8080/tede/bitstream/jspui/2817/1/license.txt7b5ba3d2445355f386edab96125d42b7MD51jspui/28172023-02-15 15:59:28.552oai:localhost: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Biblioteca Digital de Teses e Dissertaçõeshttps://tede.ufrrj.br/PUBhttps://tede.ufrrj.br/oai/requestbibliot@ufrrj.br||bibliot@ufrrj.bropendoar:2023-02-15T17:59:28Biblioteca Digital de Teses e Dissertações da UFRRJ - Universidade Federal Rural do Rio de Janeiro (UFRRJ)false |
| dc.title.por.fl_str_mv |
Estudo sobre a sensibilidade dos caprinos ? toxidez de crotal?rias t?xicas para bovinos, visando a sua utiliza??o na profilaxia |
| dc.title.alternative.por.fl_str_mv |
Study on the sensitivity of goats to the toxicity of cattle toxic crotalaria, aiming its use in prophylaxis |
| title |
Estudo sobre a sensibilidade dos caprinos ? toxidez de crotal?rias t?xicas para bovinos, visando a sua utiliza??o na profilaxia |
| spellingShingle |
Estudo sobre a sensibilidade dos caprinos ? toxidez de crotal?rias t?xicas para bovinos, visando a sua utiliza??o na profilaxia Pires, Ana Paula de Castro Crotalaria spp., , caprinos controle biol?gico goats biological control. Medicina Veterin?ria |
| title_short |
Estudo sobre a sensibilidade dos caprinos ? toxidez de crotal?rias t?xicas para bovinos, visando a sua utiliza??o na profilaxia |
| title_full |
Estudo sobre a sensibilidade dos caprinos ? toxidez de crotal?rias t?xicas para bovinos, visando a sua utiliza??o na profilaxia |
| title_fullStr |
Estudo sobre a sensibilidade dos caprinos ? toxidez de crotal?rias t?xicas para bovinos, visando a sua utiliza??o na profilaxia |
| title_full_unstemmed |
Estudo sobre a sensibilidade dos caprinos ? toxidez de crotal?rias t?xicas para bovinos, visando a sua utiliza??o na profilaxia |
| title_sort |
Estudo sobre a sensibilidade dos caprinos ? toxidez de crotal?rias t?xicas para bovinos, visando a sua utiliza??o na profilaxia |
| author |
Pires, Ana Paula de Castro |
| author_facet |
Pires, Ana Paula de Castro |
| author_role |
author |
| dc.contributor.advisor1.fl_str_mv |
Brito, Marilene de Farias |
| dc.contributor.advisor1ID.fl_str_mv |
211.517.924-20 |
| dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/7980824063026281 |
| dc.contributor.advisor-co1.fl_str_mv |
Tokarnia, Carlos Maria Antonio Hubinger |
| dc.contributor.advisor-co1ID.fl_str_mv |
239.959.637-49 |
| dc.contributor.advisor-co1Lattes.fl_str_mv |
http://lattes.cnpq.br/7809700501564538 |
| dc.contributor.referee1.fl_str_mv |
Dobereiner, Jurgen |
| dc.contributor.referee2.fl_str_mv |
Caldas, Saulo Andrade |
| dc.contributor.authorID.fl_str_mv |
057.429.074-51 |
| dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/8190878932268687 |
| dc.contributor.author.fl_str_mv |
Pires, Ana Paula de Castro |
| contributor_str_mv |
Brito, Marilene de Farias Tokarnia, Carlos Maria Antonio Hubinger Dobereiner, Jurgen Caldas, Saulo Andrade |
| dc.subject.por.fl_str_mv |
Crotalaria spp., , caprinos controle biol?gico |
| topic |
Crotalaria spp., , caprinos controle biol?gico goats biological control. Medicina Veterin?ria |
| dc.subject.eng.fl_str_mv |
goats biological control. |
| dc.subject.cnpq.fl_str_mv |
Medicina Veterin?ria |
| description |
Plant poisoning of farm animals in Brazil is known to be one of the most important causes of death. As there are not many possibilities for treatment of those cases, all efforts must focus on the application of alternative prophylactic measures, among them the use of a less sensitive animal species in areas of the occurrence of certain plants. This study aimed to ascertain the sensibility of goats to crotalarias (Crotalaria spectabilis and Crotalaria juncea), so that this animal species could be used as a prophylactic measure against those plants poisonous for cattle. In order to perform the experiments, 8 young adult goats of both sexes were used, which were randomly divided into two groups of 4 goats, e.g. one group for each plant. None of the 4 goats that received single or daily doses of Crotalaria juncea seeds, developed clinical signs of poisoning or showed changes in the biochemistry examinations, except one goat that exhibited an isolated rise in the levels of alkaline phosphatase. Out of the 4 goats that received single or daily doses of Crotalaria spectabilis seeds, three died. Among these, only the goat that received a 10g/kg single dose of the seeds survived and did not show any clinical sign or biochemical changes during the experiment. The goat that received a 20g/kg single dose of seeds died two days after the intake and exhibited loss of appetite, apathy and ruminal hypotonia. Postmortem and histopathological examination revealed marked centrilobular hemorrhagic necrosis. The goat that received daily doses of 2g/kg of Crotalaria spectabilis seeds for 35 days and died 58 days after the beginning of the experiment showed clinical signs of apathy, anorexia and a growing respiratory distress, besides the yellowish color of the blood serum. At histopathology the main lesion was interstitial pneumonia. This goat exhibited transient changes in the liver of AST, ALP, GGT, total protein, and direct and indirect bilirubin. The goat that received daily doses of 2g/kg of seeds for 150 days was euthanized in extremis. The clinical profile was loss of appetite, progressive emaciation, apathy, ruminal hypotonia and yellowish discoloration of mucous membranes and blood serum. At postmortem and histopathological examination, there was prevalence of the hepatic lesion. The most important microscopic lesions were megalocytosis and bizarre appearance of liver cells and epithelial cells of kidney tubules. Biochemistry showed transient changes in the activity of AST, ALT, ALP, GGT, total protein, urea and direct and indirect bilirubin levels. The results of the present study showed that goats are not indicated to be used as a prophylactic measure against poisoning by Crotalaria spectabilis, but can be recommended as an animal species to graze in areas invaded by Crotalaria juncea for the prevention of poisoning. |
| publishDate |
2015 |
| dc.date.issued.fl_str_mv |
2015-02-24 |
| dc.date.accessioned.fl_str_mv |
2019-08-16T15:07:06Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
| format |
masterThesis |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
PIRES, Ana Paula de Castro. Estudo sobre a sensibilidade dos caprinos ? toxidez de crotal?rias t?xicas para bovinos, visando a sua utiliza??o na profilaxia. 2015. 70 f. Disserta??o (Programa de P?s-Gradua??o em Medicina Veterin?ria (Patologia e Ci?ncias Cl?nicas)) - Universidade Federal Rural do Rio de Janeiro, Serop?dica. |
| dc.identifier.uri.fl_str_mv |
https://tede.ufrrj.br/jspui/handle/jspui/2817 |
| identifier_str_mv |
PIRES, Ana Paula de Castro. Estudo sobre a sensibilidade dos caprinos ? toxidez de crotal?rias t?xicas para bovinos, visando a sua utiliza??o na profilaxia. 2015. 70 f. Disserta??o (Programa de P?s-Gradua??o em Medicina Veterin?ria (Patologia e Ci?ncias Cl?nicas)) - Universidade Federal Rural do Rio de Janeiro, Serop?dica. |
| url |
https://tede.ufrrj.br/jspui/handle/jspui/2817 |
| dc.language.iso.fl_str_mv |
por |
| language |
por |
| dc.relation.references.por.fl_str_mv |
7 REFER?NCIAS BIBLIOGR?FICAS ADAMS, R.; GIANTURCO, M. The alkaloids of Crotalaria juncea. Journal of the American Chemical Society, v. 78, n. 9, p. 1919-1921, 1956. ANJOS, B. L. et al. Poisoning of sheep by seeds of Crotalaria retusa: Acquired resistance by continuous administration of low doses. Toxicon, v. 55, n. 1, p. 28-32, 2010. ARA?JO, M. R.; COSTA, M. C.; ECCO, R. Mannheimia haemolytica em ovinos de Minas Gerais. Pesquisa Veterin?ria Brasileira, v. 29. n. 9, p. 719-724, 2009. BARBOSA, J. D. et al. Compara??o da sensibilidade de bovinos e b?falos ? intoxica??o por Palicourea marcgravii (Rubiaceae). Pesquisa Veterin?ria Brasileira, v. 23, n. 4, p. 167-172, 2003. BARROS, C. L. S. et al. Intoxica??o experimental por Senecio brasiliensis (Compositae) em ovinos. Pesquisa Veterin?ria Brasileira, v. 9, n. 3, p. 55-67, 1989. BELLODI, C. Intoxica??o experimental de c?es com sementes de Crotalaria spectabilis (Leg. Papilionoideae). 2010. 74 p. Disserta??o (Mestrado) ? Universidade Estadual J?lio de Mesquita Filho, 2010. BURKE, J. M. et al. Sunn hemp with chicory or pearl millet to minimize gastrointestinal nematode infection in weaned goats. Journal of Animal Sciences, v. 89, p. 17-18, 2011. CARVALHO, G. D.; BRAGAN?A, H. B. N.; PORF?RIO, L. C. Principias plantas t?xicas causadoras de morte s?bita em bovinos no estado do Esp?rito Santo ? Brasil. Arquivos de Zootecnia, v. 58, p. 87-98, 2009. CHAUDHURY, J.; SINGH, D. P.; HAZRA, S. K. Sunn hemp. Central Research Institute for jute and allied (ICAR). 1978. Dispon?vel em: <http://assamagribusiness.nic.in/sunnhemp.pdf>. Acesso em: 26 nov. 2014. CHEECKE, P. R. Natural toxicants in feeds, forages and poisonous plants. 2. ed. Danville: Interstate Publishers, 1998. 479 p. CHEEKE, P. P. Toxicity and metabolism of pyrrolizidine alkaloids. Journal of Animal Science, v. 66, p. 2243-2350, 1988. CHEEKE, P. R.; GARMAN, G. R. Influence of dietary protein and sulfur amino acid levels on the toxicity of Senecio jacobaea (Tansy Ragwort) to rats. Nutrition Reports International, v. 9, p. 197-207, 1974. CLARKE, E. C. G.; CLARKE, M. L. Garner's Veterinary Toxicology. 3. ed. Bailli?re: Tindall and Cassel, 1967. 477 p. COOPLE, B. L.; GANEY, P. E.; ROTH, R. A. Liver inflammation during monocrotaline hepatotoxicity. Toxicology, v. 190, n. 3, p. 155-169, 2003. 55 COSTA, M. B. B. Aduba??o verde no Sul do Brasil. Rio de Janeiro: ASPTA, 1993. 346 p. DANTAS, A. F. M. et al. Swainsonine-induced lysosomal storage disease in goats caused by the ingestion of Turbina cordata in Northeastern Brazil. Toxicon, v. 49, p. 111-116, 2007. DEINZER, M. L. et al. Pyrrolizidine alkaloids: Their occurrence in honey from tansy ragwort (Senecio jacobaea L.). Science, v.190, p. 497-499, 1977. DICKINSON, J. O.; COOKE, M. P.; MOHAMED, P. A. Milk transfer of pyrrolizidine alkaloids in cattle. Journal of the American Veterinary Medical Association, v. 169, n. 2, p. 1192-1196, 1976. DOLLAHITE, J. W. The use of sheep and goats to control Senecio poisoning in cattle. South Veterinary, v. 25, n. 3, p. 223-226, 1972. EMMEL, M. V.; SANDERS, D. A. Crotalaria spectabilis and C. retusa poisoning of livestock. Florida Agricultural Experiment Station, v. 574, p. 1-3, 1942. ESTIMA-SILVA, P. et al. Indu??o de resist?ncia ? intoxica??o por Senecio brasiliensis em ovinos. In: ENPOS- I AMOSTRA CIENT?FICA, 11., 2009, Pelotas. Anais... Pelotas, 2009. FLETCHER, M. T et al. Pyrrolizidine alkaloids in Crotalaria taxa from Northern Australia: risk to grazing livestock. Journal of Agricultural and Food Chemistry, n. 57, p. 311-319, 2009. FLORES, A. S.; MIOTTO, S. T. S. Aspectos fitogeogr?ficos das esp?cies de Crotalaria L. (Leguminosae-Faboideae) na regi?o Sul do Brasil. Acta Botanica Brasilica, v. 19, p. 245-249, 2005. FREITAS, F. L. C. et al. Aspectos anatomopatol?gicos e bioqu?micos da coccidiose hep?tica em coelho. Revista de Patologia Tropical, v. 38, n. 2, p. 125-155, 2009. FU, P. P. et al. Pyrrolizidine alkaloids tumorigenic components in Chinese herbal medicines and dietary supplements. Journal of Food and Drugs Analysis, v. 10, n. 4, p. 198-211, 2002. GRECCO, F. B. et al. Intoxica??o experimental aguda por Senecio brasiliensis em ovinos e indu??o de resist?ncia a intoxica??o. Pesquisa Veterin?ria Brasileira, v. 32, n. 9, p. 912-916, 2012. GROSH, T. K. et al. A note on the use of sunhemp (Crotalaria juncea) seeds in the feeding of goats. Indian Journal of Animal Nutrition, v. 7, n. 3, p. 215-216, 1990. HATAYDE, M. R. et al. Estudo experimental sobre a intoxica??o de Gallus gallus domesticus com sementes de Crotalaria spectabilis. I ? Efeito em aves na fase inicial de crescimento. Brazilian Journal of Veterinary Research and Animal Science, v. 34, p. 332-336, 1997. HATAYDE, M. R. et al. Efeitos da ingest?o de sementes de Crotalaria spectabilis sobre o desempenho produtivo de galinhas poedeiras. Veterin?ria Not?cias, v. 14, n. 2, p. 19-28, 2008. 56 HOOPER, P. T. Pyrrolizidine alkaloid poisoning - Pathology with particular reference to differences in animal and plant species. In: KEELER, R.; VAN KAMPEN, K. R.; JAMES, L. F. Effects of poisonous plants on livestock. New York: Academic Press, 1978. cap. s/n, p. 600. IBGE. Produ??o da Pecu?ria Municipal. 2014. Instituto Brasileiro de Geografia e Estat?stica. Dispon?vel em: <http://ibge.gov.br>. Acesso em 26 nov 2014. IZHAKI, I.; NE?EMAN, G. Hares (Lepus spp.) as seeds dispersers of Retama raetam (Fabracea) in a sandy ladscape. Journal of Arid Environments, v. 37, p. 343-354, 1997. JI, X. et al. Variability for the presence of pyrrolizidine alkaloids in Crotalaria juncea L. Pharmazie, v. 60, n. 8, p. 620-622, 2005. JOHSON, A. E.; MOLYNEUX, R. J.; MERRIL, G. B. Chemistry of toxic range plants. Variation in pyrrolizidine, alkaloid content of Senecio, Amsinckia, and Crotalaria species. Journal of Agricultural Food Chemistry, v. 33, n. 1, p. 50-55, 1985. JONES, R. M.; SIM?O NETO, M. Recovery of pasture seed ingest by ruminants. 3. The effects of the amount of seed in the diet and of diet quality on seed recovery from sheep. Australian Journal of Experimental Agriculture, v. 27, p. 253-256, 1987. JONES, T. C.; HUNT, R. D. Veterinary Pathology. 6 ed. Philadelphia: Lea & Febinger, 1997. 1792 p. KANEKO, J. J.; HARVEY, J. W.; BRUSS, M. Clinical Biochemistry of Domestic Animals. 5. ed. Philadelphia: Gulf Professional Publishing, 1997. 932 p. KARAM, F. C.; MORAES, J. C. F.; SCHILD, A. L. Controle de Senecio spp. com pastoreio ovino de acordo com sua infesta??o e fenologia. Pesquisa Veterin?ria Brasileira, v. 33, n. 9, p. 1109-1115, 2013. KEELER, R. F.; VAN KAMPEN, K. R.; JAMES, L. F. Effects of poisonous plants on livestock. New York: Academic Press, 1978. 600 p. KERR, M. G. Exames Laboratoriais em Medicina Veterin?ria: Bioqu?mica Cl?nica e Hematologia. 2 ed. S?o Paulo: Roca, 2003. 436 p. LALICH, J. J.; MERKOW, M. S. Pulmonary arteritis produced in rats by feeding Crotalaria spectabilis. Laboratory Investigation, v. 10, p. 744-750, 1961. LOGIE, C. G.; GRUE, M. R.; LIDDELL, J. R. NMR spectroscopy of pyrrolizidine alkaloids. Phytochemistry, v. 37, p. 43-109, 1994. LOPES, O. M. N. Crotalaria juncea L. e Crotalaria spectabilis ROTH leguminosas para aduba??o verde e alimenta??o animal. Altamira: Embrapa Amaz?nia oriental, 2000. 2 p. LORENZI, H. Plantas daninhas do Brasil: terrestres, aqu?ticas, parasitas, t?xicas e medicinais. 3. ed. Nova Odessa: Plantarum, 2008. 624 p. 57 LORDELLO, L. G. E. Nematoides das plantas cultivadas. 2. ed. S?o Paulo: Nobel, 1973. 197 p. LOVESIO, C. Insufici?ncia hep?tica aguda fulminante. Libro Virtual Intramed, 2001. Dispon?vel em: http://www.enfermeriaintensiva.files.wordpress.com/2011/04/insuficiencia-aguda-hepatica-fulminante-lovesio.pdf. Acesso em: 12 Dez 2014. LUCENA, R. B. et al. Intoxica??o por alcaloides pirrolizid?nicos em ruminantes e equinos no Brasil. Pesquisa Veterin?ria Brasileira, v. 30, n. 5, p. 447-452, 2010. MAIA, L. A. et al. Natural and experimental poisoning of goats with the pyrrolizidine alkaloid producing plant Crotalaria retusa L. Journal of Veterinary Diagnostic Investigation, v. 25, n. 5, p. 592-595, 2013. MAIA, L. A. et al. Duration of an induced resistance of sheep to acute poisoning by Crotalaria retusa seeds. Ci?ncia Rural, v. 44, n. 6, p. 1054-1059, 2014. MARTIN, J. H.; LEONARD, W. H.; STAMP, D. L. Principles of field crop production. 3. ed. New York: Macmillan Publishing Co, 1976. 1118 p. MATTOCKS, A. R. Chemistry and toxicology of pyrrolizidine alkaloids. New York: Academic Press, 1986. 393 p. MEDEIROS, R. M. T.; G?RNIAK, S. L.; GUERRA, J. L. Effects of milk from goat fed Crotalaria spectabilis seeds on growing rats. Brazilian Journal of Veterinary Research and Animal Science, v. 36, n. 2, 1999. M?NDEZ, M. C.; RIET-CORREA, F. Intoxication by Senecio tweediei in cattle in sourthern Brazil. Veterinary and Human Toxicology, v, 35, n. 1, p. 55, 1993. M?NDEZ, M. C.; RIET-CORREA, F. Plantas t?xicas e micotoxicoses. 2. ed. Pelotas: Editora e Gr?fica universit?ria, 2008. 298p. MEYER, D. J.; HARVEY, J. W. Veterinary Laboratory Medicine: Interpretation and diagnosis. 3. ed. Missouri: W. B. Saunders, 2004. 351 p. MIRANDA, C. L. et al. Toxicity of Senecio jacobaea (Tansy Ragwort) in rats. Toxicology and Applied Pharmacology, v. 56, p. 431-442, 1980. MONQUEIRO, P. A. et al. Efeito de adubos verdes na supress?o de esp?cies de plantas daninhas. Planta Daninha, v. 27, n. 1, p. 85-89, 2009. MOREIRA, J. A. A. et al. Espa?amento de Crotalaria juncea L. no controle de plantas daninhas visando o cultivo subsequente do milho org?nico no sistema de plantio direto. In: CONGRESSO BRASILEIRO DA CI?NCIA DAS PLANTAS DANINHAS NA ERA DA BIOTECNOLOGIA, 18., 2012, Campo Grande. Anais... Campo Grande: SPCPD, 2012. p. 781-785. MOSJIDIS, J. A.; WANG, M. L. Crotalaria. In: KOLE, C. Wild crop relatives: Genomic and breedingre sources. Springer-Verlag: Industrial Crops, 2011. p. 63-69. 58 MOSJIDIS, J. A.; BURKE, J. M.; HESS, J. B. The facts about sunhemp toxicity. Crop Science, v. 52, p. 1469-1474, 2012. NAKAGE, A. P. M. et al. Estudo hematol?gico e hormonal de frangos de corte tratados com contaminantes do milho: Crotalaria spectabilis e Senna occidentalis. Brazilian Journal of Veterinary Research and Animal Science, v. 37, n. 5, p. 377-381, 2000. NATIONAL ACADEMY OF SCIENCE. Tropical legumes: Resources for the future. Washington: National Academy of Science, 1979. 331 p. NEAL, W. M.; RUSOFF, L. L.; AHMANN, C. F. The isolation and some properties of an alkaloid from Crotalaria spectabilis roth. Journal of the American Chemical Society, v. 572, p. 2560-2561, 1935. NICHOLAS, R. A. J. Improvements in the diagnosis and control of diseases of small ruminants caused by mycoplasmas. Small Ruminants Research, v. 45, n. 2, p. 145-149, 2002. NOBRE, D.; DAGLL, M. L. Z.; HARAGUCHI, M. Crotalaria juncea intoxication in horses. Veterinary and Human Toxicology, v. 36, n. 5, p. 445-448, 1994. NOBRE, V. M. T. et al. Acute intoxication by Crotalaria retusa in sheep. Toxicon, v. 45, n. 3, p. 347-352, 2005. PANTER, K. E.; JAMES, L. F. Natural plant toxicants in milk: a review. Journal of Animal Science, v. 68, p. 892-904, 1990. PECKHAM, J. C.; SANGSTER, L. T.; JONES, Jr. O. H. Crotalaria spectabilis poisoning in swine. Journal of the Veterinary Medical Association, v. 165, p. 633-638, 1974. PEREIRA, W. A. B. et al. Altera??es cl?nico-patol?gicas de galinhas poedeiras (Gallus gallus domesticus) intoxicadas experimentalmente com sementes de Crotalaria spectabilis (Leg. Papilionoideae). Ars Veterin?ria, v. 27, n. 1, p. 45-50, 2011. PESSOA, C. R. M. et al. Pulmonary and hepatic lesions caused by dehydropyrrolizidine alkaloid-producing plants Crotalaria juncea and Crotalaria retusa in donkeys. Toxicon, v. 71, p. 113-120, 2013. PIERCY, P. L.; RUSSOF, L. L. Crotalaria spectabilis poisoning in Louisiana livestock. Journal of American Veterinary Medical Association, v. 108, n. 1946, p. 69-72, 1946. POISONOUS properties of sunn hemp (Crotalaria juncea). Rhodesia Agricultural Journal, v. 17, 1920. 1 p. POLHILL, R. M. Crotalaria in Africa and Madagascar. Rotterdan: A. A. Balkema, 1982. 186 p. PRAKASH, A. O.; DEHADRAI, S.; JONATHAN, S. Toxicological studies on the ethanolic extract of Crotalaria juncea seeds in rats. Journal of ethnopharmacology, v. 45, n. 3, p. 167-176, 1995. 59 PURSEGLOVE, J. W. Tropical crops: Dicotyledons. Essex: Longman Group, 1981. 719 p. QUIROGA-MADRIGAL, R. R. et al. Nematode populations and enzymatic activity in rhizospheres of tropical legumes in Auburn, Alabama. Nematropica, v. 29, n. 129, p. 2000-2017, 1999. REDDY, M. R.; MURTY, V. N. Nutritive value of sunhemp hay and its supplementation to paddy straw as a complete feed for cattle. Indian Journal of Animal Sciences, v. 42, p. 558-561, 1972. REDDY, M. R.; RAO, C. V.; SUBHAN, M. A. Studies on sunhemp meal as a component of poultry feeds. Indian Veterinary Journal, v. 48, p. 984-990, 1971. REDDY, V. et al. Nutritional evaluation of sunnhemp (Crotalaria juncea) hay as sole roughage and their use in complete ration for sheep. Indian Journal of Animal Nutrition, v.16, n. 1, p. 38-43, 1999. RIET-CORREA, F. et al. Doen?as de ruminantes e equinos. 2 ed. S?o Paulo: Varela editora e livraria LTDA, 2001. 1000 p. RIET-CORREA, F. et al. Toxic plants for livestock in Brazil: economic impact, toxic species, control measures and public health implications, p. 2-14. In: PANTER, K. E.; WIERENGA, T. L.; PFISER, J. A. Poisonous plants: global research and solutions. Wallinford: CAB International, 2007. 568 p. RIET-CORREA, F. et al. Spontaneous acute poisoning by Crotalaria retusa in sheep and biological control of this plant with sheep. Toxicon, v. 58, n. 7, p. 606-609, 2011. RIET-CORREA, F., M?NDEZ, M. C.; SCHILD, A. L. Intoxica??o por plantas e micotoxicoses em animais dom?sticos. Pelotas: Editorial Hemisf?rio Sul do Brasil, 1993. 340 p. RIET-CORREA, F.; MEDEIROS, R. M. T. Intoxica??o por plantas t?xicas em ruminantes no Brasil e no Uruguai: import?ncia econ?mica, controle e riscos para a sa?de p?blica. Pesquisa Veterin?ria Brasileira, v. 21, n. 1, p. 38-42, 2001. RITCHEY, G. E. et al. Crotalaria for forage. Florida: Gainesville, 1941. 361 p. RODRIGUES, A. F.; NOBRE, M. T. Intoxica??o experimental de asininos por sementes de Crotalaria retusa e Crotalaria juncea. In: CONGRESSO DE INICIA??O CIENT?FICA DA UNIVERSIDADE FEDERAL DE CAMPINA GRANDE, 8., 2011, Campina Grande. Anais... Campina Grande, 2011. ROMIN, A. E.; FITT, R. H. The feeding of sunnhemp hay (Crotalaria juncea) as compared with cowpea hay (Vigna catjang) in a fattening ration for bullocks. Rhodesia Agricultural Journal, v. 35, p. 15-19, 1938. ROTAR, P. P.; JOY, R. J. ?Tropic Sun? sunn hemp Crotalaria juncea L. Research Extension Series, v. 36, p. 1-7, 1983. 60 ROTH, R. A. et al. Effect of monocrotaline ingestion on liver, kidney and lungs of rats. Toxicology and Applied Pharmacology, v. 60, p. 193-203, 1981. RUGGIERI, A. C. et al. Principais plantas t?xicas que afetam bovinos de corte. In: PIRES, A. V. Bovinocultura de corte. v. 2. Piracicaba: FEALQ, 2010. p. 1191-1232. S?NCHEZ, D. C. C. Evid?ncias cl?nico-patol?gicas de ovinos intoxicados experimentalmente com sementes de Crotalaria spectabilis (Leg. Papilionoideae). 2011. 50 p. Disserta??o (Mestrado) ? Universidade Estadual Paulista J?lio de Mesquita Filho, 2011. SANDERS, D. A.; SHEALY, A. L.; EMMEL, M. W. The pathology of Crotalaria spectabilis ROTH poisoning in cattle. Journal of the American Veterinary Medical Association, v. 89, n. 2, p. 150-156, 1936. SEAWRIGHT, A. A. et al. Plant toxicology. Yeeronpilly: Queensland Poisonous Plants Committee, 1984. 664 p. SILVA, J. A. A.; DANODIO, L. C.; CARLOS, J. A. Aduba??o verde em citros. Jaboticabal: FUNEP, 1999. 37 p. SILVEIRA, P. M.; RAVA, C. A. Utiliza??o de crotal?ria no controle de nematoides da raiz do feijoeiro. Santo Ant?nio de Goi?s: Embrapa Arroz e Feij?o, 2004. 2 p. SIM?O NETO, M.; JONES, R. M. Recovery of pasture seed ingested by ruminants. 2. Digestion of seed in sacco and in vitro. Recovery of 1987. Australian Journal of Experimental Agriculture, v. 27, p. 247-251, 1987. SMITH, B. P. Tratado de Medicina Interna de Grandes Animais. 3. ed. S?o Paulo: Manole, 2006. 1784 p. SOARES, M. P. et al. Controle biol?gico de Senecio spp. com pastoreio de ovinos. In: II REUNI?N ARGENTINA DE PATOLOGIA VETERINARIA, 2000, Corrientes, Argentina. Anais... Corrientes, Argentina: Universidad Nacional del Nordeste, 2000. p. 79. SOUZA, A. C.; HATAYDE, M. R.; BECHARA, G. H. Aspectos patol?gicos da intoxica??o de su?nos por sementes de Crotalaria spectabilis. Pesquisa Veterin?ria Brasileira, v. 17, n. 1, p. 12-18, 1997. STEGELMEIER, B. L. et al. Pyrrolizidine alkaloid plants, metabolism and toxicity. Journal of Analytical Toxicology, v. 8, p. 95-116, 1999. STEGELMEIER, B. L. Pyrrolizidine alkaloid- containing toxic plants (Senecio, Crotalaria, Cynoglossum, Amsinckia, Heliotropium, and Echium spp.). Veterinary clinics of North America: Food Animal Practice, v. 27, n. 2, p. 419-428, 2011. TOKARNIA, C. H. et al. Plantas t?xicas do Brasil para animais de produ??o. 2. ed. Rio de Janeiro: Helianthus, 2012. 566 p. TORRES, M. B. A. et al. Intoxica??o experimental por sementes de Crotalaria spectabilis (Leguminosae) em su?nos. Ci?ncia Rural, v. 27, n. 2, p. 302-307, 1997. 61 UBIALI, D. G. et. al. Intoxica??o aguda com sementes de Crotalaria spectabilis (Fabaceae) em su?nos. Pesquisa Veterin?ria Brasileira, v. 31, n. 4, p. 313-318, 2011. VANDONI, R. Contribui??o para o conhecimento de algumas leguminosas como forrageiras ? aceita??o, palatibilidade e toxidez. In: E. S. A. L. Q., 9, 1952, Piracicaba. Anais... Piracicaba: USP, 1952. p. 196-214. WANG, K. H. B.; SIPES, B. S.; SCHMITT, D. P. Management Rotylenchulus reniformis in pineapple, Ananas comosus, by intercycle cover. Journal of Nematology, v. 34, p. 106-114, 2002. WANG, K. H. B.; SIPES, B. S.; SCHMITT, D. P. Suppresssion of Rotylenchulus reniformis by Crotalaria juncea, Brassica napus, and Target erecta. Nematropica, v. 31, p. 237-251, 2001. WANG, P. Y. et al. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid. Toxicology Letters, v. 155, n. 3, p. 411-420, 2005. WENNY, D. G.; LEVEY, D. J. Directed seed dispersal by bellbirds in a tropical cloud forest. Proceeding of the National Academy of Sciences, v. 95, p. 6204-6207, 1998. WEST, E.; EMMEL, M. W. Plants that poison farm animals. Florida: Gainesville, 1960. 26p. WILLIAMS, M. C.; MOLYNEUX, R. J. Occurrence, concentration, and toxicity of pyrrolizidine alkaloids in Crotalaria seeds. Weed Science, v. 35, p. 476-481, 1987. YAN, C. C.; COOPER, R. A.; HUXTABLE, R. J. The comparative metabolism of the four pyrrolizidine alkaloids seneciphylline, retrorsine, monocrotaline and trichodesmine in the isolated, perfused, rat liver. Toxicology and Applied Pharmacology, v. 133, p. 277-284, 1995. ZHANG, X. L. Toxic components of the seed of Crotalaria juncea and their toxicity for pigs. Journal of Veterinary Science and Technology, v. 7, p. 13-17, 1985. |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Universidade Federal Rural do Rio de Janeiro |
| dc.publisher.program.fl_str_mv |
Programa de P?s-Gradua??o em Medicina Veterin?ria (Patologia e Ci?ncias Cl?nicas) |
| dc.publisher.initials.fl_str_mv |
UFRRJ |
| dc.publisher.country.fl_str_mv |
Brasil |
| dc.publisher.department.fl_str_mv |
Instituto de Veterin?ria |
| publisher.none.fl_str_mv |
Universidade Federal Rural do Rio de Janeiro |
| dc.source.none.fl_str_mv |
reponame:Biblioteca Digital de Teses e Dissertações da UFRRJ instname:Universidade Federal Rural do Rio de Janeiro (UFRRJ) instacron:UFRRJ |
| instname_str |
Universidade Federal Rural do Rio de Janeiro (UFRRJ) |
| instacron_str |
UFRRJ |
| institution |
UFRRJ |
| reponame_str |
Biblioteca Digital de Teses e Dissertações da UFRRJ |
| collection |
Biblioteca Digital de Teses e Dissertações da UFRRJ |
| bitstream.url.fl_str_mv |
http://localhost:8080/tede/bitstream/jspui/2817/18/2015+-+Ana+Paula+de+Castro+Pires.pdf.jpg http://localhost:8080/tede/bitstream/jspui/2817/17/2015+-+Ana+Paula+de+Castro+Pires.pdf.txt http://localhost:8080/tede/bitstream/jspui/2817/2/2015+-+Ana+Paula+de+Castro+Pires.pdf http://localhost:8080/tede/bitstream/jspui/2817/1/license.txt |
| bitstream.checksum.fl_str_mv |
cc73c4c239a4c332d642ba1e7c7a9fb2 c8517571452850bafaa6c1fd0d16625b 63fda66938c1d4191344f6e4be9305c4 7b5ba3d2445355f386edab96125d42b7 |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Biblioteca Digital de Teses e Dissertações da UFRRJ - Universidade Federal Rural do Rio de Janeiro (UFRRJ) |
| repository.mail.fl_str_mv |
bibliot@ufrrj.br||bibliot@ufrrj.br |
| _version_ |
1797220063355338752 |