Avalia??o cl?nica e laboratorial do tratamento com lactulose de c?es com doen?a renal cr?nica

Detalhes bibliográficos
Autor(a) principal: Pereira, Juliana de Abreu
Data de Publicação: 2017
Tipo de documento: Tese
Idioma: por
Título da fonte: Biblioteca Digital de Teses e Dissertações da UFRRJ
Texto Completo: https://tede.ufrrj.br/jspui/handle/jspui/2227
Resumo: Prebiotics, such as lactulosis, may favor the switch on the fermentative pattern of the colonic microbiota from proteolytic to saccharolytic, which allows bigger assimilation of nitrogenous compounds by the microrganisms of the colon. The present study aimed to evaluate, in dogs with CKD, the effect of the continued orally use of lactulosis over the nitrogenous compounds metabolisms?, the iron metabolism and on serum levels of albumin, magnesium, calcium and phosphorus. Twenty-one animals with CKD in IRIS II and III stages, under normal handling and feeding, were clinically and laboratorially evaluated by a 28 days period; divided in three groups according to treatment: T1 ? lactulosis + therapeutic diet, T2 ? lactulosis + standard treatment + therapeutic diet, T3 ? standard treatment + therapeutic diet . For the three groups (T1, T2 and T3), clinical parameters indicated anaemia and body score from regular to bad, according to the disease?s degree, during the hole treatment. The haematological and biochemical?s averages are consistent with common laboratorial findings in nephrophatic patients, with high levels of urea and creatinine; and low leves of haematocrit. For all the evaluated parameters in this study, the averages? variations during the period didn?t show any significant difference between times and treatments, with the exception of the calcemia averages that were greater for T1 group; which may indicate that for this animals? group the monotherapy with lactulosis could have increased the absorption of this mineral in those patients. With regard to iron metabolism, this study?s data revealed that the anaemia found in the dogs throughout the experimental period presented chronicity features, since the groups? means remained within the iron and transferrin references, besides high ferritin averages, without significant differences between groups and moments. The obtained data allowed to conclude that there was no difference between the proposed treatments in relation to clinical state and the biochemical and mineral profiles, such as iron metabolism; which justifies that the action mechanisms of prebiotics in nephrophatic patients should be evaluated with more details.
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spelling Botteon, Rita de C?ssia Campbell Machado826.217.807-68Botteon, Rita de C?ssia Campbell MachadoVeado, J?lio C?sar CambraiaMachado, Carlos HenriqueNobre e Castro, Maria CristinaBaldani, Cristiane Divan058.602.687-85http://lattes.cnpq.br/2881962942692907Pereira, Juliana de Abreu2018-03-15T19:04:01Z2017-04-27PEREIRA, Juliana de Abreu. Avalia??o cl?nica e laboratorial do tratamento com lactulose de c?es com doen?a renal cr?nica. 2017. 111 f. Tese (Doutorado em Medicina Veterin?ria - Ci?ncias Cl?nicas). Instituto de Veterin?ria, Universidade Federal Rural do Rio de Janeiro, Serop?dica, RJ, 2017.https://tede.ufrrj.br/jspui/handle/jspui/2227Prebiotics, such as lactulosis, may favor the switch on the fermentative pattern of the colonic microbiota from proteolytic to saccharolytic, which allows bigger assimilation of nitrogenous compounds by the microrganisms of the colon. The present study aimed to evaluate, in dogs with CKD, the effect of the continued orally use of lactulosis over the nitrogenous compounds metabolisms?, the iron metabolism and on serum levels of albumin, magnesium, calcium and phosphorus. Twenty-one animals with CKD in IRIS II and III stages, under normal handling and feeding, were clinically and laboratorially evaluated by a 28 days period; divided in three groups according to treatment: T1 ? lactulosis + therapeutic diet, T2 ? lactulosis + standard treatment + therapeutic diet, T3 ? standard treatment + therapeutic diet . For the three groups (T1, T2 and T3), clinical parameters indicated anaemia and body score from regular to bad, according to the disease?s degree, during the hole treatment. The haematological and biochemical?s averages are consistent with common laboratorial findings in nephrophatic patients, with high levels of urea and creatinine; and low leves of haematocrit. For all the evaluated parameters in this study, the averages? variations during the period didn?t show any significant difference between times and treatments, with the exception of the calcemia averages that were greater for T1 group; which may indicate that for this animals? group the monotherapy with lactulosis could have increased the absorption of this mineral in those patients. With regard to iron metabolism, this study?s data revealed that the anaemia found in the dogs throughout the experimental period presented chronicity features, since the groups? means remained within the iron and transferrin references, besides high ferritin averages, without significant differences between groups and moments. The obtained data allowed to conclude that there was no difference between the proposed treatments in relation to clinical state and the biochemical and mineral profiles, such as iron metabolism; which justifies that the action mechanisms of prebiotics in nephrophatic patients should be evaluated with more details.Prebi?ticos, como a lactulose, podem favorecer a altera??o do padr?o fermentativo da microbiota col?nica de proteol?tico para sacarol?tico; o que possibilita maior assimila??o de compostos nitrogenados pelos microrganismos do c?lon. O presente estudo teve por objetivo avaliar, em c?es com DRC, o efeito da utiliza??o continuada de lactulose por via oral, sobre o metabolismo de compostos nitrogenados; o metabolismo do ferro, e sobre as concentra??es s?ricas de albumina, magn?sio, c?lcio e f?sforo. Vinte e um animais portadores de DRC em est?gios IRIS II e III, com manejo e alimenta??o normais, foram avaliados clinicamente e laboratorialmente por um per?odo de 28 dias; divididos em tr?s grupos conforme o tratamento: T1 ? lactulose + ra??o terap?utica, T2 ? lactulose + tratamento convencional + ra??o terap?utica, T3 ? tratamento convencional + ra??o terap?utica. Para os tr?s grupos (T1, T2 e T3), os par?metros cl?nicos foram indicativos de anemia e escore corporal de regular a ruim, de acordo com o grau da enfermidade, ao longo de todo tratamento. As m?dias dos par?metros hematol?gicos e bioqu?micos s?o condizentes com achados laboratoriais comuns em nefropatas; com elevados valores de ureia e creatinina e valores decrescidos de hemat?crito. Para todos os par?metros as varia??es durante o per?odo n?o apresentaram diferen?a significativa entre os tempos e tratamentos, ? exce??o das m?dias de calcemia que foram maiores para o grupo T1; o que pode indicar que para os animais deste grupo a monoterapia com lactulose pode ter aumentado a absor??o deste mineral. Com rela??o ao metabolismo de ferro, os dados revelaram que a anemia encontrada nos c?es em todo o per?odo experimental apresentou caracter?sticas de cronicidade, uma vez que as m?dias dos grupos permaneceram dentro dos intervalos de refer?ncia para ferro e transferrina; al?m de m?dias elevadas de ferritina, sem diferen?as significativas entre grupos e momentos. Os dados obtidos permitiram concluir que n?o houve diferen?a entre os tratamentos propostos com rela??o ao estado cl?nico e aos perfis bioqu?micos e minerais, bem como ao metabolismo de ferro; o que justifica que os mecanismos de a??o dos prebi?ticos em nefropatas devem ser avaliados com maiores detalhes.Submitted by Jorge Silva (jorgelmsilva@ufrrj.br) on 2018-03-15T19:04:01Z No. of bitstreams: 1 2017 - Juliana de Abreu Pereira.pdf: 2216195 bytes, checksum: 788fd1f8f4db4f3012004d0eec09d439 (MD5)Made available in DSpace on 2018-03-15T19:04:01Z (GMT). No. of bitstreams: 1 2017 - Juliana de Abreu Pereira.pdf: 2216195 bytes, checksum: 788fd1f8f4db4f3012004d0eec09d439 (MD5) Previous issue date: 2017-04-27CAPESapplication/pdfhttps://tede.ufrrj.br/retrieve/7030/2017%20-%20Juliana%20de%20Abreu%20Pereira.pdf.jpghttps://tede.ufrrj.br/retrieve/21012/2017%20-%20Juliana%20de%20Abreu%20Pereira.pdf.jpghttps://tede.ufrrj.br/retrieve/27319/2017%20-%20Juliana%20de%20Abreu%20Pereira.pdf.jpghttps://tede.ufrrj.br/retrieve/33758/2017%20-%20Juliana%20de%20Abreu%20Pereira.pdf.jpghttps://tede.ufrrj.br/retrieve/40152/2017%20-%20Juliana%20de%20Abreu%20Pereira.pdf.jpghttps://tede.ufrrj.br/retrieve/46524/2017%20-%20Juliana%20de%20Abreu%20Pereira.pdf.jpghttps://tede.ufrrj.br/retrieve/52882/2017%20-%20Juliana%20de%20Abreu%20Pereira.pdf.jpghttps://tede.ufrrj.br/retrieve/59364/2017%20-%20Juliana%20de%20Abreu%20Pereira.pdf.jpgporUniversidade Federal Rural do Rio de JaneiroPrograma de P?s-Gradua??o em Medicina Veterin?ria (Patologia e Ci?ncias Cl?nicas)UFRRJBrasilInstituto de Veterin?riaABENSUR, H. 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dc.title.por.fl_str_mv Avalia??o cl?nica e laboratorial do tratamento com lactulose de c?es com doen?a renal cr?nica
dc.title.alternative.eng.fl_str_mv Clinical and laboratorial evaluation of the treatment with lactulosis of dogs with chronic kidney disease
title Avalia??o cl?nica e laboratorial do tratamento com lactulose de c?es com doen?a renal cr?nica
spellingShingle Avalia??o cl?nica e laboratorial do tratamento com lactulose de c?es com doen?a renal cr?nica
Pereira, Juliana de Abreu
prebiotics
nephropathy
dogs
kidney disease
prebi?ticos
nefropatia
c?es
doen?a renal
Medicina Veterin?ria
title_short Avalia??o cl?nica e laboratorial do tratamento com lactulose de c?es com doen?a renal cr?nica
title_full Avalia??o cl?nica e laboratorial do tratamento com lactulose de c?es com doen?a renal cr?nica
title_fullStr Avalia??o cl?nica e laboratorial do tratamento com lactulose de c?es com doen?a renal cr?nica
title_full_unstemmed Avalia??o cl?nica e laboratorial do tratamento com lactulose de c?es com doen?a renal cr?nica
title_sort Avalia??o cl?nica e laboratorial do tratamento com lactulose de c?es com doen?a renal cr?nica
author Pereira, Juliana de Abreu
author_facet Pereira, Juliana de Abreu
author_role author
dc.contributor.advisor1.fl_str_mv Botteon, Rita de C?ssia Campbell Machado
dc.contributor.advisor1ID.fl_str_mv 826.217.807-68
dc.contributor.referee1.fl_str_mv Botteon, Rita de C?ssia Campbell Machado
dc.contributor.referee2.fl_str_mv Veado, J?lio C?sar Cambraia
dc.contributor.referee3.fl_str_mv Machado, Carlos Henrique
dc.contributor.referee4.fl_str_mv Nobre e Castro, Maria Cristina
dc.contributor.referee5.fl_str_mv Baldani, Cristiane Divan
dc.contributor.authorID.fl_str_mv 058.602.687-85
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/2881962942692907
dc.contributor.author.fl_str_mv Pereira, Juliana de Abreu
contributor_str_mv Botteon, Rita de C?ssia Campbell Machado
Botteon, Rita de C?ssia Campbell Machado
Veado, J?lio C?sar Cambraia
Machado, Carlos Henrique
Nobre e Castro, Maria Cristina
Baldani, Cristiane Divan
dc.subject.eng.fl_str_mv prebiotics
nephropathy
dogs
kidney disease
topic prebiotics
nephropathy
dogs
kidney disease
prebi?ticos
nefropatia
c?es
doen?a renal
Medicina Veterin?ria
dc.subject.por.fl_str_mv prebi?ticos
nefropatia
c?es
doen?a renal
dc.subject.cnpq.fl_str_mv Medicina Veterin?ria
description Prebiotics, such as lactulosis, may favor the switch on the fermentative pattern of the colonic microbiota from proteolytic to saccharolytic, which allows bigger assimilation of nitrogenous compounds by the microrganisms of the colon. The present study aimed to evaluate, in dogs with CKD, the effect of the continued orally use of lactulosis over the nitrogenous compounds metabolisms?, the iron metabolism and on serum levels of albumin, magnesium, calcium and phosphorus. Twenty-one animals with CKD in IRIS II and III stages, under normal handling and feeding, were clinically and laboratorially evaluated by a 28 days period; divided in three groups according to treatment: T1 ? lactulosis + therapeutic diet, T2 ? lactulosis + standard treatment + therapeutic diet, T3 ? standard treatment + therapeutic diet . For the three groups (T1, T2 and T3), clinical parameters indicated anaemia and body score from regular to bad, according to the disease?s degree, during the hole treatment. The haematological and biochemical?s averages are consistent with common laboratorial findings in nephrophatic patients, with high levels of urea and creatinine; and low leves of haematocrit. For all the evaluated parameters in this study, the averages? variations during the period didn?t show any significant difference between times and treatments, with the exception of the calcemia averages that were greater for T1 group; which may indicate that for this animals? group the monotherapy with lactulosis could have increased the absorption of this mineral in those patients. With regard to iron metabolism, this study?s data revealed that the anaemia found in the dogs throughout the experimental period presented chronicity features, since the groups? means remained within the iron and transferrin references, besides high ferritin averages, without significant differences between groups and moments. The obtained data allowed to conclude that there was no difference between the proposed treatments in relation to clinical state and the biochemical and mineral profiles, such as iron metabolism; which justifies that the action mechanisms of prebiotics in nephrophatic patients should be evaluated with more details.
publishDate 2017
dc.date.issued.fl_str_mv 2017-04-27
dc.date.accessioned.fl_str_mv 2018-03-15T19:04:01Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
status_str publishedVersion
dc.identifier.citation.fl_str_mv PEREIRA, Juliana de Abreu. Avalia??o cl?nica e laboratorial do tratamento com lactulose de c?es com doen?a renal cr?nica. 2017. 111 f. Tese (Doutorado em Medicina Veterin?ria - Ci?ncias Cl?nicas). Instituto de Veterin?ria, Universidade Federal Rural do Rio de Janeiro, Serop?dica, RJ, 2017.
dc.identifier.uri.fl_str_mv https://tede.ufrrj.br/jspui/handle/jspui/2227
identifier_str_mv PEREIRA, Juliana de Abreu. Avalia??o cl?nica e laboratorial do tratamento com lactulose de c?es com doen?a renal cr?nica. 2017. 111 f. Tese (Doutorado em Medicina Veterin?ria - Ci?ncias Cl?nicas). Instituto de Veterin?ria, Universidade Federal Rural do Rio de Janeiro, Serop?dica, RJ, 2017.
url https://tede.ufrrj.br/jspui/handle/jspui/2227
dc.language.iso.fl_str_mv por
language por
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Aparelho Urin?rio. 10a edi??o. Editora Guanabara Koogan. p.371-386. 2004. KALANTAR-ZADEH, K.; REGIDOR, D. L.; MCALLISTER, C. J.; MICHAEL, B.; WARNOCK, D. G. Time-dependent associations between iron and mortality in hemodialys
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