S?ntese de 1,3,5-triazinas, potencialmente citot?xicas, pelo m?todo de cat?lise por transfer?ncia de fase
Autor(a) principal: | |
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Data de Publicação: | 1996 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da UFRRJ |
Texto Completo: | https://tede.ufrrj.br/jspui/handle/jspui/4185 |
Resumo: | The substituted 1,3,5-triazines show very interesting properties as medicinal, anti-fungal, and polymerization agents, herbicides, cosmetics and more recently, they have been employed in H-bond interaction studies on biomolecules, for example DNA, and also as a stationary phase in HPLC. Based on these aspects, twelve 2-X, 4-Y. 6-Z-1,3,5-triazines were synthesized, where X=Y?Z or X=Y=Z or X?Y?Z. x, Y and Z= chloro. 1-piperidinyl, 4-morpholinyl, 1-pyrrolidinyl, propanoxy and propanethioxy. The full characterization of synthesized compounds was done by spectroscopic methods such as 1H, 13C NMR, infrared and GC-Mass. Phase Transfer Catalysis was employed and showed high yields when compared with traditional methodology. The s-triazine derivatives were analysed to verify cytotoxic activity against Brine Shrimp. The assymetric tri-substituted derivative has shown the strongest activity. |
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Lima, Aurea Echevarria Aznar Neveshttp://lattes.cnpq.br/1879077396134052Lima , Aurea Echevarria Aznar NevesBernardino, Alice Maria RolimCosta, Jo?o Batista N. daFerreira, Aur?lio B. B.http://lattes.cnpq.br/0787621907541933Cavalcante, Marcia Ferreira2020-11-24T14:39:52Z1996-11-14CAVALCANTE, Marcia Ferreira. S?ntese de 1,3,5-triazinas, potencialmente citot?xicas, pelo m?todo de cat?lise por transfer?ncia de fase. 1996. 135 f. Disserta??o (Mestrado em Qu?mica) - Instituto de Ci?ncias Exatas, Universidade Federal Rural do Rio de Janeiro, Serop?dica - RJ, 1996.https://tede.ufrrj.br/jspui/handle/jspui/4185The substituted 1,3,5-triazines show very interesting properties as medicinal, anti-fungal, and polymerization agents, herbicides, cosmetics and more recently, they have been employed in H-bond interaction studies on biomolecules, for example DNA, and also as a stationary phase in HPLC. Based on these aspects, twelve 2-X, 4-Y. 6-Z-1,3,5-triazines were synthesized, where X=Y?Z or X=Y=Z or X?Y?Z. x, Y and Z= chloro. 1-piperidinyl, 4-morpholinyl, 1-pyrrolidinyl, propanoxy and propanethioxy. The full characterization of synthesized compounds was done by spectroscopic methods such as 1H, 13C NMR, infrared and GC-Mass. Phase Transfer Catalysis was employed and showed high yields when compared with traditional methodology. The s-triazine derivatives were analysed to verify cytotoxic activity against Brine Shrimp. The assymetric tri-substituted derivative has shown the strongest activity.As 1,3,5-triazinas substitu?das possuem interessantes propriedades como agentes medicinais, principalmente como antifungicidas, herbicidas, inseticidas, cosm?ticos e, recentemente, t?m sido utilizadas no estudo de intera??es do tipo liga??es-H em materiais biol?gicos, como DNA e prote?nas, e fase estacion?ria de CLAE, al?m de ativantes de polimeriza??o (copol?meros). Baseados nestes fatores, foram sintetizadas doze 2-X, 4-Y, 6-Z- 1,3,5-triazinas, onde X=Y=Z ou X=Y?Z ou X?Y?Z, podendo ser X, Y e Z = cloro, 1-piperidinil, 4-morfolinil, 1-pirrolidinil, propanoxi e propanotioxi. A caracteriza??o, dos compostos sintetizados, foi realizada atrav?s de m?todos espectrosc?picos de RMN 1H e 13C, Infravermelho e CG- Massas. A metodologia, utilizando Cat?lise por Transfer?ncia de Fase, mostrou-se bastante eficiente nos rendimentos, quando comparados com a metodologia tradicional. Foi verificada a toxidez dos derivados s-triaz?nicos utilizando-se o bioensaio "Brine Shrimp", onde o derivado trissubstitu?do assimetricamente, apresentou-se mais ativoSubmitted by Celso Magalhaes (celsomagalhaes@ufrrj.br) on 2020-11-24T14:39:52Z No. of bitstreams: 1 1996 - Marcia Ferreira Cavalcante.pdf: 1579243 bytes, checksum: 8e92cb9086b8303b8eebc63c423f390f (MD5)Made available in DSpace on 2020-11-24T14:39:52Z (GMT). No. of bitstreams: 1 1996 - Marcia Ferreira Cavalcante.pdf: 1579243 bytes, checksum: 8e92cb9086b8303b8eebc63c423f390f (MD5) Previous issue date: 1996-11-14Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico - CNPqapplication/pdfhttps://tede.ufrrj.br/retrieve/63176/1996%20-%20Marcia%20Ferreira%20Cavalcante.pdf.jpgporUniversidade Federal Rural do Rio de JaneiroPrograma de P?s-Gradua??o em Qu?micaUFRRJBrasilInstituto de Ci?ncias ExatasQu?micaQu?micaS?ntese de 1,3,5-triazinas, potencialmente citot?xicas, pelo m?todo de cat?lise por transfer?ncia de faseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da UFRRJinstname:Universidade Federal Rural do Rio de Janeiro (UFRRJ)instacron:UFRRJTHUMBNAIL1996 - Marcia Ferreira Cavalcante.pdf.jpg1996 - Marcia Ferreira Cavalcante.pdf.jpgimage/jpeg1802http://localhost:8080/tede/bitstream/jspui/4185/4/1996+-+Marcia+Ferreira+Cavalcante.pdf.jpg3279dc6248dc56a0611b2e2230e4cf30MD54TEXT1996 - Marcia Ferreira Cavalcante.pdf.txt1996 - Marcia Ferreira Cavalcante.pdf.txttext/plain51310http://localhost:8080/tede/bitstream/jspui/4185/3/1996+-+Marcia+Ferreira+Cavalcante.pdf.txtbf9cf4f22cbb7699d966075d6dbb8d69MD53ORIGINAL1996 - Marcia Ferreira Cavalcante.pdf1996 - Marcia Ferreira Cavalcante.pdfapplication/pdf1579243http://localhost:8080/tede/bitstream/jspui/4185/2/1996+-+Marcia+Ferreira+Cavalcante.pdf8e92cb9086b8303b8eebc63c423f390fMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82089http://localhost:8080/tede/bitstream/jspui/4185/1/license.txt7b5ba3d2445355f386edab96125d42b7MD51jspui/41852021-05-26 15:40:28.391oai:localhost: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Biblioteca Digital de Teses e Dissertaçõeshttps://tede.ufrrj.br/PUBhttps://tede.ufrrj.br/oai/requestbibliot@ufrrj.br||bibliot@ufrrj.bropendoar:2021-05-26T18:40:28Biblioteca Digital de Teses e Dissertações da UFRRJ - Universidade Federal Rural do Rio de Janeiro (UFRRJ)false |
dc.title.por.fl_str_mv |
S?ntese de 1,3,5-triazinas, potencialmente citot?xicas, pelo m?todo de cat?lise por transfer?ncia de fase |
title |
S?ntese de 1,3,5-triazinas, potencialmente citot?xicas, pelo m?todo de cat?lise por transfer?ncia de fase |
spellingShingle |
S?ntese de 1,3,5-triazinas, potencialmente citot?xicas, pelo m?todo de cat?lise por transfer?ncia de fase Cavalcante, Marcia Ferreira Qu?mica Qu?mica |
title_short |
S?ntese de 1,3,5-triazinas, potencialmente citot?xicas, pelo m?todo de cat?lise por transfer?ncia de fase |
title_full |
S?ntese de 1,3,5-triazinas, potencialmente citot?xicas, pelo m?todo de cat?lise por transfer?ncia de fase |
title_fullStr |
S?ntese de 1,3,5-triazinas, potencialmente citot?xicas, pelo m?todo de cat?lise por transfer?ncia de fase |
title_full_unstemmed |
S?ntese de 1,3,5-triazinas, potencialmente citot?xicas, pelo m?todo de cat?lise por transfer?ncia de fase |
title_sort |
S?ntese de 1,3,5-triazinas, potencialmente citot?xicas, pelo m?todo de cat?lise por transfer?ncia de fase |
author |
Cavalcante, Marcia Ferreira |
author_facet |
Cavalcante, Marcia Ferreira |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Lima, Aurea Echevarria Aznar Neves |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/1879077396134052 |
dc.contributor.referee1.fl_str_mv |
Lima , Aurea Echevarria Aznar Neves |
dc.contributor.referee2.fl_str_mv |
Bernardino, Alice Maria Rolim |
dc.contributor.referee3.fl_str_mv |
Costa, Jo?o Batista N. da |
dc.contributor.referee4.fl_str_mv |
Ferreira, Aur?lio B. B. |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/0787621907541933 |
dc.contributor.author.fl_str_mv |
Cavalcante, Marcia Ferreira |
contributor_str_mv |
Lima, Aurea Echevarria Aznar Neves Lima , Aurea Echevarria Aznar Neves Bernardino, Alice Maria Rolim Costa, Jo?o Batista N. da Ferreira, Aur?lio B. B. |
dc.subject.por.fl_str_mv |
Qu?mica |
topic |
Qu?mica Qu?mica |
dc.subject.cnpq.fl_str_mv |
Qu?mica |
description |
The substituted 1,3,5-triazines show very interesting properties as medicinal, anti-fungal, and polymerization agents, herbicides, cosmetics and more recently, they have been employed in H-bond interaction studies on biomolecules, for example DNA, and also as a stationary phase in HPLC. Based on these aspects, twelve 2-X, 4-Y. 6-Z-1,3,5-triazines were synthesized, where X=Y?Z or X=Y=Z or X?Y?Z. x, Y and Z= chloro. 1-piperidinyl, 4-morpholinyl, 1-pyrrolidinyl, propanoxy and propanethioxy. The full characterization of synthesized compounds was done by spectroscopic methods such as 1H, 13C NMR, infrared and GC-Mass. Phase Transfer Catalysis was employed and showed high yields when compared with traditional methodology. The s-triazine derivatives were analysed to verify cytotoxic activity against Brine Shrimp. The assymetric tri-substituted derivative has shown the strongest activity. |
publishDate |
1996 |
dc.date.issued.fl_str_mv |
1996-11-14 |
dc.date.accessioned.fl_str_mv |
2020-11-24T14:39:52Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
CAVALCANTE, Marcia Ferreira. S?ntese de 1,3,5-triazinas, potencialmente citot?xicas, pelo m?todo de cat?lise por transfer?ncia de fase. 1996. 135 f. Disserta??o (Mestrado em Qu?mica) - Instituto de Ci?ncias Exatas, Universidade Federal Rural do Rio de Janeiro, Serop?dica - RJ, 1996. |
dc.identifier.uri.fl_str_mv |
https://tede.ufrrj.br/jspui/handle/jspui/4185 |
identifier_str_mv |
CAVALCANTE, Marcia Ferreira. S?ntese de 1,3,5-triazinas, potencialmente citot?xicas, pelo m?todo de cat?lise por transfer?ncia de fase. 1996. 135 f. Disserta??o (Mestrado em Qu?mica) - Instituto de Ci?ncias Exatas, Universidade Federal Rural do Rio de Janeiro, Serop?dica - RJ, 1996. |
url |
https://tede.ufrrj.br/jspui/handle/jspui/4185 |
dc.language.iso.fl_str_mv |
por |
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por |
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info:eu-repo/semantics/openAccess |
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openAccess |
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dc.publisher.none.fl_str_mv |
Universidade Federal Rural do Rio de Janeiro |
dc.publisher.program.fl_str_mv |
Programa de P?s-Gradua??o em Qu?mica |
dc.publisher.initials.fl_str_mv |
UFRRJ |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Instituto de Ci?ncias Exatas |
publisher.none.fl_str_mv |
Universidade Federal Rural do Rio de Janeiro |
dc.source.none.fl_str_mv |
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Biblioteca Digital de Teses e Dissertações da UFRRJ |
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