Efic?cia do lotilaner no tratamento de mi?ase causada por dermatobia hominis (diptera: cuterebridae) em c?es naturalmente infestados

• Autor(a) principal: Sampaio, Rafaella Tortoriello Barbosa
• Data de Publicação: 2021
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Biblioteca Digital de Teses e Dissertações da UFRRJ
• Texto Completo: https://tede.ufrrj.br/jspui/handle/jspui/6818
• topic: Berne; Isoxazolina; Larvicida; Larvicide; Human bot-fly; Isoxazoline; Parasitologia

The human bot-fly cause skin limitations such as dermatobiosis. These are intensely uncomfortable, painful and the concomitant presence of bacterial infections and myiasis leads to aggravation of the condition. An effective treatment should eliminate or kill such existing larvae and promote wound healing as early as possible. Manual extraction of larvae by finger pressure is the most corrected treatment method, however, it can cause intense discomfort to the animal. Safe, painless and effective therapy has encouraged the search for new pharmaceutical options. The aim of the study was to evaluate the effectiveness of this lotilaner in the control of D. hominis in naturally infected dogs. For how we used 12 dogs, mixed breed, aged between one and ten years old, of both sexes, with variable weight from 10 to 20 kg, with at least three larvae in each, with at least three larvae in each, mandatory in any region of the body. The individuals were medicated with lotilaner, following the package insert recommendations for the treatment of other ectoparasitosis, at a minimum dose of 20 mg / kg, administered orally in a single dose. After 6 hours, larval removal was performed to verify the larvicidal activity of the medication. Larvae that showed minimal motility after removal were examined alive. The lotilaner efficacy was obtained by the following formula: [100 x (number of dead larvae - number of live larvae) / total number of larvae]. Totaling 98 larvae, 19 larvae recovered alive, representing an efficacy of 80.6% after six hours of lotilaner administration. It is noteworthy that as 19 larvae recovered alive, it dissipates motility, suggesting that the effective one could be higher, if the removal was carried out at a later period. It is concluded that lotilaner administered orally in a single dose of 20mg/kg was effective in controlling D. hominis in naturally infested dogs.