Estudo da transmiss?o inter- e transgeracional de altera??es metab?licas, comportamentais e card?acas na prole de camundongos obesos por duas gera??es consecutivas

Detalhes bibliográficos
Autor(a) principal: Zeca, Suelen Guedes
Data de Publicação: 2020
Tipo de documento: Tese
Idioma: por
Título da fonte: Biblioteca Digital de Teses e Dissertações da UFRRJ
Texto Completo: https://tede.ufrrj.br/jspui/handle/jspui/5745
Resumo: Epidemiological and experimental data show that maternal obesity can transmit metabolic, behavioral, and cardiovascular diseases, potentially transmitted by epigenetic mechanisms. Recent literature indicates paternal obesity's role in developing body composition and metabolic diseases by epigenetic modifications on spermatic cells. There is a lack of information about the phenomena in mammals and the dimorphic aspect of this experimental model's metabolic programming. This research aimed to understand if maternal or paternal obesity, separately, modulate the metabolism, behavior, and cardiac function in rodents, for two subsequent generations. Male and female C57BL/6J mice were fed with chow (NC, 6% lipids) or high fat (HF45 and HF60, 45 and 60% lipids, respectively) diet ad libitum for six weeks prior body composition, glycemic metabolism, and behavioral evaluation. Maternal and paternal NC, HF45, and HF60 groups, the F0 generation, were mated with NC animals to obtain F1. To boost the programming effects, the F2 generation was obtained by crossing the F1 generation within their groups. We kept all animals in a chow diet during the experimental protocol, except F0. We observed that F0-HF45 and F0-HF60 male and female had higher body weight and adiposity (female: p<0.01; male: p<0.001) and glycemic metabolism impairment (p<0.05). No significant changes were observed on females regarding pregnancy rate and litter number at birth; however, F0-HF60 females had decreased pups by the end of lactation (p<0.05). Maternal obesity had a more significant impact on MHF45 male offspring, in which F1 had increased body weight (p<0.001), adiposity (p<0.001), and impaired glycemic metabolism (p<0.05). On F2 generation, it was observed not only reduced body weight in this group (p<0.05), but also cardiac defects, showed by decreased ejection fraction (p<0.05) and increased left-ventricle (LF) end-systolic volume (p<0.05). Paternal obesity affected male and female offspring in similar proportions. We observed more significant body weight (p<0.05) and adiposity (p<0.05) in both sexes in the F1-PHF45 group and F1-PHF60 males. On F2 generation, decreased body weight was observed in male and female F2-PHF45 (p<0.05), as well as reduced adiposity in female F2-PHF45 (p<0.01), without changes in glycemic metabolism in both generations. The cardiac function was normal on F1, but a substantial reduction in the ejection fraction and increased left-ventricle (LF) end-systolic volume were detected on F2-PHF45 groups, male (p<0.05) and female (p<0.01). Therefore, we suggest that male offspring was more affected by maternal obesity, while paternal obesity affects both sexes in similar ways, especially regarding the cardiac function. Such dimorphism shows the importance of both sex's studies and the need for additional research on key epigenetic markers regarding phenotype maintenance and transmission to subsequent generations.
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spelling Almeida, Norma Aparecida dos Santos072.340.197-74Almeida, Norma Aparecida dos SantosRocha, F?bio Fagundes da|Malvar, David do CarmoSilva, Patr?cia Cristina Lisboa daAyres, Nat?lia Galito Rocha116.784.667-27http://lattes.cnpq.br/7861398897523675Zeca, Suelen Guedes2022-06-06T21:39:11Z2020-09-18ZECA, Suelen Guedes. Estudo da transmiss?o inter- e transgeracional de altera??es metab?licas, comportamentais e card?acas na prole de camundongos obesos por duas gera??es consecutivas. 2020. 99 F. Tese (Doutorado em Ci?ncias Fisiol?gicas) - Instituto de Ci?ncias Biol?gicas e da Sa?de, Universidade Federal Rural do Rio de Janeiro, Serop?dica, 2020.https://tede.ufrrj.br/jspui/handle/jspui/5745Epidemiological and experimental data show that maternal obesity can transmit metabolic, behavioral, and cardiovascular diseases, potentially transmitted by epigenetic mechanisms. Recent literature indicates paternal obesity's role in developing body composition and metabolic diseases by epigenetic modifications on spermatic cells. There is a lack of information about the phenomena in mammals and the dimorphic aspect of this experimental model's metabolic programming. This research aimed to understand if maternal or paternal obesity, separately, modulate the metabolism, behavior, and cardiac function in rodents, for two subsequent generations. Male and female C57BL/6J mice were fed with chow (NC, 6% lipids) or high fat (HF45 and HF60, 45 and 60% lipids, respectively) diet ad libitum for six weeks prior body composition, glycemic metabolism, and behavioral evaluation. Maternal and paternal NC, HF45, and HF60 groups, the F0 generation, were mated with NC animals to obtain F1. To boost the programming effects, the F2 generation was obtained by crossing the F1 generation within their groups. We kept all animals in a chow diet during the experimental protocol, except F0. We observed that F0-HF45 and F0-HF60 male and female had higher body weight and adiposity (female: p<0.01; male: p<0.001) and glycemic metabolism impairment (p<0.05). No significant changes were observed on females regarding pregnancy rate and litter number at birth; however, F0-HF60 females had decreased pups by the end of lactation (p<0.05). Maternal obesity had a more significant impact on MHF45 male offspring, in which F1 had increased body weight (p<0.001), adiposity (p<0.001), and impaired glycemic metabolism (p<0.05). On F2 generation, it was observed not only reduced body weight in this group (p<0.05), but also cardiac defects, showed by decreased ejection fraction (p<0.05) and increased left-ventricle (LF) end-systolic volume (p<0.05). Paternal obesity affected male and female offspring in similar proportions. We observed more significant body weight (p<0.05) and adiposity (p<0.05) in both sexes in the F1-PHF45 group and F1-PHF60 males. On F2 generation, decreased body weight was observed in male and female F2-PHF45 (p<0.05), as well as reduced adiposity in female F2-PHF45 (p<0.01), without changes in glycemic metabolism in both generations. The cardiac function was normal on F1, but a substantial reduction in the ejection fraction and increased left-ventricle (LF) end-systolic volume were detected on F2-PHF45 groups, male (p<0.05) and female (p<0.01). Therefore, we suggest that male offspring was more affected by maternal obesity, while paternal obesity affects both sexes in similar ways, especially regarding the cardiac function. Such dimorphism shows the importance of both sex's studies and the need for additional research on key epigenetic markers regarding phenotype maintenance and transmission to subsequent generations.Dados epidemiol?gicos e experimentais demonstram que a obesidade materna ? capaz de transmitir dist?rbios metab?licos, comportamentais e cardiovasculares na prole, transmitidas potencialmente de forma epigen?tica. Trabalhos mais recentes indicam a participa??o da obesidade paterna no desenvolvimento de altera??es na composi??o corporal e dist?rbios metab?licos atrav?s de altera??es epigen?ticas no espermatoz?ide. Pouco ainda ? conhecido sobre esse fen?meno em mam?feros, e no dimorfismo da programa??o metab?lica nesses modelos. O objetivo deste trabalho foi compreender se a obesidade materna ou paterna, separadamente, modula o metabolismo, comportamento, e fun??o card?aca em roedores, por duas gera??es consecutivas. Camundongos C57BL/6J f?meas ou machos alimentaram-se com dieta controle (NC, 6% de lip?deos) ou hiperlip?dicas (HF45 e HF60, 45 e 60% de lip?deos, respectivamente) ad libitum por seis semanas antes da avalia??o da composi??o corporal, metabolismo glic?dico e comportamental. Os grupos maternos e paternos NC, HF45 e HF60, considerados gera??o F0, foram acasalados com animais NC do sexo oposto para obten??o da gera??o F1. Para aumentar a influ?ncia da programa??o, a gera??o F2 foi obtida pelo cruzamento de camundongos F1 dentro de seu pr?prio grupo. Excetuando-se F0, todos os animais foram mantidos em NC durante todo o per?odo. Observamos que f?meas e machos F0-HF45 e F0-HF60 apresentaram maior peso corporal e adiposidade (f?meas: p<0,01; machos: p<0,001) e preju?zo no metabolismo glic?dico (p<0,05). Nas f?meas, nenhuma diferen?a significativa foi observada nas taxas de gravidez e n?mero de filhotes ao nascimento; por?m f?meas F0-HF60 apresentaram menor taxa de sobreviv?ncia dos filhotes ap?s o desmame (p< 0,05). A obesidade materna afetou em maior propor??o os filhotes machos MHF45, que na F1 apresentaram maior massa corporal (p<0,001), adiposidade (p<0,001) e preju?zo no metabolismo glic?dico (p<0,05) e, na F2 apresentaram menor peso corporal (p<0,05) e altera??es card?acas representadas pela redu??o na fra??o de eje??o (p<0,05) e aumento no volume sist?lico final do ventr?culo esquerdo (p<0,05). A obesidade paterna afetou filhotes machos e f?meas em propor??es semelhantes. Observamos maior massa corporal (p<0,05) e adiposidade (p<0,05) em ambos sexos na prole F1-PHF45 e nos machos F1-PHF60. Na F2 observamos menor peso corporal na prole PHF45 (p<0,05), com menor adiposidade nas f?meas F2-PHF45 (p<0,01), sem altera??o no metabolismo glic?dico nas duas gera??es. A fun??o card?aca apresentava-se normal na F1, mas uma redu??o substancial na fra??o de eje??o e aumento do volume sist?lico final do VE foi detectado nas proles F2-PHF45, em machos (p<0,05) e f?meas (p<0,01). Dessa forma, conclu?mos que os filhotes machos foram mais afetados pela obesidade materna, enquanto altera??es na obesidade paterna foram observadas em ambos os sexos, principalmente em rela??o aos preju?zos na fun??o card?aca. Tal dimorfismo mostra a import?ncia do estudo em ambos os sexos, bem como a necessidade de estudos adicionais para a busca de marcadores epigen?ticos chaves na manuten??o e transmiss?o destes fen?tipos ?s proles subsequentes.Submitted by Jorge Silva (jorgelmsilva@ufrrj.br) on 2022-06-06T21:39:11Z No. of bitstreams: 1 2020 - Suelen Guedes Zeca.pdf: 3091702 bytes, checksum: 230f43102416157cda462a713b6b6cca (MD5)Made available in DSpace on 2022-06-06T21:39:11Z (GMT). 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dc.title.por.fl_str_mv Estudo da transmiss?o inter- e transgeracional de altera??es metab?licas, comportamentais e card?acas na prole de camundongos obesos por duas gera??es consecutivas
dc.title.alternative.eng.fl_str_mv Studying inter- and transgenerational transmission of metabolic, behavioral, and heart phenotypes on mice offspring for two consecutive generations
title Estudo da transmiss?o inter- e transgeracional de altera??es metab?licas, comportamentais e card?acas na prole de camundongos obesos por duas gera??es consecutivas
spellingShingle Estudo da transmiss?o inter- e transgeracional de altera??es metab?licas, comportamentais e card?acas na prole de camundongos obesos por duas gera??es consecutivas
Zeca, Suelen Guedes
ecocardiograma
epigen?tica
obesidade materna e paterna
echocardiogram
epigenetic
maternal, and paternal obesity
Fisiologia
title_short Estudo da transmiss?o inter- e transgeracional de altera??es metab?licas, comportamentais e card?acas na prole de camundongos obesos por duas gera??es consecutivas
title_full Estudo da transmiss?o inter- e transgeracional de altera??es metab?licas, comportamentais e card?acas na prole de camundongos obesos por duas gera??es consecutivas
title_fullStr Estudo da transmiss?o inter- e transgeracional de altera??es metab?licas, comportamentais e card?acas na prole de camundongos obesos por duas gera??es consecutivas
title_full_unstemmed Estudo da transmiss?o inter- e transgeracional de altera??es metab?licas, comportamentais e card?acas na prole de camundongos obesos por duas gera??es consecutivas
title_sort Estudo da transmiss?o inter- e transgeracional de altera??es metab?licas, comportamentais e card?acas na prole de camundongos obesos por duas gera??es consecutivas
author Zeca, Suelen Guedes
author_facet Zeca, Suelen Guedes
author_role author
dc.contributor.advisor1.fl_str_mv Almeida, Norma Aparecida dos Santos
dc.contributor.advisor1ID.fl_str_mv 072.340.197-74
dc.contributor.referee1.fl_str_mv Almeida, Norma Aparecida dos Santos
dc.contributor.referee2.fl_str_mv Rocha, F?bio Fagundes da|
dc.contributor.referee3.fl_str_mv Malvar, David do Carmo
dc.contributor.referee4.fl_str_mv Silva, Patr?cia Cristina Lisboa da
dc.contributor.referee5.fl_str_mv Ayres, Nat?lia Galito Rocha
dc.contributor.authorID.fl_str_mv 116.784.667-27
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/7861398897523675
dc.contributor.author.fl_str_mv Zeca, Suelen Guedes
contributor_str_mv Almeida, Norma Aparecida dos Santos
Almeida, Norma Aparecida dos Santos
Rocha, F?bio Fagundes da|
Malvar, David do Carmo
Silva, Patr?cia Cristina Lisboa da
Ayres, Nat?lia Galito Rocha
dc.subject.por.fl_str_mv ecocardiograma
epigen?tica
obesidade materna e paterna
topic ecocardiograma
epigen?tica
obesidade materna e paterna
echocardiogram
epigenetic
maternal, and paternal obesity
Fisiologia
dc.subject.eng.fl_str_mv echocardiogram
epigenetic
maternal, and paternal obesity
dc.subject.cnpq.fl_str_mv Fisiologia
description Epidemiological and experimental data show that maternal obesity can transmit metabolic, behavioral, and cardiovascular diseases, potentially transmitted by epigenetic mechanisms. Recent literature indicates paternal obesity's role in developing body composition and metabolic diseases by epigenetic modifications on spermatic cells. There is a lack of information about the phenomena in mammals and the dimorphic aspect of this experimental model's metabolic programming. This research aimed to understand if maternal or paternal obesity, separately, modulate the metabolism, behavior, and cardiac function in rodents, for two subsequent generations. Male and female C57BL/6J mice were fed with chow (NC, 6% lipids) or high fat (HF45 and HF60, 45 and 60% lipids, respectively) diet ad libitum for six weeks prior body composition, glycemic metabolism, and behavioral evaluation. Maternal and paternal NC, HF45, and HF60 groups, the F0 generation, were mated with NC animals to obtain F1. To boost the programming effects, the F2 generation was obtained by crossing the F1 generation within their groups. We kept all animals in a chow diet during the experimental protocol, except F0. We observed that F0-HF45 and F0-HF60 male and female had higher body weight and adiposity (female: p<0.01; male: p<0.001) and glycemic metabolism impairment (p<0.05). No significant changes were observed on females regarding pregnancy rate and litter number at birth; however, F0-HF60 females had decreased pups by the end of lactation (p<0.05). Maternal obesity had a more significant impact on MHF45 male offspring, in which F1 had increased body weight (p<0.001), adiposity (p<0.001), and impaired glycemic metabolism (p<0.05). On F2 generation, it was observed not only reduced body weight in this group (p<0.05), but also cardiac defects, showed by decreased ejection fraction (p<0.05) and increased left-ventricle (LF) end-systolic volume (p<0.05). Paternal obesity affected male and female offspring in similar proportions. We observed more significant body weight (p<0.05) and adiposity (p<0.05) in both sexes in the F1-PHF45 group and F1-PHF60 males. On F2 generation, decreased body weight was observed in male and female F2-PHF45 (p<0.05), as well as reduced adiposity in female F2-PHF45 (p<0.01), without changes in glycemic metabolism in both generations. The cardiac function was normal on F1, but a substantial reduction in the ejection fraction and increased left-ventricle (LF) end-systolic volume were detected on F2-PHF45 groups, male (p<0.05) and female (p<0.01). Therefore, we suggest that male offspring was more affected by maternal obesity, while paternal obesity affects both sexes in similar ways, especially regarding the cardiac function. Such dimorphism shows the importance of both sex's studies and the need for additional research on key epigenetic markers regarding phenotype maintenance and transmission to subsequent generations.
publishDate 2020
dc.date.issued.fl_str_mv 2020-09-18
dc.date.accessioned.fl_str_mv 2022-06-06T21:39:11Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
status_str publishedVersion
dc.identifier.citation.fl_str_mv ZECA, Suelen Guedes. Estudo da transmiss?o inter- e transgeracional de altera??es metab?licas, comportamentais e card?acas na prole de camundongos obesos por duas gera??es consecutivas. 2020. 99 F. Tese (Doutorado em Ci?ncias Fisiol?gicas) - Instituto de Ci?ncias Biol?gicas e da Sa?de, Universidade Federal Rural do Rio de Janeiro, Serop?dica, 2020.
dc.identifier.uri.fl_str_mv https://tede.ufrrj.br/jspui/handle/jspui/5745
identifier_str_mv ZECA, Suelen Guedes. Estudo da transmiss?o inter- e transgeracional de altera??es metab?licas, comportamentais e card?acas na prole de camundongos obesos por duas gera??es consecutivas. 2020. 99 F. Tese (Doutorado em Ci?ncias Fisiol?gicas) - Instituto de Ci?ncias Biol?gicas e da Sa?de, Universidade Federal Rural do Rio de Janeiro, Serop?dica, 2020.
url https://tede.ufrrj.br/jspui/handle/jspui/5745
dc.language.iso.fl_str_mv por
language por
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