Correla??o entre o perfil de resist?ncia antimicrobiana e a bacteriocinas em Staphylococcus SPP isolados de casos de mastite bovina ocorridos no Estado do Rio de Janeiro

Pribul, Bruno Rocha

Correla??o entre o perfil de resist?ncia antimicrobiana e a bacteriocinas em Staphylococcus SPP isolados de casos de mastite bovina ocorridos no Estado do Rio de Janeiro

Detalhes bibliográficos
Autor(a) principal:	Pribul, Bruno Rocha
Data de Publicação:	2011
Tipo de documento:	Dissertação
Idioma:	por
Título da fonte:	Biblioteca Digital de Teses e Dissertações da UFRRJ
Texto Completo:	https://tede.ufrrj.br/jspui/handle/jspui/1142
Resumo:	PRIBUL, Bruno Rocha. Evaluation of Vancomycin Resistance and Susceptibility Profile Bacteriocins of staphylococci isolated from bovine mastitis in Southern State of Rio de Janeiro. 41p Thesis (Master of Veterinary Science). Instituto de Veterin?ria, Departamento de Parasitologia Animal, Universidade Federal Rural do Rio de Janeiro, Serop?dica, RJ, 2011. Bacteria of the genus Staphylococcus are among the most implicated in the etiology of mastitis. An additional difficulty in controlling bacterial infections by this genus is represented by its frequent resistance to antibiotics. The glycopeptides (eg vancomycin) appear as an alternative therapy because of the increasing strains of staphylococci resistant to beta-lactams, which are the drugs of choice in these infections. Thus, glycopeptide resistance represents a threat to the future of antimicrobial therapy in humans and animals. This study aimed to evaluate the profile of vancomycin resistance pheno-genotypically in Staphylococcus spp. milk samples from cows with mastitis. All 150 isolates (50 isolates of Staphylococcus aureus, 50 isolates of Staphylococcus intermedius and 50 isolates of Coagulase-negative Staphylococcus spp. (CNS) were evaluated using the tests of disk diffusion, agar microdilution and detection of vanA e vanB genes. The antimicrobial susceptibility test showed high resistance to beta-lactam antibiotics for all groups. In the disk diffusion test, 24% of coagulase-positive isolates showed resistance to teicoplanin (24/100) and 23% to vancomycin (23/100). In the agar microdilution test for detection of CIM, 16% of the isolates were resistant to vancomycin (16/100). Among the resistant isolates in the agar microdilution testing, 56.25% of the isolates (9 / 16) had MIC values ranging from 4-8?g/ml. Staphylococcus coagulase-negative showed no resistance to the evaluated glycopeptides. Genes for resistance to vancomycin were detected in 37.5% of vancomycin-resistant isolates (6 / 16). To seek a correlation between the presence of glycopeptide resistance and the ability of producing biofilm, tests were performed to characterize growth in Congo red agar and also detection of the biofilm adherence test in microplates. It were detected 66.66% and 90, 00%, respectively, of isolates producing biofilm. The production of "slime" presented no statistical correlation with resistance to glycopeptides. The sensitivity profile of Staphylococcus spp. was assessed against the bacteriocins produced by Lactobacillus paracasei, Lactobacillus acidophilus and Lactobacillus fermentum. Lactobacillus paracasei bacteriocins presented the highest inhibition capacity.

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spelling	Souza, Miliane Moreira Soares de1076198732http://lattes.cnpq.br/08652112146186185640401770http://lattes.cnpq.br/4109229905380811Pribul, Bruno Rocha2016-07-29T13:36:35Z2011-02-24PRIBUL, Bruno Rocha. Correla??o entre o perfil de resist?ncia antimicrobiana e a bacteriocinas em Staphylococcus SPP isolados de casos de mastite bovina ocorridos no Estado do Rio de Janeiro. 2011. 64 f. Disserta??o (Programa de P?s-Gradua??o em Ci?ncias Veterin?rias - Universidade Federal Rural do Rio de Janeiro, Serop?dica.https://tede.ufrrj.br/jspui/handle/jspui/1142PRIBUL, Bruno Rocha. Evaluation of Vancomycin Resistance and Susceptibility Profile Bacteriocins of staphylococci isolated from bovine mastitis in Southern State of Rio de Janeiro. 41p Thesis (Master of Veterinary Science). Instituto de Veterin?ria, Departamento de Parasitologia Animal, Universidade Federal Rural do Rio de Janeiro, Serop?dica, RJ, 2011. Bacteria of the genus Staphylococcus are among the most implicated in the etiology of mastitis. An additional difficulty in controlling bacterial infections by this genus is represented by its frequent resistance to antibiotics. The glycopeptides (eg vancomycin) appear as an alternative therapy because of the increasing strains of staphylococci resistant to beta-lactams, which are the drugs of choice in these infections. Thus, glycopeptide resistance represents a threat to the future of antimicrobial therapy in humans and animals. This study aimed to evaluate the profile of vancomycin resistance pheno-genotypically in Staphylococcus spp. milk samples from cows with mastitis. All 150 isolates (50 isolates of Staphylococcus aureus, 50 isolates of Staphylococcus intermedius and 50 isolates of Coagulase-negative Staphylococcus spp. (CNS) were evaluated using the tests of disk diffusion, agar microdilution and detection of vanA e vanB genes. The antimicrobial susceptibility test showed high resistance to beta-lactam antibiotics for all groups. In the disk diffusion test, 24% of coagulase-positive isolates showed resistance to teicoplanin (24/100) and 23% to vancomycin (23/100). In the agar microdilution test for detection of CIM, 16% of the isolates were resistant to vancomycin (16/100). Among the resistant isolates in the agar microdilution testing, 56.25% of the isolates (9 / 16) had MIC values ranging from 4-8?g/ml. Staphylococcus coagulase-negative showed no resistance to the evaluated glycopeptides. Genes for resistance to vancomycin were detected in 37.5% of vancomycin-resistant isolates (6 / 16). To seek a correlation between the presence of glycopeptide resistance and the ability of producing biofilm, tests were performed to characterize growth in Congo red agar and also detection of the biofilm adherence test in microplates. It were detected 66.66% and 90, 00%, respectively, of isolates producing biofilm. The production of "slime" presented no statistical correlation with resistance to glycopeptides. The sensitivity profile of Staphylococcus spp. was assessed against the bacteriocins produced by Lactobacillus paracasei, Lactobacillus acidophilus and Lactobacillus fermentum. Lactobacillus paracasei bacteriocins presented the highest inhibition capacity.PRIBUL, Bruno Rocha. Avalia??o da Resist?ncia a Vancomicina e do Perfil de Suscetibilidade a Bacteriocinas de Staphylococcus spp Isolados de Mastite Bovina da Regi?o Sul do Estado do Rio de Janeiro. 41p Disserta??o (Mestrado em Ci?ncias Veterin?rias). Instituto de Veterin?ria, Departamento de Parasitologia Animal, Universidade Federal Rural do Rio de Janeiro, Serop?dica, RJ, 2011. As bact?rias do g?nero Staphylococcus est?o entre as mais implicadas na etiologia das mastites. Uma dificuldade adicional no controle das infec??es bacterianas por este g?nero ? representada por sua freq?ente resist?ncia aos antimicrobianos. Os glicopept?deos, como a vancomicina, aparecem como uma alternativa terap?utica devido ao crescente aumento de cepas estafiloc?cicas resistentes aos betalact?micos, que s?o os f?rmacos de elei??o nestas infec??es. Desse modo, a resist?ncia aos glicopept?deos representa uma amea?a ao futuro da terapia antimicrobiana em humanos e animais. O presente trabalho buscou avaliar o perfil de resist?ncia ? vancomicina em isolados de Staphylococcus spp. oriundos de amostras de leite de vacas com mastite. Todos os 150 isolados estudados (50 Staphylococcus aureus, 50 Staphylococcus intermedius e 50 Staphylococcus spp. coagulase negativos), foram avaliados atrav?s dos testes de difus?o em disco simples, microdilui??o em ?gar e detec??o dos genes vanA e B. O teste de suscetibilidade antimicrobiana revelou elevada resist?ncia aos beta-lact?micos para todos os grupos avaliados. No ensaio de difus?o em disco, os isolados coagulasepositivos apresentaram um perfil de resist?ncia de 24% a teicoplanina (24/100) e 23% a vancomicina (23/100). No teste de microdilui??o em ?gar para detec??o da CIM, 16% dos isolados apresentaram resist?ncia ? vancomicina (16/100). Entre os isolados resistentes no teste de microdilui??o em ?gar, 56,25% dos isolados (9/16) apresentaram valores de CIM que variaram entre 4-8?g/ml. Os Staphylococcus coagulase-negativos n?o apresentaram resist?ncia aos glicopeptideos. Os genes de resist?ncia ? vancomicina foram detectados em 37,5% dos isolados vancomicina-resistentes (6/16). Para se buscar uma correla??o entre a presen?a de resist?ncia aos glicopeptideos e a capacidade de forma??o de biofilme foram realizados os testes de caracteriza??o de crescimento em ?gar vermelho congo e detec??o de biofilme pelo teste de ader?ncia em microplacas, onde foram detectados 66,66% e 90,00% respectivamente, de isolados produtores de biofilme. A produ??o de ?slime? n?o apresentou correla??o estat?stica com a resist?ncia aos glicopept?deos. O perfil de sensibilidade dos isolados de Staphylococcus spp. foi avaliado frente as bacteriocinas produzidas pelos Lactobacillus paracasei, Lactobacillus acidophillus e Lactobacillus fermentum. As bacteriocinas que apresentaram maior capacidade de inibi??o frente aos Saphylococcus spp. testados foram as produzidas pelos Lactobacillus paracaseiSubmitted by Sandra Pereira (srpereira@ufrrj.br) on 2016-07-29T13:36:35Z No. of bitstreams: 1 2011 - Bruno Rocha Pribul.pdf: 1463809 bytes, checksum: ba7b3b0f00c0b4469b45fe02ec9f8a7f (MD5)Made available in DSpace on 2016-07-29T13:36:35Z (GMT). No. of bitstreams: 1 2011 - Bruno Rocha Pribul.pdf: 1463809 bytes, checksum: ba7b3b0f00c0b4469b45fe02ec9f8a7f (MD5) Previous issue date: 2011-02-24Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico - CNPqapplication/pdfhttps://tede.ufrrj.br/retrieve/4364/2011%20-%20Bruno%20Rocha%20Pribul.pdf.jpghttps://tede.ufrrj.br/retrieve/18952/2011%20-%20Bruno%20Rocha%20Pribul.pdf.jpghttps://tede.ufrrj.br/retrieve/25287/2011%20-%20Bruno%20Rocha%20Pribul.pdf.jpghttps://tede.ufrrj.br/retrieve/31697/2011%20-%20Bruno%20Rocha%20Pribul.pdf.jpghttps://tede.ufrrj.br/retrieve/38098/2011%20-%20Bruno%20Rocha%20Pribul.pdf.jpghttps://tede.ufrrj.br/retrieve/44485/2011%20-%20Bruno%20Rocha%20Pribul.pdf.jpghttps://tede.ufrrj.br/retrieve/50871/2011%20-%20Bruno%20Rocha%20Pribul.pdf.jpghttps://tede.ufrrj.br/retrieve/57310/2011%20-%20Bruno%20Rocha%20Pribul.pdf.jpgporUniversidade Federal Rural do Rio de JaneiroPrograma de P?s-Gradua??o em Ci?ncias Veterin?riasUFRRJBrasilInstituto de Veterin?ria7. 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dc.title.por.fl_str_mv	Correla??o entre o perfil de resist?ncia antimicrobiana e a bacteriocinas em Staphylococcus SPP isolados de casos de mastite bovina ocorridos no Estado do Rio de Janeiro
title	Correla??o entre o perfil de resist?ncia antimicrobiana e a bacteriocinas em Staphylococcus SPP isolados de casos de mastite bovina ocorridos no Estado do Rio de Janeiro
spellingShingle	Correla??o entre o perfil de resist?ncia antimicrobiana e a bacteriocinas em Staphylococcus SPP isolados de casos de mastite bovina ocorridos no Estado do Rio de Janeiro Pribul, Bruno Rocha Staphylococcus spp. Mastitis. Vancomycin resistance. Bacteriocins. Staphylococcus spp. Mastite. Resist?ncia a vancomicina. Bacteriocinas Staphylococcus spp. Mastitis. Vancomycin resistance. Bacteriocins. Medicina Veterin?ria
title_short	Correla??o entre o perfil de resist?ncia antimicrobiana e a bacteriocinas em Staphylococcus SPP isolados de casos de mastite bovina ocorridos no Estado do Rio de Janeiro
title_full	Correla??o entre o perfil de resist?ncia antimicrobiana e a bacteriocinas em Staphylococcus SPP isolados de casos de mastite bovina ocorridos no Estado do Rio de Janeiro
title_fullStr	Correla??o entre o perfil de resist?ncia antimicrobiana e a bacteriocinas em Staphylococcus SPP isolados de casos de mastite bovina ocorridos no Estado do Rio de Janeiro
title_full_unstemmed	Correla??o entre o perfil de resist?ncia antimicrobiana e a bacteriocinas em Staphylococcus SPP isolados de casos de mastite bovina ocorridos no Estado do Rio de Janeiro
title_sort	Correla??o entre o perfil de resist?ncia antimicrobiana e a bacteriocinas em Staphylococcus SPP isolados de casos de mastite bovina ocorridos no Estado do Rio de Janeiro
author	Pribul, Bruno Rocha
author_facet	Pribul, Bruno Rocha
author_role	author
dc.contributor.advisor1.fl_str_mv	Souza, Miliane Moreira Soares de
dc.contributor.advisor1ID.fl_str_mv	1076198732
dc.contributor.advisor1Lattes.fl_str_mv	http://lattes.cnpq.br/0865211214618618
dc.contributor.authorID.fl_str_mv	5640401770
dc.contributor.authorLattes.fl_str_mv	http://lattes.cnpq.br/4109229905380811
dc.contributor.author.fl_str_mv	Pribul, Bruno Rocha
contributor_str_mv	Souza, Miliane Moreira Soares de
dc.subject.eng.fl_str_mv	Staphylococcus spp. Mastitis. Vancomycin resistance. Bacteriocins.
topic	Staphylococcus spp. Mastitis. Vancomycin resistance. Bacteriocins. Staphylococcus spp. Mastite. Resist?ncia a vancomicina. Bacteriocinas Staphylococcus spp. Mastitis. Vancomycin resistance. Bacteriocins. Medicina Veterin?ria
dc.subject.por.fl_str_mv	Staphylococcus spp. Mastite. Resist?ncia a vancomicina. Bacteriocinas Staphylococcus spp. Mastitis. Vancomycin resistance. Bacteriocins.
dc.subject.cnpq.fl_str_mv	Medicina Veterin?ria
description	PRIBUL, Bruno Rocha. Evaluation of Vancomycin Resistance and Susceptibility Profile Bacteriocins of staphylococci isolated from bovine mastitis in Southern State of Rio de Janeiro. 41p Thesis (Master of Veterinary Science). Instituto de Veterin?ria, Departamento de Parasitologia Animal, Universidade Federal Rural do Rio de Janeiro, Serop?dica, RJ, 2011. Bacteria of the genus Staphylococcus are among the most implicated in the etiology of mastitis. An additional difficulty in controlling bacterial infections by this genus is represented by its frequent resistance to antibiotics. The glycopeptides (eg vancomycin) appear as an alternative therapy because of the increasing strains of staphylococci resistant to beta-lactams, which are the drugs of choice in these infections. Thus, glycopeptide resistance represents a threat to the future of antimicrobial therapy in humans and animals. This study aimed to evaluate the profile of vancomycin resistance pheno-genotypically in Staphylococcus spp. milk samples from cows with mastitis. All 150 isolates (50 isolates of Staphylococcus aureus, 50 isolates of Staphylococcus intermedius and 50 isolates of Coagulase-negative Staphylococcus spp. (CNS) were evaluated using the tests of disk diffusion, agar microdilution and detection of vanA e vanB genes. The antimicrobial susceptibility test showed high resistance to beta-lactam antibiotics for all groups. In the disk diffusion test, 24% of coagulase-positive isolates showed resistance to teicoplanin (24/100) and 23% to vancomycin (23/100). In the agar microdilution test for detection of CIM, 16% of the isolates were resistant to vancomycin (16/100). Among the resistant isolates in the agar microdilution testing, 56.25% of the isolates (9 / 16) had MIC values ranging from 4-8?g/ml. Staphylococcus coagulase-negative showed no resistance to the evaluated glycopeptides. Genes for resistance to vancomycin were detected in 37.5% of vancomycin-resistant isolates (6 / 16). To seek a correlation between the presence of glycopeptide resistance and the ability of producing biofilm, tests were performed to characterize growth in Congo red agar and also detection of the biofilm adherence test in microplates. It were detected 66.66% and 90, 00%, respectively, of isolates producing biofilm. The production of "slime" presented no statistical correlation with resistance to glycopeptides. The sensitivity profile of Staphylococcus spp. was assessed against the bacteriocins produced by Lactobacillus paracasei, Lactobacillus acidophilus and Lactobacillus fermentum. Lactobacillus paracasei bacteriocins presented the highest inhibition capacity.
publishDate	2011
dc.date.issued.fl_str_mv	2011-02-24
dc.date.accessioned.fl_str_mv	2016-07-29T13:36:35Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/masterThesis
format	masterThesis
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	PRIBUL, Bruno Rocha. Correla??o entre o perfil de resist?ncia antimicrobiana e a bacteriocinas em Staphylococcus SPP isolados de casos de mastite bovina ocorridos no Estado do Rio de Janeiro. 2011. 64 f. Disserta??o (Programa de P?s-Gradua??o em Ci?ncias Veterin?rias - Universidade Federal Rural do Rio de Janeiro, Serop?dica.
dc.identifier.uri.fl_str_mv	https://tede.ufrrj.br/jspui/handle/jspui/1142
identifier_str_mv	PRIBUL, Bruno Rocha. Correla??o entre o perfil de resist?ncia antimicrobiana e a bacteriocinas em Staphylococcus SPP isolados de casos de mastite bovina ocorridos no Estado do Rio de Janeiro. 2011. 64 f. Disserta??o (Programa de P?s-Gradua??o em Ci?ncias Veterin?rias - Universidade Federal Rural do Rio de Janeiro, Serop?dica.
url	https://tede.ufrrj.br/jspui/handle/jspui/1142
dc.language.iso.fl_str_mv	por
language	por
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Correla??o entre o perfil de resist?ncia antimicrobiana e a bacteriocinas em Staphylococcus SPP isolados de casos de mastite bovina ocorridos no Estado do Rio de Janeiro

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