Ginseng administration protects skeletal muscle from oxidative stress induced by acute exercise in rats
Autor(a) principal: | |
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Data de Publicação: | 2004 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFS |
Texto Completo: | https://ri.ufs.br/handle/riufs/1449 |
Resumo: | Enzymatic activity was analyzed in the soleus, gastrocnemius (red and white) and plantaris muscles of acutely exercised rats after long-term administration of Panax ginseng extract in order to evaluate the protective role of ginseng against skeletal muscle oxidation. Ginseng extract (3, 10, 100, or 500 mg/kg) was administered orally for three months to male Wistar rats weighing 200 ± 50 g before exercise and to non-exercised rats (N = 8/group). The results showed a membrane stabilizing capacity of the extract since mitochondrial function measured on the basis of citrate synthase and 3-hydroxyacyl-CoA dehydrogenase activities was reduced, on average, by 20% (P < 0.05) after exercise but the activities remained unchanged in animals treated with a ginseng dose of 100 mg/kg. Glutathione status did not show significant changes after exercise or treatment. Lipid peroxidation, measured on the basis of malondialdehyde levels, was significantly higher in all muscles after exercise, and again was reduced by about 74% (P < 0.05) by the use of ginseng extract. The administration of ginseng extract was able to protect muscle from exercise-induced oxidative stress irrespective of fiber type. |
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Oliveira, Antônio César Cabral deVoces, Jesus A.Prieto, Julio GabrielVila, LudivinaPerez, Andrea de CastroDuarte, Igor Dimitri GamaAlvarez, Ana Izabel2015-02-04T18:26:06Z2015-02-04T18:26:06Z2004-12VOCES, J. et. al. Ginseng administration protects skeletal muscle from oxidative stress induced by acute exercise in rats. Brazilian Journal of Medical and Biological Research, Ribeirão Preto, v. 37, n. 12, dez. 2004. Disponível em: <http://dx.doi.org/10.1590/S0100-879X2004001200012>. Acesso em: 04 fev. 2015.1414-431Xhttps://ri.ufs.br/handle/riufs/1449Creative Commons Attribution LicenseEnzymatic activity was analyzed in the soleus, gastrocnemius (red and white) and plantaris muscles of acutely exercised rats after long-term administration of Panax ginseng extract in order to evaluate the protective role of ginseng against skeletal muscle oxidation. Ginseng extract (3, 10, 100, or 500 mg/kg) was administered orally for three months to male Wistar rats weighing 200 ± 50 g before exercise and to non-exercised rats (N = 8/group). The results showed a membrane stabilizing capacity of the extract since mitochondrial function measured on the basis of citrate synthase and 3-hydroxyacyl-CoA dehydrogenase activities was reduced, on average, by 20% (P < 0.05) after exercise but the activities remained unchanged in animals treated with a ginseng dose of 100 mg/kg. Glutathione status did not show significant changes after exercise or treatment. Lipid peroxidation, measured on the basis of malondialdehyde levels, was significantly higher in all muscles after exercise, and again was reduced by about 74% (P < 0.05) by the use of ginseng extract. The administration of ginseng extract was able to protect muscle from exercise-induced oxidative stress irrespective of fiber type.Brazilian Journal of Medical and Biological ResearchPanax ginsengExercícioRadicais livresPeroxidação lipídicaStatus de glutationaMitocôndriasGinseng administration protects skeletal muscle from oxidative stress induced by acute exercise in ratsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFSinstname:Universidade Federal de Sergipe (UFS)instacron:UFSinfo:eu-repo/semantics/openAccessTHUMBNAILGinsengAdministration.pdf.jpgGinsengAdministration.pdf.jpgGenerated Thumbnailimage/jpeg1578https://ri.ufs.br/jspui/bitstream/riufs/1449/4/GinsengAdministration.pdf.jpgcd474fc1def0800a192952e8c32af82cMD54TEXTGinsengAdministration.pdf.txtGinsengAdministration.pdf.txtExtracted texttext/plain34412https://ri.ufs.br/jspui/bitstream/riufs/1449/3/GinsengAdministration.pdf.txt999347f0556db1272757e327b3581a1bMD53ORIGINALGinsengAdministration.pdfGinsengAdministration.pdfapplication/pdf477103https://ri.ufs.br/jspui/bitstream/riufs/1449/1/GinsengAdministration.pdf01f202c7588843937bc46d9ac280ff85MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://ri.ufs.br/jspui/bitstream/riufs/1449/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52riufs/14492015-02-11 14:50:29.269oai:ufs.br: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Repositório InstitucionalPUBhttps://ri.ufs.br/oai/requestrepositorio@academico.ufs.bropendoar:2015-02-11T17:50:29Repositório Institucional da UFS - Universidade Federal de Sergipe (UFS)false |
dc.title.pt_BR.fl_str_mv |
Ginseng administration protects skeletal muscle from oxidative stress induced by acute exercise in rats |
title |
Ginseng administration protects skeletal muscle from oxidative stress induced by acute exercise in rats |
spellingShingle |
Ginseng administration protects skeletal muscle from oxidative stress induced by acute exercise in rats Oliveira, Antônio César Cabral de Panax ginseng Exercício Radicais livres Peroxidação lipídica Status de glutationa Mitocôndrias |
title_short |
Ginseng administration protects skeletal muscle from oxidative stress induced by acute exercise in rats |
title_full |
Ginseng administration protects skeletal muscle from oxidative stress induced by acute exercise in rats |
title_fullStr |
Ginseng administration protects skeletal muscle from oxidative stress induced by acute exercise in rats |
title_full_unstemmed |
Ginseng administration protects skeletal muscle from oxidative stress induced by acute exercise in rats |
title_sort |
Ginseng administration protects skeletal muscle from oxidative stress induced by acute exercise in rats |
author |
Oliveira, Antônio César Cabral de |
author_facet |
Oliveira, Antônio César Cabral de Voces, Jesus A. Prieto, Julio Gabriel Vila, Ludivina Perez, Andrea de Castro Duarte, Igor Dimitri Gama Alvarez, Ana Izabel |
author_role |
author |
author2 |
Voces, Jesus A. Prieto, Julio Gabriel Vila, Ludivina Perez, Andrea de Castro Duarte, Igor Dimitri Gama Alvarez, Ana Izabel |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Oliveira, Antônio César Cabral de Voces, Jesus A. Prieto, Julio Gabriel Vila, Ludivina Perez, Andrea de Castro Duarte, Igor Dimitri Gama Alvarez, Ana Izabel |
dc.subject.por.fl_str_mv |
Panax ginseng Exercício Radicais livres Peroxidação lipídica Status de glutationa Mitocôndrias |
topic |
Panax ginseng Exercício Radicais livres Peroxidação lipídica Status de glutationa Mitocôndrias |
description |
Enzymatic activity was analyzed in the soleus, gastrocnemius (red and white) and plantaris muscles of acutely exercised rats after long-term administration of Panax ginseng extract in order to evaluate the protective role of ginseng against skeletal muscle oxidation. Ginseng extract (3, 10, 100, or 500 mg/kg) was administered orally for three months to male Wistar rats weighing 200 ± 50 g before exercise and to non-exercised rats (N = 8/group). The results showed a membrane stabilizing capacity of the extract since mitochondrial function measured on the basis of citrate synthase and 3-hydroxyacyl-CoA dehydrogenase activities was reduced, on average, by 20% (P < 0.05) after exercise but the activities remained unchanged in animals treated with a ginseng dose of 100 mg/kg. Glutathione status did not show significant changes after exercise or treatment. Lipid peroxidation, measured on the basis of malondialdehyde levels, was significantly higher in all muscles after exercise, and again was reduced by about 74% (P < 0.05) by the use of ginseng extract. The administration of ginseng extract was able to protect muscle from exercise-induced oxidative stress irrespective of fiber type. |
publishDate |
2004 |
dc.date.issued.fl_str_mv |
2004-12 |
dc.date.accessioned.fl_str_mv |
2015-02-04T18:26:06Z |
dc.date.available.fl_str_mv |
2015-02-04T18:26:06Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
VOCES, J. et. al. Ginseng administration protects skeletal muscle from oxidative stress induced by acute exercise in rats. Brazilian Journal of Medical and Biological Research, Ribeirão Preto, v. 37, n. 12, dez. 2004. Disponível em: <http://dx.doi.org/10.1590/S0100-879X2004001200012>. Acesso em: 04 fev. 2015. |
dc.identifier.uri.fl_str_mv |
https://ri.ufs.br/handle/riufs/1449 |
dc.identifier.issn.none.fl_str_mv |
1414-431X |
dc.identifier.license.pt_BR.fl_str_mv |
Creative Commons Attribution License |
identifier_str_mv |
VOCES, J. et. al. Ginseng administration protects skeletal muscle from oxidative stress induced by acute exercise in rats. Brazilian Journal of Medical and Biological Research, Ribeirão Preto, v. 37, n. 12, dez. 2004. Disponível em: <http://dx.doi.org/10.1590/S0100-879X2004001200012>. Acesso em: 04 fev. 2015. 1414-431X Creative Commons Attribution License |
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https://ri.ufs.br/handle/riufs/1449 |
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eng |
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eng |
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openAccess |
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Brazilian Journal of Medical and Biological Research |
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Brazilian Journal of Medical and Biological Research |
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