Collagen-Based Films Containing Liposome-Loaded Usnic Acid as Dressing for Dermal Burn Healing
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFS |
Texto Completo: | http://www.hindawi.com/journals/bmri/2011/761593/abs/ https://ri.ufs.br/handle/riufs/618 |
Resumo: | The aim of this study was assess the effect of collagen-based films containing usnic acid as a wound dressing for dermal burn healing. Second-degree burn wounds were performed in forty-five Wistar rats, assigned into nine groups: COL—animals treated with collagen-based films; PHO—animals treated with collagen films containing empty liposomes; UAL—animals treated with collagen-based films containing usnic acid incorporated into liposomes. After 7, 14, and 21 days the animals were euthanized. On 7th day there was a moderate infiltration of neutrophils, in UAL, distributed throughout the burn wounds, whereas in COL and PHO, the severity of the reaction was slighter and still limited to the margins of the burn wounds. On the 14th day, the inflammatory reaction was less intense in UAL, with remarkable plasma cells infiltration. On the 21st day, there was reduction of the inflammation, which was predominantly composed of plasma cells in all groups, particularly in UAL. The use of the usnic acid provided more rapid substitution of type-III for type-I collagen on the 14th day, and improved the collagenization density on the 21st day. It was concluded that the use of reconstituted bovine type-I collagen-based films containing usnic acid improved burn healing process in rats |
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Nunes, Paula SantosAlbuquerque Júnior, Ricardo Luiz Cavalcanti deCavalcante, Danielle Rodrigues RibeiroDantas, Marx Diego MenesesCardoso, Juliana CordeiroBezerra, Marília dos SantosSouza, Jamille Cristina Campos deSerafini, Mairim RussoQuintans-Júnior, Lucindo JoséBonjardim, Leonardo RigoldiAraújo, Adriano Antunes de Souza2013-06-21T21:48:53Z2013-06-21T21:48:53Z2011NUNES, Paula S. et al. Collagen-based films containing liposome-loaded usnic acid as dressing for dermal burn healing. Journal of Biomedicine and Biotechnology, v. 2011, 2011. Disponível em: <http://www.hindawi.com/journals/bmri/2011/761593/>. Acesso em: 21 jun. 20131110-7251http://www.hindawi.com/journals/bmri/2011/761593/abs/https://ri.ufs.br/handle/riufs/618Creative Commons Attribution LicenseThe aim of this study was assess the effect of collagen-based films containing usnic acid as a wound dressing for dermal burn healing. Second-degree burn wounds were performed in forty-five Wistar rats, assigned into nine groups: COL—animals treated with collagen-based films; PHO—animals treated with collagen films containing empty liposomes; UAL—animals treated with collagen-based films containing usnic acid incorporated into liposomes. After 7, 14, and 21 days the animals were euthanized. On 7th day there was a moderate infiltration of neutrophils, in UAL, distributed throughout the burn wounds, whereas in COL and PHO, the severity of the reaction was slighter and still limited to the margins of the burn wounds. On the 14th day, the inflammatory reaction was less intense in UAL, with remarkable plasma cells infiltration. On the 21st day, there was reduction of the inflammation, which was predominantly composed of plasma cells in all groups, particularly in UAL. The use of the usnic acid provided more rapid substitution of type-III for type-I collagen on the 14th day, and improved the collagenization density on the 21st day. It was concluded that the use of reconstituted bovine type-I collagen-based films containing usnic acid improved burn healing process in ratsHindawiFilmes de colágenoÁcido úsnicoQueimadurasCurativosCollagen-Based Films Containing Liposome-Loaded Usnic Acid as Dressing for Dermal Burn Healinginfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFSinstname:Universidade Federal de Sergipe (UFS)instacron:UFSinfo:eu-repo/semantics/openAccessTHUMBNAILCollagenBasedFilms.pdf.jpgCollagenBasedFilms.pdf.jpgGenerated Thumbnailimage/jpeg1594https://ri.ufs.br/jspui/bitstream/riufs/618/4/CollagenBasedFilms.pdf.jpg5191787cf93ac602cb993d468361b563MD54ORIGINALCollagenBasedFilms.pdfCollagenBasedFilms.pdfapplication/pdf4857272https://ri.ufs.br/jspui/bitstream/riufs/618/1/CollagenBasedFilms.pdf0fc9f4407cc3df93140a95d9d04f4b3eMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://ri.ufs.br/jspui/bitstream/riufs/618/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52TEXTCollagenBasedFilms.pdf.txtCollagenBasedFilms.pdf.txtExtracted texttext/plain42790https://ri.ufs.br/jspui/bitstream/riufs/618/3/CollagenBasedFilms.pdf.txte9f6e38e9b0ccb88c461f20c04f7a3ddMD53riufs/6182014-09-05 20:39:05.864oai:ufs.br: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Repositório InstitucionalPUBhttps://ri.ufs.br/oai/requestrepositorio@academico.ufs.bropendoar:2014-09-05T23:39:05Repositório Institucional da UFS - Universidade Federal de Sergipe (UFS)false |
dc.title.pt_BR.fl_str_mv |
Collagen-Based Films Containing Liposome-Loaded Usnic Acid as Dressing for Dermal Burn Healing |
title |
Collagen-Based Films Containing Liposome-Loaded Usnic Acid as Dressing for Dermal Burn Healing |
spellingShingle |
Collagen-Based Films Containing Liposome-Loaded Usnic Acid as Dressing for Dermal Burn Healing Nunes, Paula Santos Filmes de colágeno Ácido úsnico Queimaduras Curativos |
title_short |
Collagen-Based Films Containing Liposome-Loaded Usnic Acid as Dressing for Dermal Burn Healing |
title_full |
Collagen-Based Films Containing Liposome-Loaded Usnic Acid as Dressing for Dermal Burn Healing |
title_fullStr |
Collagen-Based Films Containing Liposome-Loaded Usnic Acid as Dressing for Dermal Burn Healing |
title_full_unstemmed |
Collagen-Based Films Containing Liposome-Loaded Usnic Acid as Dressing for Dermal Burn Healing |
title_sort |
Collagen-Based Films Containing Liposome-Loaded Usnic Acid as Dressing for Dermal Burn Healing |
author |
Nunes, Paula Santos |
author_facet |
Nunes, Paula Santos Albuquerque Júnior, Ricardo Luiz Cavalcanti de Cavalcante, Danielle Rodrigues Ribeiro Dantas, Marx Diego Meneses Cardoso, Juliana Cordeiro Bezerra, Marília dos Santos Souza, Jamille Cristina Campos de Serafini, Mairim Russo Quintans-Júnior, Lucindo José Bonjardim, Leonardo Rigoldi Araújo, Adriano Antunes de Souza |
author_role |
author |
author2 |
Albuquerque Júnior, Ricardo Luiz Cavalcanti de Cavalcante, Danielle Rodrigues Ribeiro Dantas, Marx Diego Meneses Cardoso, Juliana Cordeiro Bezerra, Marília dos Santos Souza, Jamille Cristina Campos de Serafini, Mairim Russo Quintans-Júnior, Lucindo José Bonjardim, Leonardo Rigoldi Araújo, Adriano Antunes de Souza |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Nunes, Paula Santos Albuquerque Júnior, Ricardo Luiz Cavalcanti de Cavalcante, Danielle Rodrigues Ribeiro Dantas, Marx Diego Meneses Cardoso, Juliana Cordeiro Bezerra, Marília dos Santos Souza, Jamille Cristina Campos de Serafini, Mairim Russo Quintans-Júnior, Lucindo José Bonjardim, Leonardo Rigoldi Araújo, Adriano Antunes de Souza |
dc.subject.por.fl_str_mv |
Filmes de colágeno Ácido úsnico Queimaduras Curativos |
topic |
Filmes de colágeno Ácido úsnico Queimaduras Curativos |
description |
The aim of this study was assess the effect of collagen-based films containing usnic acid as a wound dressing for dermal burn healing. Second-degree burn wounds were performed in forty-five Wistar rats, assigned into nine groups: COL—animals treated with collagen-based films; PHO—animals treated with collagen films containing empty liposomes; UAL—animals treated with collagen-based films containing usnic acid incorporated into liposomes. After 7, 14, and 21 days the animals were euthanized. On 7th day there was a moderate infiltration of neutrophils, in UAL, distributed throughout the burn wounds, whereas in COL and PHO, the severity of the reaction was slighter and still limited to the margins of the burn wounds. On the 14th day, the inflammatory reaction was less intense in UAL, with remarkable plasma cells infiltration. On the 21st day, there was reduction of the inflammation, which was predominantly composed of plasma cells in all groups, particularly in UAL. The use of the usnic acid provided more rapid substitution of type-III for type-I collagen on the 14th day, and improved the collagenization density on the 21st day. It was concluded that the use of reconstituted bovine type-I collagen-based films containing usnic acid improved burn healing process in rats |
publishDate |
2011 |
dc.date.issued.fl_str_mv |
2011 |
dc.date.accessioned.fl_str_mv |
2013-06-21T21:48:53Z |
dc.date.available.fl_str_mv |
2013-06-21T21:48:53Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
NUNES, Paula S. et al. Collagen-based films containing liposome-loaded usnic acid as dressing for dermal burn healing. Journal of Biomedicine and Biotechnology, v. 2011, 2011. Disponível em: <http://www.hindawi.com/journals/bmri/2011/761593/>. Acesso em: 21 jun. 2013 |
dc.identifier.uri.fl_str_mv |
http://www.hindawi.com/journals/bmri/2011/761593/abs/ https://ri.ufs.br/handle/riufs/618 |
dc.identifier.issn.none.fl_str_mv |
1110-7251 |
dc.identifier.license.pt_BR.fl_str_mv |
Creative Commons Attribution License |
identifier_str_mv |
NUNES, Paula S. et al. Collagen-based films containing liposome-loaded usnic acid as dressing for dermal burn healing. Journal of Biomedicine and Biotechnology, v. 2011, 2011. Disponível em: <http://www.hindawi.com/journals/bmri/2011/761593/>. Acesso em: 21 jun. 2013 1110-7251 Creative Commons Attribution License |
url |
http://www.hindawi.com/journals/bmri/2011/761593/abs/ https://ri.ufs.br/handle/riufs/618 |
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eng |
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eng |
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openAccess |
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Hindawi |
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Hindawi |
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