Genetic factors and variability in blood pressure. A brief literature review.

Detalhes bibliográficos
Autor(a) principal: Fermino, Rogério
Data de Publicação: 2009
Outros Autores: Seabra, André, Garganta, Rui, Maia, José António Ribeiro
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista Brasileira de Cineantropometria & Desempenho Humano (Online)
Texto Completo: https://periodicos.ufsc.br/index.php/rbcdh/article/view/1980-0037.2009v11n3p341
Resumo: The main purpose of this review was to gather relevant information regarding the importance of genetic factors for the variability of blood pressure levels. A search was performed in the Pubmed database, and the following studies were selected: (1) studies reporting familial aggregation with heritability estimates, (2) linkage studies reporting only significant results, and (3) association studies between blood pressure, candidate genes and their allelic variants using a case-control design. Heritability estimates for systolic and diastolic blood pressure ranged from 14 to 68% and from 6 to 62%, respectively. We found significant linkage results for systolic blood pressure on chromosomes 2, 5, 6, 15 and 17. Relevant candidate genes presented disparate results in terms of their association with arterial hypertension. Blood pressure is a polygenic phenotype whose variation is partially mediated by genetic factors. The candidate genes identified do not sufficiently explain arterial hypertension.
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spelling Genetic factors and variability in blood pressure. A brief literature review.Fatores genéticos e variabilidade na pressão arterial. Uma breve revisão da literatura.The main purpose of this review was to gather relevant information regarding the importance of genetic factors for the variability of blood pressure levels. A search was performed in the Pubmed database, and the following studies were selected: (1) studies reporting familial aggregation with heritability estimates, (2) linkage studies reporting only significant results, and (3) association studies between blood pressure, candidate genes and their allelic variants using a case-control design. Heritability estimates for systolic and diastolic blood pressure ranged from 14 to 68% and from 6 to 62%, respectively. We found significant linkage results for systolic blood pressure on chromosomes 2, 5, 6, 15 and 17. Relevant candidate genes presented disparate results in terms of their association with arterial hypertension. Blood pressure is a polygenic phenotype whose variation is partially mediated by genetic factors. The candidate genes identified do not sufficiently explain arterial hypertension.O objetivo desta revisão foi abordar aspectos relacionados a importância dos fatores genéticos na variabilidade dos valores da pressão arterial. Foi realizada uma pesquisa na base de dados Pubmed e selecionados (1) estudos de agregação familiar com estimativas de heritabilidade, (2) estudos de linkage apenas com resultados significativos e (3) estudos de associação entre hipertensão arterial, genes candidatos e seus variantes alélicos, com base em delineamento de caso-controle. As estimativas de heritabilidade para a pressão arterial sistólica e diastólica variaram entre 14-68% e 6-62%, respectivamente. Foi verificado a presença de linkage para a pressão arterial sistólica nos cromossomas 2, 5, 6, 15 e 17. Os principais genes candidatos apresentaram resultados díspares na associação com a hipertensão. Conclui-se que a pressão arterial é um fenótipo poligênico, onde os fatores genéticos governam uma parte moderada a substancial da magnitude de sua variabilidade nas populações. Os genes candidatos identificados não explicam de modo suficientemente satisfatório a hipertensão arterial.Universidade Federal de Santa Catarina. Florianópolis, SC. Brasil2009-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion"Avaliado por Pares","Artigo Solicitado""Avaliado por Pares", "Artigo Solicitado"Bibliográficoapplication/pdfapplication/pdfhttps://periodicos.ufsc.br/index.php/rbcdh/article/view/1980-0037.2009v11n3p34110.1590/1980-0037.2009v11n3p341Brazilian Journal of Kinanthropometry and Human Performance; Vol. 11 No. 3 (2009); 341-349Revista Brasileira de Cineantropometria e Desempenho Humano; v. 11 n. 3 (2009); 341-3491980-00371415-8426reponame:Revista Brasileira de Cineantropometria & Desempenho Humano (Online)instname:Universidade Federal de Santa Catarina (UFSC)instacron:UFSCporhttps://periodicos.ufsc.br/index.php/rbcdh/article/view/1980-0037.2009v11n3p341/10337https://periodicos.ufsc.br/index.php/rbcdh/article/view/1980-0037.2009v11n3p341/16504Fermino, RogérioSeabra, AndréGarganta, RuiMaia, José António Ribeiroinfo:eu-repo/semantics/openAccess2020-01-22T10:32:20Zoai:periodicos.ufsc.br:article/10858Revistahttps://periodicos.ufsc.br/index.php/rbcdh/PUBhttps://periodicos.ufsc.br/index.php/rbcdh/oairbcdh@contato.ufsc.br || portaldeperiodicos.bu@contato.ufsc.br1980-00371415-8426opendoar:2020-01-22T10:32:20Revista Brasileira de Cineantropometria & Desempenho Humano (Online) - Universidade Federal de Santa Catarina (UFSC)false
dc.title.none.fl_str_mv Genetic factors and variability in blood pressure. A brief literature review.
Fatores genéticos e variabilidade na pressão arterial. Uma breve revisão da literatura.
title Genetic factors and variability in blood pressure. A brief literature review.
spellingShingle Genetic factors and variability in blood pressure. A brief literature review.
Fermino, Rogério
title_short Genetic factors and variability in blood pressure. A brief literature review.
title_full Genetic factors and variability in blood pressure. A brief literature review.
title_fullStr Genetic factors and variability in blood pressure. A brief literature review.
title_full_unstemmed Genetic factors and variability in blood pressure. A brief literature review.
title_sort Genetic factors and variability in blood pressure. A brief literature review.
author Fermino, Rogério
author_facet Fermino, Rogério
Seabra, André
Garganta, Rui
Maia, José António Ribeiro
author_role author
author2 Seabra, André
Garganta, Rui
Maia, José António Ribeiro
author2_role author
author
author
dc.contributor.author.fl_str_mv Fermino, Rogério
Seabra, André
Garganta, Rui
Maia, José António Ribeiro
description The main purpose of this review was to gather relevant information regarding the importance of genetic factors for the variability of blood pressure levels. A search was performed in the Pubmed database, and the following studies were selected: (1) studies reporting familial aggregation with heritability estimates, (2) linkage studies reporting only significant results, and (3) association studies between blood pressure, candidate genes and their allelic variants using a case-control design. Heritability estimates for systolic and diastolic blood pressure ranged from 14 to 68% and from 6 to 62%, respectively. We found significant linkage results for systolic blood pressure on chromosomes 2, 5, 6, 15 and 17. Relevant candidate genes presented disparate results in terms of their association with arterial hypertension. Blood pressure is a polygenic phenotype whose variation is partially mediated by genetic factors. The candidate genes identified do not sufficiently explain arterial hypertension.
publishDate 2009
dc.date.none.fl_str_mv 2009-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
"Avaliado por Pares","Artigo Solicitado"
"Avaliado por Pares", "Artigo Solicitado"
Bibliográfico
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.ufsc.br/index.php/rbcdh/article/view/1980-0037.2009v11n3p341
10.1590/1980-0037.2009v11n3p341
url https://periodicos.ufsc.br/index.php/rbcdh/article/view/1980-0037.2009v11n3p341
identifier_str_mv 10.1590/1980-0037.2009v11n3p341
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://periodicos.ufsc.br/index.php/rbcdh/article/view/1980-0037.2009v11n3p341/10337
https://periodicos.ufsc.br/index.php/rbcdh/article/view/1980-0037.2009v11n3p341/16504
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv Universidade Federal de Santa Catarina. Florianópolis, SC. Brasil
publisher.none.fl_str_mv Universidade Federal de Santa Catarina. Florianópolis, SC. Brasil
dc.source.none.fl_str_mv Brazilian Journal of Kinanthropometry and Human Performance; Vol. 11 No. 3 (2009); 341-349
Revista Brasileira de Cineantropometria e Desempenho Humano; v. 11 n. 3 (2009); 341-349
1980-0037
1415-8426
reponame:Revista Brasileira de Cineantropometria & Desempenho Humano (Online)
instname:Universidade Federal de Santa Catarina (UFSC)
instacron:UFSC
instname_str Universidade Federal de Santa Catarina (UFSC)
instacron_str UFSC
institution UFSC
reponame_str Revista Brasileira de Cineantropometria & Desempenho Humano (Online)
collection Revista Brasileira de Cineantropometria & Desempenho Humano (Online)
repository.name.fl_str_mv Revista Brasileira de Cineantropometria & Desempenho Humano (Online) - Universidade Federal de Santa Catarina (UFSC)
repository.mail.fl_str_mv rbcdh@contato.ufsc.br || portaldeperiodicos.bu@contato.ufsc.br
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