Can leucine supplementation attenuate muscle atrophy? A literature review

Detalhes bibliográficos
Autor(a) principal: Do Amaral, Rafael Bruno
Data de Publicação: 2015
Outros Autores: Martins, Carlos Eduardo Carvalho, Lancha Junior, Antonio Herbert, Painelli, Vitor de Salles
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Cineantropometria & Desempenho Humano (Online)
Texto Completo: https://periodicos.ufsc.br/index.php/rbcdh/article/view/1980-0037.2015v17n4p496
Resumo: Currently, there has been new expectations in studying strategies with the potential to mitigate the skeletal muscle atrophy that characterizes conditions such as aging, disuse, cancer, and the use of certain medications. Among them, amino acid leucine has received special attention due to its potential to stimulate specific pathways of protein synthesis in skeletal muscle. Due to the wide spread use of this amino acid by the media, several studies have been aimed at investigating the possible effectiveness of leucine against skeletal muscle atrophy. As a result, this literature review was aimed to analyze recent studies that investigated the effects of leucine supplementation on skeletal muscle atrophy in both humans and animals. Overall, the wide variations in the experimental designs developed, models studied, leucine dose, treatment duration and sample healthiness make it difficult for professionals and researchers to establish guidelines about possible therapeutic effectiveness of this nutritional strategy.
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spelling Can leucine supplementation attenuate muscle atrophy? A literature reviewA suplementação de leucina pode atenuar a atrofia muscular? Uma revisão da literaturaCurrently, there has been new expectations in studying strategies with the potential to mitigate the skeletal muscle atrophy that characterizes conditions such as aging, disuse, cancer, and the use of certain medications. Among them, amino acid leucine has received special attention due to its potential to stimulate specific pathways of protein synthesis in skeletal muscle. Due to the wide spread use of this amino acid by the media, several studies have been aimed at investigating the possible effectiveness of leucine against skeletal muscle atrophy. As a result, this literature review was aimed to analyze recent studies that investigated the effects of leucine supplementation on skeletal muscle atrophy in both humans and animals. Overall, the wide variations in the experimental designs developed, models studied, leucine dose, treatment duration and sample healthiness make it difficult for professionals and researchers to establish guidelines about possible therapeutic effectiveness of this nutritional strategy.Atualmente, surgem novas expectativas em estudar estratégias com o potencial de atenuar a atrofia muscular esquelética que caracteriza condições como o envelhecimento, o desuso, o câncer, assim como o uso de determinadas medicações. Dentre elas, o aminoácido leucina vem recebendo especial destaque devido ao seu potencial em estimular vias específicas de síntese proteica no músculo esquelético. Devido à grande disseminação do uso deste aminoácido pela mídia, diversas pesquisas vêm sendo desenvolvidas com foco na investigação de possível efetividade da leucina contra a atrofia muscular esquelética. Em virtude disso, essa revisão bibliográfica teve por objetivo analisar os estudos recentes que investigaram os efeitos da suplementação isolada de leucina sobre a atrofia muscular, tanto em humanos quanto em animais. De forma geral, as grandes variações nos desenhos experimentais desenvolvidos, nos modelos estudados, na dose de leucina empregada, na duração do protocolo de suplementação e na saudabilidade da amostra, fazem com que profissionais da área e pesquisadores sofram em poder estabelecer maiores diretrizes acerca da possível eficácia terapêutica desta estratégia nutricional. Universidade Federal de Santa Catarina. Florianópolis, SC. Brasil2015-07-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion"Avaliado por Pares","Artigo Solicitado""Avaliado por Pares", "Artigo Solicitado"Revisão de literaturainfo:eu-repo/semantics/otherapplication/pdfhttps://periodicos.ufsc.br/index.php/rbcdh/article/view/1980-0037.2015v17n4p49610.1590/1980-0037.2015v17n4p496Brazilian Journal of Kinanthropometry and Human Performance; Vol. 17 No. 4 (2015); 496-506Revista Brasileira de Cineantropometria e Desempenho Humano; v. 17 n. 4 (2015); 496-5061980-00371415-8426reponame:Revista Brasileira de Cineantropometria & Desempenho Humano (Online)instname:Universidade Federal de Santa Catarina (UFSC)instacron:UFSCenghttps://periodicos.ufsc.br/index.php/rbcdh/article/view/1980-0037.2015v17n4p496/29642Do Amaral, Rafael BrunoMartins, Carlos Eduardo CarvalhoLancha Junior, Antonio HerbertPainelli, Vitor de Sallesinfo:eu-repo/semantics/openAccess2018-12-05T09:05:58Zoai:periodicos.ufsc.br:article/36471Revistahttps://periodicos.ufsc.br/index.php/rbcdh/PUBhttps://periodicos.ufsc.br/index.php/rbcdh/oairbcdh@contato.ufsc.br || portaldeperiodicos.bu@contato.ufsc.br1980-00371415-8426opendoar:2018-12-05T09:05:58Revista Brasileira de Cineantropometria & Desempenho Humano (Online) - Universidade Federal de Santa Catarina (UFSC)false
dc.title.none.fl_str_mv Can leucine supplementation attenuate muscle atrophy? A literature review
A suplementação de leucina pode atenuar a atrofia muscular? Uma revisão da literatura
title Can leucine supplementation attenuate muscle atrophy? A literature review
spellingShingle Can leucine supplementation attenuate muscle atrophy? A literature review
Do Amaral, Rafael Bruno
title_short Can leucine supplementation attenuate muscle atrophy? A literature review
title_full Can leucine supplementation attenuate muscle atrophy? A literature review
title_fullStr Can leucine supplementation attenuate muscle atrophy? A literature review
title_full_unstemmed Can leucine supplementation attenuate muscle atrophy? A literature review
title_sort Can leucine supplementation attenuate muscle atrophy? A literature review
author Do Amaral, Rafael Bruno
author_facet Do Amaral, Rafael Bruno
Martins, Carlos Eduardo Carvalho
Lancha Junior, Antonio Herbert
Painelli, Vitor de Salles
author_role author
author2 Martins, Carlos Eduardo Carvalho
Lancha Junior, Antonio Herbert
Painelli, Vitor de Salles
author2_role author
author
author
dc.contributor.author.fl_str_mv Do Amaral, Rafael Bruno
Martins, Carlos Eduardo Carvalho
Lancha Junior, Antonio Herbert
Painelli, Vitor de Salles
description Currently, there has been new expectations in studying strategies with the potential to mitigate the skeletal muscle atrophy that characterizes conditions such as aging, disuse, cancer, and the use of certain medications. Among them, amino acid leucine has received special attention due to its potential to stimulate specific pathways of protein synthesis in skeletal muscle. Due to the wide spread use of this amino acid by the media, several studies have been aimed at investigating the possible effectiveness of leucine against skeletal muscle atrophy. As a result, this literature review was aimed to analyze recent studies that investigated the effects of leucine supplementation on skeletal muscle atrophy in both humans and animals. Overall, the wide variations in the experimental designs developed, models studied, leucine dose, treatment duration and sample healthiness make it difficult for professionals and researchers to establish guidelines about possible therapeutic effectiveness of this nutritional strategy.
publishDate 2015
dc.date.none.fl_str_mv 2015-07-08
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
"Avaliado por Pares","Artigo Solicitado"
"Avaliado por Pares", "Artigo Solicitado"
Revisão de literatura
info:eu-repo/semantics/other
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.ufsc.br/index.php/rbcdh/article/view/1980-0037.2015v17n4p496
10.1590/1980-0037.2015v17n4p496
url https://periodicos.ufsc.br/index.php/rbcdh/article/view/1980-0037.2015v17n4p496
identifier_str_mv 10.1590/1980-0037.2015v17n4p496
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://periodicos.ufsc.br/index.php/rbcdh/article/view/1980-0037.2015v17n4p496/29642
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Federal de Santa Catarina. Florianópolis, SC. Brasil
publisher.none.fl_str_mv Universidade Federal de Santa Catarina. Florianópolis, SC. Brasil
dc.source.none.fl_str_mv Brazilian Journal of Kinanthropometry and Human Performance; Vol. 17 No. 4 (2015); 496-506
Revista Brasileira de Cineantropometria e Desempenho Humano; v. 17 n. 4 (2015); 496-506
1980-0037
1415-8426
reponame:Revista Brasileira de Cineantropometria & Desempenho Humano (Online)
instname:Universidade Federal de Santa Catarina (UFSC)
instacron:UFSC
instname_str Universidade Federal de Santa Catarina (UFSC)
instacron_str UFSC
institution UFSC
reponame_str Revista Brasileira de Cineantropometria & Desempenho Humano (Online)
collection Revista Brasileira de Cineantropometria & Desempenho Humano (Online)
repository.name.fl_str_mv Revista Brasileira de Cineantropometria & Desempenho Humano (Online) - Universidade Federal de Santa Catarina (UFSC)
repository.mail.fl_str_mv rbcdh@contato.ufsc.br || portaldeperiodicos.bu@contato.ufsc.br
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