Effects of enteral glutamine treatment on animal model of sepsis

• Autor(a) principal: Sulzbacher, Maicon Machado
• Data de Publicação: 2018
• Outros Autores: Santos, Analú Bender, Basso, Renan Daniel Bueno, Hirsh, Gabriela Elisa, Ludwig, Mirna Stela, Heck, Thiago Gomes
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Saúde (Santa Maria)
• Texto Completo: https://periodicos.ufsm.br/revistasaude/article/view/31163
• topic: Sepsis; Animal Models; Glutamine; Leukopenia; Sepse; Modelos Animais; Glutamina; Leucopenia

The aim of study was to evaluate the effects of enteral glutamine treatment on clinical parameters in an animal model of sepsis. Were used 24 mice (B6129SF2/J) in two experiments: First 11 mice were divided into three groups to evaluate the animal model better to simulate the sepsis. Animals received saline (control) or faecal solution 10 or 20% (i.p), and were evaluated glycaemia and rectal temperature for 24h. Second 13 mice were divided into: Control, Sepsis, Glutamine and Sepsis+Glutamine. Glutamine was administered by gavage (1 g/kg) each 4h for 47h. Glycaemia, rectal temperature, leukocyte count and body weight was evaluated. Results: The administration of 20% faecal solution induced hypodynamic phase of sepsis with hypothermia, hypoglycaemia and low leukocyte count. The treatment with glutamine avoids the decrease in leukocyte. Conclusion: Since the immune response is essential in sepsis, the use of glutamine can be useful as adjuvant therapy in sepsis.