Safety of the novel influenza viral vector Brucella abortus vaccine in pregnant heifers

Detalhes bibliográficos
Autor(a) principal: Tabynov,Kaissar
Data de Publicação: 2016
Outros Autores: Ryskeldinova,Sholpan, Kydyrbayev,Zhailaubay, Sansyzbay,Abylai
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Ciência Rural
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782016000100114
Resumo: ABSTRACT: The present study provides the first information about the safety of a new influenza viral vector vaccine expressing the Brucella ribosomal protein L7/L12 or Omp16 containing the adjuvant Montanide Gel01 in pregnant heifers. Immunization of pregnant heifers was conducted via the conjunctival (n=10) or subcutaneous (n=10) route using cross prime and booster vaccination schedules at an interval of 28 days. The vector vaccine was evaluated in comparison with positive control groups vaccinated with B. abortus S19 (n=10) or B. abortus RB51 (n=10) and a negative (PBS+Montanide Gel01; n=10) control group. Clinical studies, thermometry, assessment of local reactogenicity and observation of abortion showed that the vector vaccine via the conjunctival or subcutaneous route was completely safe for pregnant heifers compared to the commercial vaccines B. abortus S19 or B. abortus RB51. The only single adverse event was the formation of infiltration at the site of subcutaneous injection; this reaction was not observed for the conjunctival route.
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spelling Safety of the novel influenza viral vector Brucella abortus vaccine in pregnant heifersBrucella abortusvaccineinfluenza viral vectorsafetypregnant heiferthermometryreactogenicityabortionABSTRACT: The present study provides the first information about the safety of a new influenza viral vector vaccine expressing the Brucella ribosomal protein L7/L12 or Omp16 containing the adjuvant Montanide Gel01 in pregnant heifers. Immunization of pregnant heifers was conducted via the conjunctival (n=10) or subcutaneous (n=10) route using cross prime and booster vaccination schedules at an interval of 28 days. The vector vaccine was evaluated in comparison with positive control groups vaccinated with B. abortus S19 (n=10) or B. abortus RB51 (n=10) and a negative (PBS+Montanide Gel01; n=10) control group. Clinical studies, thermometry, assessment of local reactogenicity and observation of abortion showed that the vector vaccine via the conjunctival or subcutaneous route was completely safe for pregnant heifers compared to the commercial vaccines B. abortus S19 or B. abortus RB51. The only single adverse event was the formation of infiltration at the site of subcutaneous injection; this reaction was not observed for the conjunctival route.Universidade Federal de Santa Maria2016-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782016000100114Ciência Rural v.46 n.1 2016reponame:Ciência Ruralinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSM10.1590/0103-8478cr20150497info:eu-repo/semantics/openAccessTabynov,KaissarRyskeldinova,SholpanKydyrbayev,ZhailaubaySansyzbay,Abylaieng2016-01-20T00:00:00ZRevista
dc.title.none.fl_str_mv Safety of the novel influenza viral vector Brucella abortus vaccine in pregnant heifers
title Safety of the novel influenza viral vector Brucella abortus vaccine in pregnant heifers
spellingShingle Safety of the novel influenza viral vector Brucella abortus vaccine in pregnant heifers
Tabynov,Kaissar
Brucella abortus
vaccine
influenza viral vector
safety
pregnant heifer
thermometry
reactogenicity
abortion
title_short Safety of the novel influenza viral vector Brucella abortus vaccine in pregnant heifers
title_full Safety of the novel influenza viral vector Brucella abortus vaccine in pregnant heifers
title_fullStr Safety of the novel influenza viral vector Brucella abortus vaccine in pregnant heifers
title_full_unstemmed Safety of the novel influenza viral vector Brucella abortus vaccine in pregnant heifers
title_sort Safety of the novel influenza viral vector Brucella abortus vaccine in pregnant heifers
author Tabynov,Kaissar
author_facet Tabynov,Kaissar
Ryskeldinova,Sholpan
Kydyrbayev,Zhailaubay
Sansyzbay,Abylai
author_role author
author2 Ryskeldinova,Sholpan
Kydyrbayev,Zhailaubay
Sansyzbay,Abylai
author2_role author
author
author
dc.contributor.author.fl_str_mv Tabynov,Kaissar
Ryskeldinova,Sholpan
Kydyrbayev,Zhailaubay
Sansyzbay,Abylai
dc.subject.por.fl_str_mv Brucella abortus
vaccine
influenza viral vector
safety
pregnant heifer
thermometry
reactogenicity
abortion
topic Brucella abortus
vaccine
influenza viral vector
safety
pregnant heifer
thermometry
reactogenicity
abortion
description ABSTRACT: The present study provides the first information about the safety of a new influenza viral vector vaccine expressing the Brucella ribosomal protein L7/L12 or Omp16 containing the adjuvant Montanide Gel01 in pregnant heifers. Immunization of pregnant heifers was conducted via the conjunctival (n=10) or subcutaneous (n=10) route using cross prime and booster vaccination schedules at an interval of 28 days. The vector vaccine was evaluated in comparison with positive control groups vaccinated with B. abortus S19 (n=10) or B. abortus RB51 (n=10) and a negative (PBS+Montanide Gel01; n=10) control group. Clinical studies, thermometry, assessment of local reactogenicity and observation of abortion showed that the vector vaccine via the conjunctival or subcutaneous route was completely safe for pregnant heifers compared to the commercial vaccines B. abortus S19 or B. abortus RB51. The only single adverse event was the formation of infiltration at the site of subcutaneous injection; this reaction was not observed for the conjunctival route.
publishDate 2016
dc.date.none.fl_str_mv 2016-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782016000100114
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782016000100114
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0103-8478cr20150497
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Universidade Federal de Santa Maria
publisher.none.fl_str_mv Universidade Federal de Santa Maria
dc.source.none.fl_str_mv Ciência Rural v.46 n.1 2016
reponame:Ciência Rural
instname:Universidade Federal de Santa Maria (UFSM)
instacron:UFSM
instname_str Universidade Federal de Santa Maria (UFSM)
instacron_str UFSM
institution UFSM
reponame_str Ciência Rural
collection Ciência Rural
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1749140548581588992

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