Lissencephaly and cerebellar hypoplasia in a goat
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Ciência Rural |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782013001000020 |
Resumo: | A case of lissencephaly and cerebellar hypoplasia was observed in a 30-day-old goat. The goat presented with sternal recumbence, absence of a menace response, intention tremors, ataxia, and nystagmus. The goat was euthanized and necropsied after having been hospitalised for eleven days. At necropsy, the surface of the brain was found to be smooth, the cerebral sulci and gyri were absent, and the cerebellum was reduced in size. Histologically, the grey matter and white matter were thicker and thinner than normal in cortices, respectively. The neurons were randomly arranged in the grey matter. In the cerebellum, the layers were disorganised, and cells were heterotopics. The histologic and gross lesions observed in this animal are characteristic of lissencephaly associated with cerebellar hypoplasia. The presence of a single goat affected suggests that the malformation was not of infectious origin and because lissencephaly is a malformation not previously described in goats, it is unlikely this case was inherited. |
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Lissencephaly and cerebellar hypoplasia in a goatagyria, cerebellar hypoplasiagoatmalformationsA case of lissencephaly and cerebellar hypoplasia was observed in a 30-day-old goat. The goat presented with sternal recumbence, absence of a menace response, intention tremors, ataxia, and nystagmus. The goat was euthanized and necropsied after having been hospitalised for eleven days. At necropsy, the surface of the brain was found to be smooth, the cerebral sulci and gyri were absent, and the cerebellum was reduced in size. Histologically, the grey matter and white matter were thicker and thinner than normal in cortices, respectively. The neurons were randomly arranged in the grey matter. In the cerebellum, the layers were disorganised, and cells were heterotopics. The histologic and gross lesions observed in this animal are characteristic of lissencephaly associated with cerebellar hypoplasia. The presence of a single goat affected suggests that the malformation was not of infectious origin and because lissencephaly is a malformation not previously described in goats, it is unlikely this case was inherited.Universidade Federal de Santa Maria2013-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782013001000020Ciência Rural v.43 n.10 2013reponame:Ciência Ruralinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSM10.1590/S0103-84782013001000020info:eu-repo/semantics/openAccessSantos,José Rômulo Soares dosDantas,Antônio Flavio MedeirosPessoa,Clarice Ricardo MacedoSilva,Tatiane RodriguesSimões,Sara Vilar DantasCorrea,Franklin RietPedrosa,Danieleng2013-09-13T00:00:00ZRevista |
dc.title.none.fl_str_mv |
Lissencephaly and cerebellar hypoplasia in a goat |
title |
Lissencephaly and cerebellar hypoplasia in a goat |
spellingShingle |
Lissencephaly and cerebellar hypoplasia in a goat Santos,José Rômulo Soares dos agyria, cerebellar hypoplasia goat malformations |
title_short |
Lissencephaly and cerebellar hypoplasia in a goat |
title_full |
Lissencephaly and cerebellar hypoplasia in a goat |
title_fullStr |
Lissencephaly and cerebellar hypoplasia in a goat |
title_full_unstemmed |
Lissencephaly and cerebellar hypoplasia in a goat |
title_sort |
Lissencephaly and cerebellar hypoplasia in a goat |
author |
Santos,José Rômulo Soares dos |
author_facet |
Santos,José Rômulo Soares dos Dantas,Antônio Flavio Medeiros Pessoa,Clarice Ricardo Macedo Silva,Tatiane Rodrigues Simões,Sara Vilar Dantas Correa,Franklin Riet Pedrosa,Daniel |
author_role |
author |
author2 |
Dantas,Antônio Flavio Medeiros Pessoa,Clarice Ricardo Macedo Silva,Tatiane Rodrigues Simões,Sara Vilar Dantas Correa,Franklin Riet Pedrosa,Daniel |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Santos,José Rômulo Soares dos Dantas,Antônio Flavio Medeiros Pessoa,Clarice Ricardo Macedo Silva,Tatiane Rodrigues Simões,Sara Vilar Dantas Correa,Franklin Riet Pedrosa,Daniel |
dc.subject.por.fl_str_mv |
agyria, cerebellar hypoplasia goat malformations |
topic |
agyria, cerebellar hypoplasia goat malformations |
description |
A case of lissencephaly and cerebellar hypoplasia was observed in a 30-day-old goat. The goat presented with sternal recumbence, absence of a menace response, intention tremors, ataxia, and nystagmus. The goat was euthanized and necropsied after having been hospitalised for eleven days. At necropsy, the surface of the brain was found to be smooth, the cerebral sulci and gyri were absent, and the cerebellum was reduced in size. Histologically, the grey matter and white matter were thicker and thinner than normal in cortices, respectively. The neurons were randomly arranged in the grey matter. In the cerebellum, the layers were disorganised, and cells were heterotopics. The histologic and gross lesions observed in this animal are characteristic of lissencephaly associated with cerebellar hypoplasia. The presence of a single goat affected suggests that the malformation was not of infectious origin and because lissencephaly is a malformation not previously described in goats, it is unlikely this case was inherited. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782013001000020 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782013001000020 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0103-84782013001000020 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Universidade Federal de Santa Maria |
publisher.none.fl_str_mv |
Universidade Federal de Santa Maria |
dc.source.none.fl_str_mv |
Ciência Rural v.43 n.10 2013 reponame:Ciência Rural instname:Universidade Federal de Santa Maria (UFSM) instacron:UFSM |
instname_str |
Universidade Federal de Santa Maria (UFSM) |
instacron_str |
UFSM |
institution |
UFSM |
reponame_str |
Ciência Rural |
collection |
Ciência Rural |
repository.name.fl_str_mv |
|
repository.mail.fl_str_mv |
|
_version_ |
1749140543779110912 |